DK151018C - Analogifremgangsmaade til fremstilling af benzoxazolyl- eller benzthiazolyl-4,5-dihydro-3(2h)-pyridazinoner eller deres optisk aktive antipoder eller deres additionssalte med syrer eller baser - Google Patents
Analogifremgangsmaade til fremstilling af benzoxazolyl- eller benzthiazolyl-4,5-dihydro-3(2h)-pyridazinoner eller deres optisk aktive antipoder eller deres additionssalte med syrer eller baserInfo
- Publication number
- DK151018C DK151018C DK073781A DK73781A DK151018C DK 151018 C DK151018 C DK 151018C DK 073781 A DK073781 A DK 073781A DK 73781 A DK73781 A DK 73781A DK 151018 C DK151018 C DK 151018C
- Authority
- DK
- Denmark
- Prior art keywords
- carbon atoms
- substituted
- group
- general formula
- hydrogen atom
- Prior art date
Links
- 239000002253 acid Substances 0.000 title abstract 4
- 150000003839 salts Chemical class 0.000 title abstract 4
- -1 BENZOXAZOLYL Chemical class 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 3
- 150000007513 acids Chemical class 0.000 title 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 18
- 125000000217 alkyl group Chemical group 0.000 abstract 10
- 125000003545 alkoxy group Chemical group 0.000 abstract 8
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 7
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 4
- KZBUYRJDOAKODT-UHFFFAOYSA-N Chlorine Chemical compound ClCl KZBUYRJDOAKODT-UHFFFAOYSA-N 0.000 abstract 4
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 4
- 229910052801 chlorine Inorganic materials 0.000 abstract 4
- 239000000460 chlorine Substances 0.000 abstract 4
- 229910052731 fluorine Inorganic materials 0.000 abstract 4
- 239000011737 fluorine Substances 0.000 abstract 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 3
- 150000007522 mineralic acids Chemical class 0.000 abstract 3
- 150000007524 organic acids Chemical class 0.000 abstract 3
- 235000005985 organic acids Nutrition 0.000 abstract 3
- 150000000183 1,3-benzoxazoles Chemical class 0.000 abstract 2
- OAKJQQAXSVQMHS-UHFFFAOYSA-N Hydrazine Chemical compound NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 abstract 2
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 2
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 230000029936 alkylation Effects 0.000 abstract 1
- 238000005804 alkylation reaction Methods 0.000 abstract 1
- 150000001408 amides Chemical class 0.000 abstract 1
- 150000001735 carboxylic acids Chemical class 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 150000004820 halides Chemical class 0.000 abstract 1
- 238000000926 separation method Methods 0.000 abstract 1
- 150000007970 thio esters Chemical class 0.000 abstract 1
- 125000003396 thiol group Chemical group [H]S* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
- C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
- C07C205/56—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups bound to carbon atoms of six-membered aromatic rings and carboxyl groups bound to acyclic carbon atoms of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/76—Unsaturated compounds containing keto groups
- C07C59/84—Unsaturated compounds containing keto groups containing six membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/04—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having less than three double bonds between ring members or between ring members and non-ring members
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Hospice & Palliative Care (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Steroid Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Polymerisation Methods In General (AREA)
- Eyeglasses (AREA)
- Macromonomer-Based Addition Polymer (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19803006671 DE3006671A1 (de) | 1980-02-22 | 1980-02-22 | Neue benzoxazole, deren herstellung und deren verwendung als arzneumittel |
| DE3006671 | 1980-02-22 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| DK73781A DK73781A (da) | 1981-08-23 |
| DK151018B DK151018B (da) | 1987-10-12 |
| DK151018C true DK151018C (da) | 1988-06-20 |
Family
ID=6095308
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK073781A DK151018C (da) | 1980-02-22 | 1981-02-19 | Analogifremgangsmaade til fremstilling af benzoxazolyl- eller benzthiazolyl-4,5-dihydro-3(2h)-pyridazinoner eller deres optisk aktive antipoder eller deres additionssalte med syrer eller baser |
Country Status (19)
| Country | Link |
|---|---|
| EP (1) | EP0034743B1 (enExample) |
| JP (1) | JPS56131581A (enExample) |
| AT (1) | ATE7696T1 (enExample) |
| AU (1) | AU543524B2 (enExample) |
| CA (1) | CA1166252A (enExample) |
| DE (2) | DE3006671A1 (enExample) |
| DK (1) | DK151018C (enExample) |
| ES (3) | ES499378A0 (enExample) |
| FI (1) | FI73426C (enExample) |
| GR (1) | GR74154B (enExample) |
| HK (1) | HK50785A (enExample) |
| IE (1) | IE51012B1 (enExample) |
| IL (1) | IL62181A (enExample) |
| NO (1) | NO157895C (enExample) |
| NZ (1) | NZ196313A (enExample) |
| PH (1) | PH21232A (enExample) |
| PT (1) | PT72546B (enExample) |
| SG (1) | SG885G (enExample) |
| ZA (1) | ZA811130B (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1199027A (en) * | 1981-11-12 | 1986-01-07 | Stuart D. Mills | Heterocyclic derivatives of pyridazinone, thiadiazinone, oxadiazinone and triazinone |
| JPH11503110A (ja) * | 1995-02-17 | 1999-03-23 | スミスクライン・ビーチャム・コーポレイション | Ｉｌ−８受容体拮抗剤 |
| US6211373B1 (en) | 1996-03-20 | 2001-04-03 | Smithkline Beecham Corporation | Phenyl urea antagonists of the IL-8 receptor |
| US6262113B1 (en) | 1996-03-20 | 2001-07-17 | Smithkline Beecham Corporation | IL-8 receptor antagonists |
| WO1997049286A1 (en) | 1996-06-27 | 1997-12-31 | Smithkline Beecham Corporation | Il-8 receptor antagonists |
| CZ425598A3 (cs) * | 1996-06-27 | 1999-08-11 | Smithkline Beecham Corporation | Antagonista IL-8 receptoru |
| UY32138A (es) | 2008-09-25 | 2010-04-30 | Boehringer Ingelheim Int | Amidas sustituidas del ácido 2-(2,6-dicloro-fenilamino)-6-fluoro-1-metil-1h-bencimidazol-5-carboxílico y sus sales farmacéuticamente aceptables |
| UY32470A (es) | 2009-03-05 | 2010-10-29 | Boehringer Ingelheim Int | Derivados de 2-{2-cloro-5-[(sustituido) metil]fenilamino} -1-metil]fenilamino}-1-metilbencimidazol-5-carboxamidas-n-(sustituidas) y sus sales fisiológicamente aceptables, composiciones conteniéndolos y aplicaciones |
| US8759537B2 (en) | 2010-08-20 | 2014-06-24 | Boehringer Ingelheim International Gmbh | 3H-imidazo [4, 5-C] pyridine-6-carboxamides as anti-inflammatory agents |
| US8586604B2 (en) | 2010-08-20 | 2013-11-19 | Boehringer Ingelheim International Gmbh | Inhibitors of the microsomal prostaglandin E2 synthase-1 |
| US8466186B2 (en) | 2010-12-10 | 2013-06-18 | Boehringer Ingelheim International Gmbh | Compounds |
| UY33779A (es) | 2010-12-10 | 2012-07-31 | Boehringer Ingelheim Int | ?2-(fenilamino)-1H-bencimidazol-5-carboxamidas novedosas? |
| US8486968B2 (en) | 2010-12-10 | 2013-07-16 | Boehringer Ingelheim International Gmbh | Compounds |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2516040C2 (de) * | 1974-06-10 | 1984-12-20 | Dr. Karl Thomae Gmbh, 7950 Biberach | Benzimidazole, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel |
| DE2436279A1 (de) * | 1974-07-27 | 1976-02-12 | Henkel & Cie Gmbh | Neue benzoxazol-2-yl-substituierte imidazoline und tetrahydropyrimidine, deren herstellung sowie diese enthaltende kosmetische praeparationen |
-
1980
- 1980-02-22 DE DE19803006671 patent/DE3006671A1/de not_active Withdrawn
-
1981
- 1981-02-09 AT AT81100890T patent/ATE7696T1/de active
- 1981-02-09 EP EP81100890A patent/EP0034743B1/de not_active Expired
- 1981-02-09 DE DE8181100890T patent/DE3163797D1/de not_active Expired
- 1981-02-12 ES ES499378A patent/ES499378A0/es active Granted
- 1981-02-19 GR GR64191A patent/GR74154B/el unknown
- 1981-02-19 DK DK073781A patent/DK151018C/da not_active IP Right Cessation
- 1981-02-20 CA CA000371339A patent/CA1166252A/en not_active Expired
- 1981-02-20 IL IL62181A patent/IL62181A/xx unknown
- 1981-02-20 AU AU67519/81A patent/AU543524B2/en not_active Ceased
- 1981-02-20 ZA ZA00811130A patent/ZA811130B/xx unknown
- 1981-02-20 PH PH25242A patent/PH21232A/en unknown
- 1981-02-20 NZ NZ196313A patent/NZ196313A/xx unknown
- 1981-02-20 IE IE343/81A patent/IE51012B1/en not_active IP Right Cessation
- 1981-02-20 NO NO810586A patent/NO157895C/no unknown
- 1981-02-20 PT PT72546A patent/PT72546B/pt not_active IP Right Cessation
- 1981-02-20 FI FI810535A patent/FI73426C/fi not_active IP Right Cessation
- 1981-02-20 JP JP2323281A patent/JPS56131581A/ja active Granted
-
1982
- 1982-02-12 ES ES509532A patent/ES8302699A1/es not_active Expired
- 1982-02-12 ES ES509533A patent/ES8302700A1/es not_active Expired
-
1985
- 1985-01-04 SG SG8/85A patent/SG885G/en unknown
- 1985-07-04 HK HK507/85A patent/HK50785A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JPS6334154B2 (enExample) | 1988-07-08 |
| DE3163797D1 (en) | 1984-07-05 |
| ES8206519A1 (es) | 1982-08-16 |
| JPS56131581A (en) | 1981-10-15 |
| IL62181A (en) | 1984-10-31 |
| FI73426B (fi) | 1987-06-30 |
| SG885G (en) | 1985-11-15 |
| DK151018B (da) | 1987-10-12 |
| CA1166252A (en) | 1984-04-24 |
| IE51012B1 (en) | 1986-09-03 |
| ES509533A0 (es) | 1983-01-16 |
| EP0034743B1 (de) | 1984-05-30 |
| ES509532A0 (es) | 1983-01-16 |
| GR74154B (enExample) | 1984-06-06 |
| IE810343L (en) | 1981-08-22 |
| NO157895B (no) | 1988-02-29 |
| NZ196313A (en) | 1984-07-06 |
| FI810535L (fi) | 1981-08-23 |
| IL62181A0 (en) | 1981-03-31 |
| HK50785A (en) | 1985-07-12 |
| NO810586L (no) | 1981-08-24 |
| FI73426C (fi) | 1987-10-09 |
| ES8302699A1 (es) | 1983-01-16 |
| PT72546B (de) | 1982-10-21 |
| DK73781A (da) | 1981-08-23 |
| ES8302700A1 (es) | 1983-01-16 |
| PT72546A (de) | 1981-03-01 |
| ES499378A0 (es) | 1982-08-16 |
| DE3006671A1 (de) | 1981-08-27 |
| PH21232A (en) | 1987-08-21 |
| ATE7696T1 (de) | 1984-06-15 |
| EP0034743A1 (de) | 1981-09-02 |
| NO157895C (no) | 1988-06-08 |
| ZA811130B (en) | 1982-10-27 |
| AU6751981A (en) | 1981-08-27 |
| AU543524B2 (en) | 1985-04-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PBP | Patent lapsed |