ES8206519A1 - Procedimiento para la preparacion de nuevos benzoxazoles y benzotiazoles - Google Patents
Procedimiento para la preparacion de nuevos benzoxazoles y benzotiazolesInfo
- Publication number
- ES8206519A1 ES8206519A1 ES499378A ES499378A ES8206519A1 ES 8206519 A1 ES8206519 A1 ES 8206519A1 ES 499378 A ES499378 A ES 499378A ES 499378 A ES499378 A ES 499378A ES 8206519 A1 ES8206519 A1 ES 8206519A1
- Authority
- ES
- Spain
- Prior art keywords
- carbon atoms
- substituted
- group
- general formula
- hydrogen atom
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
- C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
- C07C205/56—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups bound to carbon atoms of six-membered aromatic rings and carboxyl groups bound to acyclic carbon atoms of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/76—Unsaturated compounds containing keto groups
- C07C59/84—Unsaturated compounds containing keto groups containing six membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/04—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having less than three double bonds between ring members or between ring members and non-ring members
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Hospice & Palliative Care (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Steroid Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Eyeglasses (AREA)
- Macromonomer-Based Addition Polymer (AREA)
- Polymerisation Methods In General (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE BENZOXAZOLES Y BENZOTIAZOLES, ASI COMO DE SUS ANTIPODAS OPTICAMENTE ACTIVOS Y DE SUS SALES DE ADICION DE ACIDOS Y BASES FISIOLOGICAMENTE COMPATIBLES DE FORMULA (I), EN LA QUE X ES OXIGENO O AZUFRE, R4 Y R5 SON HIDROGENO O ALCOHILO C1-3 Y R1 PUEDE SER UNO DE VARIOS RADICALES. CONSISTE EN LA REACCION DE CICLIZACION DE UN COMPUESTO DE FORMULA (II), EN LA QUE Y ES HIDROGENO O ACILO, Z ES UN GRUPO INTERCAMBIABLE DE MODO NUCLEOFILO Y LOS DEMAS SIMBOLOS TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I). LA REACCION SE LLEVA A CABO POR CALENTAMIENTO A TEMPERATURAS ENTRE 25 Y 300GC. EN UN DISOLVENTE INERTE, EN PRESENCIA DE UN AGENTE DE CONDENSACION. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS POR SUS EFECTOS CARDIOTONICOS, HIPOTENSORES Y ANTITROMBOTICOS. *FORMULA*
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19803006671 DE3006671A1 (de) | 1980-02-22 | 1980-02-22 | Neue benzoxazole, deren herstellung und deren verwendung als arzneumittel |
Publications (2)
Publication Number | Publication Date |
---|---|
ES8206519A1 true ES8206519A1 (es) | 1982-08-16 |
ES499378A0 ES499378A0 (es) | 1982-08-16 |
Family
ID=6095308
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES499378A Granted ES499378A0 (es) | 1980-02-22 | 1981-02-12 | Procedimiento para la preparacion de nuevos benzoxazoles y benzotiazoles |
ES509533A Expired ES8302700A1 (es) | 1980-02-22 | 1982-02-12 | "procedimiento para la preparacion de nuevos benzoxazoles y benzotiazoles". |
ES509532A Granted ES509532A0 (es) | 1980-02-22 | 1982-02-12 | Procedimiento para la preparacion de nuevos benzoxazoles y benzotiazoles. |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES509533A Expired ES8302700A1 (es) | 1980-02-22 | 1982-02-12 | "procedimiento para la preparacion de nuevos benzoxazoles y benzotiazoles". |
ES509532A Granted ES509532A0 (es) | 1980-02-22 | 1982-02-12 | Procedimiento para la preparacion de nuevos benzoxazoles y benzotiazoles. |
Country Status (19)
Country | Link |
---|---|
EP (1) | EP0034743B1 (es) |
JP (1) | JPS56131581A (es) |
AT (1) | ATE7696T1 (es) |
AU (1) | AU543524B2 (es) |
CA (1) | CA1166252A (es) |
DE (2) | DE3006671A1 (es) |
DK (1) | DK151018C (es) |
ES (3) | ES499378A0 (es) |
FI (1) | FI73426C (es) |
GR (1) | GR74154B (es) |
HK (1) | HK50785A (es) |
IE (1) | IE51012B1 (es) |
IL (1) | IL62181A (es) |
NO (1) | NO157895C (es) |
NZ (1) | NZ196313A (es) |
PH (1) | PH21232A (es) |
PT (1) | PT72546B (es) |
SG (1) | SG885G (es) |
ZA (1) | ZA811130B (es) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1199027A (en) * | 1981-11-12 | 1986-01-07 | Stuart D. Mills | Heterocyclic derivatives of pyridazinone, thiadiazinone, oxadiazinone and triazinone |
WO1996025157A1 (en) | 1995-02-17 | 1996-08-22 | Smithkline Beecham Corporation | Il-8 receptor antagonists |
US6262113B1 (en) | 1996-03-20 | 2001-07-17 | Smithkline Beecham Corporation | IL-8 receptor antagonists |
US6211373B1 (en) | 1996-03-20 | 2001-04-03 | Smithkline Beecham Corporation | Phenyl urea antagonists of the IL-8 receptor |
AU3499497A (en) | 1996-06-27 | 1998-01-14 | Smithkline Beecham Corporation | Il-8 receptor antagonists |
TR199802694T2 (xx) * | 1996-06-27 | 1999-03-22 | Smithkline Beecham Corporation | IL-8 resept�r kar��tlar� |
UY32138A (es) | 2008-09-25 | 2010-04-30 | Boehringer Ingelheim Int | Amidas sustituidas del ácido 2-(2,6-dicloro-fenilamino)-6-fluoro-1-metil-1h-bencimidazol-5-carboxílico y sus sales farmacéuticamente aceptables |
UY32470A (es) | 2009-03-05 | 2010-10-29 | Boehringer Ingelheim Int | Derivados de 2-{2-cloro-5-[(sustituido) metil]fenilamino} -1-metil]fenilamino}-1-metilbencimidazol-5-carboxamidas-n-(sustituidas) y sus sales fisiológicamente aceptables, composiciones conteniéndolos y aplicaciones |
US8586604B2 (en) | 2010-08-20 | 2013-11-19 | Boehringer Ingelheim International Gmbh | Inhibitors of the microsomal prostaglandin E2 synthase-1 |
US8759537B2 (en) | 2010-08-20 | 2014-06-24 | Boehringer Ingelheim International Gmbh | 3H-imidazo [4, 5-C] pyridine-6-carboxamides as anti-inflammatory agents |
US8674113B2 (en) | 2010-12-10 | 2014-03-18 | Boehringer Ingelheim International Gmbh | Compounds |
US8466186B2 (en) | 2010-12-10 | 2013-06-18 | Boehringer Ingelheim International Gmbh | Compounds |
US8486968B2 (en) | 2010-12-10 | 2013-07-16 | Boehringer Ingelheim International Gmbh | Compounds |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2516040C2 (de) * | 1974-06-10 | 1984-12-20 | Dr. Karl Thomae Gmbh, 7950 Biberach | Benzimidazole, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel |
DE2436279A1 (de) * | 1974-07-27 | 1976-02-12 | Henkel & Cie Gmbh | Neue benzoxazol-2-yl-substituierte imidazoline und tetrahydropyrimidine, deren herstellung sowie diese enthaltende kosmetische praeparationen |
-
1980
- 1980-02-22 DE DE19803006671 patent/DE3006671A1/de not_active Withdrawn
-
1981
- 1981-02-09 EP EP81100890A patent/EP0034743B1/de not_active Expired
- 1981-02-09 DE DE8181100890T patent/DE3163797D1/de not_active Expired
- 1981-02-09 AT AT81100890T patent/ATE7696T1/de active
- 1981-02-12 ES ES499378A patent/ES499378A0/es active Granted
- 1981-02-19 GR GR64191A patent/GR74154B/el unknown
- 1981-02-19 DK DK073781A patent/DK151018C/da not_active IP Right Cessation
- 1981-02-20 FI FI810535A patent/FI73426C/fi not_active IP Right Cessation
- 1981-02-20 PH PH25242A patent/PH21232A/en unknown
- 1981-02-20 NZ NZ196313A patent/NZ196313A/xx unknown
- 1981-02-20 PT PT72546A patent/PT72546B/pt not_active IP Right Cessation
- 1981-02-20 IL IL62181A patent/IL62181A/xx unknown
- 1981-02-20 NO NO810586A patent/NO157895C/no unknown
- 1981-02-20 ZA ZA00811130A patent/ZA811130B/xx unknown
- 1981-02-20 AU AU67519/81A patent/AU543524B2/en not_active Ceased
- 1981-02-20 IE IE343/81A patent/IE51012B1/en not_active IP Right Cessation
- 1981-02-20 JP JP2323281A patent/JPS56131581A/ja active Granted
- 1981-02-20 CA CA000371339A patent/CA1166252A/en not_active Expired
-
1982
- 1982-02-12 ES ES509533A patent/ES8302700A1/es not_active Expired
- 1982-02-12 ES ES509532A patent/ES509532A0/es active Granted
-
1985
- 1985-01-04 SG SG8/85A patent/SG885G/en unknown
- 1985-07-04 HK HK507/85A patent/HK50785A/xx unknown
Also Published As
Publication number | Publication date |
---|---|
HK50785A (en) | 1985-07-12 |
NO157895C (no) | 1988-06-08 |
DK73781A (da) | 1981-08-23 |
JPS56131581A (en) | 1981-10-15 |
ES509533A0 (es) | 1983-01-16 |
PT72546B (de) | 1982-10-21 |
NO810586L (no) | 1981-08-24 |
NO157895B (no) | 1988-02-29 |
FI810535L (fi) | 1981-08-23 |
AU543524B2 (en) | 1985-04-26 |
AU6751981A (en) | 1981-08-27 |
ES499378A0 (es) | 1982-08-16 |
IL62181A0 (en) | 1981-03-31 |
IE51012B1 (en) | 1986-09-03 |
SG885G (en) | 1985-11-15 |
FI73426B (fi) | 1987-06-30 |
GR74154B (es) | 1984-06-06 |
DK151018B (da) | 1987-10-12 |
FI73426C (fi) | 1987-10-09 |
DK151018C (da) | 1988-06-20 |
CA1166252A (en) | 1984-04-24 |
EP0034743B1 (de) | 1984-05-30 |
ES8302699A1 (es) | 1983-01-16 |
EP0034743A1 (de) | 1981-09-02 |
DE3163797D1 (en) | 1984-07-05 |
PH21232A (en) | 1987-08-21 |
IL62181A (en) | 1984-10-31 |
ZA811130B (en) | 1982-10-27 |
PT72546A (de) | 1981-03-01 |
IE810343L (en) | 1981-08-22 |
ES8302700A1 (es) | 1983-01-16 |
DE3006671A1 (de) | 1981-08-27 |
ATE7696T1 (de) | 1984-06-15 |
NZ196313A (en) | 1984-07-06 |
JPS6334154B2 (es) | 1988-07-08 |
ES509532A0 (es) | 1983-01-16 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES8206519A1 (es) | Procedimiento para la preparacion de nuevos benzoxazoles y benzotiazoles | |
IT1200011B (it) | Agente immunomodulante | |
ATE50773T1 (de) | Alkylresorcinolphosphite. | |
HUT34193A (en) | Process for the production of substituted 6-aryl-1,2,4-triazolo/4,3-b/-pyridazin-derivatives and of pharmaceutic products containing such compounds | |
ATE17946T1 (de) | 3-chlor-3-phenylprop-2-en ylthiophosphorsaeureester, verfahren zu ihrer herstellung und ihre verwendung zur bekaempfung von schaedlingen. | |
ATE12039T1 (de) | Substituierte azolyl-glykolsulfonate, diese enthaltende fungizide und verfahren zu ihrer herstellung. | |
ES8403922A1 (es) | "procedimiento para preparar nuevos esteres de acido tiolfosforico" | |
DE3061105D1 (en) | Pyrazolin-5-on-yl-methyl-(di)thiophosphoric acid esters, process for their preparation and their use as pesticides | |
EG15833A (en) | Hemiorthoamide intermediates for production of benzothiazine carboxamides | |
ES8201953A1 (es) | Procedimiento para la preparacion de amidas de aminoalcoho- les y derivados del acido 2-finilpropionico |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 19970203 |