DK150603C - Analogifremgangsmaade til fremstilling af 3-(4-sulfonylphenyl)-oxazolidinonderivater eller farmaceutisk acceptable syre- eller basesalte deraf - Google Patents
Analogifremgangsmaade til fremstilling af 3-(4-sulfonylphenyl)-oxazolidinonderivater eller farmaceutisk acceptable syre- eller basesalte derafInfo
- Publication number
- DK150603C DK150603C DK467281A DK467281A DK150603C DK 150603 C DK150603 C DK 150603C DK 467281 A DK467281 A DK 467281A DK 467281 A DK467281 A DK 467281A DK 150603 C DK150603 C DK 150603C
- Authority
- DK
- Denmark
- Prior art keywords
- derivatives
- sulphonylphenyl
- oxazolidino
- analogue
- preparation
- Prior art date
Links
- -1 4-SULPHONYLPHENYL Chemical class 0.000 title 1
- 239000002253 acid Substances 0.000 title 1
- 150000003839 salts Chemical class 0.000 title 1
- IZXIZTKNFFYFOF-UHFFFAOYSA-N 2-Oxazolidone Chemical class O=C1NCCO1 IZXIZTKNFFYFOF-UHFFFAOYSA-N 0.000 abstract 1
- 208000035143 Bacterial infection Diseases 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 208000022362 bacterial infectious disease Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/18—Oxygen atoms
- C07D263/20—Oxygen atoms attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/18—Oxygen atoms
- C07D263/20—Oxygen atoms attached in position 2
- C07D263/24—Oxygen atoms attached in position 2 with hydrocarbon radicals, substituted by oxygen atoms, attached to other ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/199,698 US4340606A (en) | 1980-10-23 | 1980-10-23 | 3-(p-Alkylsulfonylphenyl)oxazolidinone derivatives as antibacterial agents |
US19969880 | 1980-10-23 |
Publications (3)
Publication Number | Publication Date |
---|---|
DK467281A DK467281A (da) | 1982-04-24 |
DK150603B DK150603B (da) | 1987-04-13 |
DK150603C true DK150603C (da) | 1987-09-28 |
Family
ID=22738648
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK467281A DK150603C (da) | 1980-10-23 | 1981-10-22 | Analogifremgangsmaade til fremstilling af 3-(4-sulfonylphenyl)-oxazolidinonderivater eller farmaceutisk acceptable syre- eller basesalte deraf |
Country Status (8)
Country | Link |
---|---|
US (1) | US4340606A (fr) |
EP (1) | EP0050827B1 (fr) |
JP (1) | JPS5799576A (fr) |
AT (1) | ATE19516T1 (fr) |
CA (1) | CA1167449A (fr) |
DE (1) | DE3174516D1 (fr) |
DK (1) | DK150603C (fr) |
IE (1) | IE52127B1 (fr) |
Families Citing this family (44)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU560666B2 (en) * | 1981-12-04 | 1987-04-16 | E.I. Du Pont De Nemours And Company | P(2-oxo oxazolidinyl)benzene sulphonamides |
US4461773A (en) * | 1982-09-15 | 1984-07-24 | E. I. Dupont De Nemours And Company | P-Oxooxazolidinylbenzene compounds as antibacterial agents |
US4705799A (en) * | 1983-06-07 | 1987-11-10 | E. I. Du Pont De Nemours And Company | Aminomethyl oxooxazolidinyl benzenes useful as antibacterial agents |
ES533097A0 (es) * | 1983-06-07 | 1985-08-01 | Du Pont | Un procedimiento para la preparacion de nuevos derivados del amino-metil-oxooxazolidinil-benzeno. |
JPS60241893A (ja) * | 1984-05-15 | 1985-11-30 | Kanegafuchi Chem Ind Co Ltd | 光学活性(s)―オキサゾリジノン誘導体の製造方法 |
CA1260948A (fr) | 1984-12-05 | 1989-09-26 | E. I. Du Pont De Nemours And Company | Derives d'aminomethyloxo-oxazolidinylbenzene, agents antibacteriens |
CA1323370C (fr) * | 1986-09-12 | 1993-10-19 | Davis H. Crater | Oxazolidinones fluoroaliphatiques |
US5036092A (en) * | 1987-10-09 | 1991-07-30 | Du Pont Merck Pharmaceutical | Aminomethyl oxooxazolidinyl azacycloalkylbenzene derivatives useful as antibacterial agents |
US5032605A (en) * | 1987-10-09 | 1991-07-16 | Du Pont Merck Pharmaceutical Company | Aminomethyl oxooxazolidinyl oxa or thia cycloalkylbenzene derivatives useful as antibacterial agents |
US4921869A (en) * | 1987-10-09 | 1990-05-01 | E. I. Du Pont De Nemours And Company | Aminomethyl oxooxazolidinyl cycloalkylbenzene derivatives useful as antibacterial agents |
US4985429A (en) * | 1987-10-09 | 1991-01-15 | E. I. Du Pont De Nemours And Company | Aminomethyl oxooxazolidinyl cycloalkylbenzene derivatives useful as antibacterial agents |
US5036093A (en) * | 1987-10-09 | 1991-07-30 | Du Pont Merck Pharmaceutical | Aminomethyl oxooxazolidinyl azacycloalkylbenzene derivatives useful as antibacterial agents |
US4965268A (en) * | 1987-10-09 | 1990-10-23 | E. I. Du Pont De Nemours And Company | Aminomethyl oxooxazolidinyl cycloalkylbenzene derivatives useful as antibacterial agents |
US5039690A (en) * | 1987-10-09 | 1991-08-13 | Du Pont Merck Pharmaceutical Company | Aminomethyl oxooxazolidinyl oxa or thia cycloalkylbenzene derivatives useful as antibacterial agents |
US4801600A (en) * | 1987-10-09 | 1989-01-31 | E. I. Du Pont De Nemours And Company | Aminomethyl oxooxazolidinyl cycloalkylbenzene derivatives useful as antibacterial agents |
US4942183A (en) * | 1987-10-16 | 1990-07-17 | E. I. Du Pont De Nemours And Company | Aminomethyl oxooxazolidinyl aroylbenzene derivatives useful as antibacterial agents |
US4977173A (en) * | 1987-10-21 | 1990-12-11 | E. I. Du Pont De Nemours And Company | Aminomethyl oxooxazolidinyl ethenylbenzene derivatives useful as antibacterial agents |
US5254577A (en) * | 1988-07-29 | 1993-10-19 | The Du Pont Merck Pharmaceutical Company | Aminomethyloxooxazolidinyl arylbenzene derivatives useful as antibacterial agents |
US5182403A (en) * | 1988-09-15 | 1993-01-26 | The Upjohn Company | Substituted 3(5'indazolyl) oxazolidin-2-ones |
US5225565A (en) * | 1988-09-15 | 1993-07-06 | The Upjohn Company | Antibacterial 3-(fused-ring substituted)phenyl-5β-amidomethyloxazolidin-2-ones |
US5231188A (en) * | 1989-11-17 | 1993-07-27 | The Upjohn Company | Tricyclic [6.5.51]-fused oxazolidinone antibacterial agents |
DE4119611A1 (de) * | 1991-06-14 | 1992-12-17 | Bayer Ag | Mittel zur bekaempfung von schaedlingen auf basis substituierter oxazolidinone, neue substituierte oxazolidinone, deren herstellung und verwendung |
JP3176626B2 (ja) * | 1991-11-01 | 2001-06-18 | ファルマシア・アンド・アップジョン・カンパニー | 抗菌剤として有用な置換アリール−およびヘテロアリールフェニルオキサゾリジノン類 |
RU2119484C1 (ru) * | 1992-12-08 | 1998-09-27 | Дзе Апджон Компани | Тропонзамещенный фенилоксазолидинон или его фармацевтически приемлемые соли или гидраты |
MX9703040A (es) * | 1995-09-12 | 1997-07-31 | Upjohn Co | Antimicrobianos de feniloxazolidinona. |
ES2166073T3 (es) * | 1996-04-11 | 2002-04-01 | Upjohn Co | Procedimiento para preparar oxazolidinonas. |
CN100387581C (zh) | 1997-11-07 | 2008-05-14 | 法玛西雅厄普约翰美国公司 | 制备唑烷酮的方法 |
US6562844B2 (en) | 1998-01-23 | 2003-05-13 | Pharmacia & Upjohn Company | Oxazolidinone combinatorial libraries, compositions and methods of preparation |
KR20010015910A (ko) | 1998-01-23 | 2001-02-26 | 로렌스 티. 마이젠헬더 | 옥사졸리디논 조합 라이브러리, 조성물 및 제조 방법 |
US7002020B1 (en) | 1998-01-23 | 2006-02-21 | Pharmacia & Upjohn Company | Oxazolidinone combinatorial libraries, compositions and methods of preparation |
WO2000045177A1 (fr) | 1999-01-27 | 2000-08-03 | Pharmacia & Upjohn Company | Dosages de modulateurs de l'activite du facteur d'elongation p |
GB9928568D0 (en) | 1999-12-03 | 2000-02-02 | Zeneca Ltd | Chemical compounds |
GB0009803D0 (en) * | 2000-04-25 | 2000-06-07 | Astrazeneca Ab | Chemical compounds |
ATE321024T1 (de) * | 2000-10-17 | 2006-04-15 | Pharmacia & Upjohn Co Llc | Verfahren zur herstellung von oxazolidinonverbindungen |
CA2464109A1 (fr) * | 2001-10-18 | 2003-12-24 | Michigan State University | Procede pour l'elaboration d'oxazolidinones et procede d'utilisation correspondant |
WO2005035530A1 (fr) | 2003-10-16 | 2005-04-21 | Symed Labs Limited | Nouvelle forme cristalline du linezolid |
KR100854211B1 (ko) * | 2003-12-18 | 2008-08-26 | 동아제약주식회사 | 신규한 옥사졸리디논 유도체, 그의 제조방법 및 이를유효성분으로 하는 항생제용 약학 조성물 |
DE602004009344T2 (de) | 2004-04-19 | 2008-07-10 | Symed Labs Ltd., Hyderabad | Neues verfahren zur herstellung von linezolid und verwandten verbindungen |
EP1768967B1 (fr) * | 2004-07-20 | 2009-04-22 | Symed Labs Limited | Nouveaux intermediaires pour linezolide et composes correspondants |
TWI389897B (zh) | 2005-02-22 | 2013-03-21 | Chugai Pharmaceutical Co Ltd | 1- (2H) -isoquinolinone derivatives |
AU2009303301B2 (en) | 2008-10-10 | 2014-09-11 | Merck Sharp & Dohme Llc | Methods for preparing oxazolidinones and compositions containing them |
KR20170040371A (ko) | 2009-02-03 | 2017-04-12 | 머크 샤프 앤드 돔 코포레이션 | R)-3-(4-(2-(2-메틸테트라졸-5-일)피리딘-5-일)-3-플루오로페닐)-5-히드록시메틸 옥사졸리딘-2-온 디히드로겐 포스페이트의 결정형 |
US8580767B2 (en) * | 2009-05-28 | 2013-11-12 | Trius Therapeutics, Inc. | Oxazolidinone containing dimer compounds, compositions and methods to make and use |
CN106279054A (zh) | 2011-02-24 | 2017-01-04 | 李药业有限公司 | 利奈唑胺及其新中间体的新制备方法 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3546241A (en) * | 1968-05-21 | 1970-12-08 | Dow Chemical Co | N-(alkylsulfinyl) ethyl-pyrrolidinones and oxazolidinones |
FR2356422A1 (fr) * | 1976-03-01 | 1978-01-27 | Delalande Sa | Nouveaux hydroxymethyl-5 oxazolidinone-2, leur procede de preparation et leur application en therapeutique |
FR2380780A2 (fr) | 1977-02-22 | 1978-09-15 | Delalande Sa | Application en therapeutique des hydroxymethyl-5 oxazolidinones-2, notamment comme antidepresseurs |
LU80081A1 (fr) | 1977-08-26 | 1979-05-15 | Delalande Sa | Nouvelles hydroxymethyl-5 oxazolidinones-2,leur procede de preparation et leur application therapeutique |
US4128654A (en) * | 1978-02-10 | 1978-12-05 | E. I. Du Pont De Nemours And Company | 5-Halomethyl-3-phenyl-2-oxazolidinones |
US4348393A (en) * | 1978-06-09 | 1982-09-07 | Delalande S.A. | N-Aryl oxazolidinones, oxazolidinethiones, pyrrolidinones, pyrrolidines and thiazolidinones |
-
1980
- 1980-10-23 US US06/199,698 patent/US4340606A/en not_active Expired - Lifetime
-
1981
- 1981-10-21 EP EP81108603A patent/EP0050827B1/fr not_active Expired
- 1981-10-21 AT AT81108603T patent/ATE19516T1/de not_active IP Right Cessation
- 1981-10-21 DE DE8181108603T patent/DE3174516D1/de not_active Expired
- 1981-10-22 JP JP56167999A patent/JPS5799576A/ja active Granted
- 1981-10-22 IE IE2478/81A patent/IE52127B1/en unknown
- 1981-10-22 DK DK467281A patent/DK150603C/da not_active IP Right Cessation
- 1981-10-22 CA CA000388496A patent/CA1167449A/fr not_active Expired
Also Published As
Publication number | Publication date |
---|---|
EP0050827B1 (fr) | 1986-04-30 |
DK467281A (da) | 1982-04-24 |
JPH0216303B2 (fr) | 1990-04-16 |
DE3174516D1 (en) | 1986-06-05 |
EP0050827A1 (fr) | 1982-05-05 |
US4340606A (en) | 1982-07-20 |
CA1167449A (fr) | 1984-05-15 |
IE52127B1 (en) | 1987-06-24 |
JPS5799576A (en) | 1982-06-21 |
ATE19516T1 (de) | 1986-05-15 |
DK150603B (da) | 1987-04-13 |
IE812478L (en) | 1982-04-23 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PBP | Patent lapsed |