DK149749C - Analogifremgangsmaade til fremstilling af n-alkyl-2-hydroxy-metyl-3,4,5-trihydroxy-piperidinderivater - Google Patents
Analogifremgangsmaade til fremstilling af n-alkyl-2-hydroxy-metyl-3,4,5-trihydroxy-piperidinderivaterInfo
- Publication number
- DK149749C DK149749C DK269178A DK269178A DK149749C DK 149749 C DK149749 C DK 149749C DK 269178 A DK269178 A DK 269178A DK 269178 A DK269178 A DK 269178A DK 149749 C DK149749 C DK 149749C
- Authority
- DK
- Denmark
- Prior art keywords
- ingrediates
- piperide
- trihydroxy
- hydroxy
- alkyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- General Chemical & Material Sciences (AREA)
- Emergency Medicine (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Endocrinology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP7593677 | 1977-06-25 | ||
JP52075936A JPS5943459B2 (ja) | 1977-06-25 | 1977-06-25 | N−アルキルピペリジン誘導体 |
Publications (3)
Publication Number | Publication Date |
---|---|
DK269178A DK269178A (da) | 1978-12-26 |
DK149749B DK149749B (da) | 1986-09-22 |
DK149749C true DK149749C (da) | 1987-03-02 |
Family
ID=13590624
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK269178A DK149749C (da) | 1977-06-25 | 1978-06-15 | Analogifremgangsmaade til fremstilling af n-alkyl-2-hydroxy-metyl-3,4,5-trihydroxy-piperidinderivater |
Country Status (12)
Country | Link |
---|---|
US (1) | US4182767A (sv) |
JP (1) | JPS5943459B2 (sv) |
AT (1) | AT365576B (sv) |
BE (1) | BE868329A (sv) |
CH (1) | CH633264A5 (sv) |
DE (1) | DE2824781C3 (sv) |
DK (1) | DK149749C (sv) |
FR (1) | FR2420529A1 (sv) |
GB (1) | GB1555654A (sv) |
IT (1) | IT1104743B (sv) |
NL (1) | NL176071C (sv) |
SE (1) | SE430333B (sv) |
Families Citing this family (66)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NO154918C (no) * | 1977-08-27 | 1987-01-14 | Bayer Ag | Analogifremgangsmaate til fremstilling av terapeutisk aktive derivater av 3,4,5-trihydroksypiperidin. |
DE2830469A1 (de) * | 1978-07-11 | 1980-01-24 | Bayer Ag | Herstellung von l-desoxy-nojirimycin und n-substituierten derivaten |
DE2835069A1 (de) * | 1978-08-10 | 1980-02-21 | Bayer Ag | N-amino-3,4,5-trihydroxypiperidine, ihre herstellung und verwendung |
DE2839309A1 (de) * | 1978-09-09 | 1980-03-27 | Bayer Ag | 3,4,5-trihydroxypiperidin-derivate |
DE2848117A1 (de) * | 1978-11-06 | 1980-05-14 | Bayer Ag | Derivate des 2-hydroxymethyl-3,4,5- trihydroxy-piperidins, ihre herstellung und verwendung zur beeinflussung des kohlenhydrat- und fettstoffwechsels |
JPS55118415A (en) * | 1979-02-28 | 1980-09-11 | Pii Papahadojiyopo Dometoriosu | Method of encapsulating biologically active substance in lipoid cell |
DE2925943A1 (de) * | 1979-06-27 | 1981-01-29 | Bayer Ag | 1-alkadien-2,4-yl-2-hydroxymethyl3,4,5-trihydroxypiperidine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
DE2942365A1 (de) * | 1979-10-19 | 1981-05-14 | Bayer Ag, 5090 Leverkusen | 2-hydroxyalkyl-3,4,5-trihydroxy-(pi)-peridine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
JPS56108767A (en) * | 1980-01-28 | 1981-08-28 | Nippon Shinyaku Co Ltd | Bismoranoline derivative |
JPS56108768A (en) * | 1980-01-28 | 1981-08-28 | Nippon Shinyaku Co Ltd | Cinnamylmoranoline derivative |
DE3007078A1 (de) * | 1980-02-26 | 1981-09-10 | Bayer Ag, 5090 Leverkusen | Neue derivate von 3,4,5-trihydroxypiperidin, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel sowie in der tierernaehrung |
DE3620645A1 (de) * | 1985-12-20 | 1987-07-02 | Bayer Ag | 3-amino-4,5-dihydroxypiperidine, verfahren zu ihrer herstellung und ihre verwendung |
US5192772A (en) * | 1987-12-09 | 1993-03-09 | Nippon Shinyaku Co. Ltd. | Therapeutic agents |
US5089520A (en) * | 1987-12-21 | 1992-02-18 | Monsanto Company | Method of inhibiting virus |
US4999360A (en) * | 1987-12-21 | 1991-03-12 | Monsanto Company | Method of inhibiting virus |
US4849430A (en) * | 1988-03-09 | 1989-07-18 | Monsanto Company | Method of inhibiting virus |
EP0344383A1 (en) * | 1988-06-02 | 1989-12-06 | Merrell Dow Pharmaceuticals Inc. | Novel alpha-Glucosidase inhibitors |
US5043416A (en) * | 1988-09-26 | 1991-08-27 | Monsanto Company | Method of inhibiting virus |
US5310745A (en) * | 1988-11-03 | 1994-05-10 | G. D. Searle & Co. | Antiviral compounds |
US4937357A (en) * | 1988-11-03 | 1990-06-26 | G. D. Searle & Co. | Intermediates for antiviral compounds |
US5003072A (en) * | 1988-11-03 | 1991-03-26 | G. D. Searle & Co. | 1,5-dideoxy-1,5-imino-D-glucitol derivatives |
US5221746A (en) * | 1988-11-03 | 1993-06-22 | G. D. Searle & Co. | 1,5-dideoxy-1,5-imino-D-glucitol derivatives |
US4876268A (en) * | 1988-11-03 | 1989-10-24 | G. D. Searle & Co. | Antiviral compounds and use thereof |
US5144037A (en) * | 1988-11-03 | 1992-09-01 | G. D. Searle & Co. | 1,5-dideoxy-1,5-imino-d-glucitol derivatives |
US4973602A (en) * | 1988-11-03 | 1990-11-27 | G. D. Searle & Co. | Antiviral compounds and a method of use thereas |
US4957926A (en) * | 1988-12-22 | 1990-09-18 | Monsanto Company | Method of treating herpesviruses |
US5103008A (en) * | 1989-08-17 | 1992-04-07 | Monsanto Company | Compound, N-butyl-deoxynojirimycin-6-phosphate |
US5043273A (en) * | 1989-08-17 | 1991-08-27 | Monsanto Company | Phosphorylated glycosidase inhibitor prodrugs |
US5536732A (en) * | 1990-04-27 | 1996-07-16 | Merrell Pharmaceuticals Inc. | N-derivatives of 1-deoxy nojirimycin |
US5252587A (en) * | 1990-04-27 | 1993-10-12 | Merrell Dow Pharmaceuticals, Inc. | N-derivatives of 1-deoxy nojirimycin |
EP0453692A1 (en) * | 1990-04-27 | 1991-10-30 | Merrell Dow Pharmaceuticals Inc. | Novel nojirimycin derivatives |
US5151519A (en) * | 1990-05-07 | 1992-09-29 | G. D. Searle & Co. | Process for the preparation of 1,5-(alkylimino)-1,5-dideoxy-d-glucitol and derivatives thereof |
US5504078A (en) * | 1990-06-08 | 1996-04-02 | Merrell Dow Pharmaceuticals Inc. | α-glucosidase inhibitors |
US5342951A (en) * | 1992-04-01 | 1994-08-30 | G.D. Searle & Co. | 2- and 3-sulfur derivatives of 1,5-iminosugars |
US5798366A (en) * | 1993-05-13 | 1998-08-25 | Monsanto Company | Method for treatment of CNS-involved lysosomal storage diseases |
US5399567A (en) * | 1993-05-13 | 1995-03-21 | Monsanto Company | Method of treating cholera |
US6291657B1 (en) * | 1993-05-13 | 2001-09-18 | Monsanto Company | Deoxygalactonojirimycin derivatives |
AU1403795A (en) * | 1994-01-13 | 1995-08-01 | G.D. Searle & Co. | Use of n-alkyl derivatives of 1,5-dideoxy-1,5-imino-d-glucitol for the treatment of hepatitis b virus infections |
US20030100532A1 (en) | 1997-02-14 | 2003-05-29 | Gary S. Jacob | Use of n-substituted-1,5-dideoxy-1,5-imino-d-glucitol compounds in combination therapy for treating hepatitis virus infections |
CA2309321A1 (en) | 1997-11-10 | 1999-05-20 | G.D. Searle & Co. | Use of alkylated iminosugars to treat multidrug resistance |
AU762125B2 (en) | 1998-02-12 | 2003-06-19 | G.D. Searle & Co. | Use of (N)-substituted-1,5-dideoxy-1,5-imino-D-glucitol compounds for treating hepatitis virus infections |
US6689759B1 (en) | 1998-02-12 | 2004-02-10 | G. D. Searle & Co. | Methods of Treating hepatitis virus infections with N-substituted-1,5-dideoxy-1,5-imino-d-glucitol compounds in combination therapy |
WO2001008672A2 (en) | 1999-02-12 | 2001-02-08 | G.D. Searle & Co. | Glucamine compounds for treating hepatitis virus infections |
AU3595500A (en) | 1999-02-12 | 2000-08-29 | G.D. Searle & Co. | Use of substituted-1,5-dideoxy-1,5-imino-d-glucitol compounds for treating hepatitis virus infections |
GB9909066D0 (en) | 1999-04-20 | 1999-06-16 | Oxford Glycosciences Uk Ltd | Therapies |
US20050032841A1 (en) * | 1999-04-20 | 2005-02-10 | Steven Walkley | Therapeutic compositions and methods of treating glycolipid storage related disorders |
NZ543741A (en) * | 2003-05-30 | 2009-10-30 | Ranbaxy Lab Ltd | Substituted pyrrole derivatives and their use as HMG-Co inhibitors |
JP2008519840A (ja) * | 2004-11-10 | 2008-06-12 | ジェンザイム・コーポレイション | 糖尿病の処置方法 |
US8026377B2 (en) * | 2005-11-08 | 2011-09-27 | Ranbaxy Laboratories, Limited | Process for (3R, 5R)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-[(4-hydroxy methyl phenyl amino) carbonyl]-pyrrol-1-yl]-3,5-dihydroxy-heptanoic acid hemi calcium salt |
AR059838A1 (es) * | 2006-03-14 | 2008-04-30 | Ranbaxy Lab Ltd | Formulaciones para dosis estabilizantes de estatina |
ES2546181T3 (es) | 2006-05-09 | 2015-09-21 | Genzyme Corporation | Métodos de tratar la enfermedad del hígado graso mediante inhibición de la síntesis de glucoesfingolípidos |
WO2008010087A2 (en) * | 2006-07-14 | 2008-01-24 | Ranbaxy Laboratories Limited | Polymorphic forms of an hmg-coa reductase inhibitor and uses thereof |
JP2010510171A (ja) * | 2006-08-21 | 2010-04-02 | ユナイテッド セラピューティクス コーポレーション | ウイルス感染症の治療のための併用療法 |
US8097728B2 (en) * | 2007-04-30 | 2012-01-17 | Philadelphia Health & Education Corporation | Iminosugar compounds with antiflavirus activity |
EP2167485B1 (en) * | 2007-05-31 | 2015-09-30 | Genzyme Corporation | 2-acylaminopropoanol-type glucosylceramide synthase inhibitors |
MX2010003603A (es) * | 2007-10-05 | 2010-06-02 | Genzyme Corp | Metodo para el tratamiento de enfermedades de riñon poliquisticas con derivados de ceramida. |
CA2731685A1 (en) | 2008-07-28 | 2010-02-04 | Genzyme Corporation | Glucosylceramide synthase inhibition for the treatment of collapsing glomerulopathy and other glomerular disease |
MX2011003517A (es) * | 2008-10-03 | 2011-05-25 | Genzyme Corp | Inhibidores de la glucosilceramida sintasa tipo 2-acilaminopropanol. |
CN102655746B (zh) | 2009-02-23 | 2016-08-03 | 联合治疗公司 | 亚氨基糖以及治疗病毒性疾病的方法 |
KR101787434B1 (ko) * | 2009-02-24 | 2017-11-15 | 유나이티드 세러퓨틱스 코오포레이션 | 이미노슈가 및 아레나바이러스성 감염을 치료하는 방법 |
EP2440205B1 (en) * | 2009-06-12 | 2014-08-27 | United Therapeutics Corporation | Iminosugars for use in the treatment of bunyaviral and togaviral diseases |
KR101459530B1 (ko) * | 2009-09-04 | 2014-11-07 | 유나이티드 세러퓨틱스 코오포레이션 | 폭스바이러스 감염의 치료 방법 |
CN102625796B (zh) * | 2009-09-04 | 2015-03-11 | 联合治疗公司 | 治疗正粘病毒感染的方法 |
CA2772813A1 (en) * | 2009-09-04 | 2011-03-10 | The Chancellor, Masters And Scholars Of The University Of Oxford | Iminosugars and methods of treating filoviral diseases |
US10328061B2 (en) | 2016-05-02 | 2019-06-25 | Florida State University Research Foundation, Inc. | Treatment of Zika virus infections using alpha-glucosidase inhibitors |
EP4106752A4 (en) | 2020-02-21 | 2024-03-20 | Florida State University Research Foundation, Inc. | TREATMENT OF HUMAN CORONAVIRUS INFECTIONS USING ALPHA-GLUCOSIDASE-GLYCOPROTEIN PROCESSING INHIBITORS |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4065562A (en) * | 1975-12-29 | 1977-12-27 | Nippon Shinyaku Co., Ltd. | Method and composition for reducing blood glucose levels |
DE2656602C3 (de) * | 1975-12-29 | 1981-11-26 | Nippon Shinyaku Co., Ltd., Kyoto | Verfahren zum Extrahieren von 2-Hydroxymethyl-3,4,5-trihydroxypiperidin aus Maulbeerpflanzen |
-
1975
- 1975-09-11 GB GB37406/75A patent/GB1555654A/en not_active Expired
-
1977
- 1977-06-25 JP JP52075936A patent/JPS5943459B2/ja not_active Expired
-
1978
- 1978-05-10 SE SE7805329A patent/SE430333B/sv not_active IP Right Cessation
- 1978-05-10 US US05/906,233 patent/US4182767A/en not_active Expired - Lifetime
- 1978-05-16 NL NLAANVRAGE7805253,A patent/NL176071C/xx not_active IP Right Cessation
- 1978-05-22 FR FR7815143A patent/FR2420529A1/fr active Granted
- 1978-06-06 DE DE2824781A patent/DE2824781C3/de not_active Expired
- 1978-06-07 IT IT49760/78A patent/IT1104743B/it active
- 1978-06-15 DK DK269178A patent/DK149749C/da not_active IP Right Cessation
- 1978-06-16 CH CH661178A patent/CH633264A5/de not_active IP Right Cessation
- 1978-06-21 BE BE188742A patent/BE868329A/xx not_active IP Right Cessation
- 1978-06-21 AT AT0451778A patent/AT365576B/de not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
FR2420529B1 (sv) | 1984-10-12 |
FR2420529A1 (fr) | 1979-10-19 |
SE7805329L (sv) | 1978-12-26 |
NL176071B (nl) | 1984-09-17 |
NL176071C (nl) | 1985-02-18 |
DE2824781B2 (sv) | 1980-01-31 |
BE868329A (fr) | 1978-10-16 |
SE430333B (sv) | 1983-11-07 |
IT7849760A0 (it) | 1978-06-07 |
DE2824781A1 (de) | 1979-01-04 |
JPS5943459B2 (ja) | 1984-10-22 |
DK149749B (da) | 1986-09-22 |
GB1555654A (en) | 1979-11-14 |
CH633264A5 (de) | 1982-11-30 |
IT1104743B (it) | 1985-10-28 |
NL7805253A (nl) | 1978-12-28 |
DK269178A (da) | 1978-12-26 |
US4182767A (en) | 1980-01-08 |
JPS5412381A (en) | 1979-01-30 |
AT365576B (de) | 1982-01-25 |
DE2824781C3 (de) | 1980-09-18 |
ATA451778A (de) | 1981-06-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PBP | Patent lapsed |