DK149599C - Fremgangsmaade til fremstilling af aminosukkerderivater kaldet trestatina, trestatin b og trestatin c eller salte deraf - Google Patents

Fremgangsmaade til fremstilling af aminosukkerderivater kaldet trestatina, trestatin b og trestatin c eller salte deraf

Info

Publication number
DK149599C
DK149599C DK61179A DK61179A DK149599C DK 149599 C DK149599 C DK 149599C DK 61179 A DK61179 A DK 61179A DK 61179 A DK61179 A DK 61179A DK 149599 C DK149599 C DK 149599C
Authority
DK
Denmark
Prior art keywords
trestatin
trestatina
salts
procedure
preparation
Prior art date
Application number
DK61179A
Other languages
Danish (da)
English (en)
Other versions
DK61179A (da
DK149599B (da
Inventor
Yasuji Suhara
Kiyoshi Ogawa
Kazuteru Yokose
Kimihiro Watanabe
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of DK61179A publication Critical patent/DK61179A/da
Publication of DK149599B publication Critical patent/DK149599B/da
Application granted granted Critical
Publication of DK149599C publication Critical patent/DK149599C/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20Carbocyclic rings
    • C07H15/22Cyclohexane rings, substituted by nitrogen atoms
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/99Enzyme inactivation by chemical treatment
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00Preparation of compounds containing saccharide radicals
    • C12P19/26Preparation of nitrogen-containing carbohydrates

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Saccharide Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DK61179A 1978-02-14 1979-02-13 Fremgangsmaade til fremstilling af aminosukkerderivater kaldet trestatina, trestatin b og trestatin c eller salte deraf DK149599C (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB583478 1978-02-14
GB583478 1978-02-14

Publications (3)

Publication Number Publication Date
DK61179A DK61179A (da) 1979-08-15
DK149599B DK149599B (da) 1986-08-04
DK149599C true DK149599C (da) 1987-06-01

Family

ID=9803510

Family Applications (1)

Application Number Title Priority Date Filing Date
DK61179A DK149599C (da) 1978-02-14 1979-02-13 Fremgangsmaade til fremstilling af aminosukkerderivater kaldet trestatina, trestatin b og trestatin c eller salte deraf

Country Status (26)

Country Link
US (1) US4273765A (xx)
EP (1) EP0003616B1 (xx)
JP (1) JPS54163511A (xx)
AR (1) AR219150A1 (xx)
AT (1) AT367451B (xx)
AU (1) AU527318B2 (xx)
CA (1) CA1121290A (xx)
DE (2) DE2905649A1 (xx)
DK (1) DK149599C (xx)
ES (1) ES477653A1 (xx)
FI (1) FI63062C (xx)
FR (1) FR2416901A1 (xx)
GR (1) GR72817B (xx)
HU (1) HU181442B (xx)
IE (1) IE47916B1 (xx)
IL (1) IL56626A0 (xx)
LU (1) LU80906A1 (xx)
MC (1) MC1253A1 (xx)
NL (1) NL7901182A (xx)
NO (1) NO153011C (xx)
NZ (1) NZ189625A (xx)
PH (1) PH15084A (xx)
PT (1) PT69218A (xx)
SE (1) SE7901276L (xx)
YU (1) YU41437B (xx)
ZA (1) ZA79528B (xx)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3166093D1 (en) 1981-01-05 1984-10-18 Takeda Chemical Industries Ltd N-substituted pseudo-aminosugars, their production and use
JPS57146713A (en) * 1981-03-09 1982-09-10 Akira Endo Hypoglycemic
US4595678A (en) * 1982-03-19 1986-06-17 Takeda Chemical Industries, Ltd. N-substituted pseudo-aminosugars and pharmaceutical compositions containing same
US4762857A (en) * 1986-05-30 1988-08-09 E. I. Du Pont De Nemours And Company Trehalose as stabilizer and tableting excipient
US4678812A (en) * 1986-05-30 1987-07-07 E. I. Du Pont De Nemours And Company Trehalose as stabilizer and tableting excipient
US4885361A (en) * 1987-07-31 1989-12-05 Hoffmann-La Roche Inc. Sulfated oligosaccharides
DE69115926T2 (de) * 1990-11-30 1996-05-30 Monoclonetics Int Verfahren zur diagnose chronischer niedriger rückenschmerzen und nackenschmerzen
TW381025B (en) * 1993-08-05 2000-02-01 Hoffmann La Roche Pharmaceutical composition containing a glucosidase inhibitor and a lipase inhibitor
PT1157696E (pt) * 2000-05-24 2007-01-31 Pfizer Tratamento da acidose ruminal com inibidores da alfa-amilase
US7022684B2 (en) * 2000-05-24 2006-04-04 Pfizer Inc. Treatment of rumen acidosis with α-amylase inhibitors
BRPI0416639A (pt) 2003-11-19 2007-01-16 Metabasis Therapeutics Inc tiromiméticos contendo fósforo
US7262318B2 (en) * 2004-03-10 2007-08-28 Pfizer, Inc. Substituted heteroaryl- and phenylsulfamoyl compounds
US20050288340A1 (en) * 2004-06-29 2005-12-29 Pfizer Inc Substituted heteroaryl- and phenylsulfamoyl compounds
MX2007005137A (es) * 2004-11-23 2007-06-22 Warner Lambert Co Derivados del acido 7-(2h-pyrazol-3-il)-3, 5-dihidroxi-heptanoico como inhibidores de hmg co-a reductasa para el tratamiento de lipidemia.
US7741317B2 (en) 2005-10-21 2010-06-22 Bristol-Myers Squibb Company LXR modulators
US7888376B2 (en) 2005-11-23 2011-02-15 Bristol-Myers Squibb Company Heterocyclic CETP inhibitors
US8404896B2 (en) 2006-12-01 2013-03-26 Bristol-Myers Squibb Company N-((3-benzyl)-2,2-(bis-phenyl)-propan-1-amine derivatives as CETP inhibitors for the treatment of atherosclerosis and cardiovascular diseases
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
EP2170930B3 (en) 2007-06-04 2013-10-02 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
RU2010145944A (ru) 2008-04-11 2012-05-20 Астеллас Фарма Инк. (Jp) Аминосахарное соединение и способ его получения
EP2328910B1 (en) 2008-06-04 2014-08-06 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
AU2009270833B2 (en) 2008-07-16 2015-02-19 Bausch Health Ireland Limited Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
WO2010093601A1 (en) 2009-02-10 2010-08-19 Metabasis Therapeutics, Inc. Novel sulfonic acid-containing thyromimetics, and methods for their use
JP2013528172A (ja) 2010-05-21 2013-07-08 ファイザー・インク 2−フェニルベンゾイルアミド
US20130156720A1 (en) 2010-08-27 2013-06-20 Ironwood Pharmaceuticals, Inc. Compositions and methods for treating or preventing metabolic syndrome and related diseases and disorders
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
CA2828343A1 (en) 2011-03-04 2012-09-13 The Scripps Research Institute Edn3-like peptides and uses thereof
MY188344A (en) 2012-03-09 2021-12-01 Biotropics Malaysia Berhad Extract formulations of rhodamnia cinerea and uses thereof
AU2014235215A1 (en) 2013-03-15 2015-10-01 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
JP2016514670A (ja) 2013-03-15 2016-05-23 シナジー ファーマシューティカルズ インコーポレイテッド 他の薬物と組み合わせたグアニル酸シクラーゼ受容体アゴニスト
AU2014255381A1 (en) 2013-04-17 2015-10-08 Pfizer Inc. N-piperidin-3-ylbenzamide derivatives for treating cardiovascular diseases
BR112015030326A2 (pt) 2013-06-05 2017-08-29 Synergy Pharmaceuticals Inc Agonistas ultrapuros de guanilato ciclase c, método de fabricar e usar os mesmos
RU2021109549A (ru) 2014-08-29 2021-05-13 Тес Фарма С.Р.Л. ИНГИБИТОРЫ α-АМИНО-β-КАРБОКСИМУКОНАТ ε-СЕМИАЛЬДЕГИД-ДЕКАРБОКСИЛАЗЫ
WO2016055901A1 (en) 2014-10-08 2016-04-14 Pfizer Inc. Substituted amide compounds
BR112019007543A2 (pt) 2016-10-14 2019-07-02 Tes Pharma S R L inibidores de ácido alfa-amino-beta-carboximuconico semialdeido decarboxilase
AR117122A1 (es) 2018-11-20 2021-07-14 Tes Pharma S R L INHIBIDORES DE LA ÁCIDO a-AMINO-b-CARBOXIMUCÓNICO SEMIALDEHÍDO DESCARBOXILASA
AU2020209215B2 (en) 2019-01-18 2023-02-02 Astrazeneca Ab PCSK9 inhibitors and methods of use thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2064092C2 (de) * 1970-12-28 1983-06-01 Bayer Ag, 5090 Leverkusen Inhibitoren für Glykosidhydrolasen aus Actinomyceten
DE2347782C3 (de) * 1973-09-22 1979-10-11 Bayer Ag, 5090 Leverkusen Aminozuckerderivate, Verfahren zu ihrer Herstellung sowie diese Verbindungen enthaltende Arzneimittel
US4062950A (en) * 1973-09-22 1977-12-13 Bayer Aktiengesellschaft Amino sugar derivatives
US4065557A (en) * 1974-03-21 1977-12-27 Bayer Aktiengesellschaft Amino sugars and their use in improving the meat:fat ratio in animals
USRE29903E (en) 1975-03-19 1979-02-06 American Cyanamid Company Antibacterial antibiotics AM31α, AM31β and AM31γ
DE2614393C3 (de) * 1976-04-02 1980-04-03 Bayer Ag, 5090 Leverkusen Aminozucker-Derivate und diese Verbindungen enthaltende Arzneimittel

Also Published As

Publication number Publication date
DE2905649A1 (de) 1979-08-16
FI790486A (fi) 1979-08-15
NL7901182A (nl) 1979-08-16
ATA108879A (de) 1981-11-15
PT69218A (en) 1979-03-01
CA1121290A (en) 1982-04-06
LU80906A1 (de) 1980-09-24
ES477653A1 (es) 1980-03-01
FR2416901A1 (fr) 1979-09-07
JPS54163511A (en) 1979-12-26
EP0003616A3 (en) 1979-09-05
NO153011B (no) 1985-09-23
NO790469L (no) 1979-08-15
PH15084A (en) 1982-07-02
EP0003616A2 (de) 1979-08-22
DK61179A (da) 1979-08-15
FI63062C (fi) 1983-04-11
AU4402879A (en) 1979-08-23
EP0003616B1 (de) 1982-02-24
DE2962165D1 (en) 1982-03-25
NO153011C (no) 1986-01-02
AU527318B2 (en) 1983-02-24
YU41437B (en) 1987-06-30
JPS643877B2 (xx) 1989-01-23
IE47916B1 (en) 1984-07-25
FI63062B (fi) 1982-12-31
AT367451B (de) 1982-07-12
HU181442B (en) 1983-07-28
AR219150A1 (es) 1980-07-31
US4273765A (en) 1981-06-16
ZA79528B (en) 1980-02-27
SE7901276L (sv) 1979-08-15
NZ189625A (en) 1981-05-01
YU34879A (en) 1983-01-21
GR72817B (xx) 1983-12-06
MC1253A1 (fr) 1980-01-14
FR2416901B1 (xx) 1980-10-24
DK149599B (da) 1986-08-04
IL56626A0 (en) 1979-05-31
IE790274L (en) 1979-08-14

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