DK146298C - Analogifremgangsmaade til fremstilling af 1-n-substituerede derivater af 4,6-di-(aminoglycosyl)-1,3-diaminocyclitoler eller syreadditionssalte deraf - Google Patents

Analogifremgangsmaade til fremstilling af 1-n-substituerede derivater af 4,6-di-(aminoglycosyl)-1,3-diaminocyclitoler eller syreadditionssalte deraf

Info

Publication number
DK146298C
DK146298C DK412474A DK412474A DK146298C DK 146298 C DK146298 C DK 146298C DK 412474 A DK412474 A DK 412474A DK 412474 A DK412474 A DK 412474A DK 146298 C DK146298 C DK 146298C
Authority
DK
Denmark
Prior art keywords
diaminocyclitols
aminoglycosyl
preparing
acid addition
addition salts
Prior art date
Application number
DK412474A
Other languages
Danish (da)
English (en)
Other versions
DK146298B (da
DK412474A (de
Inventor
Marvin Joseph Weinstein
Peter John Lowell Daniels
Gerald Howard Wagman
Raymond Testa
Alan Keith Mallams
John Jessen Wright
Tattanahalli Laksh Nagabhushan
Original Assignee
Scherico Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/452,586 external-priority patent/US4029882A/en
Application filed by Scherico Ltd filed Critical Scherico Ltd
Publication of DK412474A publication Critical patent/DK412474A/da
Priority to DK52879A priority Critical patent/DK52879A/da
Publication of DK146298B publication Critical patent/DK146298B/da
Application granted granted Critical
Publication of DK146298C publication Critical patent/DK146298C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
    • C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
    • C07H15/234—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
    • C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
    • C07H15/234—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2
    • C07H15/236—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2 a saccharide radical being substituted by an alkylamino radical in position 3 and by two substituents different from hydrogen in position 4, e.g. gentamicin complex, sisomicin, verdamycin
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
DK412474A 1973-08-06 1974-08-01 Analogifremgangsmaade til fremstilling af 1-n-substituerede derivater af 4,6-di-(aminoglycosyl)-1,3-diaminocyclitoler eller syreadditionssalte deraf DK146298C (da)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DK52879A DK52879A (da) 1974-03-19 1979-02-08 Fremgangsmaade til fremstilling af 1-n-substituerede derivater af 4,6-di-(aminoglycosyl)-1,3-diaminocyclotoler eller syreadditionssalte deraf

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US38575173A 1973-08-06 1973-08-06
US38575173 1973-08-06
US45260074A 1974-03-19 1974-03-19
US45260074 1974-03-19
US05/452,586 US4029882A (en) 1974-03-19 1974-03-19 Selective acylation of the C-1 amino group of aminoglycoside antibiotics
US45258674 1974-03-19

Publications (3)

Publication Number Publication Date
DK412474A DK412474A (de) 1975-04-01
DK146298B DK146298B (da) 1983-08-29
DK146298C true DK146298C (da) 1984-02-06

Family

ID=27409729

Family Applications (1)

Application Number Title Priority Date Filing Date
DK412474A DK146298C (da) 1973-08-06 1974-08-01 Analogifremgangsmaade til fremstilling af 1-n-substituerede derivater af 4,6-di-(aminoglycosyl)-1,3-diaminocyclitoler eller syreadditionssalte deraf

Country Status (20)

Country Link
AR (1) AR215834A1 (de)
BE (1) BE818431A (de)
BG (1) BG25804A3 (de)
CH (1) CH606076A5 (de)
CY (1) CY1018A (de)
DD (1) DD119037A5 (de)
DE (2) DE2462485A1 (de)
DK (1) DK146298C (de)
FI (1) FI62100C (de)
FR (1) FR2240015B1 (de)
GB (1) GB1473733A (de)
HK (1) HK55179A (de)
IE (1) IE40437B1 (de)
IL (1) IL45385A (de)
KE (1) KE2981A (de)
LU (1) LU70661A1 (de)
MY (1) MY8000090A (de)
NL (1) NL171587C (de)
NO (1) NO139483C (de)
SE (1) SE424994B (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4217446A (en) 1974-10-26 1980-08-12 Pfizer Inc. ωAmino-2-hydroxyalkyl derivatives of aminoglycoside antibiotics
GB1464401A (en) * 1974-10-26 1977-02-16 Pfizer Ltd Aminoglycosides
FR2405266A1 (fr) * 1975-09-08 1979-05-04 Scherico Ltd Nouveaux pseudotrisaccharides, et applications pharmaceutiques de ceux-ci
DE2861947D1 (en) * 1977-06-10 1982-09-02 Bayer Ag Selectively protected 4,6-di-o-(aminoglycosyl)-1,3-diamino-cyclitols
US4282350A (en) * 1977-08-05 1981-08-04 Schering Corporation Selective 3"-N-acylation of 1,3"-di-N-unprotected-poly-N-protected-4,6-di-O-(aminoglycosyl)-1,3-diaminocyclitols
JPS5492951A (en) * 1977-12-29 1979-07-23 Shionogi & Co Ltd Novel aminoglycoside derivative
JPS5538345A (en) * 1978-09-11 1980-03-17 Shionogi & Co Ltd Novel aminoglycoside derivative
DE2840907A1 (de) * 1978-09-20 1980-04-03 Bayer Ag Selektiv geschuetzte 4,6-di-o-(aminoglykosyl)-1,3-diaminocyclitole
DE2928183A1 (de) * 1979-07-12 1981-01-29 Bayer Ag 1-n-alkylsisomicin-derivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
CN1040177C (zh) * 1993-04-23 1998-10-14 江苏省微生物研究所 一种含1-N-乙基庆大霉素C1a或其盐的药用制剂及制备方法
AU2008326297B2 (en) 2007-11-21 2012-11-08 Cipla USA, Inc. Antibacterial aminoglycoside analogs
WO2010132760A1 (en) 2009-05-15 2010-11-18 Achaogen, Inc. Antibacterial derivatives of tobramycin
WO2010132759A1 (en) 2009-05-15 2010-11-18 Achaogen, Inc. Antibacterial derivatives of dibekacin
WO2010132765A2 (en) 2009-05-15 2010-11-18 Achaogen, Inc. Antibacterial aminoglycoside analogs
WO2010132757A2 (en) 2009-05-15 2010-11-18 Achaogen, Inc. Antibacterial aminoglycoside analogs
WO2010132768A1 (en) 2009-05-15 2010-11-18 Achaogen, Inc. Antibacterial derivatives of sisomicin
CN101575311B (zh) * 2009-06-19 2011-05-04 无锡好芳德药业有限公司 一种制备褪黑素的方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1235311B (de) * 1963-03-25 1967-03-02 Roussel Uclaf Verfahren zur Herstellung von N-Monophenylaethylneomycin B bzw. seinen therapeutisch vertraeglichen Salzen

Also Published As

Publication number Publication date
FI230474A (de) 1975-02-07
DE2437160B2 (de) 1979-01-04
IL45385A0 (en) 1974-11-29
IE40437L (en) 1975-02-06
DE2437160A1 (de) 1975-02-20
BE818431A (fr) 1975-02-03
SE7409946L (de) 1975-02-07
DE2462485C2 (de) 1987-04-09
AR215834A1 (es) 1979-11-15
FI62100C (fi) 1982-11-10
FI62100B (fi) 1982-07-30
NO139483B (no) 1978-12-11
HK55179A (en) 1979-08-17
NO742787L (de) 1975-03-03
IL45385A (en) 1978-10-31
CH606076A5 (de) 1978-10-13
NL7410363A (nl) 1975-02-10
GB1473733A (en) 1977-05-18
FR2240015A1 (de) 1975-03-07
KE2981A (en) 1979-07-20
AU7194274A (en) 1976-02-05
IE40437B1 (en) 1979-06-06
NL171587C (nl) 1983-04-18
LU70661A1 (de) 1975-05-21
SE424994B (sv) 1982-08-23
NO139483C (no) 1979-03-21
NL171587B (nl) 1982-11-16
FR2240015B1 (de) 1978-08-18
BG25804A3 (en) 1978-12-12
DE2437160C3 (de) 1979-08-30
MY8000090A (en) 1980-12-31
DK146298B (da) 1983-08-29
DK412474A (de) 1975-04-01
CY1018A (en) 1979-11-23
DD119037A5 (de) 1976-04-05
DE2462485A1 (de) 1977-04-21

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