DK1456651T3 - Selvsamlende molekyler - Google Patents

Selvsamlende molekyler

Info

Publication number
DK1456651T3
DK1456651T3 DK02781023T DK02781023T DK1456651T3 DK 1456651 T3 DK1456651 T3 DK 1456651T3 DK 02781023 T DK02781023 T DK 02781023T DK 02781023 T DK02781023 T DK 02781023T DK 1456651 T3 DK1456651 T3 DK 1456651T3
Authority
DK
Denmark
Prior art keywords
self
assembly
target
molecules
single domain
Prior art date
Application number
DK02781023T
Other languages
Danish (da)
English (en)
Inventor
Jianbing Zhang
C Roger Mackenzie
Original Assignee
Ca Nat Research Council
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ca Nat Research Council filed Critical Ca Nat Research Council
Application granted granted Critical
Publication of DK1456651T3 publication Critical patent/DK1456651T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C07K14/245—Escherichia (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/005—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies constructed by phage libraries
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/26—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/22—Immunoglobulins specific features characterized by taxonomic origin from camelids, e.g. camel, llama or dromedary
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Endocrinology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Electroluminescent Light Sources (AREA)
DK02781023T 2001-11-30 2002-11-29 Selvsamlende molekyler DK1456651T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US33409801P 2001-11-30 2001-11-30
PCT/CA2002/001829 WO2003046560A2 (en) 2001-11-30 2002-11-29 Self-assembly molecules

Publications (1)

Publication Number Publication Date
DK1456651T3 true DK1456651T3 (da) 2008-09-01

Family

ID=23305560

Family Applications (1)

Application Number Title Priority Date Filing Date
DK02781023T DK1456651T3 (da) 2001-11-30 2002-11-29 Selvsamlende molekyler

Country Status (14)

Country Link
US (1) US7655412B2 (zh)
EP (1) EP1456651B1 (zh)
JP (1) JP4471656B2 (zh)
CN (1) CN100335900C (zh)
AT (1) ATE394673T1 (zh)
AU (1) AU2002349228B2 (zh)
BR (1) BR0214621A (zh)
CA (1) CA2468583C (zh)
DE (1) DE60226486D1 (zh)
DK (1) DK1456651T3 (zh)
ES (1) ES2306794T3 (zh)
MX (1) MXPA04005134A (zh)
NZ (1) NZ532838A (zh)
WO (1) WO2003046560A2 (zh)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9321832B2 (en) 2002-06-28 2016-04-26 Domantis Limited Ligand
CN101537180B (zh) 2002-07-18 2016-02-10 莫鲁斯有限公司 抗体混合物的重组生产
USRE47770E1 (en) 2002-07-18 2019-12-17 Merus N.V. Recombinant production of mixtures of antibodies
ES2408582T3 (es) 2003-05-30 2013-06-21 Merus B.V. Biblioteca de Fab para la preparación de una mezcla de anticuerpos
US20100069614A1 (en) 2008-06-27 2010-03-18 Merus B.V. Antibody producing non-human mammals
US7713923B2 (en) 2003-06-25 2010-05-11 Massachusetts Institute Of Technology Self-assembling peptides incorporating modifications and methods of use thereof
EP2711025A3 (en) * 2003-06-25 2014-09-10 Massachusetts Institute of Technology Self-assembling peptides incorporating modifications and methods of use thereof
ATE414106T1 (de) * 2003-06-30 2008-11-15 Domantis Ltd Pegylierte single-domain-antikörper (dab)
EP2267028A3 (en) * 2003-06-30 2011-07-27 Domantis Limited Dual specific single domain antibodies (dAb) conjugated to PEG
JP5618453B2 (ja) * 2003-11-28 2014-11-05 ナショナル リサーチ カウンシル オブ カナダ 抗癌抗体およびその使用
DK1737971T3 (da) * 2004-01-20 2017-11-13 Merus Nv Blandinger af bindingsproteiner
US20090047300A1 (en) * 2005-09-27 2009-02-19 Abedelnasser Abulrob Blood-brain barrier epitopes and uses thereof
CA2669951A1 (en) * 2006-12-04 2008-06-12 Innovative Purification Technologies Pty Ltd Protein particles
WO2008144817A1 (en) * 2007-05-30 2008-12-04 Innovative Purification Technologies Pty Ltd Fluorescent protein particles
EP2692736B1 (en) 2008-10-14 2018-04-18 National Research Council Of Canada Bsa-specific antibodies
WO2010045225A1 (en) * 2008-10-14 2010-04-22 Dow Agrosciences Llc Induction of mucosal immune responses by mucosal delivery pentabody complex (mdpc)
US9327022B2 (en) 2008-10-14 2016-05-03 National Research Council Of Canada BSA-specific antibodies
WO2010060216A1 (en) * 2008-11-26 2010-06-03 National Research Council Of Canada Nanoaggregate embedded beads conjugated to single domain antibodies
WO2010102518A1 (zh) * 2009-03-13 2010-09-16 北京表源生物技术有限公司 一种融合蛋白多聚体
CN101830986A (zh) * 2009-03-13 2010-09-15 北京表源生物技术有限公司 一种融合蛋白多聚体
US20100247529A1 (en) * 2009-03-20 2010-09-30 William Patterson Cooperative and dynamic assembly of affinity complexes
EP2563816B1 (en) 2010-04-27 2014-11-12 National Research Council of Canada Anti-icam-1 single domain antibody and uses thereof
EP2621955B1 (en) 2010-10-01 2018-01-17 National Research Council of Canada Anti-ceacam6 antibodies and uses thereof
US9771416B2 (en) 2010-10-25 2017-09-26 National Research Council Of Canada Clostridium difficile-specific antibodies and uses thereof
EA201391086A1 (ru) 2011-01-28 2014-01-30 Нэшнл Рисеч Каунсил Оф Канада Конструирование иммуноглобулиновых доменов
WO2012167346A1 (en) 2011-06-10 2012-12-13 Her Majesty The Queen In Right Of Canada, As Represented By The Minister Of National Defence Anti-ricin antibodies and uses thereof
JP6170940B2 (ja) 2011-12-20 2017-07-26 アダエラータ、リミテッド パートナーシップＡｄａｅｒａｔａ， Ｌｉｍｉｔｅｄ Ｐａｒｔｎｅｒｓｈｉｐ Ｐｃｓｋ９の阻害剤としての単一ドメイン抗体
PT2838918T (pt) 2012-04-20 2019-08-23 Merus Nv Métodos e meios para a produção de moléculas heterrodiméricas do tipo ig
AU2013334451A1 (en) 2012-10-24 2015-06-04 National Research Council Of Canada Anti-Campylobacter jejuni antibodies and uses therefor
AU2014385801B2 (en) 2014-03-06 2020-11-12 National Research Council Of Canada Insulin-like growth factor 1 receptor -specific antibodies and uses thereof
CN106559993B (zh) 2014-03-06 2020-12-15 加拿大国家研究委员会 胰岛素样生长因子1受体特异性抗体及其用途
DK3114142T3 (da) 2014-03-06 2019-09-16 Nat Res Council Canada Insulinlignende vækstfaktor 1-receptorspecifikke antistoffer og anvendelser deraf
CN104004093B (zh) * 2014-06-03 2017-01-18 大连理工大学 一种抗人甲状旁腺激素的纳米抗体及其筛选方法和应用
WO2016043577A1 (en) 2014-09-16 2016-03-24 Academisch Medisch Centrum Ig-like molecules binding to bmp4
US10098973B2 (en) 2014-10-10 2018-10-16 National Research Council Of Canada Anti-tau antibody and uses thereof
US10487153B2 (en) 2015-06-10 2019-11-26 National Research Council Of Canada Carbonic anhydrase IX-specific antibodies and uses thereof
KR102406610B1 (ko) 2016-07-06 2022-06-08 내셔날 리서치 카운실 오브 캐나다 혈액-뇌 장벽을 통과이동하는 인간화 항체 및 그의 용도
WO2018109663A1 (en) 2016-12-12 2018-06-21 National Research Council Of Canada Antibody variants transmigrating the blood-brain barrier and uses thereof
WO2018138681A1 (en) 2017-01-27 2018-08-02 National Research Council Of Canada Hemagglutinin-specific antibodies and uses thereof
WO2018138709A1 (en) 2017-01-30 2018-08-02 National Research Council Of Canada Blood-brain barrier transmigrating compounds and uses thereof
WO2020086793A1 (en) * 2018-10-25 2020-04-30 Hao Shen Self-assembling protein homo-polymers
CN114099701B (zh) * 2021-11-29 2023-11-10 华中科技大学同济医学院附属协和医院 一种自组装复合多肽及其制备方法和药物

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4208479A (en) * 1977-07-14 1980-06-17 Syva Company Label modified immunoassays
US5955293A (en) * 1989-10-17 1999-09-21 New England Medical Center Hospitals, Inc. Assays for shiga toxin and shiga-like toxins
WO1994013804A1 (en) * 1992-12-04 1994-06-23 Medical Research Council Multivalent and multispecific binding proteins, their manufacture and use
US6485726B1 (en) * 1995-01-17 2002-11-26 The Brigham And Women's Hospital, Inc. Receptor specific transepithelial transport of therapeutics
US5744346A (en) * 1995-06-07 1998-04-28 Athena Neurosciences, Inc. β-secretase
WO1997033617A1 (en) * 1996-03-13 1997-09-18 Protein Design Labs, Inc. Fas ligand fusion proteins and their uses
WO1997047971A1 (en) * 1996-06-11 1997-12-18 Advanced Research & Technology Institute Methods and compositions for the use of apurinic/apyrimidinic endonucleases
WO1998018943A1 (en) * 1996-10-28 1998-05-07 Novartis Ag Method for the oligomerisation of peptides
ATE282429T1 (de) * 1997-05-12 2004-12-15 Aphton Corp Immunogene zusammensetzungen gegen den cck-b- gastrin-rezeptor und verfahren zur behandlung von tumoren
EP1039931B1 (en) * 1997-12-01 2005-04-27 Fang Fang Multivalent recombinant antibodies for treating hrv infections
US6310043B1 (en) * 1998-08-07 2001-10-30 Governors Of The University Of Alberta Treatment of bacterial infections
EP1149168A2 (en) * 1999-02-01 2001-10-31 Beth Israel Deaconess Medical Center Comp/tsp-1, comp/tsp-2 and other tsp chimeric proteins
AU3798500A (en) * 1999-04-09 2000-11-14 Hsc Research And Development Limited Partnership Verotoxin treatment of lymphomas
JP2003511061A (ja) 1999-10-08 2003-03-25 アクティブ バイオテック エイビー 変更された化学結合体化特性を有するａｂ５毒素ｂサブユニット変異体
DE19963859A1 (de) 1999-12-30 2001-07-12 Apotech Res & Dev Ltd Bi- oder Oligomer eines Di-, Tri-, Quattro- oder Pentamers von rekombinanten Fusionsproteinen
US20020041865A1 (en) * 2000-01-20 2002-04-11 Richard Austin Methods for treating tumors

Also Published As

Publication number Publication date
BR0214621A (pt) 2004-10-13
CA2468583A1 (en) 2003-06-05
US20060051292A1 (en) 2006-03-09
WO2003046560B1 (en) 2003-10-16
WO2003046560A3 (en) 2003-09-04
AU2002349228A1 (en) 2003-06-10
JP2005510719A (ja) 2005-04-21
DE60226486D1 (de) 2008-06-19
EP1456651A2 (en) 2004-09-15
MXPA04005134A (es) 2004-08-11
CA2468583C (en) 2012-05-01
WO2003046560A2 (en) 2003-06-05
EP1456651B1 (en) 2008-05-07
CN1596371A (zh) 2005-03-16
AU2002349228B2 (en) 2007-06-14
ATE394673T1 (de) 2008-05-15
ES2306794T3 (es) 2008-11-16
CN100335900C (zh) 2007-09-05
NZ532838A (en) 2008-05-30
JP4471656B2 (ja) 2010-06-02
US7655412B2 (en) 2010-02-02

Similar Documents

Publication Publication Date Title
DK1456651T3 (da) Selvsamlende molekyler
EA201100527A1 (ru) Биологические продукты
DE602004025101D1 (de) Humane anti-humane cd3-bindungsmoleküle
DE602006013029D1 (de) Anti-egfr-antikörper
MA43028B1 (fr) Anticorps bispécifiques pour pd1 et tim3
UA89017C2 (uk) ЛЮДСЬКЕ АНТИТІЛО, ЩО СПЕЦИФІЧНО ЗВ'ЯЗУЄТЬСЯ З ЛЮДСЬКИМ TNFSF13b
DE60327205D1 (de) Therapeutische antiköper mit reduzierten nebenwirkungen
EA200800812A1 (ru) Композиции антитела против cd3
WO2009088805A3 (en) Antibody targeting through a modular recognition domain
EA200401198A1 (ru) АНТИТЕЛА ПРОТИВ αvβ6
CR10563A (es) Anticuerpos monoclonales ant-il-6 y usos de los mismos
EA200400510A1 (ru) Агенты, специфически связывающие ангиопоэтин-2
CO6231038A2 (es) Proteinas de union, incluyendo anticuerpos derivados de anticuerpo y fragmentos de anticuerpo que se unen especificamente a cd154 y sus usos
DE602006006200D1 (de) Antikörper gegen 25-hydroxyvitamin d
RS52775B (en) CD19 OPTIMIZED ANTIBODY
RS52036B (en) ANGIOPOETIN-2 ANTIBODIES AND ITS USES
WO2008060367A3 (en) Human antibodies that bind cxcr4 and uses thereof
EA200800953A1 (ru) Человеческие моноклональные антитела к cd70
RS52769B (sr) Kompozicije i postupci za povećanje mineralizacije kostiju
NZ587230A (en) Antibodies directed to angiopoietin-1 and angiopoietin-2 and uses thereof
MX2009008608A (es) Anticuerpos monoclonales anti-cxcl13.
EA200801174A1 (ru) Антитела-миметики glp-2, полипептиды, композиции, способы и применения
NO932672L (no) Monokloane antistoffer mot elam-1 og anvendelser derav
NZ598770A (en) Monoclonal antibodies
EA200701452A1 (ru) Моноклональные антитела против подобного ангиопоэтину белка 4 (angptl 4)