DK1451322T3 - Il-21-antagonister - Google Patents

Il-21-antagonister

Info

Publication number
DK1451322T3
DK1451322T3 DK02773925.9T DK02773925T DK1451322T3 DK 1451322 T3 DK1451322 T3 DK 1451322T3 DK 02773925 T DK02773925 T DK 02773925T DK 1451322 T3 DK1451322 T3 DK 1451322T3
Authority
DK
Denmark
Prior art keywords
antagonists
helix
mutations
polypeptides
specificity
Prior art date
Application number
DK02773925.9T
Other languages
English (en)
Inventor
Scott R Presnell
James W West
Julia E Novak
Original Assignee
Zymogenetics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zymogenetics Inc filed Critical Zymogenetics Inc
Application granted granted Critical
Publication of DK1451322T3 publication Critical patent/DK1451322T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/026—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a baculovirus

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
DK02773925.9T 2001-11-05 2002-10-28 Il-21-antagonister DK1451322T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US33758601P 2001-11-05 2001-11-05
PCT/US2002/034502 WO2003040313A2 (en) 2001-11-05 2002-10-28 Il-21 antagonists

Publications (1)

Publication Number Publication Date
DK1451322T3 true DK1451322T3 (da) 2010-02-01

Family

ID=23321131

Family Applications (1)

Application Number Title Priority Date Filing Date
DK02773925.9T DK1451322T3 (da) 2001-11-05 2002-10-28 Il-21-antagonister

Country Status (11)

Country Link
US (3) US6929932B2 (da)
EP (2) EP2130919A1 (da)
JP (2) JP2005508179A (da)
AT (1) ATE444363T1 (da)
AU (1) AU2002336676A1 (da)
CA (1) CA2465156C (da)
DE (1) DE60233888D1 (da)
DK (1) DK1451322T3 (da)
ES (1) ES2334338T3 (da)
MX (1) MXPA04004167A (da)
WO (1) WO2003040313A2 (da)

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US6307024B1 (en) * 1999-03-09 2001-10-23 Zymogenetics, Inc. Cytokine zalpha11 Ligand
WO2004003156A2 (en) 2002-07-01 2004-01-08 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Il-21 as a regulator of immunoglobin production
US20070092485A1 (en) * 2002-11-15 2007-04-26 Zymogenetics, Inc. Cytokine zalpha11 ligand
US7718421B2 (en) * 2003-02-05 2010-05-18 Iquum, Inc. Sample processing
ES2340280T3 (es) 2003-03-14 2010-06-01 Wyeth Llc Anticuerpos dirigidos contra el receptor de il-21 humano y uso de los mismos.
US20060159655A1 (en) * 2003-03-21 2006-07-20 Wyeth Treating immunological disorders using agonists of interleukin-21 / interleukin-21 receptor
EP1641422A4 (en) * 2003-06-19 2007-08-22 Centocor Inc ANALOGUES OF INTERLEUKINE-21
US20060228331A1 (en) * 2003-10-10 2006-10-12 Novo Nordisk A/S IL-21 Derivatives and variants
EP2263684A1 (en) 2003-10-10 2010-12-22 Novo Nordisk A/S IL-21 derivatives
ES2428358T3 (es) * 2003-10-17 2013-11-07 Novo Nordisk A/S Terapia de combinación
US7993919B2 (en) 2003-11-19 2011-08-09 The United States Of America As Represented By The Department Of Health And Human Services Method of inducing memory B cell development and terminal differentiation
WO2005067956A2 (en) * 2004-01-15 2005-07-28 Novo Nordisk A/S Use of interleukin-21 for the treatment of autoimune diseases and allograft rejection
JP2008501042A (ja) * 2004-05-19 2008-01-17 ワイス 免疫グロブリン産生の調節とアトピー性疾患
ATE389960T1 (de) * 2004-06-30 2008-04-15 Tyco Electronics Nederland Bv Verbinder für elektronische bauteile
ITRM20040586A1 (it) * 2004-11-29 2005-02-28 Giuliani Spa Epitopi antigenici dell'interleuchina-21, anticorpi relativi e loro uso in campo medico.
GT200600148A (es) * 2005-04-14 2006-11-22 Metodos para el tratamiento y la prevencion de fibrosis
JP2008538290A (ja) * 2005-04-18 2008-10-23 ノボ ノルディスク アクティーゼルスカブ Ｉｌ−２１変異体
CA2611200A1 (en) * 2005-06-06 2006-12-14 Novo Nordisk A/S Stabilised il-21 compositions
ES2409835T3 (es) 2005-11-28 2013-06-28 Zymogenetics, Inc. Antagonistas de IL-21
US20080003564A1 (en) * 2006-02-14 2008-01-03 Iquum, Inc. Sample processing
JP2010507382A (ja) 2006-10-26 2010-03-11 ノヴォ ノルディスク アクティーゼルスカブ Ｉｌ−２１変異体
AU2007336184A1 (en) * 2006-12-21 2008-06-26 Novo Nordisk A/S Interleukin-21 variants with altered binding to the IL-21 receptor
KR100902340B1 (ko) * 2007-08-02 2009-06-12 한국생명공학연구원 Ｙｃ－１ 또는 ｉｌ－２１을 유효성분으로 포함하는자연살해세포 분화제 및 분화 방법
CA2910933C (en) 2007-12-07 2017-04-11 Zymogenetics, Inc. Anti-human il-21 monoclonal antibodies
EP2238241B1 (en) 2008-01-18 2013-09-11 The Brigham and Women's Hospital, Inc. Selective differentiation, identification, and modulation of human th17 cells
AR071885A1 (es) * 2008-05-23 2010-07-21 Wyeth Corp Proteinas de union al receptor de interleuquina 21
EP2296689A1 (en) * 2008-05-23 2011-03-23 Wyeth LLC Methods of treatment utilizing binding proteins of the interleukin-21 receptor
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US20130224109A1 (en) * 2010-07-20 2013-08-29 Beth Israel Deaconess Medical Center, Inc. Compositions and methods featuring il-6 and il-21 antagonists
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WO2016140921A1 (en) 2015-03-02 2016-09-09 180 Therapeutics Lp Method of treating a localized fibrotic disorder using an il-33 antagonist
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KR20210094534A (ko) 2018-10-17 2021-07-29 센티 바이오사이언시스, 인코포레이티드 병용 암 면역 요법
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JP2022530677A (ja) 2019-05-03 2022-06-30 バイオニズ リミテッド ライアビリティー カンパニー 脱毛症および脱毛症関連障害の治療ための、γｃサイトカインのシグナル伝達の効果の調節
EP4232071A4 (en) 2020-10-23 2024-08-28 Asher Biotherapeutics Inc FUSIONS WITH CD8 ANTIGEN-BINDING MOLECULES TO MODULATE IMMUNE CELL FUNCTION
US12012441B2 (en) 2020-10-26 2024-06-18 Neptune Biosciences Llc Engineered human IL-21 cytokines and methods for using the same

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Also Published As

Publication number Publication date
US6929932B2 (en) 2005-08-16
US7186805B2 (en) 2007-03-06
EP2130919A1 (en) 2009-12-09
CA2465156C (en) 2011-10-18
WO2003040313A2 (en) 2003-05-15
US7410780B2 (en) 2008-08-12
ATE444363T1 (de) 2009-10-15
CA2465156A1 (en) 2003-05-15
WO2003040313A3 (en) 2003-09-25
US20050244930A1 (en) 2005-11-03
AU2002336676A1 (en) 2003-05-19
EP1451322A2 (en) 2004-09-01
MXPA04004167A (es) 2004-07-08
ES2334338T3 (es) 2010-03-09
DE60233888D1 (de) 2009-11-12
US20070166796A1 (en) 2007-07-19
EP1451322A4 (en) 2005-02-02
US20030134390A1 (en) 2003-07-17
EP1451322B1 (en) 2009-09-30
JP2010207238A (ja) 2010-09-24
JP2005508179A (ja) 2005-03-31

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