DK1439164T3 - Hidtil ukendte phenylethanolaminforbindelser, der har beta2- acceptorexcitatorisk funktion, og deres fremstillingsmetode - Google Patents
Hidtil ukendte phenylethanolaminforbindelser, der har beta2- acceptorexcitatorisk funktion, og deres fremstillingsmetodeInfo
- Publication number
- DK1439164T3 DK1439164T3 DK02771983T DK02771983T DK1439164T3 DK 1439164 T3 DK1439164 T3 DK 1439164T3 DK 02771983 T DK02771983 T DK 02771983T DK 02771983 T DK02771983 T DK 02771983T DK 1439164 T3 DK1439164 T3 DK 1439164T3
- Authority
- DK
- Denmark
- Prior art keywords
- carbon atoms
- compounds
- beta2
- acceptor
- preparation
- Prior art date
Links
- 230000002964 excitative effect Effects 0.000 title 1
- ULSIYEODSMZIPX-UHFFFAOYSA-N phenylethanolamine Chemical class NCC(O)C1=CC=CC=C1 ULSIYEODSMZIPX-UHFFFAOYSA-N 0.000 title 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 3
- DNIAPMSPPWPWGF-GSVOUGTGSA-N (R)-(-)-Propylene glycol Chemical compound C[C@@H](O)CO DNIAPMSPPWPWGF-GSVOUGTGSA-N 0.000 abstract 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
- 125000004183 alkoxy alkyl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 abstract 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
- 229910052794 bromium Inorganic materials 0.000 abstract 1
- 206010006451 bronchitis Diseases 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 239000011737 fluorine Substances 0.000 abstract 1
- 239000000018 receptor agonist Substances 0.000 abstract 1
- 229940044601 receptor agonist Drugs 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/68—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings and hydroxy groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/04—Drugs for disorders of the respiratory system for throat disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C255/58—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton
- C07C255/59—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Pulmonology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Otolaryngology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB011282347A CN1276911C (zh) | 2001-09-30 | 2001-09-30 | 具有β2－受体兴奋作用的新型苯乙醇胺类化合物及其制法 |
| PCT/CN2002/000676 WO2003093219A1 (en) | 2001-09-30 | 2002-09-25 | NOVEL PHENYLETHANOLAMINE COMPOUNDS HAVING β2-ACCEPTOR EXCITATORY FUNCTION AND THEIR PREPARATION METHOD |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1439164T3 true DK1439164T3 (da) | 2007-08-20 |
Family
ID=4668112
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK02771983T DK1439164T3 (da) | 2001-09-30 | 2002-09-25 | Hidtil ukendte phenylethanolaminforbindelser, der har beta2- acceptorexcitatorisk funktion, og deres fremstillingsmetode |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US7098364B2 (enExample) |
| EP (1) | EP1439164B1 (enExample) |
| JP (1) | JP3990399B2 (enExample) |
| CN (1) | CN1276911C (enExample) |
| AT (1) | ATE359261T1 (enExample) |
| AU (1) | AU2002338124A1 (enExample) |
| DE (1) | DE60219500T2 (enExample) |
| DK (1) | DK1439164T3 (enExample) |
| ES (1) | ES2284926T3 (enExample) |
| RU (1) | RU2264382C1 (enExample) |
| WO (1) | WO2003093219A1 (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100497296C (zh) * | 2006-07-07 | 2009-06-10 | 沈阳药科大学 | 旋光活性的苯乙醇胺类化合物及其制法 |
| CN100431535C (zh) * | 2006-09-18 | 2008-11-12 | 锦州九泰药业有限责任公司 | 一种盐酸川丁特罗气雾剂 |
| EP1969929A1 (de) * | 2007-03-12 | 2008-09-17 | Bayer CropScience AG | Substituierte Phenylamidine und deren Verwendung als Fungizide |
| CN102477000B (zh) * | 2010-11-24 | 2013-11-06 | 沈阳药科大学 | 一种苯乙醇胺类化合物的合成方法 |
| US9784726B2 (en) | 2013-01-08 | 2017-10-10 | Atrogi Ab | Screening method, a kit, a method of treatment and a compound for use in a method of treatment |
| CN106279018B (zh) * | 2015-06-26 | 2019-01-29 | 沈阳药科大学 | β2-受体兴奋剂及其制备方法和应用 |
| GB201714734D0 (en) | 2017-09-13 | 2017-10-25 | Atrogi Ab | New compounds and uses |
| GB201714745D0 (en) | 2017-09-13 | 2017-10-25 | Atrogi Ab | New compounds and uses |
| GB201714736D0 (en) | 2017-09-13 | 2017-10-25 | Atrogi Ab | New compounds and uses |
| GB201714740D0 (en) | 2017-09-13 | 2017-10-25 | Atrogi Ab | New compounds and uses |
| GB201903832D0 (en) | 2019-03-20 | 2019-05-01 | Atrogi Ab | New compounds and methods |
| GB202205895D0 (en) | 2022-04-22 | 2022-06-08 | Atrogi Ab | New medical uses |
| CN120583945A (zh) | 2023-01-20 | 2025-09-02 | 阿托基公司 | 用于治疗或预防肌肉消耗的β2-肾上腺素能受体激动剂 |
| GB202302225D0 (en) | 2023-02-16 | 2023-04-05 | Atrogi Ab | New medical uses |
| GB202303229D0 (en) | 2023-03-06 | 2023-04-19 | Atrogi Ab | New medical uses |
| GB202403169D0 (en) | 2024-03-05 | 2024-04-17 | Atrogi Ab | New medical uses |
| WO2025238248A1 (en) | 2024-05-17 | 2025-11-20 | Atrogi Ab | USE OF β2-ADRENERGIC RECEPTOR AGONISTS IN TREATING MUSCLE WASTING |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4028398A1 (de) * | 1990-09-07 | 1992-03-12 | Thomae Gmbh Dr K | Phenylethanolamine, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
| SG55296A1 (en) * | 1996-04-12 | 1998-12-21 | Kissei Pharmaceutical | Phenylethalolaminotetralincarboxamide derivatives |
| CN1237574A (zh) * | 1998-05-29 | 1999-12-08 | 中国科学院成都有机化学研究所 | 合成苯乙醇胺类化合物的方法 |
-
2001
- 2001-09-30 CN CNB011282347A patent/CN1276911C/zh not_active Expired - Fee Related
-
2002
- 2002-09-25 JP JP2004501359A patent/JP3990399B2/ja not_active Expired - Fee Related
- 2002-09-25 EP EP02771983A patent/EP1439164B1/en not_active Expired - Lifetime
- 2002-09-25 US US10/491,028 patent/US7098364B2/en not_active Expired - Lifetime
- 2002-09-25 AU AU2002338124A patent/AU2002338124A1/en not_active Abandoned
- 2002-09-25 ES ES02771983T patent/ES2284926T3/es not_active Expired - Lifetime
- 2002-09-25 WO PCT/CN2002/000676 patent/WO2003093219A1/zh not_active Ceased
- 2002-09-25 DK DK02771983T patent/DK1439164T3/da active
- 2002-09-25 DE DE60219500T patent/DE60219500T2/de not_active Expired - Lifetime
- 2002-09-25 RU RU2004112212/04A patent/RU2264382C1/ru active
- 2002-09-25 AT AT02771983T patent/ATE359261T1/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DE60219500D1 (de) | 2007-05-24 |
| JP3990399B2 (ja) | 2007-10-10 |
| DE60219500T2 (de) | 2007-12-13 |
| EP1439164B1 (en) | 2007-04-11 |
| US7098364B2 (en) | 2006-08-29 |
| AU2002338124A1 (en) | 2003-11-17 |
| EP1439164A1 (en) | 2004-07-21 |
| HK1064664A1 (en) | 2005-02-04 |
| CN1276911C (zh) | 2006-09-27 |
| EP1439164A4 (en) | 2005-12-21 |
| RU2004112212A (ru) | 2005-09-10 |
| WO2003093219A1 (en) | 2003-11-13 |
| US20040266867A1 (en) | 2004-12-30 |
| CN1408703A (zh) | 2003-04-09 |
| RU2264382C1 (ru) | 2005-11-20 |
| ATE359261T1 (de) | 2007-05-15 |
| ES2284926T3 (es) | 2007-11-16 |
| AU2002338124A8 (en) | 2003-11-17 |
| JP2005519989A (ja) | 2005-07-07 |
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