DK1417189T3 - Acylaminothiazolderivater, fremstilling og terapeutisk anvendelse heraf - Google Patents
Acylaminothiazolderivater, fremstilling og terapeutisk anvendelse herafInfo
- Publication number
- DK1417189T3 DK1417189T3 DK02794623T DK02794623T DK1417189T3 DK 1417189 T3 DK1417189 T3 DK 1417189T3 DK 02794623 T DK02794623 T DK 02794623T DK 02794623 T DK02794623 T DK 02794623T DK 1417189 T3 DK1417189 T3 DK 1417189T3
- Authority
- DK
- Denmark
- Prior art keywords
- preparation
- therapeutic use
- acylaminothiazole derivatives
- acylaminothiazole
- derivatives
- Prior art date
Links
- 230000001225 therapeutic effect Effects 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/40—Unsubstituted amino or imino radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/42—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/44—Acylated amino or imino radicals
- C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Public Health (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0110504 | 2001-08-06 | ||
| FR0207222A FR2840899B1 (fr) | 2002-06-12 | 2002-06-12 | Derives d'acylaminothiazole, leur preparation et leur utilisation en therapeutique |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1417189T3 true DK1417189T3 (da) | 2006-05-08 |
Family
ID=26213132
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK02794623T DK1417189T3 (da) | 2001-08-06 | 2002-08-05 | Acylaminothiazolderivater, fremstilling og terapeutisk anvendelse heraf |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US7288659B2 (https=) |
| EP (1) | EP1417189B1 (https=) |
| JP (1) | JP2005500370A (https=) |
| AR (1) | AR039059A1 (https=) |
| AT (1) | ATE312828T1 (https=) |
| DE (1) | DE60208044T2 (https=) |
| DK (1) | DK1417189T3 (https=) |
| ES (1) | ES2254773T3 (https=) |
| TW (1) | TWI318974B (https=) |
| WO (1) | WO2003014095A1 (https=) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR038703A1 (es) | 2002-02-28 | 2005-01-26 | Novartis Ag | Derivados de 5-feniltiazol y uso como inhibidor de quinasa p i 3 |
| JP2006504796A (ja) * | 2002-10-09 | 2006-02-09 | ファイザー・プロダクツ・インク | 神経変性性障害を処置するためのチアゾール化合物 |
| FR2850380B1 (fr) * | 2003-01-23 | 2006-07-07 | Sanofi Synthelabo | Derives d'acylaminothiazole, leur preparation et leur utilisation en therapeutique |
| MXPA05012196A (es) * | 2003-05-12 | 2006-02-08 | Pfizer Prod Inc | Compuestos de isoxazol e isotiazol para el tratamiento de trastornos neurodegenerativos. |
| MXPA06001480A (es) * | 2003-08-06 | 2006-05-15 | Pfizer Prod Inc | Compuestos de oxazol para el tratamiento de trastornos neurodegenerativos. |
| FR2873374B1 (fr) * | 2004-07-22 | 2006-10-20 | Sanofi Synthelabo | Derives d'acylaminothiazole, leur preparation et leur application en therapeutique |
| PT1709018E (pt) | 2004-01-16 | 2011-10-24 | Sanofi Sa | Derivados de acilaminotiazole e sua aplicação como inibidores |
| AU2005209442B2 (en) * | 2004-01-16 | 2011-03-31 | Sanofi-Aventis | Acylaminothiazole derivatives, preparation method thereof and use of same in therapeutics |
| FR2865206B1 (fr) * | 2004-01-16 | 2009-02-06 | Sanofi Synthelabo | Derives d'acylaminothiazole, leur preparation et leur application en therapeutique |
| FR2865207B1 (fr) * | 2004-01-16 | 2008-10-17 | Sanofi Synthelabo | Derives d'acylaminothiazole, leur preparation et leur application en therapeutique |
| US7232820B2 (en) * | 2004-04-01 | 2007-06-19 | Pfizer Inc | Thiadiazole-amine compounds for the treatment of neurodegenerative disorders |
| US7220865B2 (en) * | 2004-04-01 | 2007-05-22 | Pfizer Inc | Isoxazole-and isothiazole-amine compounds for the treatment of neurodegenerative disorders |
| WO2007084391A2 (en) * | 2006-01-18 | 2007-07-26 | Amgen Inc. | Thiazole compounds as protein kinase b ( pkb) inhibitors |
| US7919504B2 (en) | 2007-07-17 | 2011-04-05 | Amgen Inc. | Thiadiazole modulators of PKB |
| EP2173728A2 (en) | 2007-07-17 | 2010-04-14 | Amgen Inc. | Heterocyclic modulators of pkb |
| CN109071503A (zh) * | 2016-03-31 | 2018-12-21 | 默克专利有限公司 | 用于抑制亲环素的化合物及其用途 |
| WO2019142883A1 (ja) | 2018-01-18 | 2019-07-25 | 第一三共株式会社 | ジヒドロインドリジノン誘導体 |
| KR20220031620A (ko) | 2019-07-08 | 2022-03-11 | 고쿠리츠다이가쿠호진 토쿄고교 다이가꾸 | 디하이드로인돌리지논 유도체를 사용한 인슐린 산생 세포의 제조법 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR016751A1 (es) * | 1996-11-22 | 2001-08-01 | Athena Neurosciences Inc | Metodo para inhibir la liberacion del peptido beta-amiloide en una celula, composicion farmaceutica y compuestos utiles en dicho metodo |
| JP2001504498A (ja) | 1996-11-22 | 2001-04-03 | エラン・ファーマシューティカルズ・インコーポレイテッド | Ｎ―（アリール／ヘテロアリール／アルキルアセチル）アミノ酸アミドおよびその医薬組成物、並びに該化合物を用いたβ―アミロイドペプチドの放出および／またはその合成を阻害する方法 |
| HUP0001232A3 (en) | 1996-12-23 | 2001-02-28 | Elan Pharmaceuticals Inc San F | Cycloalkyl, lactam, lactone derivatives and their thio analogues inhibiting betha-amyloid peptide release and/or its synthesis and pharmaceutical compositions containing the compounds |
| AR011164A1 (es) | 1997-02-28 | 2000-08-02 | Lilly Co Eli | Compuestos heterociclicos, composiciones farmaceuticas que los comprenden, y metodos para inhibir la liberacion del peptido beta-amiloide y/o su sintesismediante el uso de dichos compuestos |
| EP1131634A2 (en) | 1998-09-30 | 2001-09-12 | Elan Pharmaceuticals, Inc. | Determining the mechanism of beta-amyloid peptide generation |
| WO2000024392A1 (en) * | 1998-10-26 | 2000-05-04 | Sumitomo Pharmaceuticals Company, Limited | β-AMYLOID FORMATION INHIBITORS |
-
2002
- 2002-08-02 AR ARP020102935A patent/AR039059A1/es active IP Right Grant
- 2002-08-05 DE DE60208044T patent/DE60208044T2/de not_active Expired - Lifetime
- 2002-08-05 US US10/485,837 patent/US7288659B2/en not_active Expired - Lifetime
- 2002-08-05 JP JP2003519045A patent/JP2005500370A/ja active Pending
- 2002-08-05 EP EP02794623A patent/EP1417189B1/fr not_active Expired - Lifetime
- 2002-08-05 ES ES02794623T patent/ES2254773T3/es not_active Expired - Lifetime
- 2002-08-05 TW TW091117569A patent/TWI318974B/zh not_active IP Right Cessation
- 2002-08-05 DK DK02794623T patent/DK1417189T3/da active
- 2002-08-05 AT AT02794623T patent/ATE312828T1/de active
- 2002-08-05 WO PCT/FR2002/002802 patent/WO2003014095A1/fr not_active Ceased
-
2007
- 2007-09-20 US US11/858,454 patent/US20080058380A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20040171643A1 (en) | 2004-09-02 |
| US7288659B2 (en) | 2007-10-30 |
| TWI318974B (en) | 2010-01-01 |
| US20080058380A1 (en) | 2008-03-06 |
| DE60208044T2 (de) | 2006-08-17 |
| EP1417189A1 (fr) | 2004-05-12 |
| WO2003014095A1 (fr) | 2003-02-20 |
| JP2005500370A (ja) | 2005-01-06 |
| ATE312828T1 (de) | 2005-12-15 |
| DE60208044D1 (de) | 2006-01-19 |
| ES2254773T3 (es) | 2006-06-16 |
| AR039059A1 (es) | 2005-02-09 |
| EP1417189B1 (fr) | 2005-12-14 |
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