DK141409C - Fremgangsmaade og celledyrkningsenhed til dyrkning og vedligeo holdelse af levende menneskelige eller dyriske celler in vitr - Google Patents

Fremgangsmaade og celledyrkningsenhed til dyrkning og vedligeo holdelse af levende menneskelige eller dyriske celler in vitr

Info

Publication number
DK141409C
DK141409C DK197773A DK197773A DK141409C DK 141409 C DK141409 C DK 141409C DK 197773 A DK197773 A DK 197773A DK 197773 A DK197773 A DK 197773A DK 141409 C DK141409 C DK 141409C
Authority
DK
Denmark
Prior art keywords
culture
white
maintenance
procedure
animal cells
Prior art date
Application number
DK197773A
Other languages
English (en)
Other versions
DK141409B (da
Inventor
R A Knazek
P M Gullino
W R Kidwell
R L Dedrick
Original Assignee
Cellco
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cellco filed Critical Cellco
Publication of DK141409B publication Critical patent/DK141409B/da
Application granted granted Critical
Publication of DK141409C publication Critical patent/DK141409C/da

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Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M25/00Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
    • C12M25/10Hollow fibers or tubes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/10Perfusion
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/16Hollow fibers

Landscapes

  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Sustainable Development (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DK197773A 1972-05-18 1973-04-11 Fremgangsmaade og celledyrkningsenhed til dyrkning og vedligeo holdelse af levende menneskelige eller dyriske celler in vitr DK141409C (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25467872 1972-05-18
US00254678A US3821087A (en) 1972-05-18 1972-05-18 Cell culture on semi-permeable tubular membranes

Publications (2)

Publication Number Publication Date
DK141409B DK141409B (da) 1980-03-10
DK141409C true DK141409C (da) 1980-09-01

Family

ID=22965151

Family Applications (1)

Application Number Title Priority Date Filing Date
DK197773A DK141409C (da) 1972-05-18 1973-04-11 Fremgangsmaade og celledyrkningsenhed til dyrkning og vedligeo holdelse af levende menneskelige eller dyriske celler in vitr

Country Status (15)

Country Link
US (1) US3821087A (da)
JP (1) JPS546634B2 (da)
AT (1) AT325210B (da)
BE (1) BE799675A (da)
CA (1) CA1100067A (da)
CH (1) CH564086A5 (da)
DD (1) DD103925A5 (da)
DE (1) DE2319120C2 (da)
DK (1) DK141409C (da)
FR (1) FR2184960B1 (da)
GB (1) GB1395291A (da)
IT (1) IT987281B (da)
NL (1) NL162430C (da)
NO (1) NO135642C (da)
SE (1) SE386687B (da)

Families Citing this family (110)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3941662A (en) * 1971-06-09 1976-03-02 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. Apparatus for culturing cells
CH593339A5 (da) * 1973-07-02 1977-11-30 Monsanto Co
US3993560A (en) * 1975-02-27 1976-11-23 Halpern Richard M Method and apparatus for monitoring cellular activities
US4144126A (en) * 1975-05-21 1979-03-13 Beecham Group Limited Cell culture method
US4201845A (en) * 1976-04-12 1980-05-06 Monsanto Company Cell culture reactor
US4087327A (en) * 1976-04-12 1978-05-02 Monsanto Company Mammalion cell culture process
DE2726313C3 (de) * 1977-06-10 1980-02-07 Battelle-Institut E.V., 6000 Frankfurt Verfahren zur in-vitro-Biosynthese von Hormonen, insbesondere von Insulin
JPS5441171A (en) * 1977-09-08 1979-04-02 Iwatsu Electric Co Ltd Synchronous delay pulse generator
US4184922A (en) * 1977-11-11 1980-01-22 The Government Of The United States Dual circuit, woven artificial capillary bundle for cell culture
US4220725A (en) * 1978-04-03 1980-09-02 United States Of America Capillary cell culture device
US4242459A (en) * 1978-11-02 1980-12-30 Chick William L Cell culture device
US4242460A (en) * 1978-12-26 1980-12-30 Chick William L Cell culture device
JPS5636124U (da) * 1979-08-29 1981-04-07
US4298002A (en) * 1979-09-10 1981-11-03 National Patent Development Corporation Porous hydrophilic materials, chambers therefrom, and devices comprising such chambers and biologically active tissue and methods of preparation
JPS5642584A (en) * 1979-09-18 1981-04-20 Asahi Chem Ind Co Ltd Cell cultivation method
DE2940446C2 (de) * 1979-10-05 1982-07-08 B. Braun Melsungen Ag, 3508 Melsungen Züchtung von tierischen Zellen in Suspensions- und Monolayerkulturen in Fermentationsgefäßen
US4301250A (en) * 1979-11-02 1981-11-17 Merck & Co., Inc. Method of producing hepatitis B surface antigen
US4301249A (en) * 1980-07-23 1981-11-17 Merck & Co., Inc. High titer production of hepatitis A virus
US4440853A (en) * 1980-08-21 1984-04-03 Board Of Trustees Of The Leland Stanford Junior University Microbiological methods using hollow fiber membrane reactor
JPS593154U (ja) * 1982-06-25 1984-01-10 リンナイ株式会社 熱発電素子装置
CA1206433A (en) * 1982-08-06 1986-06-24 Channing R. Robertson Production of biological products using resting cells
WO1984001959A1 (en) * 1982-11-16 1984-05-24 Univ California Rapid production of biological products by fermentation in a densely-packed microbial membrane reactor
JPS59132883A (ja) * 1982-12-20 1984-07-31 モンサント・コンパニ− 生物触媒反応装置
US4937187A (en) * 1983-02-04 1990-06-26 Brown University Research Foundation Methods for separating malignant cells from clinical specimens
US4559299A (en) * 1983-02-04 1985-12-17 Brown University Research Foundation Inc. Cytotoxicity assays in cell culturing devices
US4734372A (en) * 1983-02-04 1988-03-29 Brown University Research Foundation Cell culturing methods and apparatus
SE8301193D0 (sv) * 1983-03-04 1983-03-04 Haustrup Plastic As Behallare
US4804628A (en) * 1984-10-09 1989-02-14 Endotronics, Inc. Hollow fiber cell culture device and method of operation
US4748124A (en) * 1984-10-30 1988-05-31 E. I. Du Pont De Nemours And Company Compartmentalized cell-culture device and method
GB8508976D0 (en) * 1985-04-04 1985-05-09 Davies G A Reactor unit
US4647539A (en) * 1985-05-24 1987-03-03 Endotronics, Inc. Method and apparatus for growing cells in vitro
EP0220650A3 (en) * 1985-10-21 1988-08-24 Endotronics Inc. Method and device for culturing cells
US4889812A (en) * 1986-05-12 1989-12-26 C. D. Medical, Inc. Bioreactor apparatus
US4829002A (en) * 1986-05-12 1989-05-09 Baxter International Inc. System for metering nutrient media to cell culture containers and method
US4918019A (en) * 1986-05-12 1990-04-17 C. D. Medical, Incorporated Bioreactor system with plasticizer removal
US4937194A (en) * 1986-05-12 1990-06-26 Baxter International Inc. Method for metering nutrient media to cell culture containers
US4894342A (en) * 1986-05-12 1990-01-16 C. D. Medical, Inc. Bioreactor system
JPS6312274A (ja) * 1986-07-03 1988-01-19 Takashi Mori バイオリアクタ
DE3633891A1 (de) * 1986-10-04 1988-04-07 Akzo Gmbh Verfahren und vorrichtung zum kultivieren von tierischen zellen
US4885087A (en) * 1986-11-26 1989-12-05 Kopf Henry B Apparatus for mass transfer involving biological/pharmaceutical media
US6022742A (en) * 1986-11-26 2000-02-08 Kopf; Henry B. Culture device and method
JPS63195575A (ja) * 1987-02-09 1988-08-12 Yokogawa Electric Corp サンプリングオシロスコ−プ
JPH0763354B2 (ja) * 1987-06-30 1995-07-12 リサーチ コーポレイション テクノロジーズ インコーポレイテッド 親水性隔膜と疎水性隔膜とで形成した区画室を備える細胞成長リアクタ
US4839292B1 (en) * 1987-09-11 1994-09-13 Joseph G Cremonese Cell culture flask utilizing membrane barrier
US5962490A (en) 1987-09-25 1999-10-05 Texas Biotechnology Corporation Thienyl-, furyl- and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin
DE3733636C1 (de) * 1987-10-05 1989-04-20 Schott Glaswerke Verfahren zum Vermehren von Zellen,insbesondere bei der Pruefung von Behandlungssubstanzen auf Wirksamkeit
US5158881A (en) * 1987-11-17 1992-10-27 Brown University Research Foundation Method and system for encapsulating cells in a tubular extrudate in separate cell compartments
US5418154A (en) * 1987-11-17 1995-05-23 Brown University Research Foundation Method of preparing elongated seamless capsules containing biological material
US5283187A (en) * 1987-11-17 1994-02-01 Brown University Research Foundation Cell culture-containing tubular capsule produced by co-extrusion
US5081035A (en) * 1988-04-18 1992-01-14 The University Of Michigan Bioreactor system
US4973558A (en) * 1988-04-28 1990-11-27 Endotronics, Inc. Method of culturing cells using highly gas saturated media
US5605835A (en) * 1988-05-23 1997-02-25 Regents Of The University Of Minnesota Bioreactor device with application as a bioartificial liver
US5079168A (en) * 1988-08-10 1992-01-07 Endotronics, Inc. Cell culture apparatus
WO1990002171A1 (en) * 1988-08-31 1990-03-08 Cellco Advanced Bioreactors, Inc. In vitro cell culture reactor
US5162225A (en) * 1989-03-17 1992-11-10 The Dow Chemical Company Growth of cells in hollow fibers in an agitated vessel
US4897359A (en) * 1989-03-27 1990-01-30 Bio-Response, Inc. Apparatus for oxygenating culture medium
US4912057A (en) * 1989-06-13 1990-03-27 Cancer Diagnostics, Inc. Cell chamber for chemotaxis assay
US5490933A (en) * 1991-04-04 1996-02-13 The Dow Chemical Company Self-regulated biological scrubber and/or gas stripper for the treatment of fluid streams
US5268298A (en) * 1991-04-26 1993-12-07 Life Technologies, Inc. System for delivering oxygen to a cell culture medium
US5330908A (en) * 1992-12-23 1994-07-19 The United States Of America As Represented By The Administrator, National Aeronautics And Space Administration High density cell culture system
AU7976294A (en) * 1993-11-05 1995-05-23 Regents Of The University Of California, The Improved postanatal and (in utero) fetal hematopoietic stem cell transplantation methods
US5622857A (en) * 1995-08-08 1997-04-22 Genespan Corporation High performance cell culture bioreactor and method
US5882918A (en) * 1995-08-08 1999-03-16 Genespan Corporation Cell culture incubator
US5498537A (en) * 1994-03-09 1996-03-12 Cellco, Inc. Serum-free production of packaged viral vector
US6660509B1 (en) 1995-03-28 2003-12-09 Kinetic Biosystems, Inc. Methods and devices for remediation and fermentation
US5622819A (en) * 1995-03-28 1997-04-22 Kinetic Biosystems, Inc. Centrifugal fermentation process
US20050266548A1 (en) * 1995-03-28 2005-12-01 Kbi Biopharma, Inc. Biocatalyst chamber encapsulation system for bioremediation and fermentation with improved rotor
US6214617B1 (en) 1995-03-28 2001-04-10 Kinetic Biosystems, Inc. Centrifugal fermentation process
US6133019A (en) * 1995-03-28 2000-10-17 Kinetic Biosystems, Inc. Centrifugal fermentation process
US6916652B2 (en) * 1995-03-28 2005-07-12 Kinetic Biosystems, Inc. Biocatalyst chamber encapsulation system for bioremediation and fermentation
US5523228A (en) * 1995-07-07 1996-06-04 Hmri/Clmf Hydrodynamic cell culture environment for three dimensional tissue growth
US20020182730A1 (en) * 1995-07-26 2002-12-05 Micheal L. Gruenberg Autologous immune cell therapy: cell compositions, methods and applications to treatment of human disease
US5804585A (en) 1996-04-15 1998-09-08 Texas Biotechnology Corporation Thieno-pyridine sulfonamides derivatives thereof and related compounds that modulate the activity of endothelin
US6001643A (en) * 1997-08-04 1999-12-14 C-Med Inc. Controlled hydrodynamic cell culture environment for three dimensional tissue growth
US6235196B1 (en) 1998-04-23 2001-05-22 Alliedsignal Inc. Biological wastewater treatment system
ATE373079T1 (de) * 1999-06-21 2007-09-15 Gen Hospital Corp Zellkultursysteme und verfahren für einrichtungen zur organunterstützung
US6703217B2 (en) 2000-01-31 2004-03-09 Kinetic Biosystems, Inc. Methods and devices for remediation and fermentation
JP2002112763A (ja) * 2000-10-10 2002-04-16 Nipro Corp 細胞培養容器
FR2821947B1 (fr) * 2001-03-12 2003-05-16 Canon Kk Procede et dispositif de validation de parametres definissant une image
US20030134415A1 (en) * 2001-09-19 2003-07-17 Gruenberg Micheal L. Th1 cell adoptive immunotherapy
US20030134341A1 (en) * 2001-09-19 2003-07-17 Medcell Biologics, Llc. Th1 cell adoptive immunotherapy
US6667172B2 (en) 2001-09-19 2003-12-23 The Cleveland Clinic Foundation Cell and tissue culture modeling device and apparatus and method of using same
US20040096943A1 (en) * 2002-01-28 2004-05-20 Uwe Marx Method and device for cultivating of cells at high densities and for obtaining of products from these cells
US20030175272A1 (en) * 2002-03-07 2003-09-18 Medcell Biologics, Inc. Re-activated T-cells for adoptive immunotherapy
DE10325148A1 (de) * 2002-05-31 2003-12-11 Probiogen Ag Kultursysteme zur sterilen kontinuierlichen Kultivierung von Zellen
ZA200602094B (en) * 2006-01-16 2007-11-28 Reliance Life Sciences Pvt Ltd Device for culturing and transporting cells
DE102007010866A1 (de) * 2007-03-02 2008-09-04 Leibniz-Institut für Naturstoff-Forschung und Infektionsbiologie e.V. -Hans-Knöll-Institut- Vorrichtung und Verfahren zur Durchführung von emersen Mikrokultivierungen bei Mikroorganismen und Zellen
CA2678893C (en) * 2007-03-05 2015-12-29 Caridianbct, Inc. Methods to control cell movement in hollow fiber bioreactors
US8309347B2 (en) * 2007-03-05 2012-11-13 Terumo Bct, Inc. Cell expansion system and methods of use
US8778669B2 (en) 2009-07-22 2014-07-15 Corning Incorporated Multilayer tissue culture vessel
US9057045B2 (en) * 2009-12-29 2015-06-16 Terumo Bct, Inc. Method of loading and distributing cells in a bioreactor of a cell expansion system
WO2012048275A2 (en) 2010-10-08 2012-04-12 Caridianbct, Inc. Configurable methods and systems of growing and harvesting cells in a hollow fiber bioreactor system
JP6182135B2 (ja) 2011-06-06 2017-08-16 レゲネシス ベーフェーベーアー 中空繊維バイオリアクター中での幹細胞の増幅
EP2604681B1 (en) 2011-12-12 2017-02-08 nanoAnalytics GmbH Use of an arrangement for impedance measurements across the surface of a tubular membrane manufactured from a semipermeable material
CN110229780A (zh) 2012-08-20 2019-09-13 泰尔茂比司特公司 在细胞扩增系统的生物反应器中加载和分配细胞的方法
US9005550B2 (en) 2012-10-29 2015-04-14 Corning Incorporated Multi-layered cell culture vessel with manifold grips
US10072239B1 (en) * 2013-03-05 2018-09-11 The United States Of America As Represented By The Administrator Of The Nasa Microorganism cultivation platform for human life support
EP3022284B1 (en) * 2013-07-17 2020-01-08 Scinus Holding B.V. Control of ph and dissolved gas in medium
JP6612227B2 (ja) 2013-11-16 2019-11-27 テルモ ビーシーティー、インコーポレーテッド バイオリアクターにおける細胞増殖
EP3122866B1 (en) 2014-03-25 2019-11-20 Terumo BCT, Inc. Passive replacement of media
US10077421B2 (en) 2014-04-24 2018-09-18 Terumo Bct, Inc. Measuring flow rate
JP6830059B2 (ja) 2014-09-26 2021-02-17 テルモ ビーシーティー、インコーポレーテッド スケジュール化された細胞フィーディング
EP3098304A1 (en) 2015-05-28 2016-11-30 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Hybrid cell detachment-free cell expansion system for adherent cell culturing and related proceeding protocol
WO2017004592A1 (en) 2015-07-02 2017-01-05 Terumo Bct, Inc. Cell growth with mechanical stimuli
JP7034949B2 (ja) 2016-05-25 2022-03-14 テルモ ビーシーティー、インコーポレーテッド 細胞の増殖
US11685883B2 (en) 2016-06-07 2023-06-27 Terumo Bct, Inc. Methods and systems for coating a cell growth surface
US11104874B2 (en) 2016-06-07 2021-08-31 Terumo Bct, Inc. Coating a bioreactor
US11624046B2 (en) 2017-03-31 2023-04-11 Terumo Bct, Inc. Cell expansion
CN110612344B (zh) 2017-03-31 2023-09-12 泰尔茂比司特公司 细胞扩增
WO2020036205A1 (en) * 2018-08-16 2020-02-20 Terumo Kabushiki Kaisha Cell culture substrate

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL128859C (da) * 1960-09-19
US3223595A (en) * 1962-10-01 1965-12-14 John H Brewer Culturflex apparatus and flexible tubular casing therein

Also Published As

Publication number Publication date
NO135642C (da) 1977-05-04
DK141409B (da) 1980-03-10
DE2319120C2 (de) 1982-05-27
NL7306659A (da) 1973-11-20
IT987281B (it) 1975-02-20
US3821087A (en) 1974-06-28
FR2184960B1 (da) 1976-09-17
CH564086A5 (da) 1975-07-15
DD103925A5 (da) 1974-02-12
FR2184960A1 (da) 1973-12-28
GB1395291A (en) 1975-05-21
BE799675A (fr) 1973-11-19
NL162430B (nl) 1979-12-17
JPS546634B2 (da) 1979-03-30
NL162430C (nl) 1980-05-16
DE2319120A1 (de) 1973-12-06
SE386687B (sv) 1976-08-16
NO135642B (da) 1977-01-24
AT325210B (de) 1975-10-10
JPS4941579A (da) 1974-04-18
CA1100067A (en) 1981-04-28

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