DK1406698T3 - Lipoxinanaloger som nye inhibitorer af angiogenese - Google Patents
Lipoxinanaloger som nye inhibitorer af angiogeneseInfo
- Publication number
- DK1406698T3 DK1406698T3 DK02721234T DK02721234T DK1406698T3 DK 1406698 T3 DK1406698 T3 DK 1406698T3 DK 02721234 T DK02721234 T DK 02721234T DK 02721234 T DK02721234 T DK 02721234T DK 1406698 T3 DK1406698 T3 DK 1406698T3
- Authority
- DK
- Denmark
- Prior art keywords
- lxa
- angiogenesis
- novel inhibitors
- lipoxin analogs
- epi
- Prior art date
Links
- 229930184725 Lipoxin Natural products 0.000 title 1
- 230000033115 angiogenesis Effects 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 150000002639 lipoxins Chemical class 0.000 title 1
- 208000037803 restenosis Diseases 0.000 abstract 2
- 125000000066 S-methyl group Chemical group [H]C([H])([H])S* 0.000 abstract 1
- 150000001408 amides Chemical class 0.000 abstract 1
- 150000001735 carboxylic acids Chemical class 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
- A61K31/202—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having three or more double bonds, e.g. linolenic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
- A61K31/203—Retinoic acids ; Salts thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Ophthalmology & Optometry (AREA)
- Dermatology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US27293101P | 2001-03-02 | 2001-03-02 | |
US10/086,609 US6627658B2 (en) | 2001-03-02 | 2002-03-01 | Lipoxin analogs as novel inhibitors of angiogenesis |
PCT/US2002/006404 WO2002070068A2 (en) | 2001-03-02 | 2002-03-01 | Lipoxin analogs as novel inhibitors of angiogenesis |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1406698T3 true DK1406698T3 (da) | 2009-02-09 |
Family
ID=26774943
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK02721234T DK1406698T3 (da) | 2001-03-02 | 2002-03-01 | Lipoxinanaloger som nye inhibitorer af angiogenese |
Country Status (11)
Country | Link |
---|---|
US (4) | US6627658B2 (es) |
EP (2) | EP2221089A1 (es) |
JP (3) | JP2005508282A (es) |
AT (1) | ATE412448T1 (es) |
AU (1) | AU2002252175A1 (es) |
CY (1) | CY1108670T1 (es) |
DE (1) | DE60229640D1 (es) |
DK (1) | DK1406698T3 (es) |
ES (1) | ES2316553T3 (es) |
PT (1) | PT1406698E (es) |
WO (1) | WO2002070068A2 (es) |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE504557T1 (de) | 2000-02-16 | 2011-04-15 | Brigham & Womens Hospital | Aspirin-ausgelöste lipidmediatoren |
AU2001249329A1 (en) | 2000-03-20 | 2001-10-03 | Brigham And Women's Hospital | Lipoxin analogs and methods for the treatment of periodontal disease |
US6627658B2 (en) * | 2001-03-02 | 2003-09-30 | The Brigham And Women's Hospital | Lipoxin analogs as novel inhibitors of angiogenesis |
US8722654B2 (en) | 2001-03-02 | 2014-05-13 | The Brigham And Women's Hospital, Inc. | Lipoxin analogs as novel inhibitors of angiogenesis |
US8481772B2 (en) | 2002-04-01 | 2013-07-09 | University Of Southern California | Trihydroxy polyunsaturated eicosanoid derivatives |
US7902257B2 (en) * | 2002-04-01 | 2011-03-08 | University Of Southern California | Trihydroxy polyunsaturated eicosanoid |
US7759395B2 (en) | 2002-08-12 | 2010-07-20 | The Brigham And Women's Hospital, Inc. | Use of docosatrienes, resolvins and their stable analogs in the treatment of airway diseases and asthma |
ATE449057T1 (de) * | 2002-08-12 | 2009-12-15 | Brigham & Womens Hospital | Resolvine: biotemplate zur durchführung therapeutischer anwendungen |
WO2004078143A2 (en) * | 2003-03-05 | 2004-09-16 | The Brigham And Women's Hospital Inc. | Methods for identification and uses of anti-inflammatory receptors for eicosapentaenoic acid analogs |
US20050238589A1 (en) * | 2004-04-14 | 2005-10-27 | Van Dyke Thomas E | Methods and compositions for preventing or treating periodontal diseases |
AU2005304733B2 (en) * | 2004-11-09 | 2011-04-07 | Alcon, Inc. | 5,6,7-trihydroxyheptanoic acid and analogs for the treatment of ocular diseases and diseases associated with hyperproliferative and angiogenic responses |
US8273792B2 (en) * | 2005-10-03 | 2012-09-25 | The Brigham And Women's Hospital, Inc. | Anti-inflammatory actions of neuroprotectin D1/protectin D1 and it's natural stereoisomers |
JP2009515991A (ja) | 2005-11-18 | 2009-04-16 | トラスティーズ オブ ボストン ユニバーシティ | レゾルビンを使用する骨喪失の処置および防止 |
WO2007127377A2 (en) * | 2006-04-28 | 2007-11-08 | Resolvyx Pharmaceuticals, Inc. | Combinations comprising omega-3 fatty acid compounds for the treatment of cardiovascular disease |
KR20090040323A (ko) * | 2006-07-19 | 2009-04-23 | 레솔빅스 파마슈티칼즈, 인코퍼레이티드 | 점막염의 치료를 위한 조성물과 방법 |
EP2131833A2 (en) * | 2006-10-26 | 2009-12-16 | Resolvyx Pharmaceuticals, Inc. | Use of resolvins for inhibition of bone loss |
WO2008070129A2 (en) * | 2006-12-05 | 2008-06-12 | Resolvyx Pharmaceuticals, Inc. | Compositions and methods for the treatment of inflammatory disease |
JP5417328B2 (ja) * | 2007-08-08 | 2014-02-12 | ビーエーエスエフ ソシエタス・ヨーロピア | 有機殺虫剤化合物を含む水性マイクロエマルジョン |
US20090137527A1 (en) * | 2007-09-14 | 2009-05-28 | Resolvyx Pharmaceuticals, Inc. | Compositions and methods for modulating immune function |
EP2214660A2 (en) * | 2007-10-12 | 2010-08-11 | Resolvyx Pharmaceuticals, Inc. | Omega-3 fatty acids, hydroxy polyunsaturated fatty acids, lipoxin compounds, or oxylipin compounds for the treatment of ophthalmic conditions |
WO2009058815A2 (en) * | 2007-10-29 | 2009-05-07 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Lipoxin a4 protection for retinal cells |
US7601693B2 (en) * | 2008-02-05 | 2009-10-13 | National Taiwan University | Composition for treating cancer and use thereof |
US20100105772A1 (en) * | 2008-04-25 | 2010-04-29 | Serhan Charles N | Use of novel lipid mediators to inhibit angiogenesis |
JP6490597B2 (ja) * | 2013-02-22 | 2019-03-27 | ユニヴァーシティー オブ サザン カリフォルニア | 眼の疾患および障害を治療するための方法 |
US10731132B2 (en) | 2013-03-15 | 2020-08-04 | Amniotics Ab | Methods and apparatuses for umbilical cord blood collection and isolation of cells |
EP3020398A1 (en) * | 2014-11-17 | 2016-05-18 | Nitto Denko Corporation | Compounds and formulations for reducing scarring |
EP3795179A1 (en) | 2016-06-03 | 2021-03-24 | Thetis Pharmaceuticals LLC | Compositions and methods relating to salts of specialized pro-resolving mediators of inflammation |
WO2018073615A1 (en) | 2016-10-21 | 2018-04-26 | Longboat Explorers Ab | Methods and compositions for generating hematopoietic cells |
CN110709138A (zh) | 2017-01-31 | 2020-01-17 | 布里格姆及妇女医院股份有限公司 | Alx受体配体定义炎症性疾病的生化内型 |
WO2018161175A1 (en) * | 2017-03-09 | 2018-09-13 | University Health Network | Lipoxin and lipoxin analogue mediated neuroprotection and treatments |
US20220372444A1 (en) | 2019-10-18 | 2022-11-24 | Amniotics Ab | Processes and apparatuses for obtaining amniotic mesenchymal stem cells from amniotic fluid and cells derived thereof |
WO2023168245A2 (en) | 2022-03-03 | 2023-09-07 | Thetis Pharmaceuticals Llc | Cyclodextrin complexes of specialized proresolving mediators |
Family Cites Families (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4560514A (en) | 1984-05-04 | 1985-12-24 | Bengt Samuelsson | Inflammatory lipoxin A and anti-anflammatory lipoxin B compounds |
US4576758A (en) | 1984-06-01 | 1986-03-18 | The Upjohn Company | Anti-inflammatory lipoxin B analogs |
US4780281A (en) | 1985-06-14 | 1988-10-25 | Wayne State University | Method for assay of peroxidase enzyme or reducing substrate activity |
JPS62198677A (ja) | 1986-02-26 | 1987-09-02 | Nissan Chem Ind Ltd | テトラオ−ル誘導体 |
JPH0739368B2 (ja) | 1986-10-01 | 1995-05-01 | 旭硝子株式会社 | 20,20,20−トリフルオロアラキドン酸誘導体およびその製造法 |
CA1329809C (en) | 1987-07-08 | 1994-05-24 | Nissan Chemical Industries, Ltd. | Optically active allyl alcohol and process for producing leucotriene b_ using thereof |
JPH01228994A (ja) | 1988-03-10 | 1989-09-12 | Fumie Satou | γ−シリルアリルアルコール及びその製造法 |
US5079261A (en) | 1989-04-28 | 1992-01-07 | Brigham And Women's Hospital | Use of lipoxin a4 and its derivatives as antagonists for slow-reacting substances of anaphylaxis |
JP2834512B2 (ja) | 1990-01-30 | 1998-12-09 | 帝人株式会社 | リポキシン誘導体を有効成分とする疾患治療剤 |
US5322699A (en) | 1991-02-04 | 1994-06-21 | The Rockefeller University | Leukocyte-derived CR3 modulator, integrin modulating factor-1 (IMF-1) |
US5650435A (en) | 1991-04-01 | 1997-07-22 | Madara; James L. | Modulation of inflammation related to columnar epithelia |
JP3227922B2 (ja) | 1993-01-20 | 2001-11-12 | 富士電機株式会社 | 自動販売機 |
US5441951A (en) | 1994-06-15 | 1995-08-15 | Brigham & Women's Hospital | Lipoxin compounds |
EP2107050A1 (en) * | 1993-06-15 | 2009-10-07 | The Brigham and Women's Hospital, Inc. | Lipoxin compounds |
US6048897A (en) * | 1993-06-15 | 2000-04-11 | Brigham And Women's Hospital | Lipoxin compounds and their use in treating cell proliferative disorders |
WO1995001179A1 (en) * | 1993-06-29 | 1995-01-12 | Brigham & Women's Hospital | Modulation of inflammation related to columnar epithelia |
US5750354A (en) | 1994-03-11 | 1998-05-12 | Brigham And Women's Hospital | Lipoxin transport system and uses therefor |
CA2270154A1 (en) * | 1996-10-25 | 1998-04-30 | The Government Of The United States Of America As Represented By The Sec Retary, Department Of Health And Human Services | Methods and compositions for inhibiting inflammation and angiogenesis comprising a mammalian cd97 alpha subunit |
US5837283A (en) * | 1997-03-12 | 1998-11-17 | The Regents Of The University Of California | Cationic lipid compositions targeting angiogenic endothelial cells |
WO2000009503A1 (en) * | 1998-08-13 | 2000-02-24 | Merck & Co., Inc. | Integrin receptor antagonists |
US6433202B1 (en) * | 1999-03-18 | 2002-08-13 | Brigham And Women's Hospital | Prevention of neutrophil recruitment |
CA2615917C (en) * | 1999-03-18 | 2011-10-04 | Brigham And Women's Hospital | Use of lipoxin compounds for inhibiting of tnf-(alpha)initiated neutrophil response |
ATE504557T1 (de) * | 2000-02-16 | 2011-04-15 | Brigham & Womens Hospital | Aspirin-ausgelöste lipidmediatoren |
AU2001249329A1 (en) | 2000-03-20 | 2001-10-03 | Brigham And Women's Hospital | Lipoxin analogs and methods for the treatment of periodontal disease |
US6627658B2 (en) | 2001-03-02 | 2003-09-30 | The Brigham And Women's Hospital | Lipoxin analogs as novel inhibitors of angiogenesis |
-
2002
- 2002-03-01 US US10/086,609 patent/US6627658B2/en not_active Expired - Fee Related
- 2002-03-01 AU AU2002252175A patent/AU2002252175A1/en not_active Abandoned
- 2002-03-01 DE DE60229640T patent/DE60229640D1/de not_active Expired - Lifetime
- 2002-03-01 PT PT02721234T patent/PT1406698E/pt unknown
- 2002-03-01 ES ES02721234T patent/ES2316553T3/es not_active Expired - Lifetime
- 2002-03-01 EP EP10003357A patent/EP2221089A1/en not_active Ceased
- 2002-03-01 DK DK02721234T patent/DK1406698T3/da active
- 2002-03-01 EP EP02721234A patent/EP1406698B1/en not_active Expired - Lifetime
- 2002-03-01 JP JP2002569237A patent/JP2005508282A/ja not_active Withdrawn
- 2002-03-01 WO PCT/US2002/006404 patent/WO2002070068A2/en active Application Filing
- 2002-03-01 AT AT02721234T patent/ATE412448T1/de active
-
2003
- 2003-07-08 US US10/615,361 patent/US20040053998A1/en not_active Abandoned
-
2005
- 2005-09-08 US US11/222,458 patent/US8008282B2/en not_active Expired - Fee Related
-
2007
- 2007-08-13 US US11/837,657 patent/US20080064749A1/en not_active Abandoned
-
2008
- 2008-12-29 CY CY20081101498T patent/CY1108670T1/el unknown
-
2009
- 2009-11-09 JP JP2009256184A patent/JP5302856B2/ja not_active Expired - Fee Related
-
2012
- 2012-09-05 JP JP2012195046A patent/JP2012255025A/ja not_active Ceased
Also Published As
Publication number | Publication date |
---|---|
EP1406698A2 (en) | 2004-04-14 |
CY1108670T1 (el) | 2014-04-09 |
US8008282B2 (en) | 2011-08-30 |
ES2316553T3 (es) | 2009-04-16 |
US20060009521A1 (en) | 2006-01-12 |
US20040053998A1 (en) | 2004-03-18 |
WO2002070068A2 (en) | 2002-09-12 |
JP2005508282A (ja) | 2005-03-31 |
ATE412448T1 (de) | 2008-11-15 |
PT1406698E (pt) | 2009-01-12 |
AU2002252175A1 (en) | 2002-09-19 |
US20020193431A1 (en) | 2002-12-19 |
JP2010059183A (ja) | 2010-03-18 |
US6627658B2 (en) | 2003-09-30 |
JP5302856B2 (ja) | 2013-10-02 |
JP2012255025A (ja) | 2012-12-27 |
DE60229640D1 (de) | 2008-12-11 |
US20080064749A1 (en) | 2008-03-13 |
EP1406698B1 (en) | 2008-10-29 |
WO2002070068A3 (en) | 2003-12-31 |
EP2221089A1 (en) | 2010-08-25 |
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