DK140408B - Analogifremgangsmaade til fremstilling af n-(heteroarylmethyl)-7alfa-acyl-6,14-endoetheno-eller-endoethano-tetrahydronororipaviner eller thebainer eller syreadditionssalte deraf - Google Patents

Analogifremgangsmaade til fremstilling af n-(heteroarylmethyl)-7alfa-acyl-6,14-endoetheno-eller-endoethano-tetrahydronororipaviner eller thebainer eller syreadditionssalte deraf

Info

Publication number
DK140408B
DK140408B DK336273AA DK336273A DK140408B DK 140408 B DK140408 B DK 140408B DK 336273A A DK336273A A DK 336273AA DK 336273 A DK336273 A DK 336273A DK 140408 B DK140408 B DK 140408B
Authority
DK
Denmark
Prior art keywords
thebainer
tetrahydronororipavins
endoetheno
7alfa
endoethano
Prior art date
Application number
DK336273AA
Other languages
English (en)
Other versions
DK140408C (da
Inventor
A Langbein
H Merz
G Walther
K Stockhaus
Original Assignee
Boehringer Sohn Ingelheim
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Sohn Ingelheim filed Critical Boehringer Sohn Ingelheim
Publication of DK140408B publication Critical patent/DK140408B/da
Application granted granted Critical
Publication of DK140408C publication Critical patent/DK140408C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/09—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems
    • C07D489/10—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14
    • C07D489/12—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14 the bridge containing only two carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/14—Antitussive agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK336273A 1972-06-19 1973-06-18 Analogifremgangsmaade til fremstilling af n-(heteroarylmethyl)-7alfa-acyl-6,14-endoetheno- eller -endoethano-tetrahydronororipaviner eller-thebainer eller syreadditionssalte deraf DK140408C (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2229770A DE2229770A1 (de) 1972-06-19 1972-06-19 N-(heteroarylmethyl)-7alpha-acyl6,14-endoaethenotetrahydro-nororipavine und -thebaine, deren hydrierungsprodukte und saeureadditionssalze sowie verfahren zu deren herstellung

Publications (2)

Publication Number Publication Date
DK140408B true DK140408B (da) 1979-08-20
DK140408C DK140408C (da) 1980-01-21

Family

ID=5848095

Family Applications (1)

Application Number Title Priority Date Filing Date
DK336273A DK140408C (da) 1972-06-19 1973-06-18 Analogifremgangsmaade til fremstilling af n-(heteroarylmethyl)-7alfa-acyl-6,14-endoetheno- eller -endoethano-tetrahydronororipaviner eller-thebainer eller syreadditionssalte deraf

Country Status (14)

Country Link
US (1) US3931187A (da)
JP (1) JPS5732073B2 (da)
AT (6) AT328095B (da)
BE (1) BE801083A (da)
CH (6) CH599215A5 (da)
DE (1) DE2229770A1 (da)
DK (1) DK140408C (da)
ES (5) ES416038A1 (da)
FI (1) FI56180C (da)
FR (1) FR2189054B1 (da)
GB (1) GB1430958A (da)
NL (1) NL7308482A (da)
NO (1) NO137998C (da)
SE (1) SE409035B (da)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62298530A (ja) * 1986-06-16 1987-12-25 Otsuka Pharmaceut Co Ltd 坐薬用医薬組成物
ATE377602T1 (de) 1997-03-27 2007-11-15 Toray Industries Morphinanderivate und ihre medizinische anwendung
EP2580201B1 (en) 2010-06-11 2017-08-02 Rhodes Technologies Transition metal-catalyzed processes for the preparation of n-allyl compounds and use thereof
TWI471289B (zh) 2010-06-11 2015-02-01 Rhodes Technologies 使三級胺進行ｎ－脫烷反應之方法
US9315514B2 (en) 2012-08-27 2016-04-19 Rhodes Technologies 1,3-dioxanomorphides and 1,3-dioxanocodides

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3474101A (en) * 1960-09-05 1969-10-21 Reckitt & Sons Ltd Thebaine and oripavine derivatives
GB1223445A (en) * 1968-07-18 1971-02-24 Reckitt & Colmann Prod Ltd Improvements in or relating to derivatives of morphine, their salts, and processes for their preparation
US3562279A (en) * 1969-05-15 1971-02-09 American Cyanamid Co Substituted 7,8-dihydro - 6 - methoxy-6,14-endo(etheno or ethano)morphide - 7-ketones and n-cycloalkylmethyl - 7,8-dihydro - 6 - methoxy-6,14-endo(etheno or ethano) norcodide-7-ketones
US3560505A (en) * 1969-05-15 1971-02-02 American Cyanamid Co Substituted 7-(1-alkoxy - 1 - alken-1-yl)-7,8-dihydro-6-methoxy-6,14-endo- (etheno or ethano) codides and morphides
DE2107989A1 (de) * 1971-02-19 1972-09-07 Boehringer Sohn Ingelheim N-(Furyl-methy])-morphinane, deren Säureadditionssalze sowie Verfahren zu deren Herstellung

Also Published As

Publication number Publication date
US3931187A (en) 1976-01-06
GB1430958A (en) 1976-04-07
AT328095B (de) 1976-03-10
ATA265674A (de) 1975-05-15
AT328626B (de) 1976-03-25
CH599214A5 (da) 1978-05-12
ES424307A1 (es) 1976-07-01
ES424309A1 (es) 1976-06-16
AT328096B (de) 1976-03-10
NO137998C (no) 1978-06-07
CH597234A5 (da) 1978-03-31
ATA265874A (de) 1975-05-15
AT325217B (de) 1975-10-10
CH597233A5 (da) 1978-03-31
CH596212A5 (da) 1978-03-15
ATA265774A (de) 1975-06-15
JPS5732073B2 (da) 1982-07-08
NL7308482A (da) 1973-12-21
ES424310A1 (es) 1976-06-16
CH599215A5 (da) 1978-05-12
SE409035B (sv) 1979-07-23
AT328625B (de) 1976-03-25
BE801083A (fr) 1973-12-18
FR2189054A1 (da) 1974-01-25
FR2189054B1 (da) 1976-12-31
NO137998B (no) 1978-02-27
ES424308A1 (es) 1976-06-16
FI56180B (fi) 1979-08-31
AT328097B (de) 1976-03-10
AU5704773A (en) 1974-12-19
ATA265974A (de) 1975-05-15
FI56180C (fi) 1979-12-10
JPS4961188A (da) 1974-06-13
CH598260A5 (da) 1978-04-28
DE2229770A1 (de) 1974-01-10
ES416038A1 (es) 1976-06-16
DK140408C (da) 1980-01-21

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