AT325217B - Verfahren zur herstellung von neuen n-(heteroarylmethyl)-7 alpha-acyl- 6,14-endoätheno-tetrahydro-nororipavinen und -thebainen - Google Patents

Verfahren zur herstellung von neuen n-(heteroarylmethyl)-7 alpha-acyl- 6,14-endoätheno-tetrahydro-nororipavinen und -thebainen

Info

Publication number
AT325217B
AT325217B AT494273A AT494273A AT325217B AT 325217 B AT325217 B AT 325217B AT 494273 A AT494273 A AT 494273A AT 494273 A AT494273 A AT 494273A AT 325217 B AT325217 B AT 325217B
Authority
AT
Austria
Prior art keywords
nororipavines
endoätheno
thebaines
heteroarylmethyl
tetrahydro
Prior art date
Application number
AT494273A
Other languages
English (en)
Original Assignee
Boehringer Sohn Ingelheim
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Sohn Ingelheim filed Critical Boehringer Sohn Ingelheim
Application granted granted Critical
Publication of AT325217B publication Critical patent/AT325217B/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/09—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems
    • C07D489/10—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14
    • C07D489/12—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14 the bridge containing only two carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/14—Antitussive agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT494273A 1972-06-19 1973-06-06 Verfahren zur herstellung von neuen n-(heteroarylmethyl)-7 alpha-acyl- 6,14-endoätheno-tetrahydro-nororipavinen und -thebainen AT325217B (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2229770A DE2229770A1 (de) 1972-06-19 1972-06-19 N-(heteroarylmethyl)-7alpha-acyl6,14-endoaethenotetrahydro-nororipavine und -thebaine, deren hydrierungsprodukte und saeureadditionssalze sowie verfahren zu deren herstellung

Publications (1)

Publication Number Publication Date
AT325217B true AT325217B (de) 1975-10-10

Family

ID=5848095

Family Applications (6)

Application Number Title Priority Date Filing Date
AT265674*7A AT328095B (de) 1972-06-19 1973-06-06 Verfahren zur herstellung von neuen n-(heteroarylmethyl)-7alpha-acyl-6,14-endoatheno-tetrahydro-nororipavinen
AT265874*7A AT328096B (de) 1972-06-19 1973-06-06 Verfahren zur herstellung von neuen n(heteroarylmethyl)-7alpha-acyl-6,14-endoatheno-tetrahydro-nororipavinen und -thebainen
AT265774*7A AT328625B (de) 1972-06-19 1973-06-06 Verfahren zur herstellung von neuen n-(heteroarylmethyl)-7alfa-acyl-6,14-endoatheno-tetrahydro-nororipavinen und -thebainen
AT265974*7A AT328097B (de) 1972-06-19 1973-06-06 Verfahren zur herstellung von neuen n-(heteroarylmethyl)-7alpha-acyl-6,14-endoatheno-tetrahydronororipavinen und -thebainen
AT266074*7A AT328626B (de) 1972-06-19 1973-06-06 Verfahren zur herstellung von neuen n-(heteroarylmethyl) -7alfa-acyl-6,14-endoatheno-tetrahydro-nororipavinen und -thebainen
AT494273A AT325217B (de) 1972-06-19 1973-06-06 Verfahren zur herstellung von neuen n-(heteroarylmethyl)-7 alpha-acyl- 6,14-endoätheno-tetrahydro-nororipavinen und -thebainen

Family Applications Before (5)

Application Number Title Priority Date Filing Date
AT265674*7A AT328095B (de) 1972-06-19 1973-06-06 Verfahren zur herstellung von neuen n-(heteroarylmethyl)-7alpha-acyl-6,14-endoatheno-tetrahydro-nororipavinen
AT265874*7A AT328096B (de) 1972-06-19 1973-06-06 Verfahren zur herstellung von neuen n(heteroarylmethyl)-7alpha-acyl-6,14-endoatheno-tetrahydro-nororipavinen und -thebainen
AT265774*7A AT328625B (de) 1972-06-19 1973-06-06 Verfahren zur herstellung von neuen n-(heteroarylmethyl)-7alfa-acyl-6,14-endoatheno-tetrahydro-nororipavinen und -thebainen
AT265974*7A AT328097B (de) 1972-06-19 1973-06-06 Verfahren zur herstellung von neuen n-(heteroarylmethyl)-7alpha-acyl-6,14-endoatheno-tetrahydronororipavinen und -thebainen
AT266074*7A AT328626B (de) 1972-06-19 1973-06-06 Verfahren zur herstellung von neuen n-(heteroarylmethyl) -7alfa-acyl-6,14-endoatheno-tetrahydro-nororipavinen und -thebainen

Country Status (14)

Country Link
US (1) US3931187A (de)
JP (1) JPS5732073B2 (de)
AT (6) AT328095B (de)
BE (1) BE801083A (de)
CH (6) CH597234A5 (de)
DE (1) DE2229770A1 (de)
DK (1) DK140408C (de)
ES (5) ES416038A1 (de)
FI (1) FI56180C (de)
FR (1) FR2189054B1 (de)
GB (1) GB1430958A (de)
NL (1) NL7308482A (de)
NO (1) NO137998C (de)
SE (1) SE409035B (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62298530A (ja) * 1986-06-16 1987-12-25 Otsuka Pharmaceut Co Ltd 坐薬用医薬組成物
NZ333101A (en) * 1997-03-27 2000-05-26 Toray Industries Morphinane derivatives useful for the treatment of pain
WO2011154826A1 (en) 2010-06-11 2011-12-15 Rhodes Technologies Process for n-dealkylation of tertiary amines
AU2011263417B2 (en) 2010-06-11 2014-03-27 Rhodes Technologies Transition metal-catalyzed processes for the preparation of N-allyl compounds and use thereof
US9315514B2 (en) 2012-08-27 2016-04-19 Rhodes Technologies 1,3-dioxanomorphides and 1,3-dioxanocodides

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3474101A (en) * 1960-09-05 1969-10-21 Reckitt & Sons Ltd Thebaine and oripavine derivatives
GB1223445A (en) * 1968-07-18 1971-02-24 Reckitt & Colmann Prod Ltd Improvements in or relating to derivatives of morphine, their salts, and processes for their preparation
US3560505A (en) * 1969-05-15 1971-02-02 American Cyanamid Co Substituted 7-(1-alkoxy - 1 - alken-1-yl)-7,8-dihydro-6-methoxy-6,14-endo- (etheno or ethano) codides and morphides
US3562279A (en) * 1969-05-15 1971-02-09 American Cyanamid Co Substituted 7,8-dihydro - 6 - methoxy-6,14-endo(etheno or ethano)morphide - 7-ketones and n-cycloalkylmethyl - 7,8-dihydro - 6 - methoxy-6,14-endo(etheno or ethano) norcodide-7-ketones
DE2107989A1 (de) * 1971-02-19 1972-09-07 Boehringer Sohn Ingelheim N-(Furyl-methy])-morphinane, deren Säureadditionssalze sowie Verfahren zu deren Herstellung

Also Published As

Publication number Publication date
AU5704773A (en) 1974-12-19
ES424309A1 (es) 1976-06-16
ATA265974A (de) 1975-05-15
CH599214A5 (de) 1978-05-12
FI56180B (fi) 1979-08-31
US3931187A (en) 1976-01-06
SE409035B (sv) 1979-07-23
AT328625B (de) 1976-03-25
CH596212A5 (de) 1978-03-15
BE801083A (fr) 1973-12-18
CH597234A5 (de) 1978-03-31
AT328095B (de) 1976-03-10
AT328626B (de) 1976-03-25
FI56180C (fi) 1979-12-10
AT328096B (de) 1976-03-10
FR2189054A1 (de) 1974-01-25
ES416038A1 (es) 1976-06-16
CH597233A5 (de) 1978-03-31
JPS5732073B2 (de) 1982-07-08
ATA265674A (de) 1975-05-15
ES424308A1 (es) 1976-06-16
JPS4961188A (de) 1974-06-13
NO137998C (no) 1978-06-07
AT328097B (de) 1976-03-10
ES424307A1 (es) 1976-07-01
GB1430958A (en) 1976-04-07
NL7308482A (de) 1973-12-21
CH599215A5 (de) 1978-05-12
ES424310A1 (es) 1976-06-16
DK140408C (da) 1980-01-21
ATA265874A (de) 1975-05-15
ATA265774A (de) 1975-06-15
DE2229770A1 (de) 1974-01-10
FR2189054B1 (de) 1976-12-31
NO137998B (no) 1978-02-27
CH598260A5 (de) 1978-04-28
DK140408B (da) 1979-08-20

Similar Documents

Publication Publication Date Title
AT327181B (de) Verfahren zur herstellung von neuen phenylindanestern
AT329045B (de) Verfahren zur herstellung von neuen, basisch substituierten indanderivaten
ATA993573A (de) Verfahren zur herstellung von neuen cephalosporinathern
AT325605B (de) Verfahren zur herstellung von neuen alpha-phenylindolderivaten
AT330955B (de) Verfahren zur herstellung von neuen beta-lactamen
AT327409B (de) Verfahren zur herstellung von neuen n-(heteroarylmethyl)-6,14-endoatheno-7alfa-hydroxyalkyltetrahydro-nororipavinen und -thebainen
AT325217B (de) Verfahren zur herstellung von neuen n-(heteroarylmethyl)-7 alpha-acyl- 6,14-endoätheno-tetrahydro-nororipavinen und -thebainen
CH552034A (de) Verfahren zur herstellung von neuen azopigmenten.
AT327213B (de) Verfahren zur herstellung von neuen lactamen
AT331805B (de) Verfahren zur herstellung von neuen triazinobenzimidazolen
AT326841B (de) Verfahren zur herstellung von neuen 15alfa,16alfa-methylen-4-pregnenen
AT334879B (de) Verfahren zur herstellung von neuen arylathern
AT327413B (de) Verfahren zur herstellung von neuen 15alpha,16alpha-methylen-4-ostren-17beta-olen
AT333740B (de) Verfahren zur herstellung von neuen indanderivaten
AT338229B (de) Verfahren zur herstellung von neuen aldehydolactonen
ATA1039174A (de) Verfahren zur herstellung von neuen 15alfa,16alfa-methylen-4-ostren-17beta-olen
ATA196973A (de) Verfahren zur herstellung von neuen 2-amino-4,5-dihydropyridin-3,5-dicarbon
ATA793675A (de) Verfahren zur herstellung von neuen aldehydolactonen
ATA76775A (de) Verfahren zur herstellung von neuen, basisch substituierten indanderivaten
AT325048B (de) Verfahren zur herstellung von neuen dihydro - 2 - aminoisochinolinen
AT329533B (de) Verfahren zur herstellung von neuen cyclopentanalen

Legal Events

Date Code Title Description
ELJ Ceased due to non-payment of the annual fee