AT328097B - Verfahren zur herstellung von neuen n-(heteroarylmethyl)-7alpha-acyl-6,14-endoatheno-tetrahydronororipavinen und -thebainen - Google Patents

Verfahren zur herstellung von neuen n-(heteroarylmethyl)-7alpha-acyl-6,14-endoatheno-tetrahydronororipavinen und -thebainen

Info

Publication number
AT328097B
AT328097B AT265974*7A AT265974A AT328097B AT 328097 B AT328097 B AT 328097B AT 265974 A AT265974 A AT 265974A AT 328097 B AT328097 B AT 328097B
Authority
AT
Austria
Prior art keywords
tetrahydronoripavines
endoatheno
thebaines
7alpha
heteroarylmethyl
Prior art date
Application number
AT265974*7A
Other languages
English (en)
Other versions
ATA265974A (de
Original Assignee
Boehringer Sohn Ingelheim
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Sohn Ingelheim filed Critical Boehringer Sohn Ingelheim
Publication of ATA265974A publication Critical patent/ATA265974A/de
Application granted granted Critical
Publication of AT328097B publication Critical patent/AT328097B/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/09—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems
    • C07D489/10—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14
    • C07D489/12—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14 the bridge containing only two carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/14—Antitussive agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT265974*7A 1972-06-19 1973-06-06 Verfahren zur herstellung von neuen n-(heteroarylmethyl)-7alpha-acyl-6,14-endoatheno-tetrahydronororipavinen und -thebainen AT328097B (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2229770A DE2229770A1 (de) 1972-06-19 1972-06-19 N-(heteroarylmethyl)-7alpha-acyl6,14-endoaethenotetrahydro-nororipavine und -thebaine, deren hydrierungsprodukte und saeureadditionssalze sowie verfahren zu deren herstellung

Publications (2)

Publication Number Publication Date
ATA265974A ATA265974A (de) 1975-05-15
AT328097B true AT328097B (de) 1976-03-10

Family

ID=5848095

Family Applications (6)

Application Number Title Priority Date Filing Date
AT494273A AT325217B (de) 1972-06-19 1973-06-06 Verfahren zur herstellung von neuen n-(heteroarylmethyl)-7 alpha-acyl- 6,14-endoätheno-tetrahydro-nororipavinen und -thebainen
AT265974*7A AT328097B (de) 1972-06-19 1973-06-06 Verfahren zur herstellung von neuen n-(heteroarylmethyl)-7alpha-acyl-6,14-endoatheno-tetrahydronororipavinen und -thebainen
AT265774*7A AT328625B (de) 1972-06-19 1973-06-06 Verfahren zur herstellung von neuen n-(heteroarylmethyl)-7alfa-acyl-6,14-endoatheno-tetrahydro-nororipavinen und -thebainen
AT266074*7A AT328626B (de) 1972-06-19 1973-06-06 Verfahren zur herstellung von neuen n-(heteroarylmethyl) -7alfa-acyl-6,14-endoatheno-tetrahydro-nororipavinen und -thebainen
AT265874*7A AT328096B (de) 1972-06-19 1973-06-06 Verfahren zur herstellung von neuen n(heteroarylmethyl)-7alpha-acyl-6,14-endoatheno-tetrahydro-nororipavinen und -thebainen
AT265674*7A AT328095B (de) 1972-06-19 1973-06-06 Verfahren zur herstellung von neuen n-(heteroarylmethyl)-7alpha-acyl-6,14-endoatheno-tetrahydro-nororipavinen

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT494273A AT325217B (de) 1972-06-19 1973-06-06 Verfahren zur herstellung von neuen n-(heteroarylmethyl)-7 alpha-acyl- 6,14-endoätheno-tetrahydro-nororipavinen und -thebainen

Family Applications After (4)

Application Number Title Priority Date Filing Date
AT265774*7A AT328625B (de) 1972-06-19 1973-06-06 Verfahren zur herstellung von neuen n-(heteroarylmethyl)-7alfa-acyl-6,14-endoatheno-tetrahydro-nororipavinen und -thebainen
AT266074*7A AT328626B (de) 1972-06-19 1973-06-06 Verfahren zur herstellung von neuen n-(heteroarylmethyl) -7alfa-acyl-6,14-endoatheno-tetrahydro-nororipavinen und -thebainen
AT265874*7A AT328096B (de) 1972-06-19 1973-06-06 Verfahren zur herstellung von neuen n(heteroarylmethyl)-7alpha-acyl-6,14-endoatheno-tetrahydro-nororipavinen und -thebainen
AT265674*7A AT328095B (de) 1972-06-19 1973-06-06 Verfahren zur herstellung von neuen n-(heteroarylmethyl)-7alpha-acyl-6,14-endoatheno-tetrahydro-nororipavinen

Country Status (14)

Country Link
US (1) US3931187A (de)
JP (1) JPS5732073B2 (de)
AT (6) AT325217B (de)
BE (1) BE801083A (de)
CH (6) CH597233A5 (de)
DE (1) DE2229770A1 (de)
DK (1) DK140408C (de)
ES (5) ES416038A1 (de)
FI (1) FI56180C (de)
FR (1) FR2189054B1 (de)
GB (1) GB1430958A (de)
NL (1) NL7308482A (de)
NO (1) NO137998C (de)
SE (1) SE409035B (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62298530A (ja) * 1986-06-16 1987-12-25 Otsuka Pharmaceut Co Ltd 坐薬用医薬組成物
US6187782B1 (en) 1997-03-27 2001-02-13 Toray Industries, Inc. Morphinane derivatives and medicinal use thereof
AU2011263417B2 (en) 2010-06-11 2014-03-27 Rhodes Technologies Transition metal-catalyzed processes for the preparation of N-allyl compounds and use thereof
EP2580218B1 (de) 2010-06-11 2015-02-25 Rhodes Technologies Verfahren zur n-dealkylierung von tertiären aminen
US9315514B2 (en) 2012-08-27 2016-04-19 Rhodes Technologies 1,3-dioxanomorphides and 1,3-dioxanocodides

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3474101A (en) * 1960-09-05 1969-10-21 Reckitt & Sons Ltd Thebaine and oripavine derivatives
GB1223445A (en) * 1968-07-18 1971-02-24 Reckitt & Colmann Prod Ltd Improvements in or relating to derivatives of morphine, their salts, and processes for their preparation
US3562279A (en) * 1969-05-15 1971-02-09 American Cyanamid Co Substituted 7,8-dihydro - 6 - methoxy-6,14-endo(etheno or ethano)morphide - 7-ketones and n-cycloalkylmethyl - 7,8-dihydro - 6 - methoxy-6,14-endo(etheno or ethano) norcodide-7-ketones
US3560505A (en) * 1969-05-15 1971-02-02 American Cyanamid Co Substituted 7-(1-alkoxy - 1 - alken-1-yl)-7,8-dihydro-6-methoxy-6,14-endo- (etheno or ethano) codides and morphides
DE2107989A1 (de) * 1971-02-19 1972-09-07 Boehringer Sohn Ingelheim N-(Furyl-methy])-morphinane, deren Säureadditionssalze sowie Verfahren zu deren Herstellung

Also Published As

Publication number Publication date
AT328096B (de) 1976-03-10
CH597233A5 (de) 1978-03-31
AU5704773A (en) 1974-12-19
CH599214A5 (de) 1978-05-12
FI56180C (fi) 1979-12-10
DK140408B (da) 1979-08-20
GB1430958A (en) 1976-04-07
NO137998C (no) 1978-06-07
ATA265674A (de) 1975-05-15
DE2229770A1 (de) 1974-01-10
CH597234A5 (de) 1978-03-31
ES424309A1 (es) 1976-06-16
AT328095B (de) 1976-03-10
SE409035B (sv) 1979-07-23
JPS5732073B2 (de) 1982-07-08
CH596212A5 (de) 1978-03-15
ATA265874A (de) 1975-05-15
JPS4961188A (de) 1974-06-13
CH599215A5 (de) 1978-05-12
ES424307A1 (es) 1976-07-01
US3931187A (en) 1976-01-06
NO137998B (no) 1978-02-27
FI56180B (fi) 1979-08-31
FR2189054B1 (de) 1976-12-31
FR2189054A1 (de) 1974-01-25
ES424310A1 (es) 1976-06-16
BE801083A (fr) 1973-12-18
NL7308482A (de) 1973-12-21
ES424308A1 (es) 1976-06-16
DK140408C (da) 1980-01-21
CH598260A5 (de) 1978-04-28
AT328625B (de) 1976-03-25
ES416038A1 (es) 1976-06-16
AT328626B (de) 1976-03-25
ATA265774A (de) 1975-06-15
ATA265974A (de) 1975-05-15
AT325217B (de) 1975-10-10

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Legal Events

Date Code Title Description
ELJ Ceased due to non-payment of the annual fee
ELJ Ceased due to non-payment of the annual fee