SE409035B - Analogiforfarande for framstellning av n-(faryl-och tienylmetyl)-7alfa-6,14-endoeteno-tetrahydronororipaviner och tebainer - Google Patents

Analogiforfarande for framstellning av n-(faryl-och tienylmetyl)-7alfa-6,14-endoeteno-tetrahydronororipaviner och tebainer

Info

Publication number
SE409035B
SE409035B SE7308565A SE7308565A SE409035B SE 409035 B SE409035 B SE 409035B SE 7308565 A SE7308565 A SE 7308565A SE 7308565 A SE7308565 A SE 7308565A SE 409035 B SE409035 B SE 409035B
Authority
SE
Sweden
Prior art keywords
tetrahydronororipavins
tebainer
endoeteno
7alfa
faryl
Prior art date
Application number
SE7308565A
Other languages
English (en)
Inventor
A Langbein
H Merz
G Walther
K Stockhaus
Original Assignee
Boehringer Sohn Ingelheim
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Sohn Ingelheim filed Critical Boehringer Sohn Ingelheim
Publication of SE409035B publication Critical patent/SE409035B/sv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/09—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems
    • C07D489/10—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14
    • C07D489/12—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14 the bridge containing only two carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/14—Antitussive agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
SE7308565A 1972-06-19 1973-06-18 Analogiforfarande for framstellning av n-(faryl-och tienylmetyl)-7alfa-6,14-endoeteno-tetrahydronororipaviner och tebainer SE409035B (sv)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2229770A DE2229770A1 (de) 1972-06-19 1972-06-19 N-(heteroarylmethyl)-7alpha-acyl6,14-endoaethenotetrahydro-nororipavine und -thebaine, deren hydrierungsprodukte und saeureadditionssalze sowie verfahren zu deren herstellung

Publications (1)

Publication Number Publication Date
SE409035B true SE409035B (sv) 1979-07-23

Family

ID=5848095

Family Applications (1)

Application Number Title Priority Date Filing Date
SE7308565A SE409035B (sv) 1972-06-19 1973-06-18 Analogiforfarande for framstellning av n-(faryl-och tienylmetyl)-7alfa-6,14-endoeteno-tetrahydronororipaviner och tebainer

Country Status (14)

Country Link
US (1) US3931187A (sv)
JP (1) JPS5732073B2 (sv)
AT (6) AT325217B (sv)
BE (1) BE801083A (sv)
CH (6) CH597233A5 (sv)
DE (1) DE2229770A1 (sv)
DK (1) DK140408C (sv)
ES (5) ES416038A1 (sv)
FI (1) FI56180C (sv)
FR (1) FR2189054B1 (sv)
GB (1) GB1430958A (sv)
NL (1) NL7308482A (sv)
NO (1) NO137998C (sv)
SE (1) SE409035B (sv)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62298530A (ja) * 1986-06-16 1987-12-25 Otsuka Pharmaceut Co Ltd 坐薬用医薬組成物
US6187782B1 (en) 1997-03-27 2001-02-13 Toray Industries, Inc. Morphinane derivatives and medicinal use thereof
AU2011263417B2 (en) 2010-06-11 2014-03-27 Rhodes Technologies Transition metal-catalyzed processes for the preparation of N-allyl compounds and use thereof
EP2580218B1 (en) 2010-06-11 2015-02-25 Rhodes Technologies Process for n-dealkylation of tertiary amines
US9315514B2 (en) 2012-08-27 2016-04-19 Rhodes Technologies 1,3-dioxanomorphides and 1,3-dioxanocodides

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3474101A (en) * 1960-09-05 1969-10-21 Reckitt & Sons Ltd Thebaine and oripavine derivatives
GB1223445A (en) * 1968-07-18 1971-02-24 Reckitt & Colmann Prod Ltd Improvements in or relating to derivatives of morphine, their salts, and processes for their preparation
US3562279A (en) * 1969-05-15 1971-02-09 American Cyanamid Co Substituted 7,8-dihydro - 6 - methoxy-6,14-endo(etheno or ethano)morphide - 7-ketones and n-cycloalkylmethyl - 7,8-dihydro - 6 - methoxy-6,14-endo(etheno or ethano) norcodide-7-ketones
US3560505A (en) * 1969-05-15 1971-02-02 American Cyanamid Co Substituted 7-(1-alkoxy - 1 - alken-1-yl)-7,8-dihydro-6-methoxy-6,14-endo- (etheno or ethano) codides and morphides
DE2107989A1 (de) * 1971-02-19 1972-09-07 Boehringer Sohn Ingelheim N-(Furyl-methy])-morphinane, deren Säureadditionssalze sowie Verfahren zu deren Herstellung

Also Published As

Publication number Publication date
AT328096B (de) 1976-03-10
CH597233A5 (sv) 1978-03-31
AU5704773A (en) 1974-12-19
CH599214A5 (sv) 1978-05-12
FI56180C (fi) 1979-12-10
DK140408B (da) 1979-08-20
GB1430958A (en) 1976-04-07
NO137998C (no) 1978-06-07
ATA265674A (de) 1975-05-15
DE2229770A1 (de) 1974-01-10
CH597234A5 (sv) 1978-03-31
ES424309A1 (es) 1976-06-16
AT328095B (de) 1976-03-10
JPS5732073B2 (sv) 1982-07-08
CH596212A5 (sv) 1978-03-15
ATA265874A (de) 1975-05-15
JPS4961188A (sv) 1974-06-13
AT328097B (de) 1976-03-10
CH599215A5 (sv) 1978-05-12
ES424307A1 (es) 1976-07-01
US3931187A (en) 1976-01-06
NO137998B (no) 1978-02-27
FI56180B (fi) 1979-08-31
FR2189054B1 (sv) 1976-12-31
FR2189054A1 (sv) 1974-01-25
ES424310A1 (es) 1976-06-16
BE801083A (fr) 1973-12-18
NL7308482A (sv) 1973-12-21
ES424308A1 (es) 1976-06-16
DK140408C (da) 1980-01-21
CH598260A5 (sv) 1978-04-28
AT328625B (de) 1976-03-25
ES416038A1 (es) 1976-06-16
AT328626B (de) 1976-03-25
ATA265774A (de) 1975-06-15
ATA265974A (de) 1975-05-15
AT325217B (de) 1975-10-10

Similar Documents

Publication Publication Date Title
NO138335C (no) Analogifremgangsmaate for fremstilling av fysiologisk aktive alkanolaminer
NO140381C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive arylpiperaziner
SE390819B (sv) Analogiforfarande for framstellning av piperazinyl-propyl-1,2,4-triazolinderivat
NO138566C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive 2,1,3-benzotiadiazol-derivater
NO140859C (no) Analogifremgangsmaate for fremstilling av farmakologisk aktive n-(metoksymetyl-furylmetyl)-6,7-benzomorfaner og -morfinaner
NO140731C (no) Fremgangsmaate for fremstilling av dimetyleter
SE382053B (sv) Forfarande for framstellning av bifenylylalkanoylaminopyridiner
SE383151B (sv) Forfarande for framstellning av 1-hydroxi-2-pyridoner
NO139917C (no) Analogifremgangsmaate for fremstilling av 1-aminometyl-2,2-diaryl-cyklopropankarboksamider og salter derav
SE409035B (sv) Analogiforfarande for framstellning av n-(faryl-och tienylmetyl)-7alfa-6,14-endoeteno-tetrahydronororipaviner och tebainer
SE400768B (sv) Forfarande for framstellning av 2-fenyl-6-sulfamoyl-7-klor-1,2,3,4-tetrahydro-4-kinazolinon
SE380272B (sv) Forfarande for framstellning av n-fosfonmetylglycin
SE399557B (sv) Forfarande for framstellning av tiantren-, tioxanten- och fenoxatiinderivat
SE395883B (sv) Analogiforfarande for framstellning av vissa diketoner och ketoestrar
NO139050C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive nororipavin- og tebainderivater
FI56830B (fi) Foerfarande foer framstaellning av asparaginylgrupper innehaollande biologiskt aktiva polypeptider
SE385696B (sv) Nytt forfarande for framstellning av n-(1-etyl-alfa-pyrrolidylmetyl)-2-metoxi-5-sulfamidobensamid med terapeutiska egenskaper
SE400767B (sv) Forfarande for framstellning av arylpiperazin-derivat av adenin
NO137193C (no) Fremgangsm}te for fremstilling av difenylamin og derivater derav
SE403112B (sv) Analogiforfarande for framstellning av skopolaminderivat
SE389862B (sv) Forfarande for framstellning av alfa-6-deoxitetracykliner
SE403613B (sv) Analogiforfarande for framstellning av vissa angivna 3,4,5-trimetoxiacetofenonoximkarbamatderivat
SE413510B (sv) Analogiforfarande for framstellning av n-(furyl- och tienylmetyl)-desoxi-normorfiner och norkodeiner
SE402455B (sv) Forfarande for framstellning av n-(dietylaminoetyl)-2-metoxi-5-metylsulfonyl-bensamid och dess additionssalter
DK132831B (da) Analogifremgangsmade til fremstilling af 17beta-hydroxy-2,2,17-trimethyl-4-androsten-3-on