DK1389100T3 - Hidtil ukendte fremgangsmåder til behandling og forebyggelse af smerte under anvendelse af stressaktiverede proteinkinaseinhibitorer - Google Patents
Hidtil ukendte fremgangsmåder til behandling og forebyggelse af smerte under anvendelse af stressaktiverede proteinkinaseinhibitorerInfo
- Publication number
- DK1389100T3 DK1389100T3 DK02769765T DK02769765T DK1389100T3 DK 1389100 T3 DK1389100 T3 DK 1389100T3 DK 02769765 T DK02769765 T DK 02769765T DK 02769765 T DK02769765 T DK 02769765T DK 1389100 T3 DK1389100 T3 DK 1389100T3
- Authority
- DK
- Denmark
- Prior art keywords
- stress
- treating
- protein kinase
- kinase inhibitors
- activated protein
- Prior art date
Links
- 229940045988 antineoplastic drug protein kinase inhibitors Drugs 0.000 title 1
- 239000003909 protein kinase inhibitor Substances 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US29122701P | 2001-05-16 | 2001-05-16 | |
US10/146,680 US7018999B2 (en) | 2001-05-16 | 2002-05-15 | Methods for the treatment and prevention of pain |
PCT/US2002/015667 WO2002092065A2 (en) | 2001-05-16 | 2002-05-16 | Novel methods for the treatment and prevention of pain using stress-activated protein kinase inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1389100T3 true DK1389100T3 (da) | 2008-12-08 |
Family
ID=26844179
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK02769765T DK1389100T3 (da) | 2001-05-16 | 2002-05-16 | Hidtil ukendte fremgangsmåder til behandling og forebyggelse af smerte under anvendelse af stressaktiverede proteinkinaseinhibitorer |
Country Status (13)
Country | Link |
---|---|
US (1) | US7018999B2 (da) |
EP (1) | EP1389100B1 (da) |
JP (1) | JP2004534751A (da) |
AR (1) | AR035971A1 (da) |
AT (1) | ATE410201T1 (da) |
AU (1) | AU2002342715A1 (da) |
CA (1) | CA2447091C (da) |
DE (1) | DE60229233D1 (da) |
DK (1) | DK1389100T3 (da) |
ES (1) | ES2314101T3 (da) |
HK (1) | HK1062806A1 (da) |
MX (1) | MXPA03010451A (da) |
WO (1) | WO2002092065A2 (da) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7241779B2 (en) * | 2003-12-23 | 2007-07-10 | Cephalon, Inc. | Fused pyrrolocarbazoles |
US7169802B2 (en) * | 2003-12-23 | 2007-01-30 | Cephalon, Inc. | Fused pyrrolocarbazoles |
AR074374A1 (es) | 2008-11-19 | 2011-01-12 | Cephalon Inc | Formas de un compuesto de pirrolocarbazol fusionado, composiciones que las comprenden y su uso en el tratamiento de la angiogénesis y los tumores sólidos. |
Family Cites Families (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US1381031A (en) | 1920-01-19 | 1921-06-07 | Thompson James | Dumping-wagon |
US4923986A (en) | 1987-03-09 | 1990-05-08 | Kyowa Hakko Kogyo Co., Ltd. | Derivatives of physiologically active substance K-252 |
US5093330A (en) | 1987-06-15 | 1992-03-03 | Ciba-Geigy Corporation | Staurosporine derivatives substituted at methylamino nitrogen |
JPH07113027B2 (ja) | 1987-12-24 | 1995-12-06 | 協和醗酵工業株式会社 | K−252誘導体 |
AU3064992A (en) | 1991-11-08 | 1993-06-07 | University Of Southern California | Compositions containing k-252 compounds for potentiation of neurotrophin activity |
US5621101A (en) | 1992-07-24 | 1997-04-15 | Cephalon, Inc. | Protein kinase inhibitors for treatment of neurological disorders |
US5756494A (en) | 1992-07-24 | 1998-05-26 | Cephalon, Inc. | Protein kinase inhibitors for treatment of neurological disorders |
ATE165097T1 (de) | 1993-05-28 | 1998-05-15 | Cephalon Inc | Anwendung von indolocarbazol-derivaten zur behandlung von prostataerkrankungen |
US5534426A (en) | 1993-07-19 | 1996-07-09 | The Regents Of The University Of California | Oncoprotein protein kinase |
US6514745B1 (en) | 1993-07-19 | 2003-02-04 | The Regents Of The University Of California | Oncoprotein protein kinase |
US5468872A (en) | 1993-09-16 | 1995-11-21 | Cephalon, Inc. | K-252a functional derivatives potentiate neurotrophin-3 for the treatment of neurological disorders |
WO1995022331A1 (en) | 1994-02-18 | 1995-08-24 | Cephalon, Inc. | Aqueous indolocarbazole solutions |
US5594009A (en) | 1994-10-14 | 1997-01-14 | Cephalon, Inc. | Fused pyrrolocarbazoles |
US5705511A (en) | 1994-10-14 | 1998-01-06 | Cephalon, Inc. | Fused pyrrolocarbazoles |
US6046208A (en) | 1996-01-11 | 2000-04-04 | Smithkline Beecham Corporation | Substituted imidazole compounds |
US5616724A (en) | 1996-02-21 | 1997-04-01 | Cephalon, Inc. | Fused pyrrolo[2,3-c]carbazole-6-ones |
UA67725C2 (en) | 1996-06-03 | 2004-07-15 | Cephalon Inc | K-252a derivatives and a method for improvement of functioning and cell survival enhancement |
BR9710693A (pt) | 1996-06-25 | 2000-01-11 | Cephalon Inc | Uso de um derivado de k-252a para o tratamento do nervo central ou periférico e super produção de citoquinona. |
CN1285836A (zh) | 1997-12-31 | 2001-02-28 | 赛福伦公司 | 3′-差向异构的K-252a衍生物 |
ATE212552T1 (de) | 1998-04-17 | 2002-02-15 | Tufts College | Map kinase-inhibitoren zur behandlung von durch tnf-alpha induzierte lipolyse- verursachte krankheiten |
US6811992B1 (en) | 1998-05-14 | 2004-11-02 | Ya Fang Liu | Method for identifying MLK inhibitors for the treatment of neurological conditions |
GB9811624D0 (en) | 1998-05-29 | 1998-07-29 | Merck Sharp & Dohme | Therapeutic use |
US6127401A (en) | 1998-06-05 | 2000-10-03 | Cephalon, Inc. | Bridged indenopyrrolocarbazoles |
US6207687B1 (en) | 1998-07-31 | 2001-03-27 | Merck & Co., Inc. | Substituted imidazoles having cytokine inhibitory activity |
CZ2001701A3 (cs) | 1998-08-26 | 2002-04-17 | Cephalon, Inc. | Způsob identifikace sloučeniny, která pozměňuje aktivitu kinasových proteinů s násobnou vazbou |
JP2002532503A (ja) | 1998-12-17 | 2002-10-02 | エフ.ホフマン−ラ ロシュ アーゲー | プロテインキナーゼ阻害剤としての4,5−ピラジノオキシンドール |
AU771599B2 (en) | 1998-12-17 | 2004-03-25 | F. Hoffmann-La Roche Ag | 4- and 5-alkynyloxindoles and 4- and 5-alkenyloxindoles |
EP1149093A1 (en) | 1998-12-17 | 2001-10-31 | F. Hoffmann-La Roche Ag | 4-aryloxindoles as inhibitors of jnk protein kinases |
US6841567B1 (en) | 1999-02-12 | 2005-01-11 | Cephalon, Inc. | Cyclic substituted fused pyrrolocarbazoles and isoindolones |
AU4483000A (en) | 1999-04-23 | 2000-11-10 | Vertex Pharmaceuticals Incorporated | Inhibitors of c-jun n-terminal kinases (jnk) |
AU5316900A (en) | 1999-06-03 | 2000-12-28 | Vertex Pharmaceuticals Incorporated | Inhibitors of c-jun n-terminal kinases (jnk) |
ES2260033T3 (es) | 1999-07-02 | 2006-11-01 | Stuart A. Lipton | Uso de los inhibidores p38 mapk en efermadades oftalmicas. |
HUP0202319A3 (en) | 1999-07-16 | 2004-12-28 | Warner Lambert Co | Use of mek inhibitors for the preparation of pharmaceutical compositions treating chronic pain |
SK3572002A3 (en) | 1999-08-13 | 2002-07-02 | Vertex Pharma | Inhibitors of c-jun n-terminal kinases (jnk) and other protein kinases |
NZ517578A (en) | 1999-08-19 | 2004-02-27 | Signal Pharm Inc | Pyrazoloanthrone and derivatives thereof as JNK inhibitors and their compositions |
US6399780B1 (en) | 1999-08-20 | 2002-06-04 | Cephalon, Inc. | Isomeric fused pyrrolocarbazoles and isoindolones |
WO2001091749A1 (en) | 2000-06-01 | 2001-12-06 | Merck & Co., Inc. | Use of (di-substituted-phenyl)-pyrimidinyl-imidazole derivatives as jnk-inhibitors |
AU2002228911A1 (en) | 2000-11-08 | 2002-05-21 | The General Hospital Corporation | Methods for inhibiting pain |
CA2430539C (en) | 2000-12-05 | 2010-07-13 | Vertex Pharmaceuticals Incorporated | Inhibitors of c-jun n-terminal kinases (jnk) and other protein kinases |
-
2002
- 2002-05-15 US US10/146,680 patent/US7018999B2/en not_active Expired - Fee Related
- 2002-05-15 AR ARP020101775A patent/AR035971A1/es not_active Application Discontinuation
- 2002-05-16 AT AT02769765T patent/ATE410201T1/de not_active IP Right Cessation
- 2002-05-16 MX MXPA03010451A patent/MXPA03010451A/es active IP Right Grant
- 2002-05-16 WO PCT/US2002/015667 patent/WO2002092065A2/en active Application Filing
- 2002-05-16 DK DK02769765T patent/DK1389100T3/da active
- 2002-05-16 EP EP02769765A patent/EP1389100B1/en not_active Expired - Lifetime
- 2002-05-16 CA CA2447091A patent/CA2447091C/en not_active Expired - Fee Related
- 2002-05-16 DE DE60229233T patent/DE60229233D1/de not_active Expired - Lifetime
- 2002-05-16 ES ES02769765T patent/ES2314101T3/es not_active Expired - Lifetime
- 2002-05-16 JP JP2002588983A patent/JP2004534751A/ja not_active Withdrawn
- 2002-05-16 AU AU2002342715A patent/AU2002342715A1/en not_active Abandoned
-
2004
- 2004-07-29 HK HK04105622.1A patent/HK1062806A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
ES2314101T3 (es) | 2009-03-16 |
US20030087899A1 (en) | 2003-05-08 |
CA2447091C (en) | 2012-03-27 |
EP1389100A2 (en) | 2004-02-18 |
CA2447091A1 (en) | 2002-11-21 |
ATE410201T1 (de) | 2008-10-15 |
DE60229233D1 (de) | 2008-11-20 |
MXPA03010451A (es) | 2004-05-05 |
AR035971A1 (es) | 2004-07-28 |
HK1062806A1 (en) | 2004-11-26 |
WO2002092065A3 (en) | 2003-07-31 |
WO2002092065A2 (en) | 2002-11-21 |
US7018999B2 (en) | 2006-03-28 |
EP1389100B1 (en) | 2008-10-08 |
JP2004534751A (ja) | 2004-11-18 |
AU2002342715A1 (en) | 2002-11-25 |
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