DK131858C - Analogifremgangsmade til fremstilling af 4-amino-6-arylpyrimidin-forbindelser eller syreadditionssalte deraf - Google Patents

Analogifremgangsmade til fremstilling af 4-amino-6-arylpyrimidin-forbindelser eller syreadditionssalte deraf

Info

Publication number
DK131858C
DK131858C DK480171A DK480171A DK131858C DK 131858 C DK131858 C DK 131858C DK 480171 A DK480171 A DK 480171A DK 480171 A DK480171 A DK 480171A DK 131858 C DK131858 C DK 131858C
Authority
DK
Denmark
Prior art keywords
amino
preparation
additional salts
acid additional
arylpyrimidine
Prior art date
Application number
DK480171A
Other languages
Danish (da)
English (en)
Other versions
DK131858B (da
Inventor
G G D Angelis
H J E Hess
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Priority to DK142973A priority Critical patent/DK130971B/da
Publication of DK131858B publication Critical patent/DK131858B/da
Application granted granted Critical
Publication of DK131858C publication Critical patent/DK131858C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/30—Halogen atoms or nitro radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/34—One oxygen atom
    • C07D239/36—One oxygen atom as doubly bound oxygen atom or as unsubstituted hydroxy radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/56—One oxygen atom and one sulfur atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D333/70—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
DK480171A 1970-10-05 1971-10-01 Analogifremgangsmade til fremstilling af 4-amino-6-arylpyrimidin-forbindelser eller syreadditionssalte deraf DK131858C (da)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DK142973A DK130971B (da) 1970-10-05 1973-03-16 Analogifremgangsmåde til fremstilling af 4-hydroxy-5-ethyl-6-phenylpyrimidin.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US7821670A 1970-10-05 1970-10-05

Publications (2)

Publication Number Publication Date
DK131858B DK131858B (da) 1975-09-15
DK131858C true DK131858C (da) 1976-02-16

Family

ID=22142671

Family Applications (1)

Application Number Title Priority Date Filing Date
DK480171A DK131858C (da) 1970-10-05 1971-10-01 Analogifremgangsmade til fremstilling af 4-amino-6-arylpyrimidin-forbindelser eller syreadditionssalte deraf

Country Status (16)

Country Link
US (1) US3707560A (fr)
JP (2) JPS5648511B1 (fr)
AT (4) AT315856B (fr)
AU (1) AU465734B2 (fr)
BE (1) BE773484A (fr)
CA (1) CA988519A (fr)
CH (4) CH554346A (fr)
DE (2) DE2165962C2 (fr)
DK (1) DK131858C (fr)
ES (4) ES395676A1 (fr)
FI (1) FI55502C (fr)
FR (1) FR2110227B1 (fr)
GB (2) GB1373535A (fr)
NL (1) NL168511C (fr)
SE (2) SE390304B (fr)
ZA (1) ZA716615B (fr)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3859288A (en) * 1970-10-05 1975-01-07 Pfizer Arylpyrimidines - inhibitors of platelet aggregation and bronchodilators
US3908012A (en) * 1970-10-05 1975-09-23 Pfizer Arylpyrimidines-inhibitors of platelet aggregation and bronchodilators
US3895112A (en) * 1970-10-05 1975-07-15 Pfizer Arylpyrimidines in the relaxation of smooth muscle
US3835132A (en) * 1972-02-01 1974-09-10 Shell Oil Co Morpholino-piperazinyl pyrimidines
US3950525A (en) * 1973-06-19 1976-04-13 Pfizer Inc. Relaxation of smooth muscle in a mammal
DE2343419A1 (de) * 1973-08-29 1975-03-13 Gruenenthal Chemie Verfahren zur herstellung von pyrimidinderivaten
US4725600A (en) * 1984-07-13 1988-02-16 Fujisawa Pharmaceutical Co., Ltd. Pyrimidine compounds having activity as a cardiotonic anti-hypertensive cerebrovascular vasodilator and anti-platelet aggregation agent
JPH0625157B2 (ja) * 1988-01-29 1994-04-06 宇部興産株式会社 ４―ヒドロキシピリミジン類の製造方法
US4935516A (en) * 1988-01-29 1990-06-19 Ube Industries, Ltd. Process for preparing 4-hydroxypyrimidine
DE3825647A1 (de) * 1988-07-28 1990-02-01 Geyer Gmbh & Co Christian Vorrichtung zur befestigung eines elektrischen schaltgeraetes
DE3905364A1 (de) * 1989-02-22 1990-08-23 Hoechst Ag Substituierte pyrimidin-derivate, verfahren zu ihrer herstellung und ihre verwendung als tool
EP1196411B1 (fr) * 1999-07-15 2003-09-17 Pharmacopeia, Inc. Antagonistes du recepteur b1 de la bradykinine
CN1642422A (zh) * 2002-03-15 2005-07-20 西巴特殊化学品控股有限公司 4－氨基嘧啶及其在表面抗菌处理中的应用
WO2003099284A1 (fr) * 2002-05-22 2003-12-04 Amgen Inc. Amino-pyridine, derives de pyridine et de pyridazine utilises comme ligands de recepteur vanilloide permettant de traiter une douleur
JP2006521345A (ja) * 2003-03-28 2006-09-21 ファルマシア・アンド・アップジョン・カンパニー・エルエルシー ニコチン性アセチルコリン受容体の正のアロステリック調節剤
EP1877400A1 (fr) * 2005-04-15 2008-01-16 Amgen, Inc Ligands recepteurs de vanilloide et leur utilisation dans les traitements
JP2009164373A (ja) * 2008-01-08 2009-07-23 Toshiba Corp 半導体装置
NZ601547A (en) * 2010-01-25 2014-04-30 Chdi Foundation Inc Certain kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof
ES2765805T3 (es) 2011-08-30 2020-06-11 Chdi Foundation Inc Inhibidores de kinurenina-3-monoxigenasa, composiciones farmacéuticas y métodos de uso de los mismos
CN103827095A (zh) 2011-08-30 2014-05-28 Chdi基金会股份有限公司 犬尿氨酸-3-单加氧酶抑制剂、其药物组合物及其使用方法
BR112017000922A2 (pt) 2014-07-17 2018-01-16 Chdi Foundation, Inc. métodos e composições para tratar distúrbios relacionados ao hiv

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3047462A (en) * 1959-03-06 1962-07-31 Lab Jacques Logeais Soc D Expl Quinazolone anti-inflammatory composition

Also Published As

Publication number Publication date
AT314540B (de) 1974-04-10
DE2149249B2 (de) 1974-11-07
JPS5636468A (en) 1981-04-09
FI55502C (fi) 1979-08-10
SE390304B (sv) 1976-12-13
DE2165962A1 (de) 1972-08-31
DK131858B (da) 1975-09-15
AU465734B2 (en) 1975-10-09
NL7113670A (fr) 1972-04-07
FR2110227A1 (fr) 1972-06-02
JPS578107B2 (fr) 1982-02-15
ES420209A1 (es) 1976-06-01
AT315856B (de) 1974-05-15
ES420211A1 (es) 1976-03-16
SE7410488L (fr) 1974-08-16
ES420210A1 (es) 1976-06-01
AU3425971A (en) 1973-04-12
DE2165962C2 (de) 1982-05-13
ZA716615B (en) 1972-06-28
FI55502B (fi) 1979-04-30
DE2149249C3 (de) 1975-07-03
BE773484A (fr) 1972-04-05
AT317229B (de) 1974-08-26
CA988519A (en) 1976-05-04
NL168511B (nl) 1981-11-16
US3707560A (en) 1972-12-26
JPS5648511B1 (fr) 1981-11-16
SE385885B (sv) 1976-07-26
DE2149249A1 (de) 1972-04-13
FR2110227B1 (fr) 1975-02-07
CH554875A (fr) 1974-10-15
NL168511C (nl) 1982-04-16
AT316563B (de) 1974-06-15
CH554346A (fr) 1974-09-30
CH542218A (fr) 1973-11-15
CH554876A (fr) 1974-10-15
GB1373535A (en) 1974-11-13
GB1373536A (en) 1974-11-13
ES395676A1 (es) 1974-10-16

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