AT314540B - Verfahren zur Herstellung von neuen 4-Amino-6-aryl- bzw. 6-heteroaryl-pyrimidinen und von deren Salzen - Google Patents

Verfahren zur Herstellung von neuen 4-Amino-6-aryl- bzw. 6-heteroaryl-pyrimidinen und von deren Salzen

Info

Publication number
AT314540B
AT314540B AT858071A AT858071A AT314540B AT 314540 B AT314540 B AT 314540B AT 858071 A AT858071 A AT 858071A AT 858071 A AT858071 A AT 858071A AT 314540 B AT314540 B AT 314540B
Authority
AT
Austria
Prior art keywords
pyrimidines
heteroaryl
aryl
salts
amino
Prior art date
Application number
AT858071A
Other languages
English (en)
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Application granted granted Critical
Publication of AT314540B publication Critical patent/AT314540B/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/30—Halogen atoms or nitro radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/34—One oxygen atom
    • C07D239/36—One oxygen atom as doubly bound oxygen atom or as unsubstituted hydroxy radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/56—One oxygen atom and one sulfur atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D333/70—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 2
AT858071A 1970-10-05 1971-10-05 Verfahren zur Herstellung von neuen 4-Amino-6-aryl- bzw. 6-heteroaryl-pyrimidinen und von deren Salzen AT314540B (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US7821670A 1970-10-05 1970-10-05

Publications (1)

Publication Number Publication Date
AT314540B true AT314540B (de) 1974-04-10

Family

ID=22142671

Family Applications (4)

Application Number Title Priority Date Filing Date
AT605473A AT317229B (de) 1970-10-05 1971-10-05 Verfahren zur Herstellung von neuen 4-Hydroxy-6-aryl-bzw. 6-heteroarylpyrimidinen
AT858071A AT314540B (de) 1970-10-05 1971-10-05 Verfahren zur Herstellung von neuen 4-Amino-6-aryl- bzw. 6-heteroaryl-pyrimidinen und von deren Salzen
AT00149/73A AT316563B (de) 1970-10-05 1971-10-05 Verfahren zur herstellung von neuen 4-amino-6-aryl-pyrimidinen und von deren saeureadditionssalzen
AT00148/73A AT315856B (de) 1970-10-05 1971-10-05 Verfahren zur herstellung von neuen 4-hydroxy-6-aryl-bzw.6-heteroarylpyrimidinen

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT605473A AT317229B (de) 1970-10-05 1971-10-05 Verfahren zur Herstellung von neuen 4-Hydroxy-6-aryl-bzw. 6-heteroarylpyrimidinen

Family Applications After (2)

Application Number Title Priority Date Filing Date
AT00149/73A AT316563B (de) 1970-10-05 1971-10-05 Verfahren zur herstellung von neuen 4-amino-6-aryl-pyrimidinen und von deren saeureadditionssalzen
AT00148/73A AT315856B (de) 1970-10-05 1971-10-05 Verfahren zur herstellung von neuen 4-hydroxy-6-aryl-bzw.6-heteroarylpyrimidinen

Country Status (16)

Country Link
US (1) US3707560A (de)
JP (2) JPS5648511B1 (de)
AT (4) AT317229B (de)
AU (1) AU465734B2 (de)
BE (1) BE773484A (de)
CA (1) CA988519A (de)
CH (4) CH554346A (de)
DE (2) DE2149249C3 (de)
DK (1) DK131858C (de)
ES (4) ES395676A1 (de)
FI (1) FI55502C (de)
FR (1) FR2110227B1 (de)
GB (2) GB1373536A (de)
NL (1) NL168511C (de)
SE (2) SE390304B (de)
ZA (1) ZA716615B (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3859288A (en) * 1970-10-05 1975-01-07 Pfizer Arylpyrimidines - inhibitors of platelet aggregation and bronchodilators
US3895112A (en) * 1970-10-05 1975-07-15 Pfizer Arylpyrimidines in the relaxation of smooth muscle
US3908012A (en) * 1970-10-05 1975-09-23 Pfizer Arylpyrimidines-inhibitors of platelet aggregation and bronchodilators
US3835132A (en) * 1972-02-01 1974-09-10 Shell Oil Co Morpholino-piperazinyl pyrimidines
US3950525A (en) * 1973-06-19 1976-04-13 Pfizer Inc. Relaxation of smooth muscle in a mammal
DE2343419A1 (de) * 1973-08-29 1975-03-13 Gruenenthal Chemie Verfahren zur herstellung von pyrimidinderivaten
US4725600A (en) * 1984-07-13 1988-02-16 Fujisawa Pharmaceutical Co., Ltd. Pyrimidine compounds having activity as a cardiotonic anti-hypertensive cerebrovascular vasodilator and anti-platelet aggregation agent
US4935516A (en) * 1988-01-29 1990-06-19 Ube Industries, Ltd. Process for preparing 4-hydroxypyrimidine
JPH0625157B2 (ja) * 1988-01-29 1994-04-06 宇部興産株式会社 ４―ヒドロキシピリミジン類の製造方法
DE3825647A1 (de) * 1988-07-28 1990-02-01 Geyer Gmbh & Co Christian Vorrichtung zur befestigung eines elektrischen schaltgeraetes
DE3905364A1 (de) * 1989-02-22 1990-08-23 Hoechst Ag Substituierte pyrimidin-derivate, verfahren zu ihrer herstellung und ihre verwendung als tool
ATE250053T1 (de) 1999-07-15 2003-10-15 Pharmacopeia Inc Bradikinin b1 rezeptor antagonisten
JP2005520821A (ja) * 2002-03-15 2005-07-14 チバ　スペシャルティ　ケミカルズ　ホールディング　インコーポレーテッド ４−アミノピリミジン及び表面の抗菌処理のためのその使用
ES2355472T3 (es) * 2002-05-22 2011-03-28 Amgen Inc. Derivados de aminopirimidina para su uso como ligandos del receptor vaniloide para el tratamiento del dolor.
BRPI0408815A (pt) * 2003-03-28 2006-04-04 Pharmacia & Upjohn Co Llc moduladores alostéricos positivos do receptor nicotìnico da acetilcolina
WO2006113769A1 (en) * 2005-04-15 2006-10-26 Amgen Inc. Vanilloid receptor ligands and their use in treatments
JP2009164373A (ja) * 2008-01-08 2009-07-23 Toshiba Corp 半導体装置
AU2011207229B2 (en) * 2010-01-25 2015-02-12 Chdi Foundation, Inc. Certain kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof
CN103827095A (zh) 2011-08-30 2014-05-28 Chdi基金会股份有限公司 犬尿氨酸-3-单加氧酶抑制剂、其药物组合物及其使用方法
KR102027287B1 (ko) 2011-08-30 2019-10-01 씨에이치디아이 파운데이션, 인코포레이티드 키뉴레닌-3-모노옥시게나제 억제제, 약학적 조성물 및 이의 사용 방법
WO2016011316A1 (en) 2014-07-17 2016-01-21 Chdi Foundation, Inc. Methods and compositions for treating hiv-related disorders

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3047462A (en) * 1959-03-06 1962-07-31 Lab Jacques Logeais Soc D Expl Quinazolone anti-inflammatory composition

Also Published As

Publication number Publication date
DE2149249C3 (de) 1975-07-03
NL168511B (nl) 1981-11-16
SE390304B (sv) 1976-12-13
DE2165962C2 (de) 1982-05-13
AT316563B (de) 1974-06-15
DE2149249A1 (de) 1972-04-13
AU465734B2 (en) 1975-10-09
NL7113670A (de) 1972-04-07
SE385885B (sv) 1976-07-26
FI55502C (fi) 1979-08-10
DE2149249B2 (de) 1974-11-07
GB1373535A (en) 1974-11-13
DK131858B (da) 1975-09-15
FR2110227A1 (de) 1972-06-02
JPS5636468A (en) 1981-04-09
ZA716615B (en) 1972-06-28
NL168511C (nl) 1982-04-16
ES395676A1 (es) 1974-10-16
DE2165962A1 (de) 1972-08-31
JPS578107B2 (de) 1982-02-15
CH554876A (fr) 1974-10-15
BE773484A (fr) 1972-04-05
ES420209A1 (es) 1976-06-01
CH554346A (fr) 1974-09-30
ES420210A1 (es) 1976-06-01
CH542218A (fr) 1973-11-15
JPS5648511B1 (de) 1981-11-16
AT315856B (de) 1974-05-15
US3707560A (en) 1972-12-26
FI55502B (fi) 1979-04-30
FR2110227B1 (de) 1975-02-07
ES420211A1 (es) 1976-03-16
SE7410488L (de) 1974-08-16
AU3425971A (en) 1973-04-12
GB1373536A (en) 1974-11-13
DK131858C (da) 1976-02-16
CH554875A (fr) 1974-10-15
AT317229B (de) 1974-08-26
CA988519A (en) 1976-05-04

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Legal Events

Date Code Title Description
ELJ Ceased due to non-payment of the annual fee