DK1254121T3 - Fremstilling af sulfonamider - Google Patents
Fremstilling af sulfonamiderInfo
- Publication number
- DK1254121T3 DK1254121T3 DK00903628T DK00903628T DK1254121T3 DK 1254121 T3 DK1254121 T3 DK 1254121T3 DK 00903628 T DK00903628 T DK 00903628T DK 00903628 T DK00903628 T DK 00903628T DK 1254121 T3 DK1254121 T3 DK 1254121T3
- Authority
- DK
- Denmark
- Prior art keywords
- lower alkyl
- hydrogen
- hydroxy
- alkoxy
- alkyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/69—Benzenesulfonamido-pyrimidines
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Epidemiology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP00903628A EP1254121B1 (en) | 2000-01-25 | 2000-01-25 | Preparation of sulfonamides |
| PCT/EP2000/000556 WO2001055120A1 (en) | 2000-01-25 | 2000-01-25 | Preparation of sulfonamides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1254121T3 true DK1254121T3 (da) | 2006-06-12 |
Family
ID=8163805
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK00903628T DK1254121T3 (da) | 2000-01-25 | 2000-01-25 | Fremstilling af sulfonamider |
Country Status (13)
| Country | Link |
|---|---|
| EP (1) | EP1254121B1 (pt) |
| JP (1) | JP3751882B2 (pt) |
| KR (1) | KR100495550B1 (pt) |
| CN (1) | CN1178921C (pt) |
| AT (1) | ATE316963T1 (pt) |
| AU (1) | AU2000225442A1 (pt) |
| CA (1) | CA2397258C (pt) |
| DE (1) | DE60025803T2 (pt) |
| DK (1) | DK1254121T3 (pt) |
| ES (1) | ES2255973T3 (pt) |
| MX (1) | MXPA02007192A (pt) |
| PT (1) | PT1254121E (pt) |
| WO (1) | WO2001055120A1 (pt) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2686457A1 (en) * | 2007-05-08 | 2008-11-13 | Generics [Uk] Limited | Novel polymorphic forms |
| AU2008272685B2 (en) | 2007-06-29 | 2013-04-18 | Generics [Uk] Limited | Process for introduction of hydroxyethoxy side chain in bosentan |
| EP2222649A2 (en) | 2007-10-24 | 2010-09-01 | Generics (UK) Limited | Novel crystalline forms |
| JP5535082B2 (ja) * | 2008-01-01 | 2014-07-02 | シプラ・リミテッド | ボセンタン、その多形形態及びその塩の合成方法 |
| EP2240469A2 (en) | 2008-01-24 | 2010-10-20 | Actavis Group PTC EHF | Substantially pure and a stable crystalline form of bosentan |
| JP5683276B2 (ja) * | 2008-02-08 | 2015-03-11 | ジェネリクス・［ユーケー］・リミテッド | ボセンタンの製造方法 |
| CN101279948B (zh) * | 2008-03-14 | 2010-08-11 | 苏州博鸿化工技术有限公司 | 4,6-二氯-5-(2-甲氧基苯氧基)-2,2'-二嘧啶的合成方法 |
| WO2010015623A1 (en) * | 2008-08-05 | 2010-02-11 | Farmaprojects, S. A. | Process for the preparation of endothelin receptor antagonists |
| WO2010032261A1 (en) | 2008-08-12 | 2010-03-25 | Cadila Healthcare Limited | Process for preparation of bosentan |
| US8975402B2 (en) | 2008-11-03 | 2015-03-10 | Generics [Uk] Limited | HPLC method for the analysis of bosetan and related substances and use of these substances as reference standards and markers |
| IT1393136B1 (it) * | 2009-03-11 | 2012-04-11 | Sifa Vitor S R L | Procedimento per la preparazione del bosentan |
| JP2012523444A (ja) * | 2009-04-13 | 2012-10-04 | サンド・アクチエンゲゼルシヤフト | 内皮受容体アンタゴニスト（ボセンタン）を調製するための方法 |
| EP2368884A1 (en) | 2010-03-25 | 2011-09-28 | Laboratorios Lesvi, S.L. | Process for the preparation of bosentan |
| CA2811367C (en) | 2010-10-01 | 2019-03-26 | Zach System S.P.A. | Process for preparing bosentan monohydrate and its intermediates |
| WO2013169082A1 (ko) * | 2012-05-11 | 2013-11-14 | 한올바이오파마 주식회사 | 보센탄 제어방출성 경구제제 |
| KR102004422B1 (ko) * | 2012-12-20 | 2019-07-26 | 제일약품주식회사 | 보센탄 일수화물의 제조방법, 이에 사용되는 신규 중간체 및 이의 제조방법 |
| AR095727A1 (es) | 2013-03-27 | 2015-11-04 | Actelion Pharmaceuticals Ltd | Preparación de intermediarios de pirimidina |
| CN114907275A (zh) * | 2022-04-29 | 2022-08-16 | 武汉工程大学 | 一种波生坦的制备方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2086544C1 (ru) * | 1991-06-13 | 1997-08-10 | Хоффманн-Ля Рош АГ | Бензолсульфонамидные производные пиримидина или их соли, фармацевтическая композиция для лечения заболеваний, связанных с активностью эндотелина |
| TW287160B (pt) * | 1992-12-10 | 1996-10-01 | Hoffmann La Roche | |
| HUT77534A (hu) * | 1994-12-28 | 1998-05-28 | Kowa Co. Ltd. | Pirimidinszármazékok és ezeket tartalmazó gyógyszerkészítmények |
| US5739333A (en) * | 1995-05-16 | 1998-04-14 | Tanabe Seiyaku Co., Ltd. | Sulfonamide derivative and process for preparing the same |
| WO1997009318A1 (fr) * | 1995-09-06 | 1997-03-13 | Kowa Co., Ltd. | Derives de la pyrimidine |
-
2000
- 2000-01-25 DE DE60025803T patent/DE60025803T2/de not_active Expired - Lifetime
- 2000-01-25 MX MXPA02007192A patent/MXPA02007192A/es active IP Right Grant
- 2000-01-25 JP JP2001555062A patent/JP3751882B2/ja not_active Expired - Lifetime
- 2000-01-25 AU AU2000225442A patent/AU2000225442A1/en not_active Abandoned
- 2000-01-25 ES ES00903628T patent/ES2255973T3/es not_active Expired - Lifetime
- 2000-01-25 CA CA002397258A patent/CA2397258C/en not_active Expired - Lifetime
- 2000-01-25 KR KR10-2002-7009505A patent/KR100495550B1/ko active IP Right Grant
- 2000-01-25 AT AT00903628T patent/ATE316963T1/de active
- 2000-01-25 WO PCT/EP2000/000556 patent/WO2001055120A1/en active IP Right Grant
- 2000-01-25 EP EP00903628A patent/EP1254121B1/en not_active Expired - Lifetime
- 2000-01-25 PT PT00903628T patent/PT1254121E/pt unknown
- 2000-01-25 DK DK00903628T patent/DK1254121T3/da active
- 2000-01-25 CN CNB00818643XA patent/CN1178921C/zh not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP1254121B1 (en) | 2006-02-01 |
| JP2003520857A (ja) | 2003-07-08 |
| KR20020070511A (ko) | 2002-09-09 |
| CN1178921C (zh) | 2004-12-08 |
| EP1254121A1 (en) | 2002-11-06 |
| AU2000225442A1 (en) | 2001-08-07 |
| JP3751882B2 (ja) | 2006-03-01 |
| KR100495550B1 (ko) | 2005-06-16 |
| MXPA02007192A (es) | 2002-12-09 |
| CA2397258C (en) | 2007-07-03 |
| PT1254121E (pt) | 2006-06-30 |
| ES2255973T3 (es) | 2006-07-16 |
| DE60025803D1 (de) | 2006-04-13 |
| CA2397258A1 (en) | 2001-08-02 |
| WO2001055120A1 (en) | 2001-08-02 |
| DE60025803T2 (de) | 2006-11-02 |
| ATE316963T1 (de) | 2006-02-15 |
| CN1425007A (zh) | 2003-06-18 |
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