DK1242822T3 - Fremgangsmåder til påvisning af amyloidogene proteiner - Google Patents
Fremgangsmåder til påvisning af amyloidogene proteinerInfo
- Publication number
- DK1242822T3 DK1242822T3 DK00980905T DK00980905T DK1242822T3 DK 1242822 T3 DK1242822 T3 DK 1242822T3 DK 00980905 T DK00980905 T DK 00980905T DK 00980905 T DK00980905 T DK 00980905T DK 1242822 T3 DK1242822 T3 DK 1242822T3
- Authority
- DK
- Denmark
- Prior art keywords
- aggregation
- assay
- amyloid
- peptide
- amyloid peptide
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
- G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
- G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
- G01N2333/4701—Details
- G01N2333/4709—Amyloid plaque core protein
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/28—Neurological disorders
- G01N2800/2814—Dementia; Cognitive disorders
- G01N2800/2821—Alzheimer
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Food Science & Technology (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Psychiatry (AREA)
- General Chemical & Material Sciences (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/474,970 US6399314B1 (en) | 1999-12-29 | 1999-12-29 | Methods of detection of amyloidogenic proteins |
PCT/US2000/032693 WO2001050134A2 (en) | 1999-12-29 | 2000-12-01 | Methods of detection of amyloidogenic proteins |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1242822T3 true DK1242822T3 (da) | 2008-09-29 |
Family
ID=23885720
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK00980905T DK1242822T3 (da) | 1999-12-29 | 2000-12-01 | Fremgangsmåder til påvisning af amyloidogene proteiner |
Country Status (21)
Country | Link |
---|---|
US (1) | US6399314B1 (es) |
EP (1) | EP1242822B1 (es) |
JP (1) | JP2003519383A (es) |
KR (1) | KR20020070470A (es) |
CN (1) | CN1211661C (es) |
AT (1) | ATE399323T1 (es) |
AU (1) | AU774377B2 (es) |
BR (1) | BR0016883A (es) |
CA (1) | CA2395789C (es) |
DE (1) | DE60039310D1 (es) |
DK (1) | DK1242822T3 (es) |
EA (1) | EA005582B1 (es) |
ES (1) | ES2309003T3 (es) |
HK (1) | HK1046550B (es) |
IL (2) | IL150080A0 (es) |
MX (1) | MXPA02006362A (es) |
NO (1) | NO20023163L (es) |
NZ (1) | NZ519612A (es) |
PL (1) | PL356813A1 (es) |
PT (1) | PT1242822E (es) |
WO (1) | WO2001050134A2 (es) |
Families Citing this family (59)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6913745B1 (en) | 1997-12-02 | 2005-07-05 | Neuralab Limited | Passive immunization of Alzheimer's disease |
US7964192B1 (en) | 1997-12-02 | 2011-06-21 | Janssen Alzheimer Immunotherapy | Prevention and treatment of amyloidgenic disease |
US7790856B2 (en) | 1998-04-07 | 2010-09-07 | Janssen Alzheimer Immunotherapy | Humanized antibodies that recognize beta amyloid peptide |
US6905686B1 (en) | 1997-12-02 | 2005-06-14 | Neuralab Limited | Active immunization for treatment of alzheimer's disease |
US6750324B1 (en) | 1997-12-02 | 2004-06-15 | Neuralab Limited | Humanized and chimeric N-terminal amyloid beta-antibodies |
US6761888B1 (en) * | 2000-05-26 | 2004-07-13 | Neuralab Limited | Passive immunization treatment of Alzheimer's disease |
US7179892B2 (en) * | 2000-12-06 | 2007-02-20 | Neuralab Limited | Humanized antibodies that recognize beta amyloid peptide |
US6787523B1 (en) | 1997-12-02 | 2004-09-07 | Neuralab Limited | Prevention and treatment of amyloidogenic disease |
TWI239847B (en) | 1997-12-02 | 2005-09-21 | Elan Pharm Inc | N-terminal fragment of Abeta peptide and an adjuvant for preventing and treating amyloidogenic disease |
US20080050367A1 (en) * | 1998-04-07 | 2008-02-28 | Guriq Basi | Humanized antibodies that recognize beta amyloid peptide |
US20030147882A1 (en) * | 1998-05-21 | 2003-08-07 | Alan Solomon | Methods for amyloid removal using anti-amyloid antibodies |
DE19923811C1 (de) * | 1999-05-20 | 2000-12-07 | Robert Koch Inst | Verfahren zur Diagnose TSE-induzierter Veränderungen in Geweben mittels Infrarotspektroskopie |
US6787637B1 (en) | 1999-05-28 | 2004-09-07 | Neuralab Limited | N-Terminal amyloid-β antibodies |
US6689753B1 (en) * | 1999-11-05 | 2004-02-10 | Axonyx, Inc. | β sheet breaker peptide analogs that inhibit β pleated sheet formation in amyloid β-peptide |
JP4853936B2 (ja) | 2000-08-21 | 2012-01-11 | ザ ジェネラル ホスピタル コーポレイション | 神経変性状態の診断方法 |
PE20020574A1 (es) * | 2000-12-06 | 2002-07-02 | Wyeth Corp | Anticuerpos humanizados que reconocen el peptido amiloideo beta |
US7700751B2 (en) | 2000-12-06 | 2010-04-20 | Janssen Alzheimer Immunotherapy | Humanized antibodies that recognize β-amyloid peptide |
AU2002307526B2 (en) * | 2001-04-27 | 2006-08-24 | The Brigham And Women's Hospital, Inc. | Ocular diagnosis of alzheimer's disease |
JP4235544B2 (ja) | 2001-05-31 | 2009-03-11 | アドライフ インコーポレーティッド | 欠陥折畳み蛋白質センサー方法 |
US20050026165A1 (en) | 2001-05-31 | 2005-02-03 | Cindy Orser | Detection of conformationally altered proteins and prions |
US20060057107A1 (en) * | 2001-12-21 | 2006-03-16 | Shaked Ze Ev | Combination treatment for multiple sclerosis |
MY139983A (en) * | 2002-03-12 | 2009-11-30 | Janssen Alzheimer Immunotherap | Humanized antibodies that recognize beta amyloid peptide |
US20070003552A1 (en) * | 2002-07-09 | 2007-01-04 | Gebbink Martijn F B | Cross-beta structure comprising amyloid binding proteins and methods for detection of the cross-beta structure, for modulating cross-beta structures fibril formation and for modulating cross-beta structure-mediated toxicity and method for interfering with blood coagulation |
EP1380290A1 (en) * | 2002-07-09 | 2004-01-14 | Universitair Medisch Centrum Utrecht | Cross-beta structure pathway and its therapeutic relevance |
PE20050627A1 (es) | 2003-05-30 | 2005-08-10 | Wyeth Corp | Anticuerpos humanizados que reconocen el peptido beta amiloideo |
US20050048539A1 (en) * | 2003-06-13 | 2005-03-03 | The General Hospital Corporation | Methods to monitor molecule conformation and molecule/molecule proximity |
SE0401219D0 (sv) * | 2004-05-10 | 2004-05-10 | Biochromix Ab | Metoder för detektera konformationsförändringar eller aggregering hos proteiner med hjälp av konjugerade polyelektrolyter |
US20060057671A1 (en) * | 2004-09-10 | 2006-03-16 | Orser Cindy S | Immobilized probes and methods of detecting conformationally altered prion proteins |
CA2590337C (en) | 2004-12-15 | 2017-07-11 | Neuralab Limited | Humanized amyloid beta antibodies for use in improving cognition |
EP1838349A1 (en) * | 2004-12-15 | 2007-10-03 | Neuralab, Ltd. | Amyloid beta antibodies for use in improving cognition |
WO2006066049A2 (en) * | 2004-12-15 | 2006-06-22 | Neuralab Limited | Humanized antibodies that recognize beta amyloid peptide |
JP4568840B2 (ja) * | 2004-12-28 | 2010-10-27 | 国立大学法人金沢大学 | アルツハイマー病の検査方法 |
WO2006069697A1 (en) * | 2004-12-30 | 2006-07-06 | F. Hoffmann-La Roche Ag | Colorimetrically assessing peptide characteristics |
AU2006214463B2 (en) * | 2005-02-15 | 2012-08-30 | Presympto, Inc. | Method for detecting misfolded proteins and prions |
US20090202980A1 (en) * | 2005-03-21 | 2009-08-13 | Crossbeta Biosciences B.V. | Cross-Beta Structure Comprising Amyloid Binding Proteins and Methods for Detection of the Cross-Beta Structure, for Modulating Cross-Beta Structures Fibril Formation and for Modulating Cross-Beta Structure-Mediated Toxicity and Method for Interfering With Blood Coagulation |
US8114832B2 (en) * | 2005-07-13 | 2012-02-14 | Crossbeta Biosciences B.V. | Method for detecting and/or removing a protein comprising a cross-beta structure from a pharmaceutical composition |
ATE554394T1 (de) * | 2005-07-13 | 2012-05-15 | Crossbeta Biosciences Bv | Cross-beta-struktur-bindende verbindungen |
US20070015133A1 (en) * | 2005-07-13 | 2007-01-18 | Umc Utrecht Holding B.V. | Method for detecting and/or removing protein and/or peptide comprising a cross-beta structure from an aqueous solution comprising a protein |
BRPI0613525A2 (pt) * | 2005-07-13 | 2011-05-31 | Crossbeta Biosciences Bv | métodos para produzir uma composição imunogênica, para melhorar a imunogenicidade de uma composição, para intensificar a imunogenicidade de uma composição de vacina, e para determinar a quantidade de estruturas beta-cruzadas em uma composição de vacina, usos de estruturas beta-cruzadas, e de uma composição imunogênica, vacina de subunidade, e, composição imunogênica |
US8784810B2 (en) | 2006-04-18 | 2014-07-22 | Janssen Alzheimer Immunotherapy | Treatment of amyloidogenic diseases |
CN101802609A (zh) * | 2006-07-28 | 2010-08-11 | 阿德利夫股份有限公司 | 用于诊断和治疗的肽探针 |
US8003097B2 (en) | 2007-04-18 | 2011-08-23 | Janssen Alzheimer Immunotherapy | Treatment of cerebral amyloid angiopathy |
SI2182983T1 (sl) | 2007-07-27 | 2014-09-30 | Janssen Alzheimer Immunotherapy | Zdravljenje amiloidogenih bolezni s humaniziranimi protitelesi proti abeta |
JO3076B1 (ar) | 2007-10-17 | 2017-03-15 | Janssen Alzheimer Immunotherap | نظم العلاج المناعي المعتمد على حالة apoe |
EP2058001A1 (en) * | 2007-11-08 | 2009-05-13 | Crossbeta Biosciences B.V. | Enhancement of immunogenicity of antigens |
EP2058000A1 (en) * | 2007-11-08 | 2009-05-13 | Crossbeta Biosciences B.V. | Immunogenic compositions capable of activating T cells |
US20100021390A1 (en) * | 2008-03-17 | 2010-01-28 | The Research Foundation Of State University Of New York | Fluorescent Analogs Of The Islet Amyloid Polypeptide |
US9067981B1 (en) | 2008-10-30 | 2015-06-30 | Janssen Sciences Ireland Uc | Hybrid amyloid-beta antibodies |
RU2509155C1 (ru) * | 2012-10-25 | 2014-03-10 | Федеральное государственное бюджетное учреждение науки Институт биохимии им. А.Н. Баха Российской академии наук | Способ детекции белков в амилоидном состоянии и набор для детекции белков в амилоидном состоянии |
GB201303507D0 (en) * | 2013-02-27 | 2013-04-10 | Hollfelder Florian | Assays |
US9588129B2 (en) * | 2013-03-15 | 2017-03-07 | Amira Medical Technologies Inc. | Methods for analyzing blood to detect diseases associated with abnormal protein aggregation |
CN104803993B (zh) * | 2015-03-01 | 2017-11-03 | 四川大学 | 一种具有Aβ亲和力的荧光化合物及其用途 |
CN105651752B (zh) * | 2016-02-26 | 2019-04-12 | 国家纳米科学中心 | 淀粉样蛋白的检测方法 |
CN105717182B (zh) * | 2016-03-10 | 2018-05-11 | 中南大学 | 一种用于同步检测淀粉样多肽单体和聚集体的生物传感器及其构建方法和应用 |
US11536731B2 (en) | 2017-01-23 | 2022-12-27 | Rensselaer Polytechnic Institute | Systems and methods for binding amyloid fibrils using fluorescent protein |
CN108489941B (zh) * | 2018-01-31 | 2021-07-27 | 吉林大学 | 溴酚蓝在作为检测牛胰岛素淀粉样纤维探针和作为牛胰岛素淀粉样纤维抑制剂方面的应用 |
US20210165001A1 (en) * | 2018-08-03 | 2021-06-03 | The University Of Hong Kong | Compositions and methods for detection and imaging of amyloid fibrils, amyloid plaques, rna, and nucleoli |
CN111504957B (zh) * | 2019-01-31 | 2021-12-03 | 吉林大学 | 一种维多利亚蓝b及其衍生物在制备异构化蛋白的探针或抑制剂中的应用 |
KR102258048B1 (ko) * | 2019-05-30 | 2021-05-31 | 주식회사 캔티스 | 아밀로이드 베타 올리고머의 검출 방법 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2013396A1 (en) * | 1989-04-05 | 1990-10-05 | Dennis J. Selkoe | Diagnostic method for alzheimer's disease: examination of non-neural tissue |
US5276059A (en) | 1992-07-10 | 1994-01-04 | The United States Of America As Represented By The Department Of Health And Human Services | Inhibition of diseases associated with amyloid formation |
WO1997007402A1 (en) | 1995-08-17 | 1997-02-27 | The Ontario Cancer Institute | Protein fibril assembly assay |
JPH0995444A (ja) * | 1995-10-02 | 1997-04-08 | Teijin Ltd | アミロイド蛋白凝集阻害剤 |
AU743905B2 (en) | 1997-08-14 | 2002-02-07 | Regents Of The University Of California, The | Fluorescent amyloid abeta peptides and uses thereof |
JP4537577B2 (ja) * | 1998-03-13 | 2010-09-01 | ユニバーシティ・オブ・ワシントン | アルツハイマー病及びプリオン病の治療に関する抗プラーク療法を特定するコンゴ好染性マルタ十字形アミロイドプラークのinvitroにおける形成 |
-
1999
- 1999-12-29 US US09/474,970 patent/US6399314B1/en not_active Expired - Fee Related
-
2000
- 2000-12-01 IL IL15008000A patent/IL150080A0/xx active IP Right Grant
- 2000-12-01 BR BR0016883-1A patent/BR0016883A/pt not_active Application Discontinuation
- 2000-12-01 CN CNB008178658A patent/CN1211661C/zh not_active Expired - Fee Related
- 2000-12-01 EA EA200200722A patent/EA005582B1/ru not_active IP Right Cessation
- 2000-12-01 EP EP00980905A patent/EP1242822B1/en not_active Expired - Lifetime
- 2000-12-01 DK DK00980905T patent/DK1242822T3/da active
- 2000-12-01 PT PT00980905T patent/PT1242822E/pt unknown
- 2000-12-01 PL PL00356813A patent/PL356813A1/xx not_active Application Discontinuation
- 2000-12-01 CA CA2395789A patent/CA2395789C/en not_active Expired - Fee Related
- 2000-12-01 MX MXPA02006362A patent/MXPA02006362A/es active IP Right Grant
- 2000-12-01 KR KR1020027008505A patent/KR20020070470A/ko not_active IP Right Cessation
- 2000-12-01 WO PCT/US2000/032693 patent/WO2001050134A2/en active IP Right Grant
- 2000-12-01 JP JP2001550033A patent/JP2003519383A/ja active Pending
- 2000-12-01 ES ES00980905T patent/ES2309003T3/es not_active Expired - Lifetime
- 2000-12-01 AU AU18103/01A patent/AU774377B2/en not_active Ceased
- 2000-12-01 AT AT00980905T patent/ATE399323T1/de not_active IP Right Cessation
- 2000-12-01 DE DE60039310T patent/DE60039310D1/de not_active Expired - Lifetime
- 2000-12-01 NZ NZ519612A patent/NZ519612A/en unknown
-
2002
- 2002-06-06 IL IL150080A patent/IL150080A/en not_active IP Right Cessation
- 2002-06-28 NO NO20023163A patent/NO20023163L/no not_active Application Discontinuation
- 2002-11-08 HK HK02108122.2A patent/HK1046550B/zh not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
CA2395789C (en) | 2010-03-30 |
US6399314B1 (en) | 2002-06-04 |
WO2001050134A2 (en) | 2001-07-12 |
CA2395789A1 (en) | 2001-07-12 |
AU774377B2 (en) | 2004-06-24 |
PL356813A1 (en) | 2004-07-12 |
ATE399323T1 (de) | 2008-07-15 |
NO20023163L (no) | 2002-08-27 |
BR0016883A (pt) | 2002-10-01 |
DE60039310D1 (de) | 2008-08-07 |
NO20023163D0 (no) | 2002-06-28 |
HK1046550A1 (en) | 2003-01-17 |
AU1810301A (en) | 2001-07-16 |
HK1046550B (zh) | 2008-12-19 |
NZ519612A (en) | 2004-04-30 |
EP1242822A2 (en) | 2002-09-25 |
ES2309003T3 (es) | 2008-12-16 |
PT1242822E (pt) | 2008-09-29 |
EA200200722A1 (ru) | 2002-12-26 |
EP1242822B1 (en) | 2008-06-25 |
JP2003519383A (ja) | 2003-06-17 |
IL150080A (en) | 2009-02-11 |
CN1415074A (zh) | 2003-04-30 |
KR20020070470A (ko) | 2002-09-09 |
IL150080A0 (en) | 2002-12-01 |
CN1211661C (zh) | 2005-07-20 |
MXPA02006362A (es) | 2002-11-29 |
EA005582B1 (ru) | 2005-04-28 |
WO2001050134A3 (en) | 2002-06-27 |
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