DK1242053T3 - Apparat og fremgangsmåde til fremstilling af mikropartikler under anvendelse af in-line-oplösningsmiddelekstrahering - Google Patents
Apparat og fremgangsmåde til fremstilling af mikropartikler under anvendelse af in-line-oplösningsmiddelekstraheringInfo
- Publication number
- DK1242053T3 DK1242053T3 DK00990484T DK00990484T DK1242053T3 DK 1242053 T3 DK1242053 T3 DK 1242053T3 DK 00990484 T DK00990484 T DK 00990484T DK 00990484 T DK00990484 T DK 00990484T DK 1242053 T3 DK1242053 T3 DK 1242053T3
- Authority
- DK
- Denmark
- Prior art keywords
- static mixer
- solvent extraction
- preparing microparticles
- line solvent
- combined
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
- A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
- A61P23/02—Local anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
- Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
- Y10T428/2989—Microcapsule with solid core [includes liposome]
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Anesthesiology (AREA)
- Pain & Pain Management (AREA)
- Medicinal Preparation (AREA)
- Extraction Or Liquid Replacement (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/438,656 US6495166B1 (en) | 1999-11-12 | 1999-11-12 | Apparatus and method for preparing microparticles using in-line solvent extraction |
PCT/US2000/041845 WO2001034120A1 (en) | 1999-11-12 | 2000-11-03 | Apparatus and method for preparing microparticles using in-line solvent extraction |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1242053T3 true DK1242053T3 (da) | 2005-05-30 |
Family
ID=23741486
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK00990484T DK1242053T3 (da) | 1999-11-12 | 2000-11-03 | Apparat og fremgangsmåde til fremstilling af mikropartikler under anvendelse af in-line-oplösningsmiddelekstrahering |
Country Status (11)
Country | Link |
---|---|
US (1) | US6495166B1 (da) |
EP (1) | EP1242053B1 (da) |
JP (1) | JP4838471B2 (da) |
AT (1) | ATE286722T1 (da) |
AU (1) | AU773734B2 (da) |
CA (1) | CA2390563C (da) |
DE (1) | DE60017461T2 (da) |
DK (1) | DK1242053T3 (da) |
ES (1) | ES2236035T3 (da) |
PT (1) | PT1242053E (da) |
WO (1) | WO2001034120A1 (da) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6331317B1 (en) * | 1999-11-12 | 2001-12-18 | Alkermes Controlled Therapeutics Ii Inc. | Apparatus and method for preparing microparticles |
US6705757B2 (en) * | 1999-11-12 | 2004-03-16 | Alkermes Controlled Therapeutics, Inc. Ii | Method and apparatus for preparing microparticles using in-line solvent extraction |
US6264987B1 (en) * | 2000-05-19 | 2001-07-24 | Alkermes Controlled Therapeutics Inc. Ii | Method for preparing microparticles having a selected polymer molecular weight |
US6932502B2 (en) * | 2002-05-01 | 2005-08-23 | Hewlett-Packard Development Company, L.P. | Mixing apparatus |
US20050232995A1 (en) | 2002-07-29 | 2005-10-20 | Yam Nyomi V | Methods and dosage forms for controlled delivery of paliperidone and risperidone |
JP2007515392A (ja) | 2003-04-10 | 2007-06-14 | ピーアール ファーマシューティカルズ,インコーポレイテッド | エマルジョンベースの微粒子の製造のための方法 |
CN100588423C (zh) | 2003-07-23 | 2010-02-10 | Pr药品有限公司 | 控释组合物 |
EP1728550A4 (en) * | 2004-03-23 | 2007-09-05 | Kyowa Hakko Kogyo Kk | PROCESS FOR PRODUCING COATED FINE PARTICLES |
US20070099947A1 (en) * | 2005-11-03 | 2007-05-03 | Alkermes, Inc. | Methods and compositions for the treatment of brain reward system disorders by combination therapy |
CA2736780C (en) * | 2008-09-11 | 2017-01-17 | Surmodics Pharmaceuticals, Inc. | Solvent extraction microencapsulation with tunable extraction rates |
US20100143479A1 (en) | 2008-12-04 | 2010-06-10 | Oakwood Laboratories, Llc | Method of making sustained release microparticles |
RS58312B1 (sr) | 2010-08-23 | 2019-03-29 | Alkermes Pharma Ireland Ltd | Metode za lečenje povećanja telesne mase indukovane antipsihoticima |
ES2537381T3 (es) | 2010-12-23 | 2015-06-08 | Evonik Corporation | Aparato y método para preparar una emulsión |
KR101543507B1 (ko) * | 2013-05-15 | 2015-08-11 | 씨제이헬스케어 주식회사 | 연속 공정의 미립구의 제조 방법 및 이로부터 제조된 미립구 |
EP3034159B1 (en) * | 2014-12-18 | 2020-11-04 | The Procter and Gamble Company | Static mixer and method of mixing fluids |
Family Cites Families (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL137652C (da) | 1962-07-11 | |||
BE744162A (fr) | 1969-01-16 | 1970-06-15 | Fuji Photo Film Co Ltd | Procede d'encapsulage |
US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
DE2010115A1 (de) | 1970-03-04 | 1971-09-16 | Farbenfabriken Bayer Ag, 5090 Leverkusen | Verfahren zur Herstellung von Mikrogranulaten |
DE2106526C3 (de) | 1971-02-11 | 1979-03-15 | Agfa-Gevaert Ag, 5090 Leverkusen | Verfahren und Vorrichtung zur kontinuierlichen Zubereitung photographischer Emulsionen |
JPS523342B2 (da) | 1972-01-26 | 1977-01-27 | ||
GB1413186A (en) | 1973-06-27 | 1975-11-12 | Toyo Jozo Kk | Process for encapsulation of medicaments |
US4050676A (en) | 1974-04-19 | 1977-09-27 | Yasushi Morishima | Mixing device and element therefor |
JPS523653A (en) | 1975-06-27 | 1977-01-12 | Fuji Photo Film Co Ltd | Process for producing fine polymer particles |
US4384975A (en) | 1980-06-13 | 1983-05-24 | Sandoz, Inc. | Process for preparation of microspheres |
US4389330A (en) | 1980-10-06 | 1983-06-21 | Stolle Research And Development Corporation | Microencapsulation process |
US4530840A (en) | 1982-07-29 | 1985-07-23 | The Stolle Research And Development Corporation | Injectable, long-acting microparticle formulation for the delivery of anti-inflammatory agents |
IE58110B1 (en) | 1984-10-30 | 1993-07-14 | Elan Corp Plc | Controlled release powder and process for its preparation |
GB8706148D0 (en) * | 1987-03-16 | 1987-04-23 | Exxon Chemical Patents Inc | Dispersions & emulsions |
WO1989003678A1 (en) | 1987-10-30 | 1989-05-05 | Stolle Research & Development Corporation | Low residual solvent microspheres and microencapsulation process |
IL92344A0 (en) | 1989-01-04 | 1990-07-26 | Gist Brocades Nv | Microencapsulation of bioactive substances in biocompatible polymers,microcapsules obtained and pharmaceutical preparation comprising said microcapsules |
CA2050911C (en) | 1989-05-04 | 1997-07-15 | Thomas R. Tice | Encapsulation process and products therefrom |
US5478564A (en) | 1990-02-22 | 1995-12-26 | Teva Pharmaceutical Industries, Ltd. | Preparation of microparticles for controlled release of water-soluble substances |
IT1243390B (it) | 1990-11-22 | 1994-06-10 | Vectorpharma Int | Composizioni farmaceutiche in forma di particelle atte al rilascio controllato di sostanze farmacologicamente attive e procedimento per la loro preparazione. |
HU222501B1 (hu) | 1991-06-28 | 2003-07-28 | Endorecherche Inc. | MPA-t vagy MGA-t tartalmazó nyújtott hatóanyag-felszabadulású gyógyászati készítmény és eljárás előállítására |
KR100333115B1 (ko) | 1992-11-17 | 2002-12-02 | 미츠비시 파마 코포레이션 | 항정신병약함유서방성마이크로스피어및이의제조방법 |
SK282231B6 (sk) | 1993-11-19 | 2001-12-03 | Janssen Pharmaceutica N. V. | Farmaceutický prostriedok na liečenie psychotických porúch |
PT729353E (pt) | 1993-11-19 | 2002-07-31 | Alkermes Inc | Preparacao de microparticulas biodegradaveis contendo um agente biologicamente activo |
US5650173A (en) | 1993-11-19 | 1997-07-22 | Alkermes Controlled Therapeutics Inc. Ii | Preparation of biodegradable microparticles containing a biologically active agent |
US5792477A (en) | 1996-05-07 | 1998-08-11 | Alkermes Controlled Therapeutics, Inc. Ii | Preparation of extended shelf-life biodegradable, biocompatible microparticles containing a biologically active agent |
US5945126A (en) | 1997-02-13 | 1999-08-31 | Oakwood Laboratories L.L.C. | Continuous microsphere process |
GB9718986D0 (en) | 1997-09-09 | 1997-11-12 | Danbiosyst Uk | Controlled release microsphere delivery system |
JP4575592B2 (ja) * | 1997-11-14 | 2010-11-04 | パシラ ファーマシューティカルズ インコーポレーテッド | 多小胞リポソームの製造 |
US6291013B1 (en) * | 1999-05-03 | 2001-09-18 | Southern Biosystems, Inc. | Emulsion-based processes for making microparticles |
US6331317B1 (en) * | 1999-11-12 | 2001-12-18 | Alkermes Controlled Therapeutics Ii Inc. | Apparatus and method for preparing microparticles |
-
1999
- 1999-11-12 US US09/438,656 patent/US6495166B1/en not_active Expired - Lifetime
-
2000
- 2000-11-03 ES ES00990484T patent/ES2236035T3/es not_active Expired - Lifetime
- 2000-11-03 WO PCT/US2000/041845 patent/WO2001034120A1/en active IP Right Grant
- 2000-11-03 DE DE60017461T patent/DE60017461T2/de not_active Expired - Lifetime
- 2000-11-03 PT PT00990484T patent/PT1242053E/pt unknown
- 2000-11-03 EP EP00990484A patent/EP1242053B1/en not_active Expired - Lifetime
- 2000-11-03 DK DK00990484T patent/DK1242053T3/da active
- 2000-11-03 CA CA002390563A patent/CA2390563C/en not_active Expired - Lifetime
- 2000-11-03 AU AU27508/01A patent/AU773734B2/en not_active Expired
- 2000-11-03 JP JP2001536120A patent/JP4838471B2/ja not_active Expired - Lifetime
- 2000-11-03 AT AT00990484T patent/ATE286722T1/de active
Also Published As
Publication number | Publication date |
---|---|
JP4838471B2 (ja) | 2011-12-14 |
AU773734B2 (en) | 2004-06-03 |
DE60017461T2 (de) | 2005-12-22 |
EP1242053A1 (en) | 2002-09-25 |
CA2390563A1 (en) | 2001-05-17 |
AU2750801A (en) | 2001-06-06 |
US6495166B1 (en) | 2002-12-17 |
WO2001034120B1 (en) | 2001-12-20 |
CA2390563C (en) | 2009-02-24 |
WO2001034120A1 (en) | 2001-05-17 |
ES2236035T3 (es) | 2005-07-16 |
JP2003513905A (ja) | 2003-04-15 |
DE60017461D1 (de) | 2005-02-17 |
ATE286722T1 (de) | 2005-01-15 |
EP1242053B1 (en) | 2005-01-12 |
PT1242053E (pt) | 2005-04-29 |
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