DE60017461D1 - Apparat und methode zur herstellung von mikropartikeln auf basis einer in-line lösungsmittel extraktion - Google Patents

Apparat und methode zur herstellung von mikropartikeln auf basis einer in-line lösungsmittel extraktion

Info

Publication number
DE60017461D1
DE60017461D1 DE60017461T DE60017461T DE60017461D1 DE 60017461 D1 DE60017461 D1 DE 60017461D1 DE 60017461 T DE60017461 T DE 60017461T DE 60017461 T DE60017461 T DE 60017461T DE 60017461 D1 DE60017461 D1 DE 60017461D1
Authority
DE
Germany
Prior art keywords
static mixer
solvent extraction
manufacture
line solvent
microparticles based
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60017461T
Other languages
English (en)
Other versions
DE60017461T2 (de
Inventor
L Lyons
G Wright
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alkermes Inc
Alkermes Controlled Therapeutics Inc II
Original Assignee
Alkermes Inc
Alkermes Controlled Therapeutics Inc II
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alkermes Inc, Alkermes Controlled Therapeutics Inc II filed Critical Alkermes Inc
Publication of DE60017461D1 publication Critical patent/DE60017461D1/de
Application granted granted Critical
Publication of DE60017461T2 publication Critical patent/DE60017461T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A61P23/02—Local anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2989—Microcapsule with solid core [includes liposome]

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Extraction Or Liquid Replacement (AREA)
DE60017461T 1999-11-12 2000-11-03 Apparat und methode zur herstellung von mikropartikeln auf basis einer in-line lösungsmittel extraktion Expired - Lifetime DE60017461T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US438656 1999-11-12
US09/438,656 US6495166B1 (en) 1999-11-12 1999-11-12 Apparatus and method for preparing microparticles using in-line solvent extraction
PCT/US2000/041845 WO2001034120A1 (en) 1999-11-12 2000-11-03 Apparatus and method for preparing microparticles using in-line solvent extraction

Publications (2)

Publication Number Publication Date
DE60017461D1 true DE60017461D1 (de) 2005-02-17
DE60017461T2 DE60017461T2 (de) 2005-12-22

Family

ID=23741486

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60017461T Expired - Lifetime DE60017461T2 (de) 1999-11-12 2000-11-03 Apparat und methode zur herstellung von mikropartikeln auf basis einer in-line lösungsmittel extraktion

Country Status (11)

Country Link
US (1) US6495166B1 (de)
EP (1) EP1242053B1 (de)
JP (1) JP4838471B2 (de)
AT (1) ATE286722T1 (de)
AU (1) AU773734B2 (de)
CA (1) CA2390563C (de)
DE (1) DE60017461T2 (de)
DK (1) DK1242053T3 (de)
ES (1) ES2236035T3 (de)
PT (1) PT1242053E (de)
WO (1) WO2001034120A1 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6705757B2 (en) * 1999-11-12 2004-03-16 Alkermes Controlled Therapeutics, Inc. Ii Method and apparatus for preparing microparticles using in-line solvent extraction
US6331317B1 (en) * 1999-11-12 2001-12-18 Alkermes Controlled Therapeutics Ii Inc. Apparatus and method for preparing microparticles
US6264987B1 (en) * 2000-05-19 2001-07-24 Alkermes Controlled Therapeutics Inc. Ii Method for preparing microparticles having a selected polymer molecular weight
US6932502B2 (en) * 2002-05-01 2005-08-23 Hewlett-Packard Development Company, L.P. Mixing apparatus
US20050232995A1 (en) 2002-07-29 2005-10-20 Yam Nyomi V Methods and dosage forms for controlled delivery of paliperidone and risperidone
JP2007515392A (ja) * 2003-04-10 2007-06-14 ピーアール ファーマシューティカルズ，インコーポレイテッド エマルジョンベースの微粒子の製造のための方法
US8900636B2 (en) 2003-07-23 2014-12-02 Evonik Corporation Controlled release compositions
CA2560959A1 (en) * 2004-03-23 2005-09-29 Kyowa Hakko Kogyo Co., Ltd. Method of producing coated fine particles
US20070099947A1 (en) * 2005-11-03 2007-05-03 Alkermes, Inc. Methods and compositions for the treatment of brain reward system disorders by combination therapy
EP2331082B1 (de) * 2008-09-11 2021-01-06 Evonik Corporation Lösungsmittelextraktion für mikroverkapselung mit abstimmbarer extraktionsrate
US20100143479A1 (en) 2008-12-04 2010-06-10 Oakwood Laboratories, Llc Method of making sustained release microparticles
DK2608670T3 (en) 2010-08-23 2019-02-11 Alkermes Pharma Ireland Ltd METHOD OF TREATING ANTI-SOCIETY-INDICATED WEIGHT RISE
CN104772056A (zh) * 2010-12-23 2015-07-15 赢创有限公司 用来制备乳化液的设备和方法
KR101543507B1 (ko) * 2013-05-15 2015-08-11 씨제이헬스케어 주식회사 연속 공정의 미립구의 제조 방법 및 이로부터 제조된 미립구
EP3034159B1 (de) * 2014-12-18 2020-11-04 The Procter and Gamble Company Statischer Mischer und Verfahren zum Mischen von Fluiden

Family Cites Families (30)

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NL280825A (de) 1962-07-11
BE744162A (fr) 1969-01-16 1970-06-15 Fuji Photo Film Co Ltd Procede d'encapsulage
US3773919A (en) 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
DE2010115A1 (de) 1970-03-04 1971-09-16 Farbenfabriken Bayer Ag, 5090 Leverkusen Verfahren zur Herstellung von Mikrogranulaten
DE2106526C3 (de) 1971-02-11 1979-03-15 Agfa-Gevaert Ag, 5090 Leverkusen Verfahren und Vorrichtung zur kontinuierlichen Zubereitung photographischer Emulsionen
JPS523342B2 (de) 1972-01-26 1977-01-27
GB1413186A (en) 1973-06-27 1975-11-12 Toyo Jozo Kk Process for encapsulation of medicaments
US4050676A (en) 1974-04-19 1977-09-27 Yasushi Morishima Mixing device and element therefor
JPS523653A (en) 1975-06-27 1977-01-12 Fuji Photo Film Co Ltd Process for producing fine polymer particles
US4384975A (en) 1980-06-13 1983-05-24 Sandoz, Inc. Process for preparation of microspheres
US4389330A (en) 1980-10-06 1983-06-21 Stolle Research And Development Corporation Microencapsulation process
US4530840A (en) 1982-07-29 1985-07-23 The Stolle Research And Development Corporation Injectable, long-acting microparticle formulation for the delivery of anti-inflammatory agents
IE58110B1 (en) 1984-10-30 1993-07-14 Elan Corp Plc Controlled release powder and process for its preparation
GB8706148D0 (en) * 1987-03-16 1987-04-23 Exxon Chemical Patents Inc Dispersions & emulsions
AU2810189A (en) 1987-10-30 1989-05-23 Stolle Research & Development Corporation Low residual solvent microspheres and microencapsulation process
IL92344A0 (en) 1989-01-04 1990-07-26 Gist Brocades Nv Microencapsulation of bioactive substances in biocompatible polymers,microcapsules obtained and pharmaceutical preparation comprising said microcapsules
DE69024953T3 (de) 1989-05-04 2005-01-27 Southern Research Institute, Birmingham Einkapselungsverfahren
US5478564A (en) 1990-02-22 1995-12-26 Teva Pharmaceutical Industries, Ltd. Preparation of microparticles for controlled release of water-soluble substances
IT1243390B (it) 1990-11-22 1994-06-10 Vectorpharma Int Composizioni farmaceutiche in forma di particelle atte al rilascio controllato di sostanze farmacologicamente attive e procedimento per la loro preparazione.
HU222501B1 (hu) 1991-06-28 2003-07-28 Endorecherche Inc. MPA-t vagy MGA-t tartalmazó nyújtott hatóanyag-felszabadulású gyógyászati készítmény és eljárás előállítására
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PT729353E (pt) * 1993-11-19 2002-07-31 Alkermes Inc Preparacao de microparticulas biodegradaveis contendo um agente biologicamente activo
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PL314481A1 (en) 1993-11-19 1996-09-16 Janssen Pharmaceutica Nv Microencapsulated substituted 3-piperidinyl 1,2-benzoisoxazoles and 1,2-benzoisothiazoles
US5792477A (en) 1996-05-07 1998-08-11 Alkermes Controlled Therapeutics, Inc. Ii Preparation of extended shelf-life biodegradable, biocompatible microparticles containing a biologically active agent
US5945126A (en) 1997-02-13 1999-08-31 Oakwood Laboratories L.L.C. Continuous microsphere process
GB9718986D0 (en) 1997-09-09 1997-11-12 Danbiosyst Uk Controlled release microsphere delivery system
ES2384094T3 (es) * 1997-11-14 2012-06-29 Pacira Pharmaceuticals, Inc. Producción de liposomas multivesiculares
US6291013B1 (en) * 1999-05-03 2001-09-18 Southern Biosystems, Inc. Emulsion-based processes for making microparticles
US6331317B1 (en) * 1999-11-12 2001-12-18 Alkermes Controlled Therapeutics Ii Inc. Apparatus and method for preparing microparticles

Also Published As

Publication number Publication date
ATE286722T1 (de) 2005-01-15
AU773734B2 (en) 2004-06-03
JP2003513905A (ja) 2003-04-15
PT1242053E (pt) 2005-04-29
JP4838471B2 (ja) 2011-12-14
WO2001034120A1 (en) 2001-05-17
CA2390563C (en) 2009-02-24
EP1242053B1 (de) 2005-01-12
EP1242053A1 (de) 2002-09-25
US6495166B1 (en) 2002-12-17
DE60017461T2 (de) 2005-12-22
WO2001034120B1 (en) 2001-12-20
CA2390563A1 (en) 2001-05-17
AU2750801A (en) 2001-06-06
ES2236035T3 (es) 2005-07-16
DK1242053T3 (da) 2005-05-30

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Legal Events

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