DK1225870T3 - Sammensætning og fremgangsmåde til cancerantigenimmunterapi - Google Patents
Sammensætning og fremgangsmåde til cancerantigenimmunterapiInfo
- Publication number
- DK1225870T3 DK1225870T3 DK00968692T DK00968692T DK1225870T3 DK 1225870 T3 DK1225870 T3 DK 1225870T3 DK 00968692 T DK00968692 T DK 00968692T DK 00968692 T DK00968692 T DK 00968692T DK 1225870 T3 DK1225870 T3 DK 1225870T3
- Authority
- DK
- Denmark
- Prior art keywords
- patient
- lymphocytes
- composition
- effector
- cancer antigen
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title abstract 3
- 201000011510 cancer Diseases 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title abstract 2
- 239000000427 antigen Substances 0.000 title 1
- 102000036639 antigens Human genes 0.000 title 1
- 108091007433 antigens Proteins 0.000 title 1
- 238000009169 immunotherapy Methods 0.000 title 1
- 210000001744 T-lymphocyte Anatomy 0.000 abstract 2
- 210000003162 effector t lymphocyte Anatomy 0.000 abstract 2
- 238000000338 in vitro Methods 0.000 abstract 2
- 230000004936 stimulating effect Effects 0.000 abstract 2
- 238000002619 cancer immunotherapy Methods 0.000 abstract 1
- 239000012636 effector Substances 0.000 abstract 1
- 239000000568 immunological adjuvant Substances 0.000 abstract 1
- 210000004698 lymphocyte Anatomy 0.000 abstract 1
- 230000036210 malignancy Effects 0.000 abstract 1
- 210000005259 peripheral blood Anatomy 0.000 abstract 1
- 239000011886 peripheral blood Substances 0.000 abstract 1
- 229960005486 vaccine Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/46432—Nervous system antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/4644—Cancer antigens
- A61K39/464499—Undefined tumor antigens, e.g. tumor lysate or antigens targeted by cells isolated from tumor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
- A61K2039/5152—Tumor cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
- A61K2039/5158—Antigen-pulsed cells, e.g. T-cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55522—Cytokines; Lymphokines; Interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
- A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the dose, timing or administration schedule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
- A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the cancer treated
- A61K2239/47—Brain; Nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
- A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the cancer treated
- A61K2239/49—Breast
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
- A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the cancer treated
- A61K2239/56—Kidney
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Cell Biology (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/412,681 US6406699B1 (en) | 1999-10-05 | 1999-10-05 | Composition and method of cancer antigen immunotherapy |
PCT/US2000/027399 WO2001024771A1 (fr) | 1999-10-05 | 2000-10-05 | Composition et methode d'immunotherapie antigenique anticancereuse |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1225870T3 true DK1225870T3 (da) | 2007-05-07 |
Family
ID=23634000
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK00968692T DK1225870T3 (da) | 1999-10-05 | 2000-10-05 | Sammensætning og fremgangsmåde til cancerantigenimmunterapi |
Country Status (11)
Country | Link |
---|---|
US (2) | US6406699B1 (fr) |
EP (1) | EP1225870B1 (fr) |
AT (1) | ATE349198T1 (fr) |
AU (1) | AU7856700A (fr) |
CA (1) | CA2388221C (fr) |
CY (1) | CY1106400T1 (fr) |
DE (1) | DE60032622T2 (fr) |
DK (1) | DK1225870T3 (fr) |
ES (1) | ES2279772T3 (fr) |
PT (1) | PT1225870E (fr) |
WO (1) | WO2001024771A1 (fr) |
Families Citing this family (77)
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IL143094A0 (en) * | 1998-12-02 | 2002-04-21 | Pfizer Prod Inc | METHODS AND COMPOSITIONS FOR RESTORING CONFORMATIONAL STABILITY OF A PROTEIN OF THE p53 FAMILY |
US7541184B2 (en) * | 2000-02-24 | 2009-06-02 | Invitrogen Corporation | Activation and expansion of cells |
EP1368061B1 (fr) * | 2000-10-20 | 2008-12-24 | Tsuneya Ohno | Cellules de fusion et compositions cytokiniques pour le traitement de maladies |
US20070154399A1 (en) * | 2000-10-27 | 2007-07-05 | Hadden John W | Immunotherapy for immune suppressed patients |
US6977072B2 (en) | 2000-10-27 | 2005-12-20 | Irx Therapeutics, Inc. | Vaccine immunotherapy for immune suppressed patients |
US20070025958A1 (en) | 2000-10-27 | 2007-02-01 | Hadden John W | Vaccine immunotherapy |
WO2003050135A2 (fr) | 2001-12-07 | 2003-06-19 | Board Of Regents The University Of Texas System | Utilisation de proteine b2l de parapox pour modifier les reponses immunes a des antigenes administres |
WO2003072032A2 (fr) * | 2002-02-22 | 2003-09-04 | Intracel Resources Llc | Compositions de cellules tumorales non oncogenes immunogenes steriles et methodes |
AU2003225791A1 (en) * | 2002-03-15 | 2003-09-29 | Department Of Veterans Affairs, Rehabilitation R And D Service | Methods and compositions for directing cells to target organs |
US20050084967A1 (en) | 2002-06-28 | 2005-04-21 | Xcyte Therapies, Inc. | Compositions and methods for eliminating undesired subpopulations of T cells in patients with immunological defects related to autoimmunity and organ or hematopoietic stem cell transplantation |
US20040175373A1 (en) * | 2002-06-28 | 2004-09-09 | Xcyte Therapies, Inc. | Compositions and methods for eliminating undesired subpopulations of T cells in patients with immunological defects related to autoimmunity and organ or hematopoietic stem cell transplantation |
US20040151704A1 (en) * | 2002-06-28 | 2004-08-05 | Xcyte Therapies, Inc. | Compositions and methods for restoring immune repertoire in patients with immunological defects related to autoimmunity and organ or hematopoietic stem cell transplantation |
MXPA05008936A (es) * | 2003-02-21 | 2006-05-25 | Univ Maryland | Adyuvante para vacunas con linfocitos humanos. |
MX2010005718A (es) | 2007-11-28 | 2010-08-10 | Irx Therapeutics Inc | Metodo para incrementar el efecto inmunologico. |
CA2754109A1 (fr) * | 2009-03-09 | 2010-09-16 | Tvax Biomedical, Llc | Immunotherapie cellulaire de maladie infectieuse |
EP2429585B1 (fr) | 2009-05-15 | 2018-04-18 | IRX Therapeutics, Inc. | Immunothérapie par vaccin |
AU2010328197B2 (en) | 2009-12-08 | 2015-07-16 | Irx Therapeutics, Inc. | Method of reversing immune suppression of Langerhans cells |
US10426740B1 (en) | 2010-08-18 | 2019-10-01 | Avm Biotechnology, Llc | Compositions and methods to inhibit stem cell and progenitor cell binding to lymphoid tissue and for regenerating germinal centers in lymphatic tissues |
ES2771251T3 (es) | 2013-03-01 | 2020-07-06 | Us Health | Métodos de producción de poblaciones enriquecidas de células T reactivas con tumores a partir de sangre periférica |
SI3302507T1 (sl) | 2015-05-28 | 2023-10-30 | The United States of America, as represented by The Secretary, Department of Health and Human Services, | Diagnostični postopki za t celično terapijo |
KR20230147769A (ko) | 2015-05-28 | 2023-10-23 | 카이트 파마 인코포레이티드 | T 세포 요법을 위해 환자를 컨디셔닝하는 방법 |
JP2018526428A (ja) * | 2015-09-09 | 2018-09-13 | ティーブイエーエックス バイオメディカル アイ,リミティド ライアビリティ カンパニー | 養子t細胞療法と腫瘍溶解性ウイルス補助療法とを組み合わせる方法 |
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US11781112B2 (en) * | 2016-03-06 | 2023-10-10 | Kareem Thomas Robinson | Method of generating antigen-specific immunological memory in a subject that rejects classical vaccines |
MX2018012017A (es) | 2016-04-01 | 2019-07-04 | Kite Pharma Inc | Antigeno quimerico y receptores de celulas t y metodos de uso. |
NZ746700A (en) | 2016-04-01 | 2023-04-28 | Kite Pharma Inc | Bcma binding molecules and methods of use thereof |
CA3019650C (fr) | 2016-04-01 | 2023-07-25 | Kite Pharma, Inc. | Recepteurs chimeriques et leurs procedes d'utilisation |
WO2018106958A1 (fr) * | 2016-12-07 | 2018-06-14 | Transtarget, Inc. | Procédés et compositions pour vacciner et fortifier des patients atteints d'un cancer |
ES2900233T3 (es) | 2017-02-14 | 2022-03-16 | Kite Pharma Inc | Moléculas que se unen a CD70 y métodos de uso de las mismas |
WO2018169922A2 (fr) | 2017-03-13 | 2018-09-20 | Kite Pharma, Inc. | Récepteurs antigéniques chimériques pour le mélanome et leurs utilisations |
MX2019011679A (es) | 2017-04-01 | 2019-11-01 | Avm Biotechnology Llc | Reemplazo de un pre-acondicionamiento citotoxico antes de una inmunoterapia celular. |
AR111360A1 (es) | 2017-04-03 | 2019-07-03 | Kite Pharma Inc | Tratamiento usando células t de receptor quimérico incorporando células t polifuncionales optimizadas |
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CN110662831A (zh) | 2017-05-26 | 2020-01-07 | 凯德药业股份有限公司 | 制备和使用胚胎间充质祖细胞的方法 |
KR102521245B1 (ko) * | 2017-09-15 | 2023-04-17 | 카이트 파마 인코포레이티드 | 관리 연속성 및 신원 연속성 생물학적 샘플 추적으로 환자-특이적 면역요법 절차를 수행하기 위한 방법 및 시스템 |
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WO2019152957A1 (fr) | 2018-02-02 | 2019-08-08 | Arizona Board Of Regents On Behalf Of Arizona State University | Lymphocytes t de type adn-récepteur antigénique chimérique pour immunothérapie |
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IL310416A (en) | 2018-04-12 | 2024-03-01 | Kite Pharma Inc | Chimeric T cell receptor therapy using tumor microenvironmental characteristics |
TW202003021A (zh) | 2018-06-01 | 2020-01-16 | 美商凱特製藥公司 | 嵌合抗原受體t細胞療法 |
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KR20210038922A (ko) | 2018-08-02 | 2021-04-08 | 카이트 파마 인코포레이티드 | 키메라 항원 수용체 요법 t 세포 확장 동역학 및 그의 용도 |
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EP3632446B3 (fr) | 2018-10-03 | 2024-01-24 | AVM Biotechnology, LLC | Thérapies immunoablatives |
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TW202108150A (zh) | 2019-05-03 | 2021-03-01 | 美商凱特製藥公司 | 投與嵌合抗原受體免疫療法之方法 |
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US20230293530A1 (en) | 2020-06-24 | 2023-09-21 | Yeda Research And Development Co. Ltd. | Agents for sensitizing solid tumors to treatment |
WO2022036041A1 (fr) | 2020-08-14 | 2022-02-17 | Kite Pharma, Inc | Amélioration de la fonction de cellules immunitaires |
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JP2024502599A (ja) | 2021-01-10 | 2024-01-22 | カイト ファーマ インコーポレイテッド | T細胞療法 |
JP2024507199A (ja) | 2021-02-20 | 2024-02-16 | カイト ファーマ インコーポレイテッド | 免疫療法を選択するための遺伝子マーカー |
JP2024510162A (ja) | 2021-03-11 | 2024-03-06 | カイト ファーマ インコーポレイテッド | 免疫細胞機能の改善 |
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EP4363558A1 (fr) | 2021-07-01 | 2024-05-08 | Kite Pharma, Inc. | Système fermé et procédé de fabrication de thérapie cellulaire autologue et allogène |
EP4364151A1 (fr) | 2021-07-02 | 2024-05-08 | Kite Pharma, Inc. | Procédé d'identification de variants de produits géniques à partir de constructions géniques utilisées dans des applications de thérapie cellulaire |
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IL311981A (en) | 2021-10-18 | 2024-06-01 | Kite Pharma Inc | Signaling domains for chimeric antigen receptors |
WO2023159001A1 (fr) | 2022-02-15 | 2023-08-24 | Kite Pharma, Inc. | Prédiction d'événements indésirables à partir d'une immunothérapie |
US20240091261A1 (en) | 2022-08-26 | 2024-03-21 | Kite Pharma, Inc. | Immune cell function |
US20240158869A1 (en) | 2022-10-28 | 2024-05-16 | Kite Pharma, Inc. | Factors for optimizing immunotherapy |
WO2024092152A1 (fr) | 2022-10-28 | 2024-05-02 | Kite Pharma, Inc. | Amélioration de l'efficacité et de la réponse durable de l'immunothérapie |
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US5766920A (en) | 1982-08-11 | 1998-06-16 | Cellcor, Inc. | Ex vivo activation of immune cells |
US4828991A (en) | 1984-01-31 | 1989-05-09 | Akzo N.V. | Tumor specific monoclonal antibodies |
WO1988000970A2 (fr) | 1986-08-08 | 1988-02-11 | Regents Of The University Of Minnesota | Procede de culture de leucocytes |
US5126132A (en) | 1989-08-21 | 1992-06-30 | The United States Of America As Represented By The Department Of Health And Human Services | Tumor infiltrating lymphocytes as a treatment modality for human cancer |
US5728388A (en) | 1989-10-03 | 1998-03-17 | Terman; David S. | Method of cancer treatment |
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US5725855A (en) | 1991-04-05 | 1998-03-10 | The United States Of America As Represented By The Department Of Health And Human Services | Method of treating tumors with CD8+ -depleted or CD4+ T cell subpopulations |
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US5650156A (en) * | 1993-02-22 | 1997-07-22 | Vivorx Pharmaceuticals, Inc. | Methods for in vivo delivery of nutriceuticals and compositions useful therefor |
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-
1999
- 1999-10-05 US US09/412,681 patent/US6406699B1/en not_active Expired - Lifetime
-
2000
- 2000-10-05 WO PCT/US2000/027399 patent/WO2001024771A1/fr active IP Right Grant
- 2000-10-05 AU AU78567/00A patent/AU7856700A/en not_active Abandoned
- 2000-10-05 PT PT00968692T patent/PT1225870E/pt unknown
- 2000-10-05 DE DE60032622T patent/DE60032622T2/de not_active Expired - Lifetime
- 2000-10-05 EP EP00968692A patent/EP1225870B1/fr not_active Expired - Lifetime
- 2000-10-05 ES ES00968692T patent/ES2279772T3/es not_active Expired - Lifetime
- 2000-10-05 AT AT00968692T patent/ATE349198T1/de active
- 2000-10-05 CA CA002388221A patent/CA2388221C/fr not_active Expired - Lifetime
- 2000-10-05 DK DK00968692T patent/DK1225870T3/da active
-
2001
- 2001-07-05 US US09/899,780 patent/US20020006409A1/en not_active Abandoned
-
2007
- 2007-03-20 CY CY20071100390T patent/CY1106400T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
ATE349198T1 (de) | 2007-01-15 |
EP1225870A1 (fr) | 2002-07-31 |
CA2388221C (fr) | 2007-12-04 |
EP1225870A4 (fr) | 2003-05-28 |
US20020006409A1 (en) | 2002-01-17 |
AU7856700A (en) | 2001-05-10 |
US6406699B1 (en) | 2002-06-18 |
PT1225870E (pt) | 2007-06-11 |
DE60032622D1 (de) | 2007-02-08 |
CY1106400T1 (el) | 2011-10-12 |
ES2279772T3 (es) | 2007-09-01 |
CA2388221A1 (fr) | 2001-04-12 |
EP1225870B1 (fr) | 2006-12-27 |
DE60032622T2 (de) | 2007-12-20 |
WO2001024771A1 (fr) | 2001-04-12 |
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