DK1204679T3 - Peptider som indeholder N-substituerede D-aminosyrer til at forhindre associering af Beta-strenge - Google Patents

Peptider som indeholder N-substituerede D-aminosyrer til at forhindre associering af Beta-strenge

Info

Publication number
DK1204679T3
DK1204679T3 DK00949729T DK00949729T DK1204679T3 DK 1204679 T3 DK1204679 T3 DK 1204679T3 DK 00949729 T DK00949729 T DK 00949729T DK 00949729 T DK00949729 T DK 00949729T DK 1204679 T3 DK1204679 T3 DK 1204679T3
Authority
DK
Denmark
Prior art keywords
peptide
beta
strand
substituted
nalpha
Prior art date
Application number
DK00949729T
Other languages
Danish (da)
English (en)
Inventor
Kelvin Stott
Original Assignee
Senexis Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Senexis Ltd filed Critical Senexis Ltd
Application granted granted Critical
Publication of DK1204679T3 publication Critical patent/DK1204679T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Neurology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Toxicology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Psychiatry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hospice & Palliative Care (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK00949729T 1999-07-28 2000-07-28 Peptider som indeholder N-substituerede D-aminosyrer til at forhindre associering af Beta-strenge DK1204679T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9917725.5A GB9917725D0 (en) 1999-07-28 1999-07-28 Peptides
PCT/GB2000/002923 WO2001007474A1 (en) 1999-07-28 2000-07-28 Peptides containing n-substituted d-amino acids for preventing beta-strand association

Publications (1)

Publication Number Publication Date
DK1204679T3 true DK1204679T3 (da) 2007-04-02

Family

ID=10858097

Family Applications (1)

Application Number Title Priority Date Filing Date
DK00949729T DK1204679T3 (da) 1999-07-28 2000-07-28 Peptider som indeholder N-substituerede D-aminosyrer til at forhindre associering af Beta-strenge

Country Status (13)

Country Link
US (1) US7060671B1 (ja)
EP (1) EP1204679B1 (ja)
JP (1) JP2003505470A (ja)
AT (1) ATE355302T1 (ja)
AU (1) AU767396B2 (ja)
CA (1) CA2379241A1 (ja)
DE (1) DE60033668T2 (ja)
DK (1) DK1204679T3 (ja)
ES (1) ES2282125T3 (ja)
GB (1) GB9917725D0 (ja)
NZ (1) NZ516442A (ja)
PT (1) PT1204679E (ja)
WO (1) WO2001007474A1 (ja)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001007414A1 (en) 1999-07-21 2001-02-01 The Trustees Of The University Of Pennsylvania Preparation of compounds useful for the detection of hypoxia
ES2180417B1 (es) * 2001-03-14 2004-05-16 Consejo Superior De Investigaciones Cientificas Nueva proteina sobreexpresada en cancer de prostata.
DE10117281A1 (de) * 2001-04-06 2002-10-24 Inst Molekulare Biotechnologie Peptid zur Diagnose und Therapie der Alzheimer-Demenz
DE10230141B4 (de) * 2002-07-04 2004-07-15 Priontype Gmbh Verfahren und Kit zur Anreicherung und zum Nachweis von veränderten Prion-Proteinen (PrPSc)
EP1380290A1 (en) 2002-07-09 2004-01-14 Universitair Medisch Centrum Utrecht Cross-beta structure pathway and its therapeutic relevance
EP1910844B1 (en) 2005-07-13 2012-04-18 Crossbeta Biosciences B.V. Cross-beta structure binding compounds
US8114832B2 (en) 2005-07-13 2012-02-14 Crossbeta Biosciences B.V. Method for detecting and/or removing a protein comprising a cross-beta structure from a pharmaceutical composition
GB2432586B (en) * 2005-11-25 2010-01-13 Univ Open Treatment of neurodegenerative disorders
JP2007217330A (ja) * 2006-02-16 2007-08-30 Dainippon Sumitomo Pharma Co Ltd 新規ペプチド
US8188046B2 (en) 2006-10-16 2012-05-29 University Of South Florida Amyloid beta peptides and methods of use
US7618944B2 (en) * 2007-03-01 2009-11-17 Intezyne Technologies, Inc. Encapsulated amyloid-beta peptides
GB0716885D0 (en) * 2007-08-30 2007-10-10 United Arab Emirates Universit Diagnostic agent

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH11514333A (ja) * 1995-03-14 1999-12-07 プレーシス ファーマスーティカルズ インコーポレイテッド アミロイドの凝集の調節剤
US6034211A (en) 1996-06-03 2000-03-07 Kelly; Jeffery W. β-sheet nucleating peptidomimetics
DE19725619A1 (de) 1997-06-17 1998-12-24 Fraunhofer Ges Forschung Peptide als Agonisten und/oder Inhibitoren der Amyloidbildung und Zytotoxizität sowie der Verwendung bei Alzheimer'schen Krankheit, beim Typ II Diabetes mellitus und bei spongiformen Encephalopathien
AU781292B2 (en) * 1999-03-04 2005-05-12 Praecis Pharmaceuticals Incorporated Modulators of beta-amyloid peptide aggregation comprising D-amino acids

Also Published As

Publication number Publication date
US7060671B1 (en) 2006-06-13
CA2379241A1 (en) 2001-02-01
AU6300400A (en) 2001-02-13
DE60033668T2 (de) 2007-06-21
EP1204679B1 (en) 2007-02-28
JP2003505470A (ja) 2003-02-12
ES2282125T3 (es) 2007-10-16
GB9917725D0 (en) 1999-09-29
ATE355302T1 (de) 2006-03-15
DE60033668D1 (de) 2007-04-12
NZ516442A (en) 2003-10-31
EP1204679A1 (en) 2002-05-15
WO2001007474A1 (en) 2001-02-01
AU767396B2 (en) 2003-11-06
PT1204679E (pt) 2007-05-31

Similar Documents

Publication Publication Date Title
EA200700973A1 (ru) Слитый белок, содержащий домен bh3 белка «вh3-только»
DK1204679T3 (da) Peptider som indeholder N-substituerede D-aminosyrer til at forhindre associering af Beta-strenge
DK0643726T3 (da) Peptider af humant p53-protein til anvendelse i sammensætninger, som inducerer humant T-celle-respons, og humane p53-protei
DE60040274D1 (de) Verabreichung von nukleinsäuren und proteinen an zellen
ATE368053T1 (de) Antimikrobielle peptide
ATE551048T1 (de) Proteinhydrolysate enthaltende kosmetische zusammensetzungen
RS50966B (sr) Agonisti pyy i njihova upotreba
EP2298331A3 (en) Use of transthyretin peptide/protein fusions to increase the serum half-life of pharmacologically active peptides/proteins
UY28641A1 (es) Anticuerpos
DE60030450D1 (de) Von MUC-1 abgeleitete Peptide
NO20000934D0 (no) Adipocyttspesifikke proteinhomologer
DE50112802D1 (de) Peptide, deren herstellung und verwendung zur bindung von immunglobulinen
ES2174770T1 (es) Peptidos diseñados para el diagnostico y el tratamiento de artritis reumatoide.
BRPI0511005A (pt) peptìdeos oligoméricos e seu uso para o tratamento de infecções por hiv
DE68927379D1 (de) Plättchen blockierende peptide
BRPI0606445A2 (pt) inibidores de hipersecreÇço de mucina e mÉtodos de uso
DE69834643D1 (de) Adipozyten-spezifische protein homologe
FI961044A0 (fi) Kininogeeni-inhibiittorit
ATE322503T1 (de) Gefrierschutzprotein
ATE362487T1 (de) N-substituierte l-aminosäuren enthaltende peptide,zur prävention der beta-strang assoziation
DE602004028266D1 (de) Angiogene peptide und ihre verwendungen
DK1368372T3 (da) Peptid med affinitet til det virale gp120-protein samt anvendelse deraf
DK1117682T3 (da) Chi-conotoksin-peptider som inhibitorer af neuronale amintransportere
WO2001009174A3 (en) Plant defensin variants
DK1504036T3 (da) Toxinrelaterede fragmenter af antistoffer med antimikrobiel og antiviral aktivitet