DK1200436T3 - Fremgangsmåde til fremstilling af rene stereoisomerer af tetrahydrofolsyreestersalte og tetrahydrofolsyre ved fraktioneret krystallisering af tetrahydrofolsyreestersalte - Google Patents

Fremgangsmåde til fremstilling af rene stereoisomerer af tetrahydrofolsyreestersalte og tetrahydrofolsyre ved fraktioneret krystallisering af tetrahydrofolsyreestersalte

Info

Publication number
DK1200436T3
DK1200436T3 DK00949322T DK00949322T DK1200436T3 DK 1200436 T3 DK1200436 T3 DK 1200436T3 DK 00949322 T DK00949322 T DK 00949322T DK 00949322 T DK00949322 T DK 00949322T DK 1200436 T3 DK1200436 T3 DK 1200436T3
Authority
DK
Denmark
Prior art keywords
tetrahydrofolic acid
acid salts
preparation
fractional crystallization
alphar
Prior art date
Application number
DK00949322T
Other languages
Danish (da)
English (en)
Inventor
Rudolf Moser
Viola Groehn
Hans Rudolf Mueller
Original Assignee
Merck Eprova Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Eprova Ag filed Critical Merck Eprova Ag
Application granted granted Critical
Publication of DK1200436T3 publication Critical patent/DK1200436T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4
    • C07D475/04—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4 with a nitrogen atom directly attached in position 2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
DK00949322T 1999-07-14 2000-07-12 Fremgangsmåde til fremstilling af rene stereoisomerer af tetrahydrofolsyreestersalte og tetrahydrofolsyre ved fraktioneret krystallisering af tetrahydrofolsyreestersalte DK1200436T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH01300/99A CH695217A5 (de) 1999-07-14 1999-07-14 Verfahren zur Trennung optischer Isomeren von Tetrahydrofolsäureestersalzen und Tetrahydrofolsäure.
PCT/EP2000/006647 WO2001004121A1 (de) 1999-07-14 2000-07-12 Verfahren zur herstellung reiner stereoisomeren von tetrahydrofolsäureestersalzen und tetrahydrofolsäure durch fraktionierte kristallisation von tetrahydrofolsäureestersalzen

Publications (1)

Publication Number Publication Date
DK1200436T3 true DK1200436T3 (da) 2009-02-23

Family

ID=4207222

Family Applications (1)

Application Number Title Priority Date Filing Date
DK00949322T DK1200436T3 (da) 1999-07-14 2000-07-12 Fremgangsmåde til fremstilling af rene stereoisomerer af tetrahydrofolsyreestersalte og tetrahydrofolsyre ved fraktioneret krystallisering af tetrahydrofolsyreestersalte

Country Status (13)

Country Link
US (1) US6858731B1 (ja)
EP (1) EP1200436B1 (ja)
JP (1) JP4949581B2 (ja)
CN (1) CN1206229C (ja)
AT (1) ATE412654T1 (ja)
AU (1) AU6272700A (ja)
CA (1) CA2378869C (ja)
CH (1) CH695217A5 (ja)
DE (1) DE50015428D1 (ja)
DK (1) DK1200436T3 (ja)
ES (1) ES2316375T3 (ja)
PT (1) PT1200436E (ja)
WO (1) WO2001004121A1 (ja)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH694251A5 (de) * 1999-07-14 2004-10-15 Eprova Ag Herstellung von Tetrahydropterin und Derivaten.
ITMI20020132A1 (it) * 2002-01-25 2003-07-25 Gmt Fine Chemicals Sa Processo per l'ottenimento dell'acido (6s)-5,6,7,8-tetraidrofolico
CN112351818A (zh) * 2018-07-06 2021-02-09 默克专利股份有限公司 5-甲基-(6s)-四氢叶酸和l-异亮氨酸乙酯的结晶盐

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS497416A (ja) * 1972-05-12 1974-01-23
DE3821875C1 (ja) * 1988-06-29 1990-02-15 Eprova Ag, Forschungsinstitut, Schaffhausen, Ch
CH681303A5 (ja) * 1991-01-16 1993-02-26 Eprova Ag
CH682664A5 (en) * 1991-10-15 1993-10-29 Eprova Ag Stable salts of 5,10-methylene tetrahydrofolate.
CH686369A5 (de) * 1994-05-09 1996-03-15 Eprova Ag Stabile kristalline (6S)- und (6R)-Tetrahydrofolseure.
JP3433301B2 (ja) * 1993-11-25 2003-08-04 アサヒビール株式会社 ５，６，７，８−テトラヒドロ−ｄ−ネオプテリンの有機酸塩の製造法

Also Published As

Publication number Publication date
JP2003504371A (ja) 2003-02-04
EP1200436A1 (de) 2002-05-02
CH695217A5 (de) 2006-01-31
CN1206229C (zh) 2005-06-15
CA2378869C (en) 2006-12-12
AU6272700A (en) 2001-01-30
ES2316375T3 (es) 2009-04-16
CA2378869A1 (en) 2001-01-18
ATE412654T1 (de) 2008-11-15
JP4949581B2 (ja) 2012-06-13
DE50015428D1 (de) 2008-12-11
PT1200436E (pt) 2009-02-10
EP1200436B1 (de) 2008-10-29
US6858731B1 (en) 2005-02-22
CN1360586A (zh) 2002-07-24
WO2001004121A1 (de) 2001-01-18

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