DK1183255T3 - Metalkomplekser af bicykliske polyaminosyrer, fremgangsmåde til fremstilling af disse og anvendelse af disse til medicinsk billeddiagnostik - Google Patents
Metalkomplekser af bicykliske polyaminosyrer, fremgangsmåde til fremstilling af disse og anvendelse af disse til medicinsk billeddiagnostikInfo
- Publication number
- DK1183255T3 DK1183255T3 DK00940473T DK00940473T DK1183255T3 DK 1183255 T3 DK1183255 T3 DK 1183255T3 DK 00940473 T DK00940473 T DK 00940473T DK 00940473 T DK00940473 T DK 00940473T DK 1183255 T3 DK1183255 T3 DK 1183255T3
- Authority
- DK
- Denmark
- Prior art keywords
- medical imaging
- bicyclic
- processes
- preparation
- metal complexes
- Prior art date
Links
- 238000002059 diagnostic imaging Methods 0.000 title abstract 2
- 239000002184 metal Substances 0.000 title abstract 2
- 125000002619 bicyclic group Chemical group 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 229920001308 poly(aminoacid) Polymers 0.000 title 1
- 150000001408 amides Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Polyamides (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9907283A FR2794744B1 (fr) | 1999-06-09 | 1999-06-09 | Complexes metalliques de polyaminoacides bicycliques, leur procede de preparation et leur application en imagerie medicale |
PCT/FR2000/001591 WO2000075141A1 (fr) | 1999-06-09 | 2000-06-08 | Complexes metalliques de polyaminoacides bicycliques, leur procede de preparation et leur application en imagerie medicale |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1183255T3 true DK1183255T3 (da) | 2003-06-02 |
Family
ID=9546571
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK00940473T DK1183255T3 (da) | 1999-06-09 | 2000-06-08 | Metalkomplekser af bicykliske polyaminosyrer, fremgangsmåde til fremstilling af disse og anvendelse af disse til medicinsk billeddiagnostik |
Country Status (22)
Country | Link |
---|---|
US (1) | US6440956B1 (zh) |
EP (1) | EP1183255B1 (zh) |
JP (1) | JP4719391B2 (zh) |
KR (1) | KR20020008218A (zh) |
CN (1) | CN1196702C (zh) |
AT (1) | ATE233762T1 (zh) |
AU (1) | AU5540400A (zh) |
BR (1) | BR0011436A (zh) |
CA (1) | CA2376497C (zh) |
DE (1) | DE60001564T2 (zh) |
DK (1) | DK1183255T3 (zh) |
ES (1) | ES2188556T3 (zh) |
FR (1) | FR2794744B1 (zh) |
HU (1) | HU227966B1 (zh) |
IL (2) | IL146304A0 (zh) |
MX (1) | MXPA01011439A (zh) |
NO (1) | NO321121B1 (zh) |
PL (1) | PL216974B1 (zh) |
PT (1) | PT1183255E (zh) |
RU (1) | RU2232763C2 (zh) |
TR (1) | TR200103525T2 (zh) |
WO (1) | WO2000075141A1 (zh) |
Families Citing this family (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ITMI20011706A1 (it) * | 2001-08-03 | 2003-02-03 | Bracco Imaging Spa | Agenti di contrasto radiografici ionici e non ionici, utilizzabili per l'indagine diagnostica combinata tramite raggi-x e risonanza magnetic |
US8518373B2 (en) | 2001-08-03 | 2013-08-27 | Bracco Imaging Spa | Ionic and non-ionic radiographic contrast agents for use in combined X-ray and nuclear magnetic resonance diagnostics |
FR2836916B1 (fr) * | 2002-03-05 | 2004-06-11 | Guerbet Sa | Oligomeres de chelates de gadolinium, leur application comme produits de contraste en imagerie par resonance magnetique et leurs intermediaires de synthese |
DE10307759B3 (de) * | 2003-02-19 | 2004-11-18 | Schering Ag | Trimere makrocyclisch substituierte Benzolderivate, deren Herstellung und Verwendung als Kontrastmittel sowie diese enthaltende pharmazeutische Mittel |
JP2004307356A (ja) * | 2003-04-02 | 2004-11-04 | Hamamatsu Kagaku Gijutsu Kenkyu Shinkokai | 新規なデンドリマーおよび造影剤 |
FR2856689A1 (fr) * | 2003-06-25 | 2004-12-31 | Guerbet Sa | Composes specifiques a forte relaxivite |
FR2857967B1 (fr) * | 2003-07-25 | 2015-04-24 | Centre Nat Rech Scient | Complexes de lanthanide, leur preparation et leurs utilisations |
FR2867473B1 (fr) | 2004-03-12 | 2006-06-23 | Guerbet Sa | Compose de porphyrines et utilisation a haut champ en irm |
EP1765812B1 (en) * | 2004-07-02 | 2009-04-29 | Bracco Imaging S.p.A | Contrast agents endowed with high relaxivity for use in magnetic resonance imaging (mri) which contain a chelating moiety with polyhydroxylated substituents |
FR2875410B1 (fr) * | 2004-09-23 | 2012-11-16 | Guerbet Sa | Composes de diagnostique pour le ciblage de recpteur a chimiokines |
CN100355806C (zh) * | 2005-03-04 | 2007-12-19 | 华东师范大学 | 端氨基嵌段聚氧乙烯改性的钆配合物及其合成方法 |
FR2883562B1 (fr) | 2005-03-24 | 2009-02-27 | Guerbet Sa | Chelates lipophiles et leur utilisation en imagerie |
US8986650B2 (en) | 2005-10-07 | 2015-03-24 | Guerbet | Complex folate-NOTA-Ga68 |
FR2891830B1 (fr) | 2005-10-07 | 2011-06-24 | Guerbet Sa | Composes a chaines aminoalcools courtes et complexes metalliques pour l'imagerie medicale |
US8926945B2 (en) * | 2005-10-07 | 2015-01-06 | Guerbet | Compounds comprising a biological target recognizing part, coupled to a signal part capable of complexing gallium |
FR2914303A1 (fr) * | 2007-03-28 | 2008-10-03 | Guerbet Sa | Composes pour le diagnostic de l'apoptose. |
FR2914304B1 (fr) * | 2007-03-28 | 2012-11-16 | Guerbet Sa | Composes pour le diagnostic de maladies liees a l'expression de vcam. |
DE102007058220A1 (de) | 2007-12-03 | 2009-06-04 | Bayer Schering Pharma Aktiengesellschaft | Dimere macrocyclisch substituierte Benzolderivate |
FR2942227B1 (fr) | 2009-02-13 | 2011-04-15 | Guerbet Sa | Utilisation de tampons pour la complexation de radionucleides |
IN2012DN02586A (zh) * | 2009-09-28 | 2015-08-28 | Univ Kentucky Res Found | |
DK2988756T4 (da) | 2013-04-26 | 2022-08-08 | Guerbet Sa | Formulering af kontraststof og dertil knyttet fremstillingsfremgangsmåde |
GB201610738D0 (en) * | 2016-06-20 | 2016-08-03 | Ge Healthcare As | Chelate compounds |
WO2018096082A1 (en) | 2016-11-28 | 2018-05-31 | Bayer Pharma Aktiengesellschaft | High relaxivity gadolinium chelate compounds for use in magnetic resonance imaging |
EP3558394B1 (en) * | 2016-12-21 | 2020-06-03 | GE Healthcare AS | Tetraazabicyclo-macrocycle based manganese chelate compounds suitable as mri imaging agents |
US11110186B2 (en) * | 2017-12-20 | 2021-09-07 | General Electric Company | Anionic chelate compounds |
EP4151637A1 (en) | 2018-08-06 | 2023-03-22 | Bracco Imaging SPA | Gadolinium bearing pcta-based contrast agents |
CA3120665A1 (en) | 2018-11-23 | 2020-05-28 | Bayer Aktiengesellschaft | Formulation of contrast media and process of preparation thereof |
US11370804B2 (en) | 2019-01-17 | 2022-06-28 | Guerbet | Complex of gadolinium and a chelating ligand derived from a diastereoisomerically enriched PCTA and preparation and purification process |
US11426470B2 (en) | 2019-01-17 | 2022-08-30 | Guerbet | Complex of gadolinium and a chelating ligand derived of a diastereoisomerically enriched PCTA and synthesis method |
FR3091872B1 (fr) * | 2019-01-17 | 2020-12-25 | Guerbet Sa | Complexe de gadolinium et d’un ligand chelateur derive de pcta diastereoisomeriquement enrichi et procede de synthese |
FR3091873B1 (fr) * | 2019-01-17 | 2020-12-25 | Guerbet Sa | Complexe de gadolinium et d’un ligand chelateur derive de pcta diastereoisomeriquement enrichi et procede de preparation et de purification |
US12012378B2 (en) * | 2020-07-16 | 2024-06-18 | Guerbet | Method for synthesizing 2-bromoglutaric acid diesters |
CN115722276B (zh) * | 2022-11-15 | 2024-06-18 | 江苏美亚科泽过滤技术有限公司 | 一种粒状多效吸附剂组合物及其制备方法 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3825040A1 (de) * | 1988-07-20 | 1990-01-25 | Schering Ag | 5- oder 6-ring- enthaltende makrocyclische polyaza-verbindungen, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel |
DE4001655A1 (de) * | 1990-01-18 | 1991-07-25 | Schering Ag | 6-ring enthaltende makrocyclische tetraaza-verbindungen, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel |
FR2644785B1 (fr) * | 1989-03-24 | 1991-07-05 | Guerbet Sa | Nouveaux ligands macrocycliques azotes, procede de preparation, complexes metalliques formes par ces ligands et composition de diagnostic les contenant |
US5554748A (en) * | 1989-04-07 | 1996-09-10 | Nycomed Salutar, Inc. | Adducts of macrocyclic chelants |
WO1993011800A1 (en) * | 1991-12-10 | 1993-06-24 | The Dow Chemical Company | Bicycle-polyazamacrocyclocarboxylic acid complexes, conjugates, preparation and use as contrast agents |
FR2736051B3 (fr) * | 1995-06-29 | 1997-09-26 | Guerbet Sa | Complexes metalliques de polyaminoacides, leur procede de preparation et leur utilisation en imagerie diagnostique |
-
1999
- 1999-06-09 FR FR9907283A patent/FR2794744B1/fr not_active Expired - Fee Related
-
2000
- 2000-06-08 TR TR2001/03525T patent/TR200103525T2/xx unknown
- 2000-06-08 BR BR0011436-7A patent/BR0011436A/pt not_active Application Discontinuation
- 2000-06-08 DE DE60001564T patent/DE60001564T2/de not_active Expired - Lifetime
- 2000-06-08 PT PT00940473T patent/PT1183255E/pt unknown
- 2000-06-08 EP EP00940473A patent/EP1183255B1/fr not_active Expired - Lifetime
- 2000-06-08 MX MXPA01011439A patent/MXPA01011439A/es active IP Right Grant
- 2000-06-08 AT AT00940473T patent/ATE233762T1/de active
- 2000-06-08 CA CA002376497A patent/CA2376497C/fr not_active Expired - Fee Related
- 2000-06-08 CN CNB008086060A patent/CN1196702C/zh not_active Expired - Fee Related
- 2000-06-08 RU RU2002100125/04A patent/RU2232763C2/ru not_active IP Right Cessation
- 2000-06-08 ES ES00940473T patent/ES2188556T3/es not_active Expired - Lifetime
- 2000-06-08 HU HU0201468A patent/HU227966B1/hu not_active IP Right Cessation
- 2000-06-08 IL IL14630400A patent/IL146304A0/xx active IP Right Grant
- 2000-06-08 AU AU55404/00A patent/AU5540400A/en not_active Abandoned
- 2000-06-08 WO PCT/FR2000/001591 patent/WO2000075141A1/fr not_active Application Discontinuation
- 2000-06-08 PL PL352483A patent/PL216974B1/pl unknown
- 2000-06-08 KR KR1020017015705A patent/KR20020008218A/ko not_active Application Discontinuation
- 2000-06-08 DK DK00940473T patent/DK1183255T3/da active
- 2000-06-08 US US09/589,345 patent/US6440956B1/en not_active Expired - Lifetime
- 2000-06-08 JP JP2001502423A patent/JP4719391B2/ja not_active Expired - Lifetime
-
2001
- 2001-11-01 IL IL146304A patent/IL146304A/en not_active IP Right Cessation
- 2001-12-07 NO NO20015991A patent/NO321121B1/no not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
HU227966B1 (en) | 2012-07-30 |
JP4719391B2 (ja) | 2011-07-06 |
CA2376497A1 (fr) | 2000-12-14 |
FR2794744B1 (fr) | 2001-09-21 |
TR200103525T2 (tr) | 2002-05-21 |
DE60001564D1 (de) | 2003-04-10 |
IL146304A0 (en) | 2002-07-25 |
PL216974B1 (pl) | 2014-05-30 |
PL352483A1 (en) | 2003-08-25 |
EP1183255A1 (fr) | 2002-03-06 |
IL146304A (en) | 2006-04-10 |
EP1183255B1 (fr) | 2003-03-05 |
MXPA01011439A (es) | 2002-06-04 |
NO321121B1 (no) | 2006-03-20 |
KR20020008218A (ko) | 2002-01-29 |
NO20015991D0 (no) | 2001-12-07 |
DE60001564T2 (de) | 2003-12-11 |
RU2232763C2 (ru) | 2004-07-20 |
ATE233762T1 (de) | 2003-03-15 |
NO20015991L (no) | 2002-02-06 |
CN1196702C (zh) | 2005-04-13 |
FR2794744A1 (fr) | 2000-12-15 |
AU5540400A (en) | 2000-12-28 |
US6440956B1 (en) | 2002-08-27 |
CN1354751A (zh) | 2002-06-19 |
HUP0201468A2 (en) | 2002-08-28 |
JP2003501430A (ja) | 2003-01-14 |
PT1183255E (pt) | 2003-06-30 |
WO2000075141A1 (fr) | 2000-12-14 |
ES2188556T3 (es) | 2003-07-01 |
HUP0201468A3 (en) | 2010-01-28 |
BR0011436A (pt) | 2002-03-05 |
CA2376497C (fr) | 2009-10-20 |
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