DK114689A - Magnetisk protein-konjugat, dets fremstilling og anvendelse - Google Patents
Magnetisk protein-konjugat, dets fremstilling og anvendelseInfo
- Publication number
- DK114689A DK114689A DK114689A DK114689A DK114689A DK 114689 A DK114689 A DK 114689A DK 114689 A DK114689 A DK 114689A DK 114689 A DK114689 A DK 114689A DK 114689 A DK114689 A DK 114689A
- Authority
- DK
- Denmark
- Prior art keywords
- production
- conjugates
- protein conjugate
- protein
- magnetic protein
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54353—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals with ligand attached to the carrier via a chemical coupling agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5094—Microcapsules containing magnetic carrier material, e.g. ferrite for drug targeting
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
- C07K1/1133—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by redox-reactions involving cystein/cystin side chains
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof
- C07K17/02—Peptides being immobilised on, or in, an organic carrier
- C07K17/06—Peptides being immobilised on, or in, an organic carrier attached to the carrier via a bridging agent
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0081—Purging biological preparations of unwanted cells
- C12N5/0087—Purging against subsets of blood cells, e.g. purging alloreactive T cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
- G01N33/54326—Magnetic particles
- G01N33/5434—Magnetic particles using magnetic particle immunoreagent carriers which constitute new materials per se
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2446/00—Magnetic particle immunoreagent carriers
- G01N2446/80—Magnetic particle immunoreagent carriers characterised by the agent used to coat the magnetic particles, e.g. lipids
- G01N2446/90—Magnetic particle immunoreagent carriers characterised by the agent used to coat the magnetic particles, e.g. lipids characterised by small molecule linker used to couple immunoreagents to magnetic particles
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Pharmacology & Pharmacy (AREA)
- Biotechnology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Urology & Nephrology (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Analytical Chemistry (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Zoology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Food Science & Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Oncology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE3807904A DE3807904A1 (de) | 1988-03-10 | 1988-03-10 | Magnetische protein-konjugate, verfahren zu ihrer herstellung und ihre verwendung |
Publications (2)
Publication Number | Publication Date |
---|---|
DK114689D0 DK114689D0 (da) | 1989-03-09 |
DK114689A true DK114689A (da) | 1989-09-11 |
Family
ID=6349346
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK114689A DK114689A (da) | 1988-03-10 | 1989-03-09 | Magnetisk protein-konjugat, dets fremstilling og anvendelse |
Country Status (13)
Country | Link |
---|---|
US (1) | US5672687A (da) |
EP (1) | EP0332022B1 (da) |
JP (1) | JP2756297B2 (da) |
KR (1) | KR0142876B1 (da) |
AT (1) | ATE114667T1 (da) |
AU (1) | AU626540B2 (da) |
CA (1) | CA1339199C (da) |
DE (2) | DE3807904A1 (da) |
DK (1) | DK114689A (da) |
ES (1) | ES2064373T3 (da) |
FI (1) | FI102077B (da) |
PT (1) | PT89963B (da) |
YU (1) | YU49189A (da) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS62197425A (ja) * | 1986-02-25 | 1987-09-01 | Toyo Soda Mfg Co Ltd | 球状熱可塑性樹脂の製造方法 |
US5169754A (en) * | 1990-10-31 | 1992-12-08 | Coulter Corporation | Biodegradable particle coatings having a protein covalently immobilized by means of a crosslinking agent and processes for making same |
EP0772776B1 (de) | 1994-07-27 | 2000-03-22 | Herbert Dr. Pilgrimm | Superparamagnetische teilchen, verfahren zur herstellung und deren verwendung |
WO2001020042A2 (en) * | 1999-09-15 | 2001-03-22 | Miraibio Inc. | Method for processing biological samples |
JP2003514773A (ja) * | 1999-09-28 | 2003-04-22 | ウニヴェルジテート チューリッヒ | 血清及び血漿中のプリオン結合活性を有する因子並びに伝染性海綿状脳障害を検出するための薬剤 |
DE10108857A1 (de) * | 2001-02-14 | 2002-09-19 | Hans-Dieter Hunger | Bioaktive und biokompatible Konjugate mit magnetischen Eigenschaften und Verfahren zu deren Herstellung |
EP1419786A1 (en) | 2002-11-13 | 2004-05-19 | Bracco Imaging S.p.A. | Method for the selective and quantitative functionalization of immunoglobulin fab fragments, conjugate compounds obtained with the same and compositions thereof |
US7164010B1 (en) | 2005-09-28 | 2007-01-16 | Academia Sinica | Molecular magnetic protein |
US9018006B2 (en) | 2010-07-23 | 2015-04-28 | The University Of Toledo | Stable Tregs and related materials and methods |
CN113049811A (zh) * | 2021-03-22 | 2021-06-29 | 深圳市亚辉龙生物科技股份有限公司 | 纳米磁珠包被物及其制备方法、检测试剂和检测试剂盒 |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4671958A (en) * | 1982-03-09 | 1987-06-09 | Cytogen Corporation | Antibody conjugates for the delivery of compounds to target sites |
FR2523445A1 (fr) * | 1982-03-17 | 1983-09-23 | Sanofi Sa | Nouveaux conjugues associant, par liaison covalente, une enzyme et un anticorps, et associations medicamenteuses utilisant lesdits conjugues |
NO155316C (no) * | 1982-04-23 | 1987-03-11 | Sintef | Fremgangsmaate for fremstilling av magnetiske polymerpartikler. |
EP0109653A3 (en) * | 1982-11-17 | 1986-01-29 | Otsuka Pharmaceutical Co., Ltd. | Process for preparing urokinase complex |
JPS59134763A (ja) * | 1983-01-20 | 1984-08-02 | Eisai Co Ltd | セクレチン関連誘導体 |
US4735796A (en) * | 1983-12-08 | 1988-04-05 | Gordon Robert T | Ferromagnetic, diamagnetic or paramagnetic particles useful in the diagnosis and treatment of disease |
IL71547A (en) * | 1983-04-13 | 1989-09-28 | Chem Fab Corp | Reinforced fluoropolymer composite and its manufacture |
US4554088A (en) * | 1983-05-12 | 1985-11-19 | Advanced Magnetics Inc. | Magnetic particles for use in separations |
US4698302A (en) * | 1983-05-12 | 1987-10-06 | Advanced Magnetics, Inc. | Enzymatic reactions using magnetic particles |
US4659839A (en) * | 1984-10-10 | 1987-04-21 | Mallinckrodt, Inc. | Coupling agents for radiolabeled antibody fragments |
US4795698A (en) * | 1985-10-04 | 1989-01-03 | Immunicon Corporation | Magnetic-polymer particles |
US5002883A (en) * | 1987-10-30 | 1991-03-26 | Abbott Laboratories | Covalent attachment of antibodies and antigens to solid phases using extended length heterobifunctional coupling agents |
-
1988
- 1988-03-10 DE DE3807904A patent/DE3807904A1/de active Granted
-
1989
- 1989-02-28 DE DE58908667T patent/DE58908667D1/de not_active Expired - Lifetime
- 1989-02-28 AT AT89103479T patent/ATE114667T1/de not_active IP Right Cessation
- 1989-02-28 ES ES89103479T patent/ES2064373T3/es not_active Expired - Lifetime
- 1989-02-28 EP EP89103479A patent/EP0332022B1/de not_active Expired - Lifetime
- 1989-03-08 YU YU00491/89A patent/YU49189A/xx unknown
- 1989-03-08 FI FI891098A patent/FI102077B/fi not_active IP Right Cessation
- 1989-03-09 PT PT89963A patent/PT89963B/pt not_active IP Right Cessation
- 1989-03-09 JP JP1055265A patent/JP2756297B2/ja not_active Expired - Lifetime
- 1989-03-09 DK DK114689A patent/DK114689A/da not_active Application Discontinuation
- 1989-03-09 AU AU31135/89A patent/AU626540B2/en not_active Ceased
- 1989-03-09 CA CA000593247A patent/CA1339199C/en not_active Expired - Fee Related
- 1989-03-10 KR KR1019890002941A patent/KR0142876B1/ko not_active IP Right Cessation
-
1995
- 1995-01-19 US US08/375,232 patent/US5672687A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
DE58908667D1 (de) | 1995-01-12 |
AU3113589A (en) | 1989-09-14 |
DE3807904C2 (da) | 1992-02-20 |
JPH02152997A (ja) | 1990-06-12 |
FI891098A (fi) | 1989-09-11 |
AU626540B2 (en) | 1992-08-06 |
DE3807904A1 (de) | 1989-09-21 |
US5672687A (en) | 1997-09-30 |
EP0332022A3 (de) | 1991-07-17 |
JP2756297B2 (ja) | 1998-05-25 |
DK114689D0 (da) | 1989-03-09 |
ATE114667T1 (de) | 1994-12-15 |
YU49189A (en) | 1991-08-31 |
ES2064373T3 (es) | 1995-02-01 |
FI102077B1 (fi) | 1998-10-15 |
PT89963A (pt) | 1989-11-10 |
FI102077B (fi) | 1998-10-15 |
EP0332022B1 (de) | 1994-11-30 |
CA1339199C (en) | 1997-08-05 |
KR890014471A (ko) | 1989-10-23 |
PT89963B (pt) | 1994-05-31 |
FI891098A0 (fi) | 1989-03-08 |
EP0332022A2 (de) | 1989-09-13 |
KR0142876B1 (ko) | 1998-07-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
AHB | Application shelved due to non-payment |