DK1141250T3 - Intein-formidler cyklisering af peptider - Google Patents
Intein-formidler cyklisering af peptiderInfo
- Publication number
- DK1141250T3 DK1141250T3 DK99966402T DK99966402T DK1141250T3 DK 1141250 T3 DK1141250 T3 DK 1141250T3 DK 99966402 T DK99966402 T DK 99966402T DK 99966402 T DK99966402 T DK 99966402T DK 1141250 T3 DK1141250 T3 DK 1141250T3
- Authority
- DK
- Denmark
- Prior art keywords
- intein
- peptides
- methods
- target peptide
- cyclic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/50—Cyclic peptides containing at least one abnormal peptide link
- C07K7/52—Cyclic peptides containing at least one abnormal peptide link with only normal peptide links in the ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1055—Protein x Protein interaction, e.g. two hybrid selection
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Crystallography & Structural Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Computational Biology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11272398P | 1998-12-18 | 1998-12-18 | |
US15807799P | 1999-10-07 | 1999-10-07 |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1141250T3 true DK1141250T3 (da) | 2006-07-10 |
Family
ID=26810271
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK99966402T DK1141250T3 (da) | 1998-12-18 | 1999-12-18 | Intein-formidler cyklisering af peptider |
Country Status (11)
Country | Link |
---|---|
US (2) | US7354756B1 (fr) |
EP (1) | EP1141250B1 (fr) |
JP (1) | JP4544601B2 (fr) |
CN (1) | CN1179040C (fr) |
AT (1) | ATE318894T1 (fr) |
AU (1) | AU781215B2 (fr) |
CA (1) | CA2355934A1 (fr) |
DE (1) | DE69930164T2 (fr) |
DK (1) | DK1141250T3 (fr) |
ES (1) | ES2260956T3 (fr) |
WO (1) | WO2000036093A2 (fr) |
Families Citing this family (41)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU6781700A (en) * | 1999-08-17 | 2001-03-13 | Health Research Institute | Genetic system and self-cleaving inteins derived therefrom, bioseparations and protein purification employing same, and methods for determining critical, generalizable amino acid residues for varying intein activity |
US7378248B2 (en) | 2000-03-06 | 2008-05-27 | Rigel Pharmaceuticals, Inc. | In vivo production of cyclic peptides for inhibiting protein-protein interaction |
US7252952B2 (en) * | 2000-03-06 | 2007-08-07 | Rigel Pharmaceuticals, Inc. | In vivo production of cyclic peptides for inhibiting protein—protein interaction |
US7566765B2 (en) | 2000-03-06 | 2009-07-28 | Rigel Pharmaceuticals, Inc. | Heterocyclic compounds containing a nine-membered carbon-nitrogen ring |
EP1263777A2 (fr) | 2000-03-06 | 2002-12-11 | Rigel Pharmaceuticals, Inc. | Production in vivo de peptides cycliques |
EP1229330B1 (fr) * | 2000-07-26 | 2007-02-21 | Japan Science and Technology Agency | Sonde permettant d'analyser une interaction protéine/protéine et méthode d'analyse utilisant cette sonde |
US7279304B2 (en) | 2000-12-18 | 2007-10-09 | President And Fellows Of Harvard College | Methods for preparation of macrocyclic molecules and macrocyclic molecules prepared thereby |
WO2002074930A2 (fr) * | 2001-03-20 | 2002-09-26 | The Pennsylvania State Research Foundation | Inteines trans pour rearrangement de domaine proteique et biopolymerisation |
EP1468090B1 (fr) | 2002-01-08 | 2014-10-29 | Agrivida, Inc. | Plantes transgeniques exprimant civps ou des proteines a inteine modifiee et procede associe |
US7250551B2 (en) | 2002-07-24 | 2007-07-31 | President And Fellows Of Harvard College | Transgenic mice expressing inducible human p25 |
JP4287633B2 (ja) * | 2002-09-18 | 2009-07-01 | 独立行政法人科学技術振興機構 | オルガネラ局在タンパク質の解析方法と解析材料 |
FI20021726A0 (fi) * | 2002-09-27 | 2002-09-27 | Ctt Cancer Targeting Tech Oy | Menetelmä peptidien tuottamiseksi |
US20040198958A1 (en) * | 2002-12-11 | 2004-10-07 | Ming-Qun Xu | Carrier-ligand fusions and uses thereof |
WO2005115433A2 (fr) * | 2004-05-24 | 2005-12-08 | Rigel Pharmaceuticals, Inc. | Procedes de cyclisation de polymeres synthetiques |
WO2008076938A1 (fr) * | 2006-12-14 | 2008-06-26 | University Of Iowa Research Foundation | Méthode de fabrication de polypeptides cycliques à partir d'intéines |
EP2106446A4 (fr) * | 2007-01-10 | 2010-06-16 | Univ Saskatchewan | Stabilisation de structures de peptides cycliques |
CN101638642B (zh) * | 2008-08-01 | 2012-02-22 | 中国农业科学院生物技术研究所 | 提高了热稳定性及蛋白酶抗性的环化植酸酶 |
WO2010135277A2 (fr) | 2009-05-18 | 2010-11-25 | Brown University | Analogues de glur6 cyclique, procédés de traitement et d'utilisation |
US10407742B2 (en) | 2009-11-06 | 2019-09-10 | Agrivida, Inc. | Intein-modified enzymes, their production and industrial applications |
US8420387B2 (en) | 2009-11-06 | 2013-04-16 | Agrivida, Inc. | Intein-modified enzymes, their production and industrial applications |
US9464333B2 (en) | 2009-11-06 | 2016-10-11 | Agrivida, Inc. | Intein-modified enzymes, their production and industrial applications |
US9598700B2 (en) | 2010-06-25 | 2017-03-21 | Agrivida, Inc. | Methods and compositions for processing biomass with elevated levels of starch |
US10443068B2 (en) | 2010-06-25 | 2019-10-15 | Agrivida, Inc. | Plants with engineered endogenous genes |
WO2012019928A1 (fr) | 2010-08-13 | 2012-02-16 | Guntram Christiansen | Présentation de peptide modifiée |
EP2665744B1 (fr) * | 2011-01-20 | 2015-04-08 | University Of Rochester | Composés macrocycliques ayant un squelette hybride peptidique/non-peptidique et procédés pour leur préparation |
CN106244622B (zh) | 2011-03-07 | 2020-06-12 | 谷万达公司 | 在工程植物中表达多种蛋白的表达盒和表达载体及制备工程植物和生产可溶性糖的方法 |
CA2850411C (fr) | 2011-09-28 | 2023-08-15 | Era Biotech, S.A. | Inteines divisees et leurs utilisations |
EP4219549A1 (fr) * | 2012-06-27 | 2023-08-02 | The Trustees of Princeton University | Intéines fendues, conjugués et leurs utilisations |
BR112015007466B1 (pt) | 2012-10-03 | 2022-10-11 | Agrivida, Inc | Protease inteína-modificada, cassete de expressão, hospedeiro, método de produção de uma protease e detergente |
DE102013016002A1 (de) | 2013-09-26 | 2015-03-26 | Forschungszentrum Jülich GmbH | Zyklische, Amyloid-Beta-bindende Peptide und deren Verwendung |
US10995118B2 (en) | 2013-09-26 | 2021-05-04 | Forschungszentrum Juelich Gmbh | Amyloid-beta-binding peptides and the use thereof for the treatment and diagnosis of alzheimer's disease |
EP3087088B1 (fr) | 2013-12-23 | 2022-05-25 | University Of Rochester | Procédés et compositions pour la synthèse ribosomique de peptides macrocycliques |
JP6525171B2 (ja) | 2015-04-13 | 2019-06-05 | 国立研究開発法人産業技術総合研究所 | 環状化サイトカイン及びその製法 |
CN106749497B (zh) * | 2017-02-06 | 2020-10-30 | 陈铭 | 套索多肽的化学全合成 |
GB201702938D0 (en) * | 2017-02-23 | 2017-04-12 | Univ Southampton | Methods of generating and screening compartmentalised peptides libraries |
ES2895224T3 (es) * | 2017-04-26 | 2022-02-18 | Hunan Zonsen Peplib Biotech Co Ltd | Procedimiento de construcción de biblioteca de péptidos |
EP4218784A3 (fr) | 2017-05-22 | 2023-09-13 | National Hellenic Research Foundation | Modulateurs macrocycliques de mauvais repliement et d'agrégation de protéines associés à une maladie |
KR102000490B1 (ko) * | 2018-01-12 | 2019-10-01 | 전남대학교산학협력단 | 가용성이 개선된 살모넬라균 편모 유래 플라젤린 단백질 발현 형질전환체, 그 제조방법 및 용도 |
GB201909491D0 (en) * | 2019-07-01 | 2019-08-14 | Governing Council Of The Univ Of Toronto | Detection of protein to protein interactions |
US20220372496A1 (en) * | 2019-09-24 | 2022-11-24 | MVRIX Co., Ltd. | Nano-perforator having improved anti-viral activity |
CN115093470B (zh) * | 2022-06-30 | 2023-03-24 | 广州市乾相生物科技有限公司 | 内含肽Mtu RecA突变体及其在生产谷胱甘肽GSH中的应用 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5643758A (en) * | 1987-03-10 | 1997-07-01 | New England Biolabs, Inc. | Production and purification of a protein fused to a binding protein |
DE69333667T2 (de) * | 1992-12-09 | 2006-02-02 | New England Biolabs, Inc., Beverly | Kontrollierbare Zwischensequenzen enthaltende modifizierte Proteine und Verfahren zur deren Herstellung |
US6194544B1 (en) | 1993-07-09 | 2001-02-27 | Smithkline Beecham Corporation | Cyclic semi-random peptide libraries |
US5498531A (en) * | 1993-09-10 | 1996-03-12 | President And Fellows Of Harvard College | Intron-mediated recombinant techniques and reagents |
EP1642980A1 (fr) | 1995-06-28 | 2006-04-05 | New England Biolabs, Inc. | Protéines modifiées et procédé de leur obtention. |
-
1999
- 1999-12-18 EP EP99966402A patent/EP1141250B1/fr not_active Expired - Lifetime
- 1999-12-18 DE DE69930164T patent/DE69930164T2/de not_active Expired - Lifetime
- 1999-12-18 DK DK99966402T patent/DK1141250T3/da active
- 1999-12-18 JP JP2000588342A patent/JP4544601B2/ja not_active Expired - Fee Related
- 1999-12-18 WO PCT/US1999/030162 patent/WO2000036093A2/fr active IP Right Grant
- 1999-12-18 AU AU21948/00A patent/AU781215B2/en not_active Ceased
- 1999-12-18 ES ES99966402T patent/ES2260956T3/es not_active Expired - Lifetime
- 1999-12-18 CA CA002355934A patent/CA2355934A1/fr not_active Abandoned
- 1999-12-18 US US09/868,469 patent/US7354756B1/en not_active Expired - Fee Related
- 1999-12-18 CN CNB998158143A patent/CN1179040C/zh not_active Expired - Fee Related
- 1999-12-18 AT AT99966402T patent/ATE318894T1/de active
-
2007
- 2007-02-01 US US11/670,112 patent/US7846710B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
AU781215B2 (en) | 2005-05-12 |
DE69930164T2 (de) | 2006-11-23 |
ATE318894T1 (de) | 2006-03-15 |
US7354756B1 (en) | 2008-04-08 |
US20070207502A1 (en) | 2007-09-06 |
AU2194800A (en) | 2000-07-03 |
EP1141250A2 (fr) | 2001-10-10 |
CN1179040C (zh) | 2004-12-08 |
JP2003534768A (ja) | 2003-11-25 |
WO2000036093A2 (fr) | 2000-06-22 |
WO2000036093A9 (fr) | 2001-08-16 |
US7846710B2 (en) | 2010-12-07 |
CN1354788A (zh) | 2002-06-19 |
DE69930164D1 (de) | 2006-04-27 |
CA2355934A1 (fr) | 2000-06-22 |
WO2000036093A3 (fr) | 2000-10-19 |
EP1141250B1 (fr) | 2006-03-01 |
JP4544601B2 (ja) | 2010-09-15 |
ES2260956T3 (es) | 2006-11-01 |
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