DK1115721T3 - Pyrimidonderivater - Google Patents

Pyrimidonderivater

Info

Publication number
DK1115721T3
DK1115721T3 DK99944815T DK99944815T DK1115721T3 DK 1115721 T3 DK1115721 T3 DK 1115721T3 DK 99944815 T DK99944815 T DK 99944815T DK 99944815 T DK99944815 T DK 99944815T DK 1115721 T3 DK1115721 T3 DK 1115721T3
Authority
DK
Denmark
Prior art keywords
pyrimidone
Prior art date
Application number
DK99944815T
Other languages
Danish (da)
English (en)
Inventor
Kazutoshi Mitsubishi Watanabe
Ryoichi Mitsubishi Chem C Ando
Ken-Ichi Mitsubishi Chem Saito
Rie Mitsubishi Chem C Kawamoto
Aya Mitsubishi Chem Corp Shoda
Original Assignee
Mitsubishi Chem Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitsubishi Chem Corp filed Critical Mitsubishi Chem Corp
Application granted granted Critical
Publication of DK1115721T3 publication Critical patent/DK1115721T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
DK99944815T 1998-09-25 1999-09-24 Pyrimidonderivater DK1115721T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP27127798 1998-09-25
JP30526698 1998-10-27
PCT/JP1999/005224 WO2000018758A1 (en) 1998-09-25 1999-09-24 Pyrimidone derivatives

Publications (1)

Publication Number Publication Date
DK1115721T3 true DK1115721T3 (da) 2004-04-19

Family

ID=26549626

Family Applications (1)

Application Number Title Priority Date Filing Date
DK99944815T DK1115721T3 (da) 1998-09-25 1999-09-24 Pyrimidonderivater

Country Status (16)

Country Link
US (1) US7256199B1 (de)
EP (1) EP1115721B1 (de)
JP (1) JP2002525366A (de)
KR (1) KR20010087362A (de)
CN (1) CN1328552A (de)
AR (1) AR023052A1 (de)
AT (1) ATE256123T1 (de)
AU (1) AU5759999A (de)
CA (1) CA2345065A1 (de)
CO (1) CO5180553A1 (de)
DE (1) DE69913545T2 (de)
DK (1) DK1115721T3 (de)
ES (1) ES2214045T3 (de)
PT (1) PT1115721E (de)
TW (1) TWI241298B (de)
WO (1) WO2000018758A1 (de)

Families Citing this family (63)

* Cited by examiner, † Cited by third party
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EP1136486A1 (de) * 2000-03-23 2001-09-26 Sanofi-Synthelabo 2-(Indanylamino)pyrimidon und 2-(Tetrahydronaphtalenylamino)pyrimidinon Derivate
EP1136482A1 (de) 2000-03-23 2001-09-26 Sanofi-Synthelabo 2-Amino-3-(alkyl)-pyrimidonderivate als GSK3beta-Hemmer
AU2001262150A1 (en) * 2000-03-23 2001-10-03 Mitsubishi Pharma Corporation 2-(nitrogen-heterocyclic)pyrimidone derivatives
JP2005289808A (ja) * 2000-03-23 2005-10-20 Sanofi-Aventis ３−置換−４−ピリミドン誘導体
US7189717B2 (en) 2000-04-26 2007-03-13 Eisai Co., Ltd. Medicinal compositions promoting bowel movement
EP1184383A1 (de) * 2000-09-01 2002-03-06 Sanofi-Synthelabo 9-[Alkyl], 9-[(Heteroaryl)alkyl] und 9-[(Aryl)alkyl]-2-pyridinyl-6,7,8,9-tetrahydropyrimido[1,2-a]pyrimidin-4-on Derivate
SI1315731T1 (en) 2000-09-01 2005-02-28 Sanofi-Aventis 2-pyridinyl-6,7,8,9-tetrahydropyrimido(1,2-a)pyrimidin-4-one and 7-pyridinyl-2,3-dihydroimidazo(1,2-a)pyrimidin-5(1h)one derivatives
EP1184385A1 (de) * 2000-09-01 2002-03-06 Sanofi-Synthelabo 1-[Alkyl], 1-[(Heteroaryl)alkyl] und 1[(Aryl)alkyl]-7-pyridin-4-yl-2,3-dihydroimidazo[1,2-a]pyrimidin-5(1H)-on Derivate
EP1184384A1 (de) * 2000-09-01 2002-03-06 Sanofi-Synthelabo 1-Alkyl, 1-(Heteroaryl)alkyl und 1-(Aryl)alkyl-7-pyridin-4-ylimidazo[1,2-a]pyrimidin-5(1H)-on Derivate
AU2002337498B2 (en) 2001-09-21 2006-08-10 Mitsubishi Pharma Corporation 3-substituted-4-pyrimidone derivatives
EP1295885A1 (de) * 2001-09-21 2003-03-26 Sanofi-Synthelabo Substituierte 2-pyridinyl-6,7,8,9-tetrahydropyrimido(1,2-a)pyrimidin-4-on- und 7-pyridinyl-2,3-dihydroimidazo(1,2-a)pyrimidin-5(1H)onderivate
EP1340761A1 (de) * 2002-02-28 2003-09-03 Sanofi-Synthelabo Substituierte 2-Pyridinyl-6,7,8,9-tetrahydropyrimido[1,2-a]pyrimidin-4-on und 7-Pyridinyl-2,3-dihydroimidazo[1,2-a]pyrimidin-5(1H)onderivate
EP1340760A1 (de) * 2002-02-28 2003-09-03 Sanofi-Synthelabo Substituierte 2-Pyrimidinyl-6,7,8,9-tetrahydro[1,2-a]pyrimidin-4-on und 7-Pyrimidinyl-2,3-dihydroimidazo[1,2-a]pyrimidin-5(1H)onderivate
CN1810802B (zh) * 2001-09-21 2011-04-27 三菱制药株式会社 3-取代的-4-嘧啶酮衍生物
WO2003037888A1 (en) * 2001-09-21 2003-05-08 Mitsubishi Pharma Corporation 3-substituted-4-pyrimidone derivatives
PT1674456E (pt) 2001-09-21 2008-09-11 Sanofi Aventis Utilização de 2-fluoro-3-cetoésteres para preparar 3-fluoro- 6,7,8,9-tetra-hidro-4-h-pirimido[1,2-a]pirimidin-4-onas
TWI301834B (en) 2001-10-22 2008-10-11 Eisai R&D Man Co Ltd Pyrimidone compound and pharmaceutical composition including the same
TWI330183B (de) 2001-10-22 2010-09-11 Eisai R&D Man Co Ltd
AR038368A1 (es) 2002-02-01 2005-01-12 Novartis Ag Compuestos n-pirimidin-2-il-aminas sustituidas como inhibidores de ige, una composicion farmaceutica y el uso de dichos compuestos para la preparacion de un medicamento
MXPA04008364A (es) * 2002-02-28 2005-07-26 Sanofi Aventis Derivados de 2-piridinil y 2-pirimidinil-6, 7, 8, 9-tetrahidropirmido [1,2-a] pirimidin-4-ona substituidos por heteroarilo.
EP1340758A1 (de) * 2002-02-28 2003-09-03 Sanofi-Synthelabo Heteroarylsubstituierte 2-Pyridinyl-6,7,8,9-tetrahydro[1,2-a]pyridin-4-on und 7-Pyridinyl-2,3-dihydroimidazo[1,2-a]pyrimidin-5(1H)onderivate
EP1348708A1 (de) * 2002-02-28 2003-10-01 Sanofi-Synthelabo Heteroarylsubstituierte 2-Pyrimidinyl-6,7,8,9-tetrahydropyrimido[1,2-a]pyrimidin-4-on und 7-Pyrimidinyl-2,3-dihydroimidazo[1,2-a]pyrimidin-5(1H)onderivate
EP1340759A1 (de) 2002-02-28 2003-09-03 Sanofi-Synthelabo 1-Alkyl, 1-(Heteroaryl)alkyl und 1-(Aryl)alkyl-7-pyrimidin-4-ylimidazo[1,2-a]pyrimidin-5(1H)-on Derivate
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US7683069B2 (en) * 2002-12-16 2010-03-23 Mitsubishi Tanabe Pharma Corporation 3-substituted-4-pyrimidone derivatives
TWI357408B (en) * 2003-03-26 2012-02-01 Mitsubishi Tanabe Pharma Corp 3-substituted-4-pyrimidone derivatives
DE10320785A1 (de) 2003-05-09 2004-11-25 Bayer Healthcare Ag 6-Arylmethyl-substituierte Pyrazolopyrimidine
DE10328479A1 (de) 2003-06-25 2005-01-13 Bayer Ag 6-Arylamino-5-cyano-4-pyrimidinone
DE102004001873A1 (de) * 2004-01-14 2005-09-29 Bayer Healthcare Ag Cyanopyrimidinone
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JP2009506069A (ja) 2005-08-26 2009-02-12 ブレインセルス，インコーポレイティド ムスカリン性受容体調節による神経発生
EP2258359A3 (de) 2005-08-26 2011-04-06 Braincells, Inc. Neurogenese durch Modulation des Muscarinrezeptors mit Sabcomelin
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CN101360720A (zh) * 2005-11-15 2009-02-04 阿斯利康(瑞典)有限公司 新颖的2-氨基嘧啶酮衍生物及其用途
CN101360722A (zh) * 2005-11-15 2009-02-04 阿斯利康(瑞典)有限公司 新颖的2-氨基嘧啶衍生物及其用途
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
TW200813015A (en) * 2006-03-15 2008-03-16 Mitsubishi Pharma Corp 2-(cyclic amino)-pyrimidone derivatives
EP2004630A4 (de) * 2006-04-05 2010-05-19 Astrazeneca Ab 2-aminopyrimidin-4-one und ihre verwendung zur behandlung bzw. prävention a-bedingter pathologien
EP2377531A2 (de) 2006-05-09 2011-10-19 Braincells, Inc. Neurogenese mittels Angiotensin-Modulation
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
AR064660A1 (es) * 2006-12-26 2009-04-15 Mitsubishi Tanabe Pharma Corp Derivados de pirimidinona 6-heterociclica 2-sustituida, medicamentos que los contienen y usos para prevenir y/o tratar enfermedades neurodegenerativas entre otras
EP1992621A1 (de) 2007-05-16 2008-11-19 Sanofi-Aventis Heteroarylamid-substituierte Pyrimidon-Derivate zur Behandlung von neurodegenerativen Krankheiten
EP1992624A1 (de) * 2007-05-16 2008-11-19 Sanofi-Aventis Heteroarylamid-Pyrimidon-Verbindungen
EP1992625A1 (de) * 2007-05-16 2008-11-19 Sanofi-Aventis Arylamid-Pyrimidon-Verbindungen
WO2009066084A1 (en) * 2007-11-21 2009-05-28 F. Hoffmann-La Roche Ag 2 -morpholinopyrimidines and their use as pi3 kinase inhibitors
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PL2603511T3 (pl) 2010-08-12 2017-08-31 Boehringer Ingelheim Int Pochodne 6-cykloalkilo-1,5-dihydropirazolo[3,4-d]pirymidyn-4-onu i ich zastosowanie jako inhibitorów PDE9A
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Also Published As

Publication number Publication date
DE69913545D1 (en) 2004-01-22
CN1328552A (zh) 2001-12-26
ES2214045T3 (es) 2004-09-01
AR023052A1 (es) 2002-09-04
CO5180553A1 (es) 2002-07-30
DE69913545T2 (de) 2004-09-16
EP1115721A1 (de) 2001-07-18
TWI241298B (en) 2005-10-11
PT1115721E (pt) 2004-04-30
AU5759999A (en) 2000-04-17
EP1115721B1 (de) 2003-12-10
US7256199B1 (en) 2007-08-14
CA2345065A1 (en) 2000-04-06
ATE256123T1 (de) 2003-12-15
JP2002525366A (ja) 2002-08-13
KR20010087362A (ko) 2001-09-15
WO2000018758A1 (en) 2000-04-06

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