DK111445B - Fremgangsmåde til fremstilling af phenoxy- eller phenylmercaptosubstituerede monocarboxylsyreforbindelser eller salte heraf. - Google Patents

Fremgangsmåde til fremstilling af phenoxy- eller phenylmercaptosubstituerede monocarboxylsyreforbindelser eller salte heraf.

Info

Publication number
DK111445B
DK111445B DK26262AA DK26262A DK111445B DK 111445 B DK111445 B DK 111445B DK 26262A A DK26262A A DK 26262AA DK 26262 A DK26262 A DK 26262A DK 111445 B DK111445 B DK 111445B
Authority
DK
Denmark
Prior art keywords
phenylmercapto
phenoxy
salts
preparation
monocarboxylic acid
Prior art date
Application number
DK26262AA
Other languages
Danish (da)
English (en)
Inventor
E Schultz
J Sprague
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of DK111445B publication Critical patent/DK111445B/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/76—Unsaturated compounds containing keto groups
    • C07C59/90—Unsaturated compounds containing keto groups containing singly bound oxygen-containing groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
    • C07C45/29—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups
    • C07C45/292—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups with chromium derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C07C45/46—Friedel-Crafts reactions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/84—Ketones containing a keto group bound to a six-membered aromatic ring containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/09—Preparation of carboxylic acids or their salts, halides or anhydrides from carboxylic acid esters or lactones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/16—Preparation of carboxylic acids or their salts, halides or anhydrides by oxidation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/353—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by isomerisation; by change of size of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/36—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by hydrogenation of carbon-to-carbon unsaturated bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/363—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/367—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by introduction of functional groups containing oxygen only in singly bound form
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/373—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by introduction of functional groups containing oxygen only in doubly bound form
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/377—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by splitting-off hydrogen or functional groups; by hydrogenolysis of functional groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/41—Preparation of salts of carboxylic acids
    • C07C51/412—Preparation of salts of carboxylic acids by conversion of the acids, their salts, esters or anhydrides with the same carboxylic acid part
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
    • C07C59/66—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings
    • C07C59/68—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings the oxygen atom of the ether group being bound to a non-condensed six-membered aromatic ring
    • C07C59/70—Ethers of hydroxy-acetic acid, e.g. substitutes on the ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/76—Unsaturated compounds containing keto groups
    • C07C59/84—Unsaturated compounds containing keto groups containing six membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/32—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing keto groups
    • C07C65/40—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing keto groups containing singly bound oxygen-containing groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Paper (AREA)
DK26262AA 1961-01-19 1962-01-19 Fremgangsmåde til fremstilling af phenoxy- eller phenylmercaptosubstituerede monocarboxylsyreforbindelser eller salte heraf. DK111445B (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US8363561A 1961-01-19 1961-01-19

Publications (1)

Publication Number Publication Date
DK111445B true DK111445B (da) 1968-08-26

Family

ID=22179683

Family Applications (2)

Application Number Title Priority Date Filing Date
DK26262AA DK111445B (da) 1961-01-19 1962-01-19 Fremgangsmåde til fremstilling af phenoxy- eller phenylmercaptosubstituerede monocarboxylsyreforbindelser eller salte heraf.
DK375863AA DK113286B (da) 1961-01-19 1963-08-06 Fremgangsmåde til fremstilling af phenoxy- eller phenylmercaptoderivater af monocarboxylsyrer eller salte heraf.

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK375863AA DK113286B (da) 1961-01-19 1963-08-06 Fremgangsmåde til fremstilling af phenoxy- eller phenylmercaptoderivater af monocarboxylsyrer eller salte heraf.

Country Status (15)

Country Link
AT (1) AT245558B (de)
BE (1) BE612755A (de)
CH (2) CH454830A (de)
CY (1) CY360A (de)
DE (1) DE1468201C2 (de)
DK (2) DK111445B (de)
ES (1) ES273990A1 (de)
FI (2) FI41548B (de)
FR (1) FR6189M (de)
GB (1) GB998835A (de)
MY (1) MY6700039A (de)
NL (3) NL6918625A (de)
NO (1) NO115029B (de)
OA (1) OA01269A (de)
SE (2) SE318865B (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3320306A (en) * 1964-01-29 1967-05-16 Merck & Co Inc Process for the preparation of 4-(2-methylenealkanoyl)phenoxy alkanoic acids by decarboxylation
GB1108575A (en) * 1964-06-16 1968-04-03 Merck & Co Inc Preparation of substituted phenoxyacetic acids
US4887995A (en) * 1985-01-22 1989-12-19 University Of Pittsburgh Method of treating sickle cell anemia
DE3512179A1 (de) * 1985-04-03 1986-12-04 Merck Patent Gmbh, 6100 Darmstadt Fotoinitiatoren fuer die fotopolymerisation in waessrigen systemen
US4731473A (en) * 1986-04-04 1988-03-15 Merck & Co., Inc. Compounds useful in treating sickle cell anemia
US4699926A (en) * 1986-04-04 1987-10-13 Merck & Co., Inc. Compounds useful in treating sickle cell anemia
US4731381A (en) * 1986-04-04 1988-03-15 Merck & Co., Inc. Method of treating a person for sickle cell anemia
US5741818A (en) 1995-06-07 1998-04-21 University Of Saskatchewan Semicarbazones having CNS activity and pharmaceutical preparations containing same
KR20010020201A (ko) 1997-04-22 2001-03-15 코센시스 인크 탄소고리 및 헤테로고리 치환된 세미카르바존 및 티오세미카르바존과 그들의 사용 방법
EP0947494A1 (de) * 1998-03-30 1999-10-06 F. Hoffmann-La Roche Ag Phenoxyessigsäure- und Phenoxymethyltetrazolderivate mit Antitumoraktivität

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH211819A (de) * 1937-09-18 1940-10-15 Chem Ind Basel Verfahren zur Herstellung eines Azofarbstoffes.
CH211822A (de) * 1937-09-18 1940-10-15 Chem Ind Basel Verfahren zur Herstellung eines Azofarbstoffes.
CH291376A (de) * 1950-02-13 1953-06-15 Lilly Co Eli Verfahren zur Herstellung von o-(N-2-(B-Oxy-äthoxy)-3-oxymerkuri-propyl-carbamido)-phenoxyessigsäure.
US2694069A (en) * 1952-10-24 1954-11-09 Searle & Co Basic esters of hydroxy-and alkoxy-substituted phenyloxoalkenoic acids and their salts

Also Published As

Publication number Publication date
NL273765A (de)
CH454830A (de) 1968-04-30
NO115029B (de) 1968-07-08
NL6918625A (de) 1970-02-23
FI42539B (de) 1970-06-01
SE332168B (de) 1971-02-01
FR6189M (de) 1968-07-22
GB998835A (en) 1965-07-21
BE612755A (fr) 1962-07-17
SE318865B (de) 1969-12-22
MY6700039A (en) 1967-12-31
ES273990A1 (es) 1962-06-16
CY360A (en) 1967-01-13
NL129087C (de)
FI41548B (de) 1969-09-01
DE1468201C2 (de) 1972-06-08
DE1468201B1 (de) 1971-11-11
DK113286B (da) 1969-03-10
AT245558B (de) 1966-03-10
CH452500A (de) 1968-05-31
OA01269A (fr) 1969-02-15

Similar Documents

Publication Publication Date Title
DK121231B (da) Fremgangsmåde til fremstilling af derivater af 7-aminocephalosporansyre eller salte deraf.
DK111445B (da) Fremgangsmåde til fremstilling af phenoxy- eller phenylmercaptosubstituerede monocarboxylsyreforbindelser eller salte heraf.
DK104460C (da) Fremgangsmåde til fremstilling af 2-methyl-3-hydroxypyridiner eller syreadditionssalte deraf.
DK109779C (da) Fremgangsmåde til fremstilling af 3-aminopyrazinamidoguanidinforbindelser eller syreadditionssalte heraf.
DK102962C (da) Fremgangsmåde til fremstilling af 4-amino-quinolinforbindelser eller syreadditionssalte deraf.
DK105205C (da) Fremgangsmåde til fremstilling af pyridyl- eller pyrazyloxyalkylaminoalkylaminer eller syreadditionssalte heraf.
DK106147C (da) Fremgangsmåde til fremstilling af aminoquinolinforbindelser eller syreadditionssalte deraf.
DK103017C (da) Fremgangsmåde til fremstilling af basisk substituerede dibenzocycloheptadien- eller dibenzocycloheptatrienforbindelser eller syreadditionssalte deraf.
DK103941C (da) Fremgangsmåde til fremstilling af 3-thiocarbamoyl-phenthiazinforbindelser eller syreadditionssalte deraf.
DK104937C (da) Fremgangsmåde til fremstilling af imidazolidinon- eller imidazolidinthioforbindelser eller syreadditionssalte deraf.
DK103672C (da) Fremgangsmåde til fremstilling af phenylpropanolaminer eller syreadditionssalte heraf.
DK103023C (da) Fremgangsmåde til fremstilling af 5-aryl-benzodiazepinforbindelser eller syreadditionssalte deraf.
DK110091C (da) Fremgangsmåde til fremstilling af substituerede diphenylalkylaminer eller syreadditionssalte heraf.
DK102807C (da) Fremgangsmåde til fremstilling af substituerede diphenylalkenylaminer eller syreadditionssalte heraf.
DK120595B (da) Fremgangsmåde til fremstilling af 6-aminopenicillansyrederivater eller salte heraf.
DK105067C (da) Fremgangsmåde til fremstilling af benzimidazolforbindelser eller syreadditionssalte deraf.
DK117147B (da) Fremgangsmåde til fremstilling af (3-aminopyrazinoyl)-guanidinforbindelser eller syreadditionssalte deraf.
DK99408C (da) Fremgangsmåde til fremstilling af thiobarbitursyreforbindelser eller salte deraf.
DK97941C (da) Fremgangsmåde til fremstilling af 8-hydroxypenilsyre eller salte heraf.
DK101687C (da) Fremgangsmåde til fremstilling af dihydrofusidinsyre eller salte deraf.
DK97351C (da) Fremgangsmåde til fremstilling af dihydrolysergsyrederivater eller salte heraf.
DK100566C (da) Fremgangsmåde til fremstilling af 4-amino-quinolinforbindelser eller syreadditionssalte deraf.
DK100495C (da) Fremgangsmåde til fremstilling af 4-amino-quinolinforbindelser eller syreadditionssalte deraf.
DK97586C (da) Fremgangsmåde til fremstilling af 10-polyalkylpyrrolidylmethyl-phenthiazinforbindelser eller syreadditionssalte deraf.
DK97516C (da) Fremgangsmåde til fremstilling af 10-polyalkylpyrrolidylmethyl-phenthiazinforbindelser eller syreadditionssalte deraf.