DK1086124T3 - Nye cyclosporiner - Google Patents

Nye cyclosporiner

Info

Publication number
DK1086124T3
DK1086124T3 DK99932697T DK99932697T DK1086124T3 DK 1086124 T3 DK1086124 T3 DK 1086124T3 DK 99932697 T DK99932697 T DK 99932697T DK 99932697 T DK99932697 T DK 99932697T DK 1086124 T3 DK1086124 T3 DK 1086124T3
Authority
DK
Denmark
Prior art keywords
cyclosporins
new
novel cyclosporins
new cyclosporins
pharmaceuticals
Prior art date
Application number
DK99932697T
Other languages
Danish (da)
English (en)
Inventor
Ernst Ellmerer-Mueller
Dagmar Broessner
Najib Maslouh
Horst-Dieter Ambrosi
Gerhard Jas
Gunter Fischer
Original Assignee
Chem Ag C
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chem Ag C filed Critical Chem Ag C
Application granted granted Critical
Publication of DK1086124T3 publication Critical patent/DK1086124T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C07K7/645—Cyclosporins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Rheumatology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DK99932697T 1998-06-12 1999-06-10 Nye cyclosporiner DK1086124T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP98110761 1998-06-12
PCT/EP1999/004012 WO1999065933A1 (fr) 1998-06-12 1999-06-10 Nouvelles cyclosporines

Publications (1)

Publication Number Publication Date
DK1086124T3 true DK1086124T3 (da) 2004-03-29

Family

ID=8232110

Family Applications (1)

Application Number Title Priority Date Filing Date
DK99932697T DK1086124T3 (da) 1998-06-12 1999-06-10 Nye cyclosporiner

Country Status (19)

Country Link
US (1) US6583265B1 (fr)
EP (1) EP1086124B1 (fr)
JP (1) JP4477777B2 (fr)
KR (1) KR20010052766A (fr)
CN (1) CN1205220C (fr)
AT (1) ATE254630T1 (fr)
AU (1) AU760168B2 (fr)
BR (1) BR9911160A (fr)
CA (1) CA2334730C (fr)
DE (1) DE69912952T2 (fr)
DK (1) DK1086124T3 (fr)
ES (1) ES2212583T3 (fr)
HU (1) HUP0102833A3 (fr)
IL (1) IL139825A0 (fr)
MX (1) MXPA00012218A (fr)
NO (1) NO20006282L (fr)
PL (1) PL344599A1 (fr)
PT (1) PT1086124E (fr)
WO (1) WO1999065933A1 (fr)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2001237939A1 (en) * 2000-02-08 2001-08-20 Gulgun Tezel Methods for treating glaucoma
US6784156B2 (en) 2001-03-05 2004-08-31 Enanta Pharmaceuticals, Inc. Cyclosporins for the treatment of respiratory diseases
KR100465012B1 (ko) * 2001-05-11 2005-01-13 주식회사 엘지생활건강 모발 성장 효과를 갖는 사이클로스포린 3 위치 유도체를유효성분으로 하는 모발 성장 촉진제
US20030087813A1 (en) 2001-10-12 2003-05-08 Or Yat Sun Cyclosporin analogs for the treatment of lung diseases
KR20040039622A (ko) * 2002-11-04 2004-05-12 주식회사 엘지생활건강 모발 성장 효과를 갖는 사이클로스포린 3 위치 유도체를유효성분으로 하는 모발 성장 촉진제
US7012065B2 (en) 2003-02-07 2006-03-14 Enanta Pharmaceuticals, Inc. Cyclosporins for the treatment of immune disorders
EP1742652A2 (fr) * 2004-04-08 2007-01-17 Novartis AG Nim811 utilise dansla prevention ou le traitement de l'ischemie cerebrale et de lesions cerebrales et de la moelle epiniere
MX2007003538A (es) * 2004-10-01 2008-01-16 Scynexis Inc Derivados de ciclosporina 3-eter y 3-tioeter sustituidos para el tratamiento y prevencion de infeccion de hepatitis c.
US7196161B2 (en) * 2004-10-01 2007-03-27 Scynexis Inc. 3-ether and 3-thioether substituted cyclosporin derivatives for the treatment and prevention of hepatitis C infection
CA2623865A1 (fr) 2005-09-30 2007-04-12 Scynexis, Inc. Procedes et compositions pharmaceutiques pour traiter et prevenir une infection par le virus de l'hepatite c
WO2007041631A1 (fr) 2005-09-30 2007-04-12 Scynexis, Inc. Derives d'arylalkyle et d'heteroarylalkyle de cyclosporine a utilises pour traiter et prevenir une infection virale
DK2023918T3 (da) 2006-05-19 2011-04-26 Scynexis Inc Cyclosporiner til behandlingen og forebyggelse af okulære lidelser
CN101502196A (zh) * 2006-06-02 2009-08-05 克洛德·安妮·佩里西恩 激活电子的管理
US7576057B2 (en) 2006-11-20 2009-08-18 Scynexis, Inc. Cyclic peptides
WO2008127613A1 (fr) * 2007-04-11 2008-10-23 Scynexis, Inc. Compositions pharmaceutiques inédites
CA2724523A1 (fr) 2008-06-06 2010-01-07 Scynexis, Inc. Nouveaux peptides macrocycliques
WO2009148615A1 (fr) * 2008-06-06 2009-12-10 Scynexis, Inc. Analogues de la cyclosporine et leur utilisation dans le traitement d'infections par le vhc
EP2313157A2 (fr) 2008-07-10 2011-04-27 Allergan, Inc. Dérivés de cyclosporine pour traiter des maladies et états oculaires et dermiques
CN102307892A (zh) * 2008-12-31 2012-01-04 西尼克斯公司 环孢菌素a的衍生物
US20100305047A1 (en) * 2009-05-27 2010-12-02 Allergan, Inc. Cyclosporin derivatives for enhancing the growth of hair
WO2010138423A1 (fr) * 2009-05-27 2010-12-02 Allergan, Inc. Dérivés de cyclosporine pour traiter des maladies et états inflammatoires
WO2011082289A1 (fr) 2009-12-30 2011-07-07 Scynexis Inc. Analogues de cyclosporine
US9217015B2 (en) 2010-07-16 2015-12-22 S&T Global Inc. Cyclosporin derivatives for the treatment and prevention of a viral infection
CN103153330B (zh) 2010-08-12 2017-08-18 美国科技环球有限公司 新的环孢霉素衍生物在病毒感染的治疗和预防中的应用
JP5805773B2 (ja) 2010-10-12 2015-11-10 アラーガン、インコーポレイテッドＡｌｌｅｒｇａｎ，Ｉｎｃｏｒｐｏｒａｔｅｄ シクロスポリンアナログ
EP2627664B1 (fr) * 2010-10-12 2018-04-04 Allergan, Inc. Analogues de cyclosporine
US9890198B2 (en) 2010-12-03 2018-02-13 S&T Global Inc. Cyclosporin derivatives and uses thereof
JP6144627B2 (ja) 2010-12-15 2017-06-07 コントラヴィア ファーマシューティカルズ、インク． アミノ酸１および３で修飾されたシクロスポリン類似体分子
GB201711749D0 (en) * 2017-07-21 2017-09-06 Cypralis Ltd Cyclosporin analogues and uses thereof
CN111449050A (zh) * 2019-01-20 2020-07-28 睿诺医疗科技（上海）有限公司 环孢菌素类似物及其用途
TW202128211A (zh) * 2019-10-12 2021-08-01 大陸商睿諾醫療科技（上海）有限公司 腎毒素引起的腎損傷的治療和預防
WO2021209003A1 (fr) * 2020-04-15 2021-10-21 Farsight Medical Technology (Shanghai) Co., Ltd. Prévention et traitement de lésions d'organe
GB202207348D0 (en) 2022-05-19 2022-07-06 Cypralis Ltd Macrocyclic compounds and uses thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0194972B1 (fr) * 1985-03-11 1992-07-29 Sandoz Ag Cyclosporines
KR100441220B1 (ko) 1995-07-17 2005-02-24 체-헴 아게 항-hiv효과를갖는사이클로스포린유도체
FR2757522B1 (fr) * 1996-12-24 1999-01-29 Rhone Poulenc Rorer Sa Derives de cyclosporine, leur preparation et les compositions pharmaceutiques qui les contiennent
FR2757521B1 (fr) * 1996-12-24 1999-01-29 Rhone Poulenc Rorer Sa Nouveaux derives de cyclosporine, leur preparation et les compositions pharmaceutiques qui les contiennent
FR2757520B1 (fr) * 1996-12-24 1999-01-29 Rhone Poulenc Rorer Sa Derive de cyclosporine, sa preparation et les compositions pharmaceutiques qui le contiennent

Also Published As

Publication number Publication date
CA2334730C (fr) 2009-09-29
CA2334730A1 (fr) 1999-12-23
ES2212583T3 (es) 2004-07-16
NO20006282D0 (no) 2000-12-11
JP2002518406A (ja) 2002-06-25
KR20010052766A (ko) 2001-06-25
JP4477777B2 (ja) 2010-06-09
CN1205220C (zh) 2005-06-08
DE69912952D1 (en) 2003-12-24
EP1086124B1 (fr) 2003-11-19
EP1086124A1 (fr) 2001-03-28
AU760168B2 (en) 2003-05-08
WO1999065933A1 (fr) 1999-12-23
PT1086124E (pt) 2004-04-30
PL344599A1 (en) 2001-11-05
IL139825A0 (en) 2002-02-10
NO20006282L (no) 2001-02-12
DE69912952T2 (de) 2004-09-02
HUP0102833A3 (en) 2002-03-28
CN1305493A (zh) 2001-07-25
MXPA00012218A (es) 2002-04-24
AU4899399A (en) 2000-01-05
US6583265B1 (en) 2003-06-24
BR9911160A (pt) 2001-04-03
HUP0102833A2 (hu) 2002-01-28
ATE254630T1 (de) 2003-12-15

Similar Documents

Publication Publication Date Title
DK1086124T3 (da) Nye cyclosporiner
IL145430A0 (en) N-cyanomethyl amides, processes for the preparation thereof and pharmaceutical compositions containing the same
CA2400268A1 (fr) Derives de pyrrolopyrimidinone, procedes d'elaboration et d'utilisation
DK1109831T3 (da) Cytotoksiske peptider modificeret ved store eller lipofile dele
DE69830504D1 (de) Antithrombotische mitteln
DK0891325T3 (da) Para-substituerede phenylpropansyrederivater som integrinantagonister
RU95101048A (ru) Производные пролинамида, фармкомпозиция на их основе
EA200400432A1 (ru) Производные мочевины
GB9914486D0 (en) Medicaments
CA2446944A1 (fr) Derives d'acides amines anti-inflammatoires et immunomodulateurs, leur preparation et leur utilisation
HUP0102579A2 (hu) Antiangiogén hatású peptid gyógyszervegyületek, azokat tartalmazó gyógyszerkészítmények és alkalmazásuk
ES2103857T3 (es) Peptidos ciclicos y su uso.
ATE202337T1 (de) Cyclopropylalkansäurederivate
AR025307A1 (es) Compuesto de liberacion sostenida de un peptido, microparticulas, composicion farmaceutica y el uso de dicho compuesto para la fabricacion de un medicamento
MY135218A (en) 2,6-quinolinyl and 2,6-naphthyl derivatives and their use in the treatment of vla-4 dependent diseases
SE9903291D0 (sv) New process
HUP0401080A2 (hu) Új görcsoldó sószármazékok, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények
PT1079849E (pt) Utilizacao de proteinas hmg para a preparacao de medicamentos com actividade citotoxica
SE0102440D0 (sv) New compound
IL157540A (en) Pharmaceutical compositions comprising n-(aryl)-2-arylethenesulfonamides, some such novel compounds and process for their preparation
MY120683A (en) New phenylamidine derivatives, processes for their preparation and their use as pharmaceuticals.
DK1180094T3 (da) Kondenserede polycykliske aminosyrer som farmaceutiske midler
WO2001081298A3 (fr) Acides carboxyliques cycliques comme antagonistes d'integrines
SE9800865D0 (sv) New Process
ATE293635T1 (de) Streptograminderivate, ihre herstellung und sie enthaltende zubereitungen