DK1079834T3 - Stabile sammensætninger omfattende levosimendan og alginsyre - Google Patents
Stabile sammensætninger omfattende levosimendan og alginsyreInfo
- Publication number
- DK1079834T3 DK1079834T3 DK99916943T DK99916943T DK1079834T3 DK 1079834 T3 DK1079834 T3 DK 1079834T3 DK 99916943 T DK99916943 T DK 99916943T DK 99916943 T DK99916943 T DK 99916943T DK 1079834 T3 DK1079834 T3 DK 1079834T3
- Authority
- DK
- Denmark
- Prior art keywords
- levosimendan
- alginic acid
- stable compositions
- compositions
- stable
- Prior art date
Links
- WHXMKTBCFHIYNQ-SECBINFHSA-N levosimendan Chemical compound C[C@@H]1CC(=O)NN=C1C1=CC=C(NN=C(C#N)C#N)C=C1 WHXMKTBCFHIYNQ-SECBINFHSA-N 0.000 title abstract 4
- 229960000692 levosimendan Drugs 0.000 title abstract 4
- 229960001126 alginic acid Drugs 0.000 title abstract 2
- 235000010443 alginic acid Nutrition 0.000 title abstract 2
- 229920000615 alginic acid Polymers 0.000 title abstract 2
- 239000000783 alginic acid Substances 0.000 title abstract 2
- 150000004781 alginic acids Chemical class 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title abstract 2
- 206010007559 Cardiac failure congestive Diseases 0.000 abstract 1
- 206010019280 Heart failures Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Heart & Thoracic Surgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Inorganic Chemistry (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Jellies, Jams, And Syrups (AREA)
- Detergent Compositions (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FI980902A FI980902A7 (fi) | 1998-04-23 | 1998-04-23 | Levosimendaanin stabiileja koostumuksia |
| PCT/FI1999/000331 WO1999055337A1 (en) | 1998-04-23 | 1999-04-23 | Stabile compositions comprising levosimendan and alginic acid |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1079834T3 true DK1079834T3 (da) | 2003-04-07 |
Family
ID=8551576
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK99916943T DK1079834T3 (da) | 1998-04-23 | 1999-04-23 | Stabile sammensætninger omfattende levosimendan og alginsyre |
Country Status (32)
| Country | Link |
|---|---|
| US (1) | US6531458B1 (cs) |
| EP (1) | EP1079834B1 (cs) |
| JP (1) | JP4475809B2 (cs) |
| KR (1) | KR100590622B1 (cs) |
| CN (1) | CN1165309C (cs) |
| AT (1) | ATE231395T1 (cs) |
| AU (1) | AU756338B2 (cs) |
| BG (1) | BG64766B1 (cs) |
| BR (1) | BR9909867A (cs) |
| CA (1) | CA2329232C (cs) |
| CZ (1) | CZ290911B6 (cs) |
| DE (1) | DE69905034T2 (cs) |
| DK (1) | DK1079834T3 (cs) |
| EA (1) | EA002428B1 (cs) |
| EE (1) | EE04143B1 (cs) |
| ES (1) | ES2191426T3 (cs) |
| FI (1) | FI980902A7 (cs) |
| GE (1) | GEP20032942B (cs) |
| HR (1) | HRP20000703B1 (cs) |
| HU (1) | HUP0105446A3 (cs) |
| ID (1) | ID26650A (cs) |
| IL (2) | IL138950A0 (cs) |
| MX (1) | MXPA00010368A (cs) |
| NO (1) | NO318575B1 (cs) |
| NZ (1) | NZ507455A (cs) |
| PL (1) | PL192274B1 (cs) |
| PT (1) | PT1079834E (cs) |
| RS (1) | RS49955B (cs) |
| SK (1) | SK284600B6 (cs) |
| TR (1) | TR200003101T2 (cs) |
| WO (1) | WO1999055337A1 (cs) |
| ZA (1) | ZA200005630B (cs) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FI980901A7 (fi) * | 1998-04-23 | 1999-10-24 | Orion Yhtymae Oyj | Levosimendaania säädellysti vapauttavia oraalisia koostumuksia |
| FI109659B (fi) * | 1999-09-10 | 2002-09-30 | Orion Yhtymae Oyj | Levosimendaanin farmaseuttisia liuoksia |
| FI20010233A0 (fi) * | 2001-02-08 | 2001-02-08 | Orion Corp | Menetelmä sydämen vajaatoiminnan hoitoon |
| WO2002064120A1 (fr) * | 2001-02-13 | 2002-08-22 | Taisho Pharmaceutical Co., Ltd. | Preparations de gel a usage interne |
| JP2008533109A (ja) * | 2005-03-14 | 2008-08-21 | オリオン コーポレーション | 利尿を促進するための複合治療 |
| JP6770754B2 (ja) * | 2015-11-06 | 2020-10-21 | カリノファルム・ゲーエムベーハーＣａｒｉｎｏｐｈａｒｍ Ｇｍｂｈ | 輸液又は注射として及び輸液濃縮物の静脈内投与のためのレボシメンダンの改善された調製物 |
| JP2023507626A (ja) | 2019-12-16 | 2023-02-24 | テナックス・セラピューティクス，インコーポレイテッド | 駆出率が保たれた心不全を伴う肺高血圧症（ＰＨ－ＨＦ－ｐＥＦ）を治療するためのレボシメンダン |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1509866A (en) | 1975-06-10 | 1978-05-04 | Johnson & Johnson | Enteric coated digestive enzyme compositions |
| AU555304B2 (en) * | 1982-04-05 | 1986-09-18 | Merck Sharp & Dohme Limited | Stabilization of drugs in alginic acid and magnesium hydroxide granules |
| EP0123291A2 (en) | 1983-04-20 | 1984-10-31 | Kyowa Hakko Kogyo Co., Ltd. | Method for stabilizing interferon |
| US4906630A (en) * | 1985-11-22 | 1990-03-06 | Rorer Pharmaceutical Corporation | Method of increasing cardiac contractility using pharmaceutical compositions comprising benzodiazinone- pyridazinone or hydroxy-pyrazolyl compounds |
| US4716042A (en) * | 1986-06-16 | 1987-12-29 | American Home Products Corporation | Stabilized coated aspirin tablets |
| GB8903130D0 (en) | 1989-02-11 | 1989-03-30 | Orion Yhtymae Oy | Substituted pyridazinones |
| GB2251615B (en) * | 1991-01-03 | 1995-02-08 | Orion Yhtymae Oy | (-)-[[4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl]hydrazono]pro panedinitrile |
| GB2266841A (en) | 1992-05-06 | 1993-11-17 | Orion Yhtymae Oy | Compounds for use as anti-ischemic medicaments |
| GB9614098D0 (en) * | 1996-07-05 | 1996-09-04 | Orion Yhtymae Oy | Transdermal delivery of levosimendan |
| FI973804A7 (fi) * | 1997-09-26 | 1999-03-27 | Orion Yhtymae Oy | Levosimendaanin oraalisia koostumuksia |
-
1998
- 1998-04-23 FI FI980902A patent/FI980902A7/fi unknown
-
1999
- 1999-04-23 PL PL343722A patent/PL192274B1/pl not_active IP Right Cessation
- 1999-04-23 SK SK1555-2000A patent/SK284600B6/sk not_active IP Right Cessation
- 1999-04-23 CZ CZ20003779A patent/CZ290911B6/cs not_active IP Right Cessation
- 1999-04-23 PT PT99916943T patent/PT1079834E/pt unknown
- 1999-04-23 TR TR2000/03101T patent/TR200003101T2/xx unknown
- 1999-04-23 AU AU35248/99A patent/AU756338B2/en not_active Ceased
- 1999-04-23 RS YUP-640/00A patent/RS49955B/sr unknown
- 1999-04-23 IL IL13895099A patent/IL138950A0/xx active IP Right Grant
- 1999-04-23 CA CA002329232A patent/CA2329232C/en not_active Expired - Fee Related
- 1999-04-23 WO PCT/FI1999/000331 patent/WO1999055337A1/en active IP Right Grant
- 1999-04-23 MX MXPA00010368A patent/MXPA00010368A/es active IP Right Grant
- 1999-04-23 JP JP2000545535A patent/JP4475809B2/ja not_active Expired - Lifetime
- 1999-04-23 AT AT99916943T patent/ATE231395T1/de not_active IP Right Cessation
- 1999-04-23 HU HU0105446A patent/HUP0105446A3/hu unknown
- 1999-04-23 EA EA200001097A patent/EA002428B1/ru not_active IP Right Cessation
- 1999-04-23 ID IDW20002368A patent/ID26650A/id unknown
- 1999-04-23 GE GEAP19995638A patent/GEP20032942B/en unknown
- 1999-04-23 CN CNB998053805A patent/CN1165309C/zh not_active Expired - Fee Related
- 1999-04-23 KR KR1020007011789A patent/KR100590622B1/ko not_active Expired - Fee Related
- 1999-04-23 DK DK99916943T patent/DK1079834T3/da active
- 1999-04-23 EE EEP200000616A patent/EE04143B1/xx not_active IP Right Cessation
- 1999-04-23 BR BR9909867-9A patent/BR9909867A/pt not_active Application Discontinuation
- 1999-04-23 NZ NZ507455A patent/NZ507455A/en unknown
- 1999-04-23 US US09/673,793 patent/US6531458B1/en not_active Expired - Fee Related
- 1999-04-23 EP EP99916943A patent/EP1079834B1/en not_active Expired - Lifetime
- 1999-04-23 ES ES99916943T patent/ES2191426T3/es not_active Expired - Lifetime
- 1999-04-23 HR HR20000703A patent/HRP20000703B1/xx not_active IP Right Cessation
- 1999-04-23 DE DE69905034T patent/DE69905034T2/de not_active Expired - Lifetime
-
2000
- 2000-10-11 IL IL138950A patent/IL138950A/en not_active IP Right Cessation
- 2000-10-12 ZA ZA200005630A patent/ZA200005630B/en unknown
- 2000-10-20 NO NO20005312A patent/NO318575B1/no not_active IP Right Cessation
- 2000-11-17 BG BG104958A patent/BG64766B1/bg unknown
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