DK1079819T3 - Hydroxamsyrederivater som antibakterielle lægemidler - Google Patents

Hydroxamsyrederivater som antibakterielle lægemidler

Info

Publication number
DK1079819T3
DK1079819T3 DK99922317T DK99922317T DK1079819T3 DK 1079819 T3 DK1079819 T3 DK 1079819T3 DK 99922317 T DK99922317 T DK 99922317T DK 99922317 T DK99922317 T DK 99922317T DK 1079819 T3 DK1079819 T3 DK 1079819T3
Authority
DK
Denmark
Prior art keywords
group
alkyl
acid derivatives
hydroxamic acid
antibacterial drugs
Prior art date
Application number
DK99922317T
Other languages
Danish (da)
English (en)
Inventor
Michael George Hunter
Raymond Paul Beckett
John Martin Clements
Mark Whittaker
Zoe Marie Spavold
Original Assignee
Vernalis Oxford Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vernalis Oxford Ltd filed Critical Vernalis Oxford Ltd
Application granted granted Critical
Publication of DK1079819T3 publication Critical patent/DK1079819T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4453—Non condensed piperidines, e.g. piperocaine only substituted in position 1, e.g. propipocaine, diperodon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4402—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 2, e.g. pheniramine, bisacodyl
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Pyridine Compounds (AREA)
DK99922317T 1998-05-16 1999-05-14 Hydroxamsyrederivater som antibakterielle lægemidler DK1079819T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9810464.9A GB9810464D0 (en) 1998-05-16 1998-05-16 Hydroxamic acid derivatives
PCT/GB1999/001541 WO1999059568A1 (en) 1998-05-16 1999-05-14 Hydroxamic acid derivatives as antibacterials

Publications (1)

Publication Number Publication Date
DK1079819T3 true DK1079819T3 (da) 2007-04-10

Family

ID=10832125

Family Applications (1)

Application Number Title Priority Date Filing Date
DK99922317T DK1079819T3 (da) 1998-05-16 1999-05-14 Hydroxamsyrederivater som antibakterielle lægemidler

Country Status (23)

Country Link
US (3) US6441042B1 (xx)
EP (2) EP1079819B1 (xx)
JP (1) JP2002515427A (xx)
KR (1) KR100634089B1 (xx)
CN (1) CN1300210A (xx)
AT (1) ATE347356T1 (xx)
AU (1) AU754063B2 (xx)
BR (1) BR9910488A (xx)
CA (1) CA2332713C (xx)
CY (1) CY1106452T1 (xx)
DE (1) DE69934309T2 (xx)
DK (1) DK1079819T3 (xx)
ES (1) ES2278444T3 (xx)
GB (2) GB9810464D0 (xx)
HU (1) HUP0102290A3 (xx)
IL (2) IL139059A0 (xx)
NO (1) NO20005782L (xx)
NZ (1) NZ507560A (xx)
PL (1) PL344438A1 (xx)
PT (1) PT1079819E (xx)
TR (1) TR200003376T2 (xx)
WO (1) WO1999059568A1 (xx)
ZA (1) ZA200006131B (xx)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69917221T2 (de) * 1998-02-07 2005-05-04 Vernalis (Oxford) Ltd., Abington Antibakterielle mittel
GB9810464D0 (en) * 1998-05-16 1998-07-15 British Biotech Pharm Hydroxamic acid derivatives
EP1210330B1 (en) * 1999-08-10 2005-04-20 Vernalis (Oxford) Ltd Antibacterial agents
WO2001040198A2 (fr) * 1999-11-30 2001-06-07 Aventis Pharma S.A. Derives macrocycliques de l'acide hydroxamique et leur utilisation en tant qu'antimicrobiens
FR2801591B1 (fr) * 1999-11-30 2002-03-01 Aventis Pharma Sa Derives macrocycliques de l'acide hydroxamique, leur preparation et les compositions qui les contiennent
GB9929979D0 (en) * 1999-12-17 2000-02-09 Darwin Discovery Ltd Hydroxamic acid derivatives
AU2268401A (en) * 1999-12-17 2001-06-25 Versicor Inc Novel succinate compounds, compositions and methods of use and preparation
WO2002028829A2 (en) * 2000-09-25 2002-04-11 Questcor Pharmaceuticals, Inc. Peptide deformylase inhibitors
ATE298565T1 (de) * 2000-11-23 2005-07-15 Vernalis Oxford Ltd N-formyl hydroxylamine derivate als inhibitoren der bakteriellen polypeptid deformylase zur behandlung von mikrobiellen infektionen
JP2004532826A (ja) * 2001-03-19 2004-10-28 スローン−ケッタリング インスティトゥート フォー カンサー リサーチ （ｓ，ｒ，ｒ）−（−）−アクチノニンおよびそのアナログの不斉合成、ならびにそれらの使用
EP1383729A4 (en) * 2001-04-05 2006-04-19 Smithkline Beecham Corp DEFORMYLASE PEPTIDE INHIBITORS
GB0128943D0 (en) * 2001-12-04 2002-01-23 Novo Pharmaceuticals De Ltd Bacterial enzyme inhibitors
JP4190862B2 (ja) * 2001-12-18 2008-12-03 シャープ株式会社 表示装置およびその駆動方法
GB0208579D0 (en) * 2002-04-13 2002-05-22 British Biotech Pharm Antibacterial agents
DE10320453A1 (de) * 2003-05-08 2004-11-25 Morphochem AG Aktiengesellschaft für kombinatorische Chemie Neue Bioisostere von Actinonin
US8993641B2 (en) * 2007-11-29 2015-03-31 Innolex Investment Corporation Preservation of cosmetics, toiletry and pharmaceutical compositions
DE102011088962A1 (de) * 2011-12-19 2013-06-20 Beiersdorf Ag Wirkstoffkombinationen aus einer oder mehreren Carbonsäuren, insbesondereHydroxycarbonsäuren, und einer oder mehreren physiologisch unbedenklichen Hydroxamsäure sowie kosmetische oder dermatologische Zubereitungen, solcheWirkstoffkombinationen enthaltend
WO2016201288A1 (en) 2015-06-12 2016-12-15 Brown University Novel antibacterial compounds and methods of making and using same
BR112019025979B1 (pt) * 2017-06-29 2022-12-20 Kimberly-Clark Worldwide, Inc Método para inibir o crescimento microbiano em um produto, lenço umedecido, e, emulsão
CN108672095A (zh) * 2018-05-04 2018-10-19 广东省资源综合利用研究所 γ-羟基烷基羟肟酸及其制备方法与应用
US11555010B2 (en) 2019-07-25 2023-01-17 Brown University Diamide antimicrobial agents

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1028921A (en) * 1962-01-23 1966-05-11 Ranjeet Bhagwan Singh New antibiotic
US4303662A (en) * 1980-11-24 1981-12-01 E. R. Squibb & Sons, Inc. Carboxyacyl, mercapto and acylmercapto derivatives of heterobicyclo compounds
JPH0670019B2 (ja) * 1989-07-21 1994-09-07 明治製菓株式会社 新抗生物質ｓｆ２１９７ｃ物質およびその製造法
GB8919251D0 (en) * 1989-08-24 1989-10-04 British Bio Technology Compounds
JPH03157372A (ja) * 1989-11-13 1991-07-05 Yamanouchi Pharmaceut Co Ltd Ｙｌ―０１８６９ｐ物質及びその製造法
WO1992022523A2 (en) * 1991-06-14 1992-12-23 Research Corporation Technologies, Inc. Peptide derivatives of collagenase inhibitor
GB9223904D0 (en) * 1992-11-13 1993-01-06 British Bio Technology Inhibition of cytokine production
CA2170158A1 (en) * 1993-08-23 1995-03-02 Roy A. Black Inhibitors of tnf-alpha secretion
JP3157372B2 (ja) 1993-11-29 2001-04-16 三洋電機株式会社 フィルタ
AU695507B2 (en) * 1994-06-22 1998-08-13 British Biotech Pharmaceuticals Limited Metalloproteinase inhibitors
US5532265A (en) * 1994-11-30 1996-07-02 The Board Of Trustees Of The Leland Stanford Junior University Treatment of central nervous system inflammatory disease with matrix metalloprotease inhibitors
GB9507799D0 (en) 1995-04-18 1995-05-31 British Biotech Pharm Metalloproteinase inhibitors
US6281245B1 (en) * 1996-10-28 2001-08-28 Versicor, Inc. Methods for solid-phase synthesis of hydroxylamine compounds and derivatives, and combinatorial libraries thereof
ATE290878T1 (de) * 1996-12-06 2005-04-15 Fonden Til Fremme Af Eksperime Inhibierung von invasiver remodulierung
ZA9711121B (en) * 1996-12-13 1998-06-23 Handelman Joseph H Reduction of hair growth.
DE69917221T2 (de) * 1998-02-07 2005-05-04 Vernalis (Oxford) Ltd., Abington Antibakterielle mittel
GB9810464D0 (en) * 1998-05-16 1998-07-15 British Biotech Pharm Hydroxamic acid derivatives

Also Published As

Publication number Publication date
US6441042B1 (en) 2002-08-27
NO20005782L (no) 2001-01-15
IL139059A (en) 2006-12-31
IL139059A0 (en) 2001-11-25
DE69934309T2 (de) 2007-07-05
NZ507560A (en) 2003-06-30
BR9910488A (pt) 2001-01-09
PT1079819E (pt) 2007-03-30
PL344438A1 (en) 2001-11-05
CA2332713C (en) 2008-04-01
WO1999059568A1 (en) 1999-11-25
TR200003376T2 (tr) 2001-03-21
KR20010034861A (ko) 2001-04-25
CY1106452T1 (el) 2011-10-12
ATE347356T1 (de) 2006-12-15
GB2353708A (en) 2001-03-07
EP1754477A3 (en) 2007-03-14
DE69934309D1 (de) 2007-01-18
US7323563B2 (en) 2008-01-29
GB0024789D0 (en) 2000-11-22
HUP0102290A2 (hu) 2001-11-28
HUP0102290A3 (en) 2001-12-28
AU3942199A (en) 1999-12-06
NO20005782D0 (no) 2000-11-15
ZA200006131B (en) 2002-01-30
JP2002515427A (ja) 2002-05-28
EP1079819B1 (en) 2006-12-06
ES2278444T3 (es) 2007-08-01
EP1079819A1 (en) 2001-03-07
US6992190B2 (en) 2006-01-31
KR100634089B1 (ko) 2006-10-17
CN1300210A (zh) 2001-06-20
AU754063B2 (en) 2002-10-31
EP1754477A2 (en) 2007-02-21
CA2332713A1 (en) 1999-11-25
US20060211732A1 (en) 2006-09-21
GB9810464D0 (en) 1998-07-15
US20020198241A1 (en) 2002-12-26

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