DK1078263T3 - Fremgangsmåde til direkte selektion af antigen-specifikke T-celler - Google Patents
Fremgangsmåde til direkte selektion af antigen-specifikke T-cellerInfo
- Publication number
- DK1078263T3 DK1078263T3 DK99924167T DK99924167T DK1078263T3 DK 1078263 T3 DK1078263 T3 DK 1078263T3 DK 99924167 T DK99924167 T DK 99924167T DK 99924167 T DK99924167 T DK 99924167T DK 1078263 T3 DK1078263 T3 DK 1078263T3
- Authority
- DK
- Denmark
- Prior art keywords
- cells
- antigen
- product
- labeled
- specific
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 4
- 210000001744 T-lymphocyte Anatomy 0.000 title abstract 3
- 239000000427 antigen Substances 0.000 title abstract 3
- 102000036639 antigens Human genes 0.000 title abstract 3
- 108091007433 antigens Proteins 0.000 title abstract 3
- 210000004027 cell Anatomy 0.000 abstract 4
- 238000000926 separation method Methods 0.000 abstract 2
- 238000004458 analytical method Methods 0.000 abstract 1
- 238000005119 centrifugation Methods 0.000 abstract 1
- 238000000684 flow cytometry Methods 0.000 abstract 1
- 238000002372 labelling Methods 0.000 abstract 1
- 239000006249 magnetic particle Substances 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 230000002285 radioactive effect Effects 0.000 abstract 1
- 230000000638 stimulation Effects 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56966—Animal cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/10—Cellular immunotherapy characterised by the cell type used
- A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
- A61K40/46—Viral antigens
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
- G01N33/5047—Cells of the immune system
- G01N33/505—Cells of the immune system involving T-cells
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Cell Biology (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Food Science & Technology (AREA)
- Pathology (AREA)
- Zoology (AREA)
- General Physics & Mathematics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Tropical Medicine & Parasitology (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Genetics & Genomics (AREA)
- Veterinary Medicine (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Wood Science & Technology (AREA)
- Virology (AREA)
- General Engineering & Computer Science (AREA)
- Toxicology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8513698P | 1998-05-11 | 1998-05-11 | |
| PCT/US1999/010200 WO1999058977A1 (en) | 1998-05-11 | 1999-05-10 | Method of direct selection of antigen-specific t cells |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1078263T3 true DK1078263T3 (da) | 2009-11-02 |
Family
ID=22189678
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK99924167T DK1078263T3 (da) | 1998-05-11 | 1999-05-10 | Fremgangsmåde til direkte selektion af antigen-specifikke T-celler |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US6576428B1 (enExample) |
| EP (1) | EP1078263B1 (enExample) |
| JP (1) | JP4601166B2 (enExample) |
| AT (1) | ATE437366T1 (enExample) |
| AU (1) | AU765085B2 (enExample) |
| CA (1) | CA2330678C (enExample) |
| DE (1) | DE69941150D1 (enExample) |
| DK (1) | DK1078263T3 (enExample) |
| ES (1) | ES2328650T3 (enExample) |
| WO (1) | WO1999058977A1 (enExample) |
Families Citing this family (70)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2191677T3 (es) * | 1992-10-21 | 2003-09-16 | Stefan Miltenyi | Seleccion directa de celulas mediante un producto de secrecion. |
| US7166423B1 (en) | 1992-10-21 | 2007-01-23 | Miltenyi Biotec Gmbh | Direct selection of cells by secretion product |
| KR20010072957A (ko) * | 1998-08-24 | 2001-07-31 | 추후보정 | H2 수용체 작용제 및 기타 t-세포 활성화제를 사용한t-세포(cd4+ 및 cd8+) 활성화 및 보호 방법 |
| US7807377B2 (en) * | 1998-10-20 | 2010-10-05 | Salvatore Albani | Method of isolating antigen-specific T cells employing artificial antigen presenting cells |
| US20020044656A1 (en) * | 1999-10-13 | 2002-04-18 | Brant L. Candelore | Interfacing a conditional access circuit to a digital device using input and output stream switching |
| US7572631B2 (en) | 2000-02-24 | 2009-08-11 | Invitrogen Corporation | Activation and expansion of T cells |
| US7541184B2 (en) * | 2000-02-24 | 2009-06-02 | Invitrogen Corporation | Activation and expansion of cells |
| ATE367816T1 (de) | 2000-05-12 | 2007-08-15 | Univ Oregon Health & Science | Verwendung von niedrigen dosen estrogen in kombination mit immunotherapeutischen verbindungen zur behandlung von immunkrankheiten |
| US7462486B2 (en) | 2000-05-12 | 2008-12-09 | Oregon Health & Science University | Methods of selecting T cell receptor V peptides for therapeutic use |
| JP2002365286A (ja) * | 2000-11-13 | 2002-12-18 | Kyogo Ito | 細胞性免疫検出法およびその医薬への応用 |
| US20090137416A1 (en) | 2001-01-16 | 2009-05-28 | Regeneron Pharmaceuticals, Inc. | Isolating Cells Expressing Secreted Proteins |
| US6919183B2 (en) | 2001-01-16 | 2005-07-19 | Regeneron Pharmaceuticals, Inc. | Isolating cells expressing secreted proteins |
| GB0118337D0 (en) * | 2001-07-27 | 2001-09-19 | Lonza Biologics Plc | Method for selecting antibody expressing cells |
| EP1473564A4 (en) * | 2001-09-18 | 2008-12-10 | Greenpeptide Co Ltd | METHOD FOR DETECTING CELL IMMUNITY AND ITS APPLICATION TO MEDICAMENTS |
| US20050084967A1 (en) * | 2002-06-28 | 2005-04-21 | Xcyte Therapies, Inc. | Compositions and methods for eliminating undesired subpopulations of T cells in patients with immunological defects related to autoimmunity and organ or hematopoietic stem cell transplantation |
| US20040175373A1 (en) * | 2002-06-28 | 2004-09-09 | Xcyte Therapies, Inc. | Compositions and methods for eliminating undesired subpopulations of T cells in patients with immunological defects related to autoimmunity and organ or hematopoietic stem cell transplantation |
| AU2003253684A1 (en) * | 2002-06-28 | 2004-01-19 | Xcyte Therapies, Inc. | Compositions and methods for restoring immune repertoire in patients with immunological defects related to autoimmunity and organ or hematopoietic stem cell transplantation |
| EP1420253B1 (de) * | 2002-08-23 | 2006-05-31 | Deutsches Rheuma-Forschungszentrum Berlin | Verfahren zum Nachweis und zur Isolierung von T-Lymphozyten, die ein definiertes Antigen erkennen |
| EP1570267B1 (en) | 2002-12-03 | 2011-10-12 | UCB Pharma, S.A. | Assay for identifying antibody producing cells |
| US20040248205A1 (en) * | 2003-04-16 | 2004-12-09 | Stern Lawrence J. | Major histocompatibility complex (MHC)-peptide arrays |
| DK1623017T3 (da) * | 2003-05-08 | 2011-01-10 | Life Technologies Corp | Frembringelse og isolering af antigenspecifikke T-celler |
| EP1658498A1 (en) | 2003-08-20 | 2006-05-24 | Celltech R & D Limited | Methods for obtaining antibodies |
| WO2005031357A2 (en) * | 2003-09-24 | 2005-04-07 | Ucl Biomedica Plc. | Cell sample analysis |
| US20060051358A1 (en) * | 2004-05-24 | 2006-03-09 | Baylor Research Institute | Immune response assessment method |
| WO2005118884A1 (en) * | 2004-05-28 | 2005-12-15 | The United States Of America As Represented By The Secretary Of The Navy | A method for the rapid diagnosis of infectious disease by detection and quantitation of microorganism induced cytokines |
| GB0412973D0 (en) * | 2004-06-10 | 2004-07-14 | Celltech R&D Ltd | Identification of antibody producing cells |
| US8053197B2 (en) | 2004-07-30 | 2011-11-08 | Oregon Health & Science University | Methods for detecting and treating autoimmune disorders |
| EP1812563B1 (en) * | 2004-10-29 | 2013-04-10 | Benaroya Research Institute at Virginia Mason | Methods of generating antigen-specific cd4+cd25+ regulatory t cells, compositions and methods of use |
| WO2006124356A2 (en) * | 2005-05-16 | 2006-11-23 | The Rockefeller University | Method for isolating dermal papilla cells and uses thereof |
| US7867765B2 (en) | 2005-12-28 | 2011-01-11 | The General Hospital Corporation | Blood cell sorting methods and systems |
| EP1878744A1 (en) * | 2006-07-13 | 2008-01-16 | Max-Delbrück-Centrum für Molekulare Medizin (MDC) | Epitope-tag for surface-expressed T-cell receptor proteins, uses thereof and method of selecting host cells expressing them |
| EP2079483A4 (en) * | 2006-07-29 | 2010-10-20 | Robert Lamar Bjork Jr | BISPECIFIC MONOCLONAL ANTIBODIES (SPECIFIC FOR CD3 AND CD11B) THERAPEUTIC MEDICAMENTS |
| CN101221171B (zh) * | 2007-12-11 | 2011-07-20 | 广州益善生物技术有限公司 | 用于骨代谢生化标志物检测的液相芯片及其制备方法 |
| WO2009103753A1 (en) * | 2008-02-20 | 2009-08-27 | Ablynx Nv | Methods for identifying and/or sorting cells by secreted molecule and kits for performing such methods |
| EP2306959A2 (en) * | 2008-07-11 | 2011-04-13 | The General Hospital Corporation | Magnetic apparatus for blood separation |
| US8309306B2 (en) * | 2008-11-12 | 2012-11-13 | Nodality, Inc. | Detection composition |
| GB0823553D0 (en) * | 2008-12-24 | 2009-01-28 | Immunosolv Ltd | Cell separation technique |
| US20120045827A1 (en) * | 2009-03-09 | 2012-02-23 | Biofactura, Inc. | Separation of antigen-specific memory b cells with a conjugated biopolymer surface |
| US8790916B2 (en) | 2009-05-14 | 2014-07-29 | Genestream, Inc. | Microfluidic method and system for isolating particles from biological fluid |
| CN102033129A (zh) * | 2009-09-29 | 2011-04-27 | 上海英伯肯医学生物技术有限公司 | 用抗原刺激的细胞免疫反应来检测病原微生物的方法及测试笔 |
| EP2390661B1 (en) | 2010-05-02 | 2015-06-24 | Miltenyi Biotec GmbH | An anchoring/capturing means for selecting or analyzing a CHO cell according to a product secreted by the CHO cell |
| WO2012048298A2 (en) | 2010-10-08 | 2012-04-12 | Caridianbct, Inc. | Methods and systems of growing and harvesting cells in a hollow fiber bioreactor system with control conditions |
| EP2518504A1 (en) * | 2011-04-29 | 2012-10-31 | Miltenyi Biotec GmbH | A method for the quantitative and qualitative characterization of antigen-specific T cells recognizing a specific antigen |
| JP2014516538A (ja) | 2011-05-26 | 2014-07-17 | ジーニウス バイオテクノロジー インベストメンツ リミテッド ライアビリティ カンパニー | 調節された免疫優勢療法 |
| US10434121B2 (en) | 2011-12-22 | 2019-10-08 | Yeda Research And Development Co. Ltd. | Combination therapy for a stable and long term engraftment using specific protocols for T/B cell depletion |
| BR112015004374B1 (pt) | 2012-08-29 | 2021-02-09 | Inguran, Llc | método de manipulação celular magnética |
| US10379026B2 (en) | 2012-08-29 | 2019-08-13 | Inguran, Llc | Cell processing using magnetic particles |
| TWI675044B (zh) | 2012-11-14 | 2019-10-21 | 美商再生元醫藥公司 | 重組細胞表面捕捉蛋白質 |
| WO2015073918A1 (en) | 2013-11-16 | 2015-05-21 | Terumo Bct, Inc. | Expanding cells in a bioreactor |
| US11008547B2 (en) | 2014-03-25 | 2021-05-18 | Terumo Bct, Inc. | Passive replacement of media |
| CN103901188B (zh) * | 2014-04-11 | 2016-08-24 | 苏州浩欧博生物医药有限公司 | 一种吸入过敏原的化学发光定量检测试剂盒及其制备方法和检测方法 |
| WO2016049421A1 (en) | 2014-09-26 | 2016-03-31 | Terumo Bct, Inc. | Scheduled feed |
| WO2017004592A1 (en) | 2015-07-02 | 2017-01-05 | Terumo Bct, Inc. | Cell growth with mechanical stimuli |
| CN109153975A (zh) * | 2015-12-28 | 2019-01-04 | 诺华股份有限公司 | 制备嵌合抗原受体表达细胞的方法 |
| US11965175B2 (en) | 2016-05-25 | 2024-04-23 | Terumo Bct, Inc. | Cell expansion |
| US11104874B2 (en) | 2016-06-07 | 2021-08-31 | Terumo Bct, Inc. | Coating a bioreactor |
| US11685883B2 (en) | 2016-06-07 | 2023-06-27 | Terumo Bct, Inc. | Methods and systems for coating a cell growth surface |
| CN109715788A (zh) * | 2016-06-28 | 2019-05-03 | 金纽斯生物科技公司 | 用于免疫疗法的t细胞组合物 |
| US11629332B2 (en) | 2017-03-31 | 2023-04-18 | Terumo Bct, Inc. | Cell expansion |
| US11624046B2 (en) | 2017-03-31 | 2023-04-11 | Terumo Bct, Inc. | Cell expansion |
| US12234441B2 (en) | 2017-03-31 | 2025-02-25 | Terumo Bct, Inc. | Cell expansion |
| EP3662057A4 (en) * | 2017-08-01 | 2021-04-28 | Benaroya Research Institute at Virginia Mason | PRO-ALLERGIC SPECIFIC T-LYMPHOCYTES IDENTIFICATION AND SEPARATION PROCESSES |
| CN110857948B (zh) * | 2018-08-24 | 2025-01-21 | 武汉纳达康生物科技有限公司 | H7禽流感病毒抗体磁免疫化学发光检测试剂盒及其应用 |
| CN112930355A (zh) * | 2018-10-19 | 2021-06-08 | 苏黎世联邦理工学院 | 嵌合分子 |
| WO2021030606A1 (en) * | 2019-08-14 | 2021-02-18 | Sanford Burnham Prebys Medical Discovery Institute | Methods and devices for rare cell capture |
| JP2022093945A (ja) * | 2020-12-14 | 2022-06-24 | 株式会社山田養蜂場本社 | B細胞数増加剤 |
| GB2619893A (en) | 2021-03-23 | 2023-12-20 | Terumo Bct Inc | Cell capture and expansion |
| US12209689B2 (en) | 2022-02-28 | 2025-01-28 | Terumo Kabushiki Kaisha | Multiple-tube pinch valve assembly |
| USD1099116S1 (en) | 2022-09-01 | 2025-10-21 | Terumo Bct, Inc. | Display screen or portion thereof with a graphical user interface for displaying cell culture process steps and measurements of an associated bioreactor device |
| CN117433867A (zh) * | 2023-10-24 | 2024-01-23 | 深圳联合医学科技有限公司 | 阴道微生物的荧光染色液及检测阴道微生物的方法 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4230685A (en) | 1979-02-28 | 1980-10-28 | Northwestern University | Method of magnetic separation of cells and the like, and microspheres for use therein |
| US4452773A (en) | 1982-04-05 | 1984-06-05 | Canadian Patents And Development Limited | Magnetic iron-dextran microspheres |
| GB8408127D0 (en) | 1984-03-29 | 1984-05-10 | Nyegaard & Co As | Contrast agents |
| US4770183A (en) | 1986-07-03 | 1988-09-13 | Advanced Magnetics Incorporated | Biologically degradable superparamagnetic particles for use as nuclear magnetic resonance imaging agents |
| IL91414A0 (en) | 1988-08-31 | 1990-04-29 | Zynaxis Technologies Inc | Reagents and methods for the determination of analytes |
| US5385707A (en) | 1988-12-28 | 1995-01-31 | Stefan Miltenyi | Metal matrices for use in high gradient magnetic separation of biological materials and method for coating the same |
| ATE114507T1 (de) | 1988-12-28 | 1994-12-15 | Stefan Miltenyi | Verfahren sowie materialien zur hochgraduierten magnetischen abspaltung biologischer materialien. |
| ES2191677T3 (es) * | 1992-10-21 | 2003-09-16 | Stefan Miltenyi | Seleccion directa de celulas mediante un producto de secrecion. |
| US5635363A (en) | 1995-02-28 | 1997-06-03 | The Board Of Trustees Of The Leland Stanford Junior University | Compositions and methods for the detection, quantitation and purification of antigen-specific T cells |
| WO1996037208A1 (en) | 1995-05-25 | 1996-11-28 | Baxter International Inc. | Allogeneic cell therapy for cancer following allogeneic stem cell transplantation |
| WO1997005239A1 (en) | 1995-07-25 | 1997-02-13 | Celltherapy, Inc. | Autologous immune cell therapy: cell compositions, methods and applications to treatment of human disease |
| AU740222C (en) | 1996-03-20 | 2002-10-10 | Genzyme Corporation | A method for identifying cytotoxic T-cell epitopes |
| CA2254975C (en) | 1996-05-23 | 2008-12-16 | The Scripps Research Institute | Mhc class ii antigen-presenting systems and methods for activating cd4+ t cells |
| US5750356A (en) | 1996-05-31 | 1998-05-12 | Anergen, Inc. | Method for monitoring T cell reactivity |
-
1999
- 1999-05-10 DE DE69941150T patent/DE69941150D1/de not_active Expired - Lifetime
- 1999-05-10 US US09/309,199 patent/US6576428B1/en not_active Expired - Lifetime
- 1999-05-10 WO PCT/US1999/010200 patent/WO1999058977A1/en not_active Ceased
- 1999-05-10 DK DK99924167T patent/DK1078263T3/da active
- 1999-05-10 AU AU40736/99A patent/AU765085B2/en not_active Ceased
- 1999-05-10 CA CA002330678A patent/CA2330678C/en not_active Expired - Lifetime
- 1999-05-10 JP JP2000548729A patent/JP4601166B2/ja not_active Expired - Lifetime
- 1999-05-10 ES ES99924167T patent/ES2328650T3/es not_active Expired - Lifetime
- 1999-05-10 AT AT99924167T patent/ATE437366T1/de not_active IP Right Cessation
- 1999-05-10 EP EP99924167A patent/EP1078263B1/en not_active Expired - Lifetime
-
2003
- 2003-05-23 US US10/445,391 patent/US20040023377A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| JP2002514765A (ja) | 2002-05-21 |
| AU4073699A (en) | 1999-11-29 |
| ES2328650T3 (es) | 2009-11-16 |
| US6576428B1 (en) | 2003-06-10 |
| US20040023377A1 (en) | 2004-02-05 |
| ATE437366T1 (de) | 2009-08-15 |
| DE69941150D1 (de) | 2009-09-03 |
| CA2330678C (en) | 2009-04-07 |
| WO1999058977A1 (en) | 1999-11-18 |
| EP1078263B1 (en) | 2009-07-22 |
| CA2330678A1 (en) | 1999-11-18 |
| AU765085B2 (en) | 2003-09-11 |
| JP4601166B2 (ja) | 2010-12-22 |
| EP1078263A1 (en) | 2001-02-28 |
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