CA2330678C - Method of direct selection of antigen-specific t cells - Google Patents
Method of direct selection of antigen-specific t cells Download PDFInfo
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- CA2330678C CA2330678C CA002330678A CA2330678A CA2330678C CA 2330678 C CA2330678 C CA 2330678C CA 002330678 A CA002330678 A CA 002330678A CA 2330678 A CA2330678 A CA 2330678A CA 2330678 C CA2330678 C CA 2330678C
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- A61K40/00—Cellular immunotherapy
- A61K40/10—Cellular immunotherapy characterised by the cell type used
- A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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- A61K40/00—Cellular immunotherapy
- A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
- A61K40/46—Viral antigens
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
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- G—PHYSICS
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- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
- G01N33/5047—Cells of the immune system
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Applications Claiming Priority (3)
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| US8513698P | 1998-05-11 | 1998-05-11 | |
| US60/085,136 | 1998-05-11 | ||
| PCT/US1999/010200 WO1999058977A1 (en) | 1998-05-11 | 1999-05-10 | Method of direct selection of antigen-specific t cells |
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| CA2330678A1 CA2330678A1 (en) | 1999-11-18 |
| CA2330678C true CA2330678C (en) | 2009-04-07 |
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| ES2191677T3 (es) * | 1992-10-21 | 2003-09-16 | Stefan Miltenyi | Seleccion directa de celulas mediante un producto de secrecion. |
| US7166423B1 (en) | 1992-10-21 | 2007-01-23 | Miltenyi Biotec Gmbh | Direct selection of cells by secretion product |
| KR20010072957A (ko) * | 1998-08-24 | 2001-07-31 | 추후보정 | Ｈ2 수용체 작용제 및 기타 ｔ-세포 활성화제를 사용한ｔ-세포(ｃｄ4+ 및 ｃｄ8+) 활성화 및 보호 방법 |
| US7807377B2 (en) * | 1998-10-20 | 2010-10-05 | Salvatore Albani | Method of isolating antigen-specific T cells employing artificial antigen presenting cells |
| US20020044656A1 (en) * | 1999-10-13 | 2002-04-18 | Brant L. Candelore | Interfacing a conditional access circuit to a digital device using input and output stream switching |
| US7572631B2 (en) | 2000-02-24 | 2009-08-11 | Invitrogen Corporation | Activation and expansion of T cells |
| US7541184B2 (en) * | 2000-02-24 | 2009-06-02 | Invitrogen Corporation | Activation and expansion of cells |
| ATE367816T1 (de) | 2000-05-12 | 2007-08-15 | Univ Oregon Health & Science | Verwendung von niedrigen dosen estrogen in kombination mit immunotherapeutischen verbindungen zur behandlung von immunkrankheiten |
| US7462486B2 (en) | 2000-05-12 | 2008-12-09 | Oregon Health & Science University | Methods of selecting T cell receptor V peptides for therapeutic use |
| JP2002365286A (ja) * | 2000-11-13 | 2002-12-18 | Kyogo Ito | 細胞性免疫検出法およびその医薬への応用 |
| US20090137416A1 (en) | 2001-01-16 | 2009-05-28 | Regeneron Pharmaceuticals, Inc. | Isolating Cells Expressing Secreted Proteins |
| US6919183B2 (en) | 2001-01-16 | 2005-07-19 | Regeneron Pharmaceuticals, Inc. | Isolating cells expressing secreted proteins |
| GB0118337D0 (en) * | 2001-07-27 | 2001-09-19 | Lonza Biologics Plc | Method for selecting antibody expressing cells |
| EP1473564A4 (en) * | 2001-09-18 | 2008-12-10 | Greenpeptide Co Ltd | METHOD FOR DETECTING CELL IMMUNITY AND ITS APPLICATION TO MEDICAMENTS |
| US20050084967A1 (en) * | 2002-06-28 | 2005-04-21 | Xcyte Therapies, Inc. | Compositions and methods for eliminating undesired subpopulations of T cells in patients with immunological defects related to autoimmunity and organ or hematopoietic stem cell transplantation |
| US20040175373A1 (en) * | 2002-06-28 | 2004-09-09 | Xcyte Therapies, Inc. | Compositions and methods for eliminating undesired subpopulations of T cells in patients with immunological defects related to autoimmunity and organ or hematopoietic stem cell transplantation |
| AU2003253684A1 (en) * | 2002-06-28 | 2004-01-19 | Xcyte Therapies, Inc. | Compositions and methods for restoring immune repertoire in patients with immunological defects related to autoimmunity and organ or hematopoietic stem cell transplantation |
| EP1420253B1 (de) * | 2002-08-23 | 2006-05-31 | Deutsches Rheuma-Forschungszentrum Berlin | Verfahren zum Nachweis und zur Isolierung von T-Lymphozyten, die ein definiertes Antigen erkennen |
| EP1570267B1 (en) | 2002-12-03 | 2011-10-12 | UCB Pharma, S.A. | Assay for identifying antibody producing cells |
| US20040248205A1 (en) * | 2003-04-16 | 2004-12-09 | Stern Lawrence J. | Major histocompatibility complex (MHC)-peptide arrays |
| DK1623017T3 (da) * | 2003-05-08 | 2011-01-10 | Life Technologies Corp | Frembringelse og isolering af antigenspecifikke T-celler |
| EP1658498A1 (en) | 2003-08-20 | 2006-05-24 | Celltech R & D Limited | Methods for obtaining antibodies |
| WO2005031357A2 (en) * | 2003-09-24 | 2005-04-07 | Ucl Biomedica Plc. | Cell sample analysis |
| US20060051358A1 (en) * | 2004-05-24 | 2006-03-09 | Baylor Research Institute | Immune response assessment method |
| WO2005118884A1 (en) * | 2004-05-28 | 2005-12-15 | The United States Of America As Represented By The Secretary Of The Navy | A method for the rapid diagnosis of infectious disease by detection and quantitation of microorganism induced cytokines |
| GB0412973D0 (en) * | 2004-06-10 | 2004-07-14 | Celltech R&D Ltd | Identification of antibody producing cells |
| US8053197B2 (en) | 2004-07-30 | 2011-11-08 | Oregon Health & Science University | Methods for detecting and treating autoimmune disorders |
| EP1812563B1 (en) * | 2004-10-29 | 2013-04-10 | Benaroya Research Institute at Virginia Mason | Methods of generating antigen-specific cd4+cd25+ regulatory t cells, compositions and methods of use |
| WO2006124356A2 (en) * | 2005-05-16 | 2006-11-23 | The Rockefeller University | Method for isolating dermal papilla cells and uses thereof |
| US7867765B2 (en) | 2005-12-28 | 2011-01-11 | The General Hospital Corporation | Blood cell sorting methods and systems |
| EP1878744A1 (en) * | 2006-07-13 | 2008-01-16 | Max-Delbrück-Centrum für Molekulare Medizin (MDC) | Epitope-tag for surface-expressed T-cell receptor proteins, uses thereof and method of selecting host cells expressing them |
| EP2079483A4 (en) * | 2006-07-29 | 2010-10-20 | Robert Lamar Bjork Jr | BISPECIFIC MONOCLONAL ANTIBODIES (SPECIFIC FOR CD3 AND CD11B) THERAPEUTIC MEDICAMENTS |
| CN101221171B (zh) * | 2007-12-11 | 2011-07-20 | 广州益善生物技术有限公司 | 用于骨代谢生化标志物检测的液相芯片及其制备方法 |
| WO2009103753A1 (en) * | 2008-02-20 | 2009-08-27 | Ablynx Nv | Methods for identifying and/or sorting cells by secreted molecule and kits for performing such methods |
| EP2306959A2 (en) * | 2008-07-11 | 2011-04-13 | The General Hospital Corporation | Magnetic apparatus for blood separation |
| US8309306B2 (en) * | 2008-11-12 | 2012-11-13 | Nodality, Inc. | Detection composition |
| GB0823553D0 (en) * | 2008-12-24 | 2009-01-28 | Immunosolv Ltd | Cell separation technique |
| US20120045827A1 (en) * | 2009-03-09 | 2012-02-23 | Biofactura, Inc. | Separation of antigen-specific memory b cells with a conjugated biopolymer surface |
| US8790916B2 (en) | 2009-05-14 | 2014-07-29 | Genestream, Inc. | Microfluidic method and system for isolating particles from biological fluid |
| CN102033129A (zh) * | 2009-09-29 | 2011-04-27 | 上海英伯肯医学生物技术有限公司 | 用抗原刺激的细胞免疫反应来检测病原微生物的方法及测试笔 |
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- 1999-05-10 CA CA002330678A patent/CA2330678C/en not_active Expired - Lifetime
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- 1999-05-10 AT AT99924167T patent/ATE437366T1/de not_active IP Right Cessation
- 1999-05-10 EP EP99924167A patent/EP1078263B1/en not_active Expired - Lifetime
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| DK1078263T3 (da) | 2009-11-02 |
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| EP1078263A1 (en) | 2001-02-28 |
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