DK1044015T3 - Formuleringer med amylinagonistpeptider og insulin - Google Patents
Formuleringer med amylinagonistpeptider og insulinInfo
- Publication number
- DK1044015T3 DK1044015T3 DK98902423T DK98902423T DK1044015T3 DK 1044015 T3 DK1044015 T3 DK 1044015T3 DK 98902423 T DK98902423 T DK 98902423T DK 98902423 T DK98902423 T DK 98902423T DK 1044015 T3 DK1044015 T3 DK 1044015T3
- Authority
- DK
- Denmark
- Prior art keywords
- approximately
- formulations
- insulin
- amylin agonist
- agonist peptides
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Diabetes (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Endocrinology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Dermatology (AREA)
- Genetics & Genomics (AREA)
- Emergency Medicine (AREA)
- Biophysics (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Toxicology (AREA)
- Immunology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/US1998/000288 WO1999034822A1 (en) | 1998-01-09 | 1998-01-09 | Formulations for amylin agonist peptides |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1044015T3 true DK1044015T3 (da) | 2008-12-08 |
Family
ID=22266167
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK98902423T DK1044015T3 (da) | 1998-01-09 | 1998-01-09 | Formuleringer med amylinagonistpeptider og insulin |
Country Status (9)
Country | Link |
---|---|
EP (1) | EP1044015B1 (de) |
JP (1) | JP4353544B2 (de) |
AT (1) | ATE410182T1 (de) |
AU (1) | AU760609B2 (de) |
CA (1) | CA2365742C (de) |
DE (1) | DE69840106D1 (de) |
DK (1) | DK1044015T3 (de) |
ES (1) | ES2316161T3 (de) |
WO (1) | WO1999034822A1 (de) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2016950B1 (de) | 1996-08-08 | 2011-01-05 | Amylin Pharmaceuticals, Inc. | Pharmazeutische Zusammensetzung mit einem Exendin-4-Peptid |
US5783556A (en) * | 1996-08-13 | 1998-07-21 | Genentech, Inc. | Formulated insulin-containing composition |
US7312196B2 (en) * | 1997-01-08 | 2007-12-25 | Amylin Pharmaceuticals, Inc. | Formulations for amylin agonist peptides |
JP4647736B2 (ja) * | 1999-09-30 | 2011-03-09 | 小林製薬株式会社 | 薬剤発散具 |
EP2036539A1 (de) | 2007-09-11 | 2009-03-18 | Novo Nordisk A/S | Stabile Formulierungen aus Amylin und dessen Analogen |
CN101822822A (zh) * | 2009-03-04 | 2010-09-08 | 北京德众万全药物技术开发有限公司 | 一种普兰林肽的药物组合物及其制备方法 |
JP2009149684A (ja) * | 2009-03-11 | 2009-07-09 | Amylin Pharmaceut Inc | アミリン作動薬ペプチド用製剤 |
CN102145164B (zh) * | 2010-12-16 | 2013-02-27 | 深圳市健元医药科技有限公司 | 一种更加稳定的iapp类似物注射剂 |
US9399065B2 (en) | 2012-04-16 | 2016-07-26 | Biodel Inc. | Magnesium compositions for modulating the pharmacokinetics and injection site pain of insulin |
UA116217C2 (uk) | 2012-10-09 | 2018-02-26 | Санофі | Пептидна сполука як подвійний агоніст рецепторів glp1-1 та глюкагону |
CN104902919B (zh) | 2012-12-21 | 2018-11-20 | 赛诺菲 | Glp1/gip双重激动剂或glp1/gip/胰高血糖素三重激动剂 |
EP3080152A1 (de) | 2013-12-13 | 2016-10-19 | Sanofi | Nicht-acylierte exendin-4-peptidanaloga |
TW201609799A (zh) | 2013-12-13 | 2016-03-16 | 賽諾菲公司 | 雙重glp-1/gip受體促效劑 |
TW201609797A (zh) | 2013-12-13 | 2016-03-16 | 賽諾菲公司 | 雙重glp-1/升糖素受體促效劑 |
EP3080150B1 (de) | 2013-12-13 | 2018-08-01 | Sanofi | Exendin-4-peptidanaloga als duale glp-1/gip-rezeptoragonisten |
TW201625670A (zh) | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | 衍生自exendin-4之雙重glp-1/升糖素受體促效劑 |
TW201625669A (zh) | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | 衍生自艾塞那肽-4(Exendin-4)之肽類雙重GLP-1/升糖素受體促效劑 |
TW201625668A (zh) | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | 作為胜肽性雙重glp-1/昇糖素受體激動劑之艾塞那肽-4衍生物 |
CA2947587C (en) | 2014-05-02 | 2022-10-18 | The Research Foundation For The State University Of New York | Islet amyloid polypeptides with improved solubility |
US9932381B2 (en) | 2014-06-18 | 2018-04-03 | Sanofi | Exendin-4 derivatives as selective glucagon receptor agonists |
AR105319A1 (es) | 2015-06-05 | 2017-09-27 | Sanofi Sa | Profármacos que comprenden un conjugado agonista dual de glp-1 / glucagón conector ácido hialurónico |
TW201706291A (zh) | 2015-07-10 | 2017-02-16 | 賽諾菲公司 | 作為選擇性肽雙重glp-1/升糖素受體促效劑之新毒蜥外泌肽(exendin-4)衍生物 |
CN107952064B (zh) * | 2016-10-14 | 2023-10-20 | 江苏豪森药业集团有限公司 | 含有聚乙二醇洛塞那肽的药物制剂及其制备方法 |
WO2018144671A1 (en) | 2017-02-01 | 2018-08-09 | The Research Foundation For The State University Of New York | Mutant islet amyloid polypeptides with improved solubility and methods for using the same |
TWI762706B (zh) | 2017-08-24 | 2022-05-01 | 丹麥商諾佛 儂迪克股份有限公司 | Glp-1組成物及其用途 |
US11110063B2 (en) | 2017-08-25 | 2021-09-07 | MAIA Pharmaceuticals, Inc. | Storage stable sincalide formulations |
TW202140063A (zh) | 2020-02-18 | 2021-11-01 | 丹麥商諾佛 儂迪克股份有限公司 | 醫藥配方 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4654324A (en) * | 1981-08-27 | 1987-03-31 | Eli Lilly And Company | Human proinsulin pharmaceutical formulations |
US5321008A (en) * | 1991-01-10 | 1994-06-14 | Amylin Pharmaceuticals, Inc. | Methods and compositions for treatment of diabetes mellitus, hypoglycemia, and other conditions |
DK0567626T3 (da) * | 1991-11-19 | 2001-12-17 | Amylin Pharmaceuticals Inc | Amylin-agonist-peptider og anvendelse deraf |
US6143718A (en) * | 1995-06-07 | 2000-11-07 | Amylin Pharmaceuticals, Inc. | Treatment of Type II diabetes mellutis with amylin agonists |
US7910548B2 (en) * | 1997-06-06 | 2011-03-22 | Amylin Pharmaceuticals, Inc. | Methods for treating obesity |
-
1998
- 1998-01-09 DK DK98902423T patent/DK1044015T3/da active
- 1998-01-09 JP JP53493999A patent/JP4353544B2/ja not_active Expired - Fee Related
- 1998-01-09 CA CA2365742A patent/CA2365742C/en not_active Expired - Fee Related
- 1998-01-09 DE DE69840106T patent/DE69840106D1/de not_active Expired - Lifetime
- 1998-01-09 AU AU59094/98A patent/AU760609B2/en not_active Ceased
- 1998-01-09 WO PCT/US1998/000288 patent/WO1999034822A1/en active IP Right Grant
- 1998-01-09 EP EP98902423A patent/EP1044015B1/de not_active Expired - Lifetime
- 1998-01-09 ES ES98902423T patent/ES2316161T3/es not_active Expired - Lifetime
- 1998-01-09 AT AT98902423T patent/ATE410182T1/de not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
JP2002511103A (ja) | 2002-04-09 |
CA2365742A1 (en) | 1999-07-15 |
EP1044015A4 (de) | 2001-05-23 |
AU5909498A (en) | 1999-07-26 |
ATE410182T1 (de) | 2008-10-15 |
ES2316161T3 (es) | 2009-04-01 |
EP1044015B1 (de) | 2008-10-08 |
JP4353544B2 (ja) | 2009-10-28 |
DE69840106D1 (de) | 2008-11-20 |
EP1044015A1 (de) | 2000-10-18 |
CA2365742C (en) | 2013-04-30 |
AU760609B2 (en) | 2003-05-15 |
WO1999034822A1 (en) | 1999-07-15 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DK1044015T3 (da) | Formuleringer med amylinagonistpeptider og insulin | |
ES2569949T3 (es) | Formulaciones farmacéuticas que comprenden un péptido complejado con una dicetopiperazina | |
US5766582A (en) | Stable, aqueous alfa interferon solution formulations | |
HU202761B (en) | Process for producing stabilized erythropoietin compositions | |
CA2295140A1 (en) | Stable insulin formulations | |
JPH0430926B2 (de) | ||
WO2003101395A3 (en) | Formulations for amylin agonist peptides | |
CN102614134A (zh) | Vegf拮抗剂制剂 | |
ES2089011T3 (es) | Excipiente lipidico de administracion nasal y aplicacion topica. | |
EA200700389A1 (ru) | Стабильный при хранении инфузионный раствор дигидроптеридинонов | |
JP3927248B2 (ja) | Hgf凍結乾燥製剤 | |
JP2009091363A (ja) | Pthの安定化水溶液注射剤 | |
AR040529A1 (es) | Formulaciones de hgh en alta concentracion que contienen 1,2-propilenglicol | |
ATE228005T1 (de) | Pharmazeutische formulierungen aus corticotropin freisetzenden faktor mit verbesserter stabilitaet in fluessiger form | |
CN1802171B (zh) | 不包含血清白蛋白的人红细胞生成素的稳定水溶液 | |
JPS6416724A (en) | Stable and injectable vinca dimer salt solution | |
JPH06247872A (ja) | 高濃度tcf製剤 | |
US4963529A (en) | Stable growth hormone releasing factor preparation | |
JP2004010511A (ja) | Pthの安定化水溶液注射剤 | |
Uebel et al. | Stability evaluation of a prostaglandin E1 saline solution packed in insulin syringes | |
JP4707327B2 (ja) | ポリペプタイド類の吸着防止剤 | |
JPH1149698A (ja) | 安定性を向上させたラクトフェリンの水性製剤 | |
AHMAD et al. | Stability of chlorpheniramine maleate in cough syrups | |
JPH10298102A (ja) | カルシトニン注射液 | |
JP2005232177A (ja) | Hgh含有医薬組成物 |