DK1040097T3 - Stoffer, som åbner kaliumkanaler - Google Patents

Stoffer, som åbner kaliumkanaler

Info

Publication number
DK1040097T3
DK1040097T3 DK98963249T DK98963249T DK1040097T3 DK 1040097 T3 DK1040097 T3 DK 1040097T3 DK 98963249 T DK98963249 T DK 98963249T DK 98963249 T DK98963249 T DK 98963249T DK 1040097 T3 DK1040097 T3 DK 1040097T3
Authority
DK
Denmark
Prior art keywords
substances
potassium channels
open potassium
opening
potassium channel
Prior art date
Application number
DK98963249T
Other languages
Danish (da)
English (en)
Inventor
William A Carroll
James P Sullivan
Irene Drizin
Henry Q Zhang
Mark W Holladay
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/206,055 external-priority patent/US6265417B1/en
Application filed by Abbott Lab filed Critical Abbott Lab
Application granted granted Critical
Publication of DK1040097T3 publication Critical patent/DK1040097T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
    • C07C45/29—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups
    • C07C45/298—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups with manganese derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/36—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nutrition Science (AREA)
  • Urology & Nephrology (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Glass Compositions (AREA)
  • Iron Core Of Rotating Electric Machines (AREA)
  • Quinoline Compounds (AREA)
  • Feeding And Controlling Fuel (AREA)
  • Pyridine Compounds (AREA)
  • Ladders (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Toys (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogen, Water And Hydrids (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
DK98963249T 1997-12-18 1998-12-16 Stoffer, som åbner kaliumkanaler DK1040097T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US99339297A 1997-12-18 1997-12-18
US09/206,055 US6265417B1 (en) 1997-12-18 1998-12-04 Potassium channel openers
PCT/US1998/026780 WO1999031059A1 (en) 1997-12-18 1998-12-16 Potassium channel openers

Publications (1)

Publication Number Publication Date
DK1040097T3 true DK1040097T3 (da) 2004-08-02

Family

ID=26901004

Family Applications (1)

Application Number Title Priority Date Filing Date
DK98963249T DK1040097T3 (da) 1997-12-18 1998-12-16 Stoffer, som åbner kaliumkanaler

Country Status (22)

Country Link
US (1) US20010036950A1 (de)
EP (1) EP1040097B1 (de)
JP (1) JP2002508354A (de)
CN (1) CN1158259C (de)
AT (1) ATE264303T1 (de)
AU (1) AU756505B2 (de)
BG (1) BG64309B1 (de)
BR (1) BR9813634A (de)
CA (1) CA2314948A1 (de)
DE (1) DE69823227T2 (de)
DK (1) DK1040097T3 (de)
ES (1) ES2222000T3 (de)
HK (1) HK1032583A1 (de)
HU (1) HUP0100112A3 (de)
IL (1) IL135985A0 (de)
NO (1) NO317099B1 (de)
NZ (1) NZ504371A (de)
PL (1) PL341298A1 (de)
PT (1) PT1040097E (de)
SK (1) SK8732000A3 (de)
TR (1) TR200001715T2 (de)
WO (1) WO1999031059A1 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6593335B1 (en) * 1997-12-18 2003-07-15 Abbott Laboratories Potassium channel openers
US6265417B1 (en) 1997-12-18 2001-07-24 Abbott Laboratories Potassium channel openers
US6191140B1 (en) 1998-10-28 2001-02-20 Abbott Laboratories Pyrano, piperidino, and thiopyrano compounds and methods of use
CA2348165A1 (en) * 1998-10-28 2000-05-04 Abbott Laboratories Dihydropyridine compounds and methods of use
US6642222B2 (en) * 1998-10-28 2003-11-04 Abbott Laboratories Pyrano, piperidino, and thiopyrano compounds and methods of use
US6518279B2 (en) 1999-03-04 2003-02-11 Abbott Laboratories Cyclopentanone dihydropyridine compounds useful as potassium channel openers
KR20030026979A (ko) * 2000-07-18 2003-04-03 야마노우치세이야쿠 가부시키가이샤 디시아노피리딘 유도체를 포함하는 의약
CA2476824A1 (en) * 2002-02-19 2003-08-28 Abbott Laboratories Iodination of 4-fluoro-benzaldehyde

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2658804A1 (de) * 1976-12-24 1978-07-06 Bayer Ag Kreislaufbeeinflussende mittel
DE2747513A1 (de) * 1977-10-22 1979-05-03 Bayer Ag Dihydropyridine mit schwefelhaltigen estergruppierungen
US4777167A (en) * 1986-04-09 1988-10-11 Ortho Pharmaceutical Corporation Pharmaceutically useful substituted thiacycloalkeno [3,2-b]pyridines, compositions and method of use
US4879384A (en) * 1988-06-15 1989-11-07 Ortho Pharmaceutical Corporation Preparation of thiocycloalkno [3,2-b] pyridines
US5075440A (en) * 1990-05-03 1991-12-24 Ortho Pharmaceutical Corporation Novel pyrido[2,3-f](1,4)thiazepines and pyrido[3,2-b](1,5)benzothiazepines
JP3285963B2 (ja) * 1991-10-21 2002-05-27 インペリアル・ケミカル・インダストリーズ・ピーエルシー 治療剤
GB9318935D0 (en) * 1992-10-20 1993-10-27 Zeneca Ltd Heterocyclic derivatives
DE4424678A1 (de) * 1994-07-13 1996-01-18 Bayer Ag Dioxo-thiopyrano-pyridin-carbonsäure-derivate

Also Published As

Publication number Publication date
EP1040097B1 (de) 2004-04-14
DE69823227T2 (de) 2005-03-10
IL135985A0 (en) 2001-05-20
WO1999031059A1 (en) 1999-06-24
EP1040097A1 (de) 2000-10-04
HK1032583A1 (en) 2001-07-27
BG104594A (en) 2001-03-30
NO20003104D0 (no) 2000-06-16
ES2222000T3 (es) 2005-01-16
CN1282321A (zh) 2001-01-31
TR200001715T2 (tr) 2000-12-21
BR9813634A (pt) 2000-10-17
PL341298A1 (en) 2001-04-09
CN1158259C (zh) 2004-07-21
AU756505B2 (en) 2003-01-16
BG64309B1 (bg) 2004-09-30
ATE264303T1 (de) 2004-04-15
SK8732000A3 (en) 2000-11-07
JP2002508354A (ja) 2002-03-19
NO317099B1 (no) 2004-08-09
HUP0100112A3 (en) 2004-05-28
DE69823227D1 (de) 2004-05-19
PT1040097E (pt) 2004-08-31
CA2314948A1 (en) 1999-06-24
NO20003104L (no) 2000-08-17
US20010036950A1 (en) 2001-11-01
HUP0100112A2 (hu) 2001-08-28
AU1830799A (en) 1999-07-05
NZ504371A (en) 2002-02-01

Similar Documents

Publication Publication Date Title
DE60019121D1 (de) Kaliumkanäleöffner
MY140767A (en) Compounds, methods and compositions
TW200519569A (en) Cold plate
AU2003297318A1 (en) Methods and compositions for treating cancer using 15986, 2188, 20743, 9148, 9151, 9791, 44252, 14184, 42461, 8204, 7970, 25552, 21657, 26492, 2411, 15088, 1905, 28899, 63380, 33935, 10480, 12686, 25501, 17694, 15701, 53062, 49908, 21612, 38949, 6216, 46863, 9235, 2201, 6985, 9883, 12238, 18057, 21617, 39228, 49928, 54476.
MX9804588A (es) Uso de composiciones que comprenden blanqueador de halogeno para suavidad mejorada a la piel.
NL1002246A1 (nl) Door een laser bestraald electronenkanon.
MXPA03010019A (es) COMPOSICIoN PARA TRATAR EL ESTREnIMIENTO INDUCIDO POR FaRMACOS CON 15-CETO-PROSTAGLANDINAS.
ZA200005161B (en) Anti-inflammatory, antibacterial benzyl phenol agents.
WO2001009096A3 (en) Potassium channel openers
DK1040097T3 (da) Stoffer, som åbner kaliumkanaler
SE9702649D0 (sv) Relä med tvångsstyrda kontaktsatser
TR200003202T1 (tr) Potasyum kanalı açıcılar olarak faydalı siklopentanon dihidropiridin bileşikleri
WO2004032840A3 (en) Compounds, compositions, and methods
MXPA03007071A (es) Aminaldionas como abridores del canal de potasio.
WO2002062762A3 (en) Potassium channel openers
NO20001758L (no) FremgangsmÕter og blandinger for behandling av leddgikt
WO2000034285A3 (en) Substituted benzofuranoindoles and indenoindoles as novel potassium channel openers
DK1259510T3 (da) Tricyklisk dihydropyrazolon og tricyklisk dihydroxiozolon, som åbner kaliumkanaler
WO2000024741A3 (en) Dihydropyridine compounds and their use as potassium channel openers
WO2001083480A3 (en) Dihydropyridine compounds and methods of use
UA32710A (uk) Гідропривод
JO2054B1 (en) Zubaydah bath
UA28499A (uk) Метальник
BR0106789A (pt) Taxanos substituìdos com carbonato de c10