DK0977856T3 - LAG-3 splejsningsvarianter - Google Patents

LAG-3 splejsningsvarianter

Info

Publication number
DK0977856T3
DK0977856T3 DK98934908T DK98934908T DK0977856T3 DK 0977856 T3 DK0977856 T3 DK 0977856T3 DK 98934908 T DK98934908 T DK 98934908T DK 98934908 T DK98934908 T DK 98934908T DK 0977856 T3 DK0977856 T3 DK 0977856T3
Authority
DK
Denmark
Prior art keywords
lag
nucleotidic
seq
code
sequences
Prior art date
Application number
DK98934908T
Other languages
Danish (da)
English (en)
Inventor
Frederic Triebel
Renato Mastrangeli
Sergio Romagnani
Original Assignee
Inst Nat Sante Rech Med
Roussy Inst Gustave
Applied Research Systems
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inst Nat Sante Rech Med, Roussy Inst Gustave, Applied Research Systems filed Critical Inst Nat Sante Rech Med
Application granted granted Critical
Publication of DK0977856T3 publication Critical patent/DK0977856T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Toxicology (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Mechanical Coupling Of Light Guides (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Resistance Heating (AREA)
  • Branch Pipes, Bends, And The Like (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK98934908T 1997-06-18 1998-06-03 LAG-3 splejsningsvarianter DK0977856T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP97401404A EP0900841A1 (fr) 1997-06-18 1997-06-18 Variantes d'épissure de LAG-3
EP98934908A EP0977856B1 (fr) 1997-06-18 1998-06-03 Variants de lag-3 obtenus par epissage

Publications (1)

Publication Number Publication Date
DK0977856T3 true DK0977856T3 (da) 2004-12-20

Family

ID=8229784

Family Applications (1)

Application Number Title Priority Date Filing Date
DK98934908T DK0977856T3 (da) 1997-06-18 1998-06-03 LAG-3 splejsningsvarianter

Country Status (18)

Country Link
EP (2) EP0900841A1 (fr)
JP (1) JP2002505582A (fr)
KR (1) KR100552526B1 (fr)
CN (1) CN1181201C (fr)
AT (1) ATE274057T1 (fr)
AU (1) AU740147B2 (fr)
BR (1) BR9810925A (fr)
CA (1) CA2293735A1 (fr)
DE (1) DE69825741T2 (fr)
DK (1) DK0977856T3 (fr)
EA (1) EA003086B1 (fr)
EE (1) EE04378B1 (fr)
ES (1) ES2227862T3 (fr)
HK (1) HK1027377A1 (fr)
IL (2) IL133544A0 (fr)
NO (1) NO996097L (fr)
PT (1) PT977856E (fr)
WO (1) WO1998058059A1 (fr)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030100359A1 (en) * 2000-10-04 2003-05-29 Loose Timothy C. Audio network for gaming machines
ATE519779T1 (de) * 2001-09-19 2011-08-15 Roussy Inst Gustave An das glu-pro motiv-bindende proteine und peptide, diese enthaltende therapeutische zusammensetzungen und deren anwendungen
SE0103423D0 (sv) * 2001-10-12 2001-10-12 Astrazeneca Ab Polymorphism
US20040258678A1 (en) * 2002-02-22 2004-12-23 Genentech, Inc. Compositions and methods for the treatment of immune related diseases
US7367886B2 (en) 2003-01-16 2008-05-06 Wms Gaming Inc. Gaming system with surround sound
US7364508B2 (en) 2003-01-16 2008-04-29 Wms Gaming, Inc. Gaming machine environment having controlled audio and visual media presentation
US7867085B2 (en) 2003-01-16 2011-01-11 Wms Gaming Inc. Gaming machine environment having controlled audio and visual media presentation
US8313374B2 (en) 2003-02-14 2012-11-20 Wms Gaming Inc. Gaming machine having improved audio control architecture
AU2004217526B2 (en) * 2003-02-28 2010-02-04 St. Jude Children's Research Hospital Inc. T cell regulation
FR2902101B1 (fr) * 2006-06-12 2012-12-28 Scras Peptides a activite anti-proliferative
WO2008063391A2 (fr) 2006-11-10 2008-05-29 Wms Gaming Inc. Jeux de pari à structure de jeu multiniveau
AR072999A1 (es) 2008-08-11 2010-10-06 Medarex Inc Anticuerpos humanos que se unen al gen 3 de activacion linfocitaria (lag-3) y los usos de estos
UY34887A (es) 2012-07-02 2013-12-31 Bristol Myers Squibb Company Una Corporacion Del Estado De Delaware Optimización de anticuerpos que se fijan al gen de activación de linfocitos 3 (lag-3) y sus usos
RS64268B1 (sr) 2013-09-20 2023-07-31 Bristol Myers Squibb Co Kombinacija anti-lag-3 antitela i anti-pd-1 antitela za lečenje tumora
US9412222B2 (en) 2013-09-20 2016-08-09 Igt Coordinated gaming machine attract via gaming machine cameras
JOP20200094A1 (ar) 2014-01-24 2017-06-16 Dana Farber Cancer Inst Inc جزيئات جسم مضاد لـ pd-1 واستخداماتها
CR20160425A (es) 2014-03-14 2017-05-26 Novartis Ag Moléculas de anticuerpos que se unen a lag-3 y usos de las mismas
TWI693232B (zh) 2014-06-26 2020-05-11 美商宏觀基因股份有限公司 與pd-1和lag-3具有免疫反應性的共價結合的雙抗體和其使用方法
JO3663B1 (ar) 2014-08-19 2020-08-27 Merck Sharp & Dohme الأجسام المضادة لمضاد lag3 وأجزاء ربط الأنتيجين
TWI773646B (zh) 2015-06-08 2022-08-11 美商宏觀基因股份有限公司 結合lag-3的分子和其使用方法
HUE056201T2 (hu) 2015-07-30 2022-02-28 Macrogenics Inc PD-1-hez kötõdõ molekulák és alkalmazásukra szolgáló eljárások
TWI756187B (zh) 2015-10-09 2022-03-01 美商再生元醫藥公司 抗ｌａｇ３抗體及其用途
TWI758267B (zh) 2015-12-14 2022-03-21 美商宏觀基因股份有限公司 對於pd-1和ctla-4具有免疫反應性的雙特異性分子及其使用方法
CN109069570A (zh) 2015-12-16 2018-12-21 默沙东公司 抗lag3抗体和抗原结合片段
SG11201907208XA (en) 2017-02-10 2019-09-27 Regeneron Pharma Radiolabeled anti-lag3 antibodies for immuno-pet imaging
WO2018222722A2 (fr) 2017-05-30 2018-12-06 Bristol-Myers Squibb Company Compositions comprenant un anticorps anti-lag-3 ou un anticorps anti-lag-3 et un anticorps anti-pd-1 ou anti-pd-l1
HRP20231457T1 (hr) 2017-05-30 2024-05-10 Bristol-Myers Squibb Company Liječenje lag-3-pozitivnih tumora
JP2022532490A (ja) 2019-05-13 2022-07-15 リジェネロン・ファーマシューティカルズ・インコーポレイテッド 癌の治療における有効性の増強のためのｐｄ－１阻害剤とｌａｇ－３阻害剤の組み合わせ

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE135747T1 (de) * 1986-08-21 1996-04-15 Univ Columbia Für das t-zell oberflächenprotein t4 kodierende dna und verwendung von t4-fragmenten bei der behandlung von aids
FR2656800B1 (fr) * 1990-01-08 1992-05-15 Roussy Inst Gustave Nouvelles proteines produits par les lymphocytes humains, sequence d'adn codant pour ces proteines et applications pharmaceutiques et biologiques.
PT758383E (pt) * 1994-05-06 2007-05-31 Roussy Inst Gustave Fracções polipeptídicas solúveis da ptroteína lag-3; processo de produção; composição terapêutica; anticorpos anti-idiotipo

Also Published As

Publication number Publication date
JP2002505582A (ja) 2002-02-19
PT977856E (pt) 2005-01-31
AU740147B2 (en) 2001-11-01
CN1181201C (zh) 2004-12-22
EE9900581A (xx) 2000-08-15
IL133544A0 (en) 2001-04-30
DE69825741D1 (de) 2004-09-23
EA003086B1 (ru) 2002-12-26
AU8435598A (en) 1999-01-04
IL133544A (en) 2006-12-31
NO996097L (no) 2000-02-17
EA200000038A1 (ru) 2000-06-26
WO1998058059A1 (fr) 1998-12-23
DE69825741T2 (de) 2005-09-01
NO996097D0 (no) 1999-12-09
KR100552526B1 (ko) 2006-02-14
ATE274057T1 (de) 2004-09-15
EP0977856A1 (fr) 2000-02-09
CA2293735A1 (fr) 1998-12-23
EP0900841A1 (fr) 1999-03-10
HK1027377A1 (en) 2001-01-12
EE04378B1 (xx) 2004-10-15
ES2227862T3 (es) 2005-04-01
EP0977856B1 (fr) 2004-08-18
CN1260833A (zh) 2000-07-19
BR9810925A (pt) 2000-08-15
KR20010013539A (ko) 2001-02-26

Similar Documents

Publication Publication Date Title
DK0977856T3 (da) LAG-3 splejsningsvarianter
AU7550098A (en) System for expressing hyperthermostable protein
ATE460429T1 (de) Polypeptide enthaltend extrazellulären domäne von il-20ra und/oderr il-20rb
DE69636495D1 (de) Multi-tumor abweichende wachstumsgene
ATE399858T1 (de) Blütenorgan-spezifische promotersequenzen
DK2256205T3 (da) Porphorymonas gingivalis-polypeptider og -polynukleotider
CY1106978T1 (el) Ενζυμα φωσφοδιεστερασης
NZ508439A (en) Novel endometriosis-associated gene
DK0870833T3 (da) Gener for ultrathermostabile proteaser
DE60015042D1 (de) Nukleotidsequenzen, welche für das dapF-Gen kodieren
ES2124694T3 (es) Clonacion de la n-metil-hidantoinasa.
HUP0001969A2 (hu) Az NNT-1 neurotróf faktor
SE9801098D0 (sv) Receptors
WO2000017232A3 (fr) Proteine regulatrice issue de keratinocytes humains
DE69831584T2 (de) Polypeptide mit wasserkanalaktivität und dna sequenzen
ATE180015T1 (de) N-carbamoylsarcosin-amidohydrolase, kloniert
DE60036676D1 (de) G-protein-gekoppelter rezeptor-ähnliche proteine
DE60021707D1 (de) Beta-primeverosidase gen
WO1999060117A3 (fr) Polypeptide prax-1
TH14326A (th) โปรตีเอสและสารประกอบดีเอนเอที่เกี่ยวข้อง
TH19876A (th) จีนที่ประมวลรหัสและวิธีสำหรับแสดงลักษณะเอนไซม์ชนิดใหม่