US6331543B1
(en)
|
1996-11-01 |
2001-12-18 |
Nitromed, Inc. |
Nitrosated and nitrosylated phosphodiesterase inhibitors, compositions and methods of use
|
DE19752952A1
(de)
|
1997-11-28 |
1999-06-02 |
Merck Patent Gmbh |
Thienopyrimidine
|
US6410584B1
(en)
|
1998-01-14 |
2002-06-25 |
Cell Pathways, Inc. |
Method for inhibiting neoplastic cells with indole derivatives
|
US6248308B1
(en)
*
|
1998-04-14 |
2001-06-19 |
Sepracor Inc. |
Methods of using norastemizole in combination with leukotriene inhibitors to treat or prevent asthma
|
DE19819023A1
(de)
*
|
1998-04-29 |
1999-11-04 |
Merck Patent Gmbh |
Thienopyrimidine
|
US6200771B1
(en)
|
1998-10-15 |
2001-03-13 |
Cell Pathways, Inc. |
Method of using a novel phosphodiesterase in pharmaceutical screeing to identify compounds for treatment of neoplasia
|
US6133271A
(en)
*
|
1998-11-19 |
2000-10-17 |
Cell Pathways, Inc. |
Method for inhibiting neoplastic cells and related conditions by exposure thienopyrimidine derivatives
|
US6187779B1
(en)
|
1998-11-20 |
2001-02-13 |
Cell Pathways, Inc. |
Method for inhibiting neoplastic cells and related conditions by exposure to 2,8-disubstituted quinazoline derivatives
|
US6369092B1
(en)
|
1998-11-23 |
2002-04-09 |
Cell Pathways, Inc. |
Method for treating neoplasia by exposure to substituted benzimidazole derivatives
|
US6034099A
(en)
*
|
1998-11-24 |
2000-03-07 |
Cell Pathways, Inc. |
Method for inhibiting neoplastic lesions by administering 4-(arylmethylene)- 2, 3- dihydro-pyrazol-3-ones
|
US6077842A
(en)
*
|
1998-11-24 |
2000-06-20 |
Cell Pathways, Inc. |
Method of inhibiting neoplastic cells with pyrazolopyridylpyridazinone derivatives
|
US6486155B1
(en)
|
1998-11-24 |
2002-11-26 |
Cell Pathways Inc |
Method of inhibiting neoplastic cells with isoquinoline derivatives
|
US6020379A
(en)
*
|
1999-02-19 |
2000-02-01 |
Cell Pathways, Inc. |
Position 7 substituted indenyl-3-acetic acid derivatives and amides thereof for the treatment of neoplasia
|
WO2000059912A1
(fr)
*
|
1999-03-30 |
2000-10-12 |
Nippon Soda Co., Ltd. |
Composes de thienopyrimidine et leurs sels, et procede de preparation desdits composes et sels
|
DE19928146A1
(de)
*
|
1999-06-19 |
2000-12-21 |
Merck Patent Gmbh |
Thienopyrimidine
|
DE19942474A1
(de)
*
|
1999-09-06 |
2001-03-15 |
Merck Patent Gmbh |
Pyrazolo[4,3-d]pyrimidine
|
DE19943815A1
(de)
*
|
1999-09-14 |
2001-03-15 |
Merck Patent Gmbh |
Verwendung von Thienopyrimidinen
|
DE19944604A1
(de)
*
|
1999-09-17 |
2001-03-22 |
Merck Patent Gmbh |
Aminderivate
|
DE10001021A1
(de)
*
|
2000-01-13 |
2001-07-19 |
Merck Patent Gmbh |
Pharmazeutische Zubereitung
|
DE10031584A1
(de)
|
2000-06-29 |
2002-01-10 |
Merck Patent Gmbh |
5-Aminoalkyl-pyrazolo[4,3-d]pyrimidine
|
DE10031585A1
(de)
|
2000-06-29 |
2002-01-10 |
Merck Patent Gmbh |
2-Aminoalkyl-thieno[2,3-d]pyrimidine
|
DE10042997A1
(de)
*
|
2000-09-01 |
2002-03-14 |
Merck Patent Gmbh |
Thienopyrimidine
|
CA2423981A1
(en)
*
|
2000-09-29 |
2003-03-28 |
Kimiko Ichikawa |
Thienopyrimidine compounds and salts thereof and process for the preparation of the same
|
DE10064994A1
(de)
*
|
2000-12-23 |
2002-07-04 |
Merck Patent Gmbh |
Sulfamidothienopyrimidine
|
DE10103647A1
(de)
*
|
2001-01-27 |
2002-08-01 |
Merck Patent Gmbh |
Verfahren zur Herstellung eines Pyrazolo (4,3-d) pyrimidinderivates
|
CA2436209A1
(en)
*
|
2001-01-31 |
2002-08-08 |
Merck Patent Gmbh |
Pharmaceutical formulation containing pyrazolo[4,3-d]pyrimidine and nitrates or thienopyrimidines and nitrates
|
WO2002062343A2
(en)
*
|
2001-02-02 |
2002-08-15 |
Merck Patent Gmbh |
PHARMACEUTICAL FORMULATION COMPRISING PYRAZOLO[4,3-d]PYRIMIDINES AND ENDOTHELIN RECEPTOR ANTAGONISTS OR THIENOPYRIMIDINES AND ENDOTHELIN RECEPTOR ANTAGONISTS
|
EP1401840A4
(en)
*
|
2001-04-30 |
2007-05-16 |
Bayer Corp |
NEW 4-AMINO-5,6-SUBSTITUTED THIOPHENO 2,3 D | PYRIMIDINE
|
DE10148883A1
(de)
*
|
2001-10-04 |
2003-04-10 |
Merck Patent Gmbh |
Pyrimidinderivate
|
WO2003035653A1
(fr)
*
|
2001-10-26 |
2003-05-01 |
Nippon Soda Co.,Ltd. |
Compose pyridothienopyrimidine et son sel
|
US6962940B2
(en)
|
2002-03-20 |
2005-11-08 |
Celgene Corporation |
(+)-2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione: methods of using and compositions thereof
|
US7893101B2
(en)
|
2002-03-20 |
2011-02-22 |
Celgene Corporation |
Solid forms comprising (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione, compositions thereof, and uses thereof
|
US7208516B2
(en)
|
2002-03-20 |
2007-04-24 |
Celgene Corporation |
Methods of the treatment of psoriatic arthritis using (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione
|
US7276529B2
(en)
|
2002-03-20 |
2007-10-02 |
Celgene Corporation |
Methods of the treatment or prevention of exercise-induced asthma using (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione
|
DE10224462A1
(de)
*
|
2002-06-03 |
2003-12-11 |
Bayer Ag |
Verwendung von cGMP stimulierenden Verbindungen
|
TW200410975A
(en)
*
|
2002-09-26 |
2004-07-01 |
Nihon Nohyaku Co Ltd |
New pesticide and method for using it, new substituted thienopyrimidine derivative, its intermediate, and method for producing it
|
JP2004137270A
(ja)
*
|
2002-09-26 |
2004-05-13 |
Nippon Nohyaku Co Ltd |
新規除草剤、その使用方法、新規置換チエノピリミジン誘導体及びその中間体並びにそれらの製造方法
|
ES2217956B1
(es)
|
2003-01-23 |
2006-04-01 |
Almirall Prodesfarma, S.A. |
Nuevos derivados de 4-aminotieno(2,3-d)pirimidin-6-carbonitrilo.
|
NZ542097A
(en)
|
2003-04-29 |
2008-12-24 |
Pfizer Ltd |
5,7-Diaminopyrazolo[4,3-d]pyrimidines useful in the treatment of hypertension
|
DE10351436A1
(de)
*
|
2003-11-04 |
2005-06-09 |
Merck Patent Gmbh |
Verwendung von Thienopyrimidinen
|
GB0327323D0
(en)
*
|
2003-11-24 |
2003-12-31 |
Pfizer Ltd |
Novel pharmaceuticals
|
US7572799B2
(en)
*
|
2003-11-24 |
2009-08-11 |
Pfizer Inc |
Pyrazolo[4,3-d]pyrimidines as Phosphodiesterase Inhibitors
|
BRPI0509731A
(pt)
|
2004-04-07 |
2007-09-25 |
Pfizer |
pirazol[4,3-d]pirimidinas
|
GB0420722D0
(en)
|
2004-09-17 |
2004-10-20 |
Addex Pharmaceuticals Sa |
Novel allosteric modulators
|
ES2259891B1
(es)
*
|
2004-11-30 |
2007-11-01 |
Laboratorios Almirall S.A. |
Nuevos derivados de piridotienopirimidina.
|
ES2259892B1
(es)
*
|
2004-11-30 |
2007-11-01 |
Laboratorios Almirall S.A. |
Nuevos derivados de piridotienopirimidina.
|
US8506934B2
(en)
|
2005-04-29 |
2013-08-13 |
Robert I. Henkin |
Methods for detection of biological substances
|
WO2006135080A1
(ja)
*
|
2005-06-14 |
2006-12-21 |
Aska Pharmaceutical Co., Ltd. |
チエノピリミジン誘導体
|
WO2007056208A2
(en)
*
|
2005-11-02 |
2007-05-18 |
Cytovia, Inc. |
N-arylalkyl-thienopyrimidin-4-amines and analogs as activators of caspases and inducers of apoptosis and the use thereof
|
US20070213305A1
(en)
*
|
2005-11-02 |
2007-09-13 |
Cytovia, Inc. |
N-alkyl-N-aryl-thienopyrimidin-4-amines and analogs as activators of caspases and inducers of apoptosis and the use thereof
|
US20070099877A1
(en)
*
|
2005-11-02 |
2007-05-03 |
Cytovia, Inc. |
N-aryl-thienopyrimidin-4-amines and analogs as activators of caspases and inducers of apoptosis and the use thereof
|
NZ568694A
(en)
|
2005-11-09 |
2011-09-30 |
Zalicus Inc |
Method, compositions, and kits for the treatment of medical conditions
|
WO2007063934A1
(ja)
*
|
2005-12-02 |
2007-06-07 |
Mitsubishi Tanabe Pharma Corporation |
脂環式複素環化合物
|
AR059898A1
(es)
|
2006-03-15 |
2008-05-07 |
Janssen Pharmaceutica Nv |
Derivados de 3-ciano-piridona 1,4-disustituida y su uso como moduladores alostericos de los receptores mglur2
|
US8293489B2
(en)
|
2007-01-31 |
2012-10-23 |
Henkin Robert I |
Methods for detection of biological substances
|
TW200845978A
(en)
|
2007-03-07 |
2008-12-01 |
Janssen Pharmaceutica Nv |
3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives
|
TW200900065A
(en)
|
2007-03-07 |
2009-01-01 |
Janssen Pharmaceutica Nv |
3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives
|
CA2697399C
(en)
|
2007-09-14 |
2016-01-19 |
Ortho-Mcneil-Janssen Pharmaceuticals, Inc. |
1,3-disubstituted 4-(aryl-x-phenyl)-1h-pyridin-2-ones
|
RS51660B
(en)
|
2007-09-14 |
2011-10-31 |
Ortho-Mcneil-Janssen Pharmaceuticals Inc. |
1`, 3`-DISUPSTITUATED-4-PHENYL-3,4,5,6-TETRAHYDRO-2H, 1`H- [1,4`] BIPYRIDINYL-2`-ONE
|
NZ585348A
(en)
*
|
2007-10-19 |
2012-02-24 |
Boehringer Ingelheim Int |
Heterocycle-substituted piperazino-dihydrothienopyrimidines
|
US8580801B2
(en)
|
2008-07-23 |
2013-11-12 |
Robert I. Henkin |
Phosphodiesterase inhibitor treatment
|
WO2010025890A1
(en)
|
2008-09-02 |
2010-03-11 |
Ortho-Mcneil-Janssen Pharmaceuticals, Inc |
3-azabicyclo[3.1.0]hexyl derivatives as modulators of metabotropic glutamate receptors
|
US8691813B2
(en)
|
2008-11-28 |
2014-04-08 |
Janssen Pharmaceuticals, Inc. |
Indole and benzoxazine derivatives as modulators of metabotropic glutamate receptors
|
EP2430031B1
(en)
|
2009-05-12 |
2013-04-17 |
Janssen Pharmaceuticals, Inc. |
1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
|
MY153913A
(en)
|
2009-05-12 |
2015-04-15 |
Janssen Pharmaceuticals Inc |
7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
|
EP2430022B1
(en)
|
2009-05-12 |
2013-11-20 |
Janssen Pharmaceuticals, Inc. |
1,2,4-Triazolo[4,3-a]pyridine derivatives and their use for the treatment or prevention of neurological and psychiatric disorders
|
KR101147550B1
(ko)
*
|
2009-10-22 |
2012-05-17 |
한국과학기술연구원 |
단백질 키나아제 저해활성을 가지는 2,7-치환된 티에노[3,2-d]피리미딘 화합물
|
EP2540728B1
(en)
*
|
2010-02-17 |
2019-04-10 |
Takeda Pharmaceutical Company Limited |
Heterocyclic compound
|
WO2012062750A1
(en)
|
2010-11-08 |
2012-05-18 |
Janssen Pharmaceuticals, Inc. |
1,2,4-TRIAZOLO[4,3-a]PYRIDINE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS
|
EP2643320B1
(en)
|
2010-11-08 |
2015-03-04 |
Janssen Pharmaceuticals, Inc. |
1,2,4-TRIAZOLO[4,3-a]PYRIDINE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS
|
AU2011328203B2
(en)
|
2010-11-08 |
2015-03-19 |
Janssen Pharmaceuticals, Inc. |
1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mGluR2 receptors
|
MX2014000648A
(es)
|
2011-07-19 |
2014-09-25 |
Infinity Pharmaceuticals Inc |
Compuestos heterociclicos y sus usos.
|
US20150119399A1
(en)
|
2012-01-10 |
2015-04-30 |
President And Fellows Of Harvard College |
Beta-cell replication promoting compounds and methods of their use
|
US20150297601A1
(en)
|
2012-10-05 |
2015-10-22 |
Robert I. Henkin |
Phosphodiesterase inhibitor treatment
|
JO3368B1
(ar)
|
2013-06-04 |
2019-03-13 |
Janssen Pharmaceutica Nv |
مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2
|
JO3367B1
(ar)
|
2013-09-06 |
2019-03-13 |
Janssen Pharmaceutica Nv |
مركبات 2،1، 4- ثلاثي زولو [3،4-a] بيريدين واستخدامها بصفة منظمات تفارغية موجبة لمستقبلات ميجلور 2
|
LT3431106T
(lt)
|
2014-01-21 |
2021-02-10 |
Janssen Pharmaceutica Nv |
Deriniai, apimantys 2 potipio metabotropinio glutamaterginio receptoriaus teigiamus alosterinius moduliatorius arba ortosterinius agonistus, ir jų panaudojimas
|
KR20220038826A
(ko)
|
2014-01-21 |
2022-03-29 |
얀센 파마슈티카 엔.브이. |
대사 조절형 글루탐산 작동성 수용체 제2아형의 양성 알로스테릭 조절제 또는 오르토스테릭 작동제를 포함하는 조합 및 그 용도
|
WO2015126944A1
(en)
|
2014-02-18 |
2015-08-27 |
Henkin Robert I |
Methods and compositions for diagnosing and treating loss and/or distortion of taste or smell
|
ES2749433T3
(es)
|
2014-06-23 |
2020-03-20 |
Celgene Corp |
Apremilast para el tratamiento de una enfermedad hepática o una anomalía de la función hepática
|
CN109311868B
(zh)
|
2015-12-22 |
2022-04-01 |
尚医治疗有限责任公司 |
用于治疗癌症和炎性疾病的化合物
|
EP3571205B1
(en)
|
2017-01-22 |
2023-08-30 |
Sunshine Lake Pharma Co., Ltd. |
Thienopyrimidine derivative and use thereof in medicine
|
IL310023A
(en)
|
2017-06-21 |
2024-03-01 |
SHY Therapeutics LLC |
Compounds interacting with the RAS superfamily for the treatment of cancer, inflammation, RAS pathology and fibrotic diseases
|