DK0931083T3 - Fremgangsmåde til fremstilling af ecteinascidinforbindelser - Google Patents
Fremgangsmåde til fremstilling af ecteinascidinforbindelserInfo
- Publication number
- DK0931083T3 DK0931083T3 DK97942526T DK97942526T DK0931083T3 DK 0931083 T3 DK0931083 T3 DK 0931083T3 DK 97942526 T DK97942526 T DK 97942526T DK 97942526 T DK97942526 T DK 97942526T DK 0931083 T3 DK0931083 T3 DK 0931083T3
- Authority
- DK
- Denmark
- Prior art keywords
- ecteinascidin
- compounds
- formation
- ecteinascidin compounds
- preparation
- Prior art date
Links
- PKVRCIRHQMSYJX-AIFWHQITSA-N trabectedin Chemical class C([C@@]1(C(OC2)=O)NCCC3=C1C=C(C(=C3)O)OC)S[C@@H]1C3=C(OC(C)=O)C(C)=C4OCOC4=C3[C@H]2N2[C@@H](O)[C@H](CC=3C4=C(O)C(OC)=C(C)C=3)N(C)[C@H]4[C@@H]21 PKVRCIRHQMSYJX-AIFWHQITSA-N 0.000 title abstract 5
- 238000000034 method Methods 0.000 title abstract 4
- XXPXYPLPSDPERN-UHFFFAOYSA-N Ecteinascidin 743 Natural products COc1cc2C(NCCc2cc1O)C(=O)OCC3N4C(O)C5Cc6cc(C)c(OC)c(O)c6C(C4C(S)c7c(OC(=O)C)c(C)c8OCOc8c37)N5C XXPXYPLPSDPERN-UHFFFAOYSA-N 0.000 abstract 2
- 230000015572 biosynthetic process Effects 0.000 abstract 2
- 229960000977 trabectedin Drugs 0.000 abstract 2
- 229930190585 Saframycin Natural products 0.000 abstract 1
- 239000002246 antineoplastic agent Substances 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
- 238000006257 total synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
- C07D317/64—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Saccharide Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/715,541 US5721362A (en) | 1996-09-18 | 1996-09-18 | Process for producing ecteinascidin compounds |
| PCT/US1997/016470 WO1998012198A1 (en) | 1996-09-18 | 1997-09-17 | Process for producing ecteinascidin compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0931083T3 true DK0931083T3 (da) | 2003-05-26 |
Family
ID=24874473
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK97942526T DK0931083T3 (da) | 1996-09-18 | 1997-09-17 | Fremgangsmåde til fremstilling af ecteinascidinforbindelser |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US5721362A (cs) |
| EP (1) | EP0931083B1 (cs) |
| JP (1) | JP4425995B2 (cs) |
| KR (1) | KR100358832B1 (cs) |
| CN (1) | CN1096463C (cs) |
| AT (1) | ATE232868T1 (cs) |
| AU (1) | AU738282B2 (cs) |
| BR (1) | BR9712073B1 (cs) |
| CA (1) | CA2266081C (cs) |
| CZ (1) | CZ299596B6 (cs) |
| DE (1) | DE69719201T2 (cs) |
| DK (1) | DK0931083T3 (cs) |
| ES (1) | ES2192273T3 (cs) |
| HU (1) | HU229407B1 (cs) |
| IL (2) | IL128993A0 (cs) |
| NO (1) | NO325345B1 (cs) |
| NZ (1) | NZ334704A (cs) |
| PL (1) | PL188572B1 (cs) |
| PT (1) | PT931083E (cs) |
| RU (1) | RU2194709C2 (cs) |
| WO (1) | WO1998012198A1 (cs) |
Families Citing this family (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL138856A0 (en) * | 1998-04-06 | 2001-10-31 | Univ Illinois | Semi-synthetic ecteinascidins |
| US6316214B1 (en) * | 1998-05-11 | 2001-11-13 | The Board Of Trustees Of The University Of Illinois | ETM-775 metabolite of ecteinascidin 743 |
| US6124292A (en) * | 1998-09-30 | 2000-09-26 | President And Fellows Of Harvard College | Synthetic analogs of ecteinascidin-743 |
| MY164077A (en) * | 1999-05-13 | 2017-11-30 | Pharma Mar Sa | Compositions and uses of et743 for treating cancer |
| AR035842A1 (es) * | 1999-05-14 | 2004-07-21 | Pharma Mar Sa | Metodo de hemisintesis para la formacion de compuestos intermediarios y derivados y de estructuras relacionadas con la ecteinascidina y de tetrahidroisoquinolinfenoles y compuestos intermediarios de aplicacion en dicho metodo |
| GB9918178D0 (en) * | 2000-05-15 | 1999-10-06 | Pharma Mar Sa | Synthetic methods |
| BG65893B1 (bg) * | 1999-05-14 | 2010-04-30 | Pharma Mar S.A. | Полусинтетичен метод и нови съединения |
| JP2003520801A (ja) | 2000-01-19 | 2003-07-08 | ザ・トラスティーズ・オブ・コランビア・ユニバーシティー・イン・ザ・シティー・オブ・ニューヨーク | サフラマイシン−エクテイナシジン系列の化合物、それらの使用及び合成 |
| CA2400614C (en) * | 2000-02-11 | 2010-10-19 | President And Fellows Of Harvard College | Synthetic process for an intermediate for ecteinascidin and phthalascidin compounds |
| US6815544B2 (en) | 2000-02-11 | 2004-11-09 | President And Fellows Of Harvard College | Synthetic process for an intermediate for ecteinascidin and phthalascidin compounds |
| US6569859B1 (en) | 2000-02-22 | 2003-05-27 | President And Fellows Of Harvard College | Synthetic analogs of ecteinascidin-743 |
| US7919493B2 (en) * | 2000-04-12 | 2011-04-05 | Pharma Mar, S.A. | Anititumoral ecteinascidin derivatives |
| IL152094A (en) * | 2000-04-12 | 2011-10-31 | Pharma Mar Sa | History of actinacidin and pharmaceutical preparations containing them as anti-cancer substances |
| US7420051B2 (en) * | 2000-05-15 | 2008-09-02 | Pharma Mar, S.A. | Synthetic process for the manufacture of an ecteinaschidin compound |
| IL152125A (en) * | 2000-05-15 | 2008-04-13 | Pharma Mar Sa | Process for the manufacture of ecteinascidin derivatives |
| MXPA02011319A (es) * | 2000-05-15 | 2003-06-06 | Pharma Mar Sa | Analogos antitumorales de ecteinascidina 743. |
| AU2002239565B2 (en) * | 2000-11-03 | 2007-11-15 | President And Fellows Of Harvard College | Saframycins, analogues and uses thereof |
| JP4391083B2 (ja) * | 2000-11-06 | 2009-12-24 | ファルマ・マール・ソシエダード・アノニマ | 効果的な抗腫瘍治療 |
| GB0117402D0 (en) | 2001-07-17 | 2001-09-05 | Pharma Mar Sa | New antitumoral derivatives of et-743 |
| GB0119243D0 (en) * | 2001-08-07 | 2001-10-03 | Pharma Mar Sa | Antitumoral analogs of ET-743 |
| JP4208469B2 (ja) * | 2002-01-29 | 2009-01-14 | 独立行政法人科学技術振興機構 | エクテナサイジン類の全合成方法、エクテナサイジン類に類縁構造を持つ前記全合成用中間体化合物類、及び該中間体化合物類の合成方法 |
| GB0202544D0 (en) * | 2002-02-04 | 2002-03-20 | Pharma Mar Sa | The synthesis of naturally occuring ecteinascidins and related compounds |
| GB0312407D0 (en) * | 2003-05-29 | 2003-07-02 | Pharma Mar Sau | Treatment |
| US7183054B2 (en) | 2003-06-03 | 2007-02-27 | President And Fellows Of Harvard College | Assay for identifying biological targets of polynucleotide-binding compounds |
| GB0324201D0 (en) * | 2003-10-15 | 2003-11-19 | Pharma Mar Sau | Improved antitumoral combinations |
| SI1689404T1 (sl) * | 2003-11-13 | 2009-02-28 | Pharma Mar Sau | Kombinacija et-743 s 5-fluorouracil pro zdravili za zdravljenje raka |
| GB0326486D0 (en) * | 2003-11-14 | 2003-12-17 | Pharma Mar Sau | Combination treatment |
| CA2545054A1 (en) * | 2003-11-14 | 2005-06-02 | Pharma Mar, S.A. | Combination therapy comprising the use of et-743 and paclitaxel for treating cancer |
| WO2006005602A2 (en) * | 2004-07-09 | 2006-01-19 | Pharma Mar, S.A. | Use of ecteinascidin in the treatment of cancer in patients with low level of brca1 |
| CN100396178C (zh) * | 2004-08-06 | 2008-06-25 | 中国科学院海洋研究所 | 一种玻璃海鞘的全人工养殖方法及简易型连续投饵装置 |
| JP2008514688A (ja) * | 2004-09-29 | 2008-05-08 | ファルマ・マル・エス・アー， ソシエダッド・ユニペルソナル | 抗炎症剤としてのエクテイナシジン化合物 |
| KR101287918B1 (ko) * | 2004-10-26 | 2013-07-19 | 오르토 바이오테크 프로덕츠 엘.피. | 엑티나시딘 ７４３과 조합된 페길화된 리포좀 독소루비신 |
| RS50510B (sr) | 2004-10-29 | 2010-03-02 | Pharma Mar S.A., Sociedad Unipersonal | Formulacije koje sadrže ekteinascidin i disaharid |
| GB0522082D0 (en) * | 2005-10-31 | 2005-12-07 | Pharma Mar Sa | Formulations |
| CN101157929B (zh) * | 2007-02-02 | 2012-05-23 | 中国科学院上海有机化学研究所 | 番红霉素的生物合成基因簇 |
| EP2201141A1 (en) * | 2007-10-19 | 2010-06-30 | Pharma Mar S.A. | Prognostic molecular markers for et-743 treatment |
| EP2576569B1 (en) | 2010-05-25 | 2015-01-14 | Pharma Mar S.A. | Synthetic process for the manufacture of ecteinascidin compounds and intermediates |
| ES2719091T3 (es) | 2010-11-12 | 2019-07-08 | Pharma Mar Sa | Terapia de combinación con un inhibidor mitótico |
| CN103304478B (zh) * | 2013-06-28 | 2016-04-20 | 四川大学 | 一类合成renieramycins型生物碱的中间体及其制备方法 |
| CN104557850B (zh) * | 2013-10-29 | 2019-07-30 | 江苏盛迪医药有限公司 | 一种海鞘碱-743中间体的制备方法 |
| CN103709101B (zh) * | 2013-12-19 | 2016-06-29 | 四川大学 | 一类renieramycin G的合成中间体及其制备方法 |
| JOP20190254A1 (ar) | 2017-04-27 | 2019-10-27 | Pharma Mar Sa | مركبات مضادة للأورام |
| CN111518110B (zh) * | 2019-02-01 | 2023-11-03 | 博瑞生物医药（苏州）股份有限公司 | 一种海鞘素化合物及其中间体的制备方法 |
| CN110092802B (zh) * | 2019-06-21 | 2022-01-07 | 爱斯特（成都）生物制药股份有限公司 | 一种制备曲贝替定中间体的方法 |
| US20220315605A1 (en) * | 2019-06-27 | 2022-10-06 | Msn Laboratories Private Limited, R&D Center | IMPROVED PROCESS FOR THE PREPARATON OF PURE (1'R,6R,6aR,7R,13S,14S,16R)-5-(ACETYLOXY)-3',4',6,6a,7,13,14,16-OCTAHYDRO-6',8,14-TRIHYDROXY-7',9-DIMETHOXY-4,10,23-TRIMETHYLSPIRO[6,16-(EPITHIOPROPANOXYMETH ANO)-7,13-IMINO-12H-1,3-DIOXOLO[7,8]ISOQUINO[3,2-b][3]BENZAZOCINE-20,1'(2'H)-ISOQUINOLIN]-19-ONE POLYMORPH THERE OF |
| CN118924688A (zh) | 2019-11-21 | 2024-11-12 | 法马马有限公司 | 用鲁比卡丁制剂治疗小细胞肺癌的方法 |
| CN114621245A (zh) * | 2020-12-11 | 2022-06-14 | 江苏恒瑞医药股份有限公司 | 一种曲贝替定中间体的晶型及其制备方法 |
| US12303506B2 (en) | 2022-01-20 | 2025-05-20 | Extrovis Ag | Trabectedin composition |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5089273A (en) * | 1986-06-09 | 1992-02-18 | Board Of Trustees Of The University Of Illinois | Ecteinascidins 729, 743, 745, 759A, 759B and 770 |
| US5256663A (en) * | 1986-06-09 | 1993-10-26 | The Board Of Trustees Of The University Of Illinois | Compositions comprising ecteinascidins and a method of treating herpes simplex virus infections therewith |
| US5149804A (en) * | 1990-11-30 | 1992-09-22 | The Board Of Trustees Of The University Of Illinois | Ecteinascidins 736 and 722 |
| DE3923985C1 (cs) * | 1989-07-20 | 1990-06-28 | Daimler-Benz Aktiengesellschaft, 7000 Stuttgart, De | |
| GB2252781B (en) * | 1991-02-14 | 1994-08-17 | Sanwa Shutter Corp | Architectural shutter curtain device |
| US5478932A (en) * | 1993-12-02 | 1995-12-26 | The Board Of Trustees Of The University Of Illinois | Ecteinascidins |
-
1996
- 1996-09-18 US US08/715,541 patent/US5721362A/en not_active Expired - Lifetime
-
1997
- 1997-09-17 RU RU99105564/04A patent/RU2194709C2/ru active
- 1997-09-17 WO PCT/US1997/016470 patent/WO1998012198A1/en not_active Ceased
- 1997-09-17 KR KR1019997002328A patent/KR100358832B1/ko not_active Expired - Lifetime
- 1997-09-17 PL PL97332206A patent/PL188572B1/pl unknown
- 1997-09-17 HU HU0000068A patent/HU229407B1/hu unknown
- 1997-09-17 DK DK97942526T patent/DK0931083T3/da active
- 1997-09-17 AT AT97942526T patent/ATE232868T1/de active
- 1997-09-17 IL IL12899397A patent/IL128993A0/xx active IP Right Grant
- 1997-09-17 CA CA002266081A patent/CA2266081C/en not_active Expired - Lifetime
- 1997-09-17 AU AU44205/97A patent/AU738282B2/en not_active Expired
- 1997-09-17 PT PT97942526T patent/PT931083E/pt unknown
- 1997-09-17 BR BRPI9712073-1B1A patent/BR9712073B1/pt not_active IP Right Cessation
- 1997-09-17 DE DE69719201T patent/DE69719201T2/de not_active Expired - Lifetime
- 1997-09-17 ES ES97942526T patent/ES2192273T3/es not_active Expired - Lifetime
- 1997-09-17 EP EP97942526A patent/EP0931083B1/en not_active Expired - Lifetime
- 1997-09-17 CN CN97199846A patent/CN1096463C/zh not_active Expired - Lifetime
- 1997-09-17 CZ CZ0091499A patent/CZ299596B6/cs not_active IP Right Cessation
- 1997-09-17 JP JP51483798A patent/JP4425995B2/ja not_active Expired - Lifetime
- 1997-09-17 NZ NZ334704A patent/NZ334704A/xx not_active IP Right Cessation
-
1999
- 1999-03-15 IL IL128993A patent/IL128993A/en not_active IP Right Cessation
- 1999-03-17 NO NO19991301A patent/NO325345B1/no not_active IP Right Cessation
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