DK0919540T3 - Fremgangsmåde til fremstilling af oprenset krystallinsk iohexol - Google Patents
Fremgangsmåde til fremstilling af oprenset krystallinsk iohexolInfo
- Publication number
- DK0919540T3 DK0919540T3 DK97308629T DK97308629T DK0919540T3 DK 0919540 T3 DK0919540 T3 DK 0919540T3 DK 97308629 T DK97308629 T DK 97308629T DK 97308629 T DK97308629 T DK 97308629T DK 0919540 T3 DK0919540 T3 DK 0919540T3
- Authority
- DK
- Denmark
- Prior art keywords
- iohexole
- preparation
- purified crystalline
- iohexol
- residual solvents
- Prior art date
Links
- NTHXOOBQLCIOLC-UHFFFAOYSA-N iohexol Chemical compound OCC(O)CN(C(=O)C)C1=C(I)C(C(=O)NCC(O)CO)=C(I)C(C(=O)NCC(O)CO)=C1I NTHXOOBQLCIOLC-UHFFFAOYSA-N 0.000 abstract 2
- 229960001025 iohexol Drugs 0.000 abstract 2
- 239000013557 residual solvent Substances 0.000 abstract 2
- 238000001035 drying Methods 0.000 abstract 1
- 230000008030 elimination Effects 0.000 abstract 1
- 238000003379 elimination reaction Methods 0.000 abstract 1
- 238000001914 filtration Methods 0.000 abstract 1
- 239000012530 fluid Substances 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000746 purification Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/22—Separation; Purification; Stabilisation; Use of additives
- C07C231/24—Separation; Purification
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Steroid Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (12)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PT101919A PT101919B (pt) | 1996-09-30 | 1996-09-30 | Um processo para a purificacao de tohexol |
| AU42807/97A AU696647B1 (en) | 1996-09-30 | 1997-10-21 | Process for the preparation of crystalline and solvent free iohexol |
| ZA9709448A ZA979448B (en) | 1996-09-30 | 1997-10-22 | Process for the preparation of crystalline and solvent free iohexol. |
| HU9701706A HU219881B (hu) | 1996-09-30 | 1997-10-22 | Eljárás kristályos és oldószermentes iohexol elõállítására és az elõállított iohexol |
| NO974898A NO307927B1 (no) | 1996-09-30 | 1997-10-23 | FremgangsmÕte ved rensing av ioheksol |
| EP97308629A EP0919540B1 (en) | 1996-09-30 | 1997-10-29 | Process for the preparation of purified crystalline iohexol |
| US08/964,339 US6469208B1 (en) | 1996-09-30 | 1997-11-04 | Process for the preparation of crystalline and solvent free iohexol |
| CZ973499A CZ285922B6 (cs) | 1996-09-30 | 1997-11-05 | Způsob průmyslové výroby krystalického iohexolu |
| JP9302830A JP3045697B2 (ja) | 1996-09-30 | 1997-11-05 | 残留溶媒量の少ない結晶質イオヘキソールの製造方法 |
| CN97122538A CN1217314A (zh) | 1996-09-30 | 1997-11-12 | 制备晶态的且不含溶剂的碘己醇的方法 |
| CA002223373A CA2223373A1 (en) | 1996-09-30 | 1997-12-03 | Process for the preparation of crystalline and solvent free iohexol |
| BR9706099A BR9706099A (pt) | 1996-09-30 | 1997-12-16 | Processo para a preparação de iohexol cristalino isento de solventes e iohexol cristalino obtido |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0919540T3 true DK0919540T3 (da) | 2003-01-13 |
Family
ID=89995677
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK97308629T DK0919540T3 (da) | 1996-09-30 | 1997-10-29 | Fremgangsmåde til fremstilling af oprenset krystallinsk iohexol |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US6469208B1 (cs) |
| EP (1) | EP0919540B1 (cs) |
| JP (1) | JP3045697B2 (cs) |
| CN (1) | CN1217314A (cs) |
| AT (1) | ATE224359T1 (cs) |
| AU (1) | AU696647B1 (cs) |
| BR (1) | BR9706099A (cs) |
| CA (1) | CA2223373A1 (cs) |
| CZ (1) | CZ285922B6 (cs) |
| DE (1) | DE69715638T2 (cs) |
| DK (1) | DK0919540T3 (cs) |
| ES (1) | ES2183092T3 (cs) |
| HU (1) | HU219881B (cs) |
| NO (1) | NO307927B1 (cs) |
| PT (1) | PT101919B (cs) |
| TW (1) | TW457225B (cs) |
| ZA (1) | ZA979448B (cs) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ITMI20010773A1 (it) * | 2001-04-11 | 2002-10-11 | Chemi Spa | Processo per la produzione di ioexolo ad elevata purezza |
| KR20030032184A (ko) * | 2001-10-16 | 2003-04-26 | 동국제약 주식회사 | 이오헥솔의 결정화방법 |
| DE602004019685D1 (de) * | 2003-12-26 | 2009-04-09 | Allergan Inc | DISUBSTITUIERTE CHALCOGENOXIME MIT ANTAGONISTISCHER WIRKUNG AM RAR(Gamma)-RETINOIDREZEPTOR |
| NO20053676D0 (no) * | 2005-07-29 | 2005-07-29 | Amersham Health As | Crystallisation Process |
| NO20053687D0 (no) * | 2005-07-29 | 2005-07-29 | Amersham Health As | Crystallisation Process. |
| PT103391B (pt) * | 2005-11-24 | 2008-10-30 | Hovione Farmaciencia S A | Processo para fabrico de lohexol |
| FR2899581B1 (fr) * | 2006-04-07 | 2008-06-27 | Guerbet Sa | Procede d'atomisation du ioxilan |
| EP3113802A1 (en) * | 2014-03-04 | 2017-01-11 | Otsuka Pharmaceutical Co., Ltd. | Iohexol powder and method of using the same |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1548594A (en) * | 1976-06-11 | 1979-07-18 | Nyegaard & Co As | Triiodoisophthalic acid amides |
| US5204086A (en) * | 1982-10-01 | 1993-04-20 | Nycomed Imaging As | X-ray contrast agent |
| US5191119A (en) * | 1983-10-20 | 1993-03-02 | Cook Imaging Corp. | Process for producing non-ionic radiographic contrast media utilizing N-allylation |
| US5527926A (en) * | 1990-11-26 | 1996-06-18 | Bracco International B.V. | Methods and compositions for using non-ionic contrast agents to reduce the risk of clot formation in diagnostic procedures |
| AU642066B2 (en) * | 1991-01-25 | 1993-10-07 | Nanosystems L.L.C. | X-ray contrast compositions useful in medical imaging |
| IL110391A (en) * | 1993-07-30 | 1998-12-06 | Zambon Spa | Process for the formation of infamidol |
| US5705929A (en) | 1995-05-23 | 1998-01-06 | Fibercorp. Inc. | Battery capacity monitoring system |
| PT101720A (pt) * | 1995-06-08 | 1997-01-31 | Hovione Sociedade Quimica S A | Processo para a purificacao e cristalizacao de iopamidol |
-
1996
- 1996-09-30 PT PT101919A patent/PT101919B/pt not_active IP Right Cessation
-
1997
- 1997-10-21 AU AU42807/97A patent/AU696647B1/en not_active Ceased
- 1997-10-22 ZA ZA9709448A patent/ZA979448B/xx unknown
- 1997-10-22 HU HU9701706A patent/HU219881B/hu not_active IP Right Cessation
- 1997-10-23 NO NO974898A patent/NO307927B1/no not_active IP Right Cessation
- 1997-10-29 AT AT97308629T patent/ATE224359T1/de active
- 1997-10-29 DE DE69715638T patent/DE69715638T2/de not_active Expired - Lifetime
- 1997-10-29 EP EP97308629A patent/EP0919540B1/en not_active Expired - Lifetime
- 1997-10-29 ES ES97308629T patent/ES2183092T3/es not_active Expired - Lifetime
- 1997-10-29 DK DK97308629T patent/DK0919540T3/da active
- 1997-11-04 US US08/964,339 patent/US6469208B1/en not_active Expired - Lifetime
- 1997-11-05 CZ CZ973499A patent/CZ285922B6/cs not_active IP Right Cessation
- 1997-11-05 JP JP9302830A patent/JP3045697B2/ja not_active Expired - Fee Related
- 1997-11-07 TW TW086116640A patent/TW457225B/zh not_active IP Right Cessation
- 1997-11-12 CN CN97122538A patent/CN1217314A/zh active Pending
- 1997-12-03 CA CA002223373A patent/CA2223373A1/en not_active Abandoned
- 1997-12-16 BR BR9706099A patent/BR9706099A/pt not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| PT101919B (pt) | 2000-01-31 |
| HUP9701706A3 (en) | 1999-12-28 |
| CZ349997A3 (cs) | 1999-07-14 |
| DE69715638D1 (de) | 2002-10-24 |
| EP0919540B1 (en) | 2002-09-18 |
| US6469208B1 (en) | 2002-10-22 |
| HU9701706D0 (en) | 1997-12-29 |
| ZA979448B (en) | 1998-07-29 |
| JP3045697B2 (ja) | 2000-05-29 |
| HUP9701706A2 (hu) | 1999-06-28 |
| CA2223373A1 (en) | 1999-06-03 |
| HU219881B (hu) | 2001-08-28 |
| ATE224359T1 (de) | 2002-10-15 |
| CZ285922B6 (cs) | 1999-11-17 |
| NO307927B1 (no) | 2000-06-19 |
| NO974898L (no) | 1999-04-26 |
| AU696647B1 (en) | 1998-09-17 |
| NO974898D0 (no) | 1997-10-23 |
| BR9706099A (pt) | 1999-07-13 |
| DE69715638T2 (de) | 2003-08-07 |
| JPH11158136A (ja) | 1999-06-15 |
| ES2183092T3 (es) | 2003-03-16 |
| EP0919540A1 (en) | 1999-06-02 |
| PT101919A (pt) | 1998-04-30 |
| CN1217314A (zh) | 1999-05-26 |
| TW457225B (en) | 2001-10-01 |
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