DK0915870T3 - Substituerede bisindolylmaleimider til bekæmpelse af celleprofileration - Google Patents
Substituerede bisindolylmaleimider til bekæmpelse af celleprofilerationInfo
- Publication number
- DK0915870T3 DK0915870T3 DK97918934T DK97918934T DK0915870T3 DK 0915870 T3 DK0915870 T3 DK 0915870T3 DK 97918934 T DK97918934 T DK 97918934T DK 97918934 T DK97918934 T DK 97918934T DK 0915870 T3 DK0915870 T3 DK 0915870T3
- Authority
- DK
- Denmark
- Prior art keywords
- cell profiling
- bisindolylmaleimides
- substituted
- combat
- combat cell
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2207896P | 1996-07-29 | 1996-07-29 | |
| US4849697P | 1997-06-03 | 1997-06-03 | |
| PCT/EP1997/003888 WO1998004551A1 (fr) | 1996-07-29 | 1997-07-19 | Bis-indolylmaleimides substitues destines a inhiber la proliferation cellulaire |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0915870T3 true DK0915870T3 (da) | 2003-02-03 |
Family
ID=26695475
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK97918934T DK0915870T3 (da) | 1996-07-29 | 1997-07-19 | Substituerede bisindolylmaleimider til bekæmpelse af celleprofileration |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US6228877B1 (fr) |
| EP (1) | EP0915870B1 (fr) |
| JP (1) | JP2000516588A (fr) |
| KR (1) | KR20000029640A (fr) |
| CN (1) | CN1077571C (fr) |
| AR (1) | AR007969A1 (fr) |
| AT (1) | ATE224889T1 (fr) |
| AU (1) | AU740011B2 (fr) |
| BR (1) | BR9711607A (fr) |
| CA (1) | CA2262089A1 (fr) |
| CO (1) | CO4900054A1 (fr) |
| DE (1) | DE69715870T2 (fr) |
| DK (1) | DK0915870T3 (fr) |
| ES (1) | ES2183163T3 (fr) |
| HR (1) | HRP970415A2 (fr) |
| MA (1) | MA24354A1 (fr) |
| PE (1) | PE91598A1 (fr) |
| PT (1) | PT915870E (fr) |
| TR (1) | TR199900186T2 (fr) |
| WO (1) | WO1998004551A1 (fr) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1127500C (zh) * | 1998-03-17 | 2003-11-12 | 弗·哈夫曼-拉罗切有限公司 | 抑制细胞增殖的取代双吲哚基马来酰亚胺 |
| US6350786B1 (en) | 1998-09-22 | 2002-02-26 | Hoffmann-La Roche Inc. | Stable complexes of poorly soluble compounds in ionic polymers |
| US6559164B1 (en) | 1999-10-12 | 2003-05-06 | Hoffmann-La Roche Inc. | Substituted pyrroles suitable for continuous infusion |
| DK1224181T3 (da) * | 1999-10-12 | 2004-04-13 | Hoffmann La Roche | Substituerede pyrroler som antiproliferative midler til behandling af cancer |
| US6313143B1 (en) | 1999-12-16 | 2001-11-06 | Hoffmann-La Roche Inc. | Substituted pyrroles |
| US6281356B1 (en) * | 1999-12-22 | 2001-08-28 | Hoffmann-La Roche Inc. | Substituted pyrroles |
| US6326501B1 (en) * | 2000-04-19 | 2001-12-04 | Hoffmann-La Roche Inc. | Methylation of indole compounds using dimethyl carbonate |
| US7129250B2 (en) * | 2000-05-19 | 2006-10-31 | Aegera Therapeutics Inc. | Neuroprotective and anti-proliferative compounds |
| CA2308994A1 (fr) * | 2000-05-19 | 2001-11-19 | Aegera Therapeutics Inc. | Composes neuroprotecteurs |
| TWI335221B (en) | 2001-09-27 | 2011-01-01 | Alcon Inc | Inhibtors of glycogen synthase kinase-3 (gsk-3) for treating glaucoma |
| US20030143185A1 (en) * | 2001-10-29 | 2003-07-31 | Shearwater Corporation | Polymer conjugates of protein kinase C inhibitors |
| CA2393720C (fr) * | 2002-07-12 | 2010-09-14 | Eli Lilly And Company | Monochlorhydrate de 3-(1-methyl-1h-indol-3-yl)-4-[[1-(pyridin-2-ylmethyl)piperidin-4-yl]-1h-indol-3-yl]-1h-pyrrole-2,5-dione cristallin |
| RS51826B (en) | 2005-02-09 | 2012-02-29 | Arqule Inc. | MALEIMID DERIVATIVES, PHARMACEUTICAL COMPOSITIONS AND THE PROCESS OF CANCER TREATMENT |
| KR20090100363A (ko) | 2006-12-19 | 2009-09-23 | 노파르티스 아게 | 키나제 억제제로서의 인돌릴말레이미드 유도체 |
| CN101801937A (zh) | 2007-06-22 | 2010-08-11 | 艾科尔公司 | 喹唑啉酮化合物及其使用方法 |
| US8304425B2 (en) * | 2007-06-22 | 2012-11-06 | Arqule, Inc. | Pyrrolidinone, pyrrolidine-2,5-dione, pyrrolidine and thiosuccinimide derivatives, compositions and methods for treatment of cancer |
| JP5490688B2 (ja) | 2007-06-22 | 2014-05-14 | アークル インコーポレイテッド | 癌の治療のためのインドリルピロリジン |
| GB201111427D0 (en) * | 2011-07-05 | 2011-08-17 | Amakem Nv | Novel bisindolylmaleimides, pan-pkc inhibitors |
| EP3741375A1 (fr) | 2014-07-17 | 2020-11-25 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Procédés de traitement de maladies associées aux jonctions neuromusculaires |
| WO2016207366A1 (fr) | 2015-06-26 | 2016-12-29 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Méthodes et compositions pharmaceutiques de traitement d'infections virales |
| CN105777751B (zh) * | 2016-04-26 | 2018-12-11 | 浙江工业大学 | 一种双芳基马来酰亚胺类化合物及其药学上可接受的盐及其制备方法和应用 |
| CN107973785B (zh) * | 2017-11-27 | 2019-12-31 | 浙江工业大学上虞研究院有限公司 | 一种用于检测银离子的荧光探针及其制备方法和应用 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SK75289A3 (en) | 1988-02-10 | 1998-05-06 | Hoffmann La Roche | Substituted pyrroles, their use for producing a drug, and the drug on their base |
| US5380746A (en) | 1989-05-05 | 1995-01-10 | Goedecke Aktiengesellschaft | Bis-(1H-indol-3-YL)-maleinimide derivatives, processes for the preparation thereof and pharmaceutical compositions containing them |
| IL94274A0 (en) * | 1989-05-05 | 1991-03-10 | Goedecke Ag | Maleinimide derivatives,process for the preparation thereof and pharmaceutical compositions containing the same |
| JPH0539289A (ja) | 1991-02-15 | 1993-02-19 | Masahiro Irie | 無水マレイン酸誘導体およびその製造方法 |
| EP0630241A1 (fr) | 1992-03-20 | 1994-12-28 | The Wellcome Foundation Limited | Derives d'indole presentant une action antivirale |
| DE4217964A1 (de) | 1992-05-30 | 1993-12-02 | Goedecke Ag | Indolocarbazol-Imide und deren Verwendung |
-
1997
- 1997-07-15 PE PE1997000629A patent/PE91598A1/es not_active Application Discontinuation
- 1997-07-19 DE DE69715870T patent/DE69715870T2/de not_active Expired - Fee Related
- 1997-07-19 DK DK97918934T patent/DK0915870T3/da active
- 1997-07-19 PT PT97918934T patent/PT915870E/pt unknown
- 1997-07-19 CA CA002262089A patent/CA2262089A1/fr not_active Abandoned
- 1997-07-19 EP EP97918934A patent/EP0915870B1/fr not_active Expired - Lifetime
- 1997-07-19 AT AT97918934T patent/ATE224889T1/de not_active IP Right Cessation
- 1997-07-19 TR TR1999/00186T patent/TR199900186T2/xx unknown
- 1997-07-19 KR KR1019997000711A patent/KR20000029640A/ko active IP Right Grant
- 1997-07-19 BR BR9711607A patent/BR9711607A/pt not_active IP Right Cessation
- 1997-07-19 ES ES97918934T patent/ES2183163T3/es not_active Expired - Lifetime
- 1997-07-19 AU AU42963/97A patent/AU740011B2/en not_active Ceased
- 1997-07-19 CN CN97196783A patent/CN1077571C/zh not_active Expired - Fee Related
- 1997-07-19 JP JP10508452A patent/JP2000516588A/ja not_active Ceased
- 1997-07-19 WO PCT/EP1997/003888 patent/WO1998004551A1/fr active IP Right Grant
- 1997-07-22 AR ARP970103308A patent/AR007969A1/es unknown
- 1997-07-25 CO CO97042636A patent/CO4900054A1/es unknown
- 1997-07-25 HR HR60/048,496A patent/HRP970415A2/hr not_active Application Discontinuation
- 1997-07-29 MA MA24743A patent/MA24354A1/fr unknown
-
1998
- 1998-12-22 US US09/218,404 patent/US6228877B1/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JP2000516588A (ja) | 2000-12-12 |
| TR199900186T2 (xx) | 1999-03-22 |
| CA2262089A1 (fr) | 1998-02-05 |
| PE91598A1 (es) | 1998-12-24 |
| CN1226248A (zh) | 1999-08-18 |
| EP0915870B1 (fr) | 2002-09-25 |
| DE69715870D1 (de) | 2002-10-31 |
| AU4296397A (en) | 1998-02-20 |
| WO1998004551A1 (fr) | 1998-02-05 |
| AR007969A1 (es) | 1999-11-24 |
| CN1077571C (zh) | 2002-01-09 |
| KR20000029640A (ko) | 2000-05-25 |
| DE69715870T2 (de) | 2003-06-18 |
| ATE224889T1 (de) | 2002-10-15 |
| HRP970415A2 (en) | 1998-08-31 |
| PT915870E (pt) | 2003-01-31 |
| EP0915870A1 (fr) | 1999-05-19 |
| MA24354A1 (fr) | 1998-07-01 |
| AU740011B2 (en) | 2001-10-25 |
| ES2183163T3 (es) | 2003-03-16 |
| US6228877B1 (en) | 2001-05-08 |
| BR9711607A (pt) | 1999-08-24 |
| CO4900054A1 (es) | 2000-03-27 |
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