DK0891362T3 - Pyrrolopyrrolon derivater som inhibitorer for neutrofil elastase - Google Patents

Pyrrolopyrrolon derivater som inhibitorer for neutrofil elastase

Info

Publication number
DK0891362T3
DK0891362T3 DK97915439T DK97915439T DK0891362T3 DK 0891362 T3 DK0891362 T3 DK 0891362T3 DK 97915439 T DK97915439 T DK 97915439T DK 97915439 T DK97915439 T DK 97915439T DK 0891362 T3 DK0891362 T3 DK 0891362T3
Authority
DK
Denmark
Prior art keywords
inhibitors
neutrophil elastase
pyrrolopyrrolone
derivatives
pyrrolopyrrolone derivatives
Prior art date
Application number
DK97915439T
Other languages
Danish (da)
English (en)
Inventor
Michael Dennis Dowle
Harry Finch
Lee Andrew Harrison
Graham George Adam Inglis
Martin Redpath Johnson
Simon John Fawcett Macdonald
Pritom Shah
Robin Andrew Smith
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9606508.1A external-priority patent/GB9606508D0/en
Priority claimed from GBGB9623001.6A external-priority patent/GB9623001D0/en
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Application granted granted Critical
Publication of DK0891362T3 publication Critical patent/DK0891362T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/14—Nitrogen atoms not forming part of a nitro radical

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Dermatology (AREA)
  • Vascular Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DK97915439T 1996-03-28 1997-03-26 Pyrrolopyrrolon derivater som inhibitorer for neutrofil elastase DK0891362T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9606508.1A GB9606508D0 (en) 1996-03-28 1996-03-28 Chemical componds
GBGB9623001.6A GB9623001D0 (en) 1996-11-05 1996-11-05 Chemical compounds
PCT/EP1997/001530 WO1997036903A1 (en) 1996-03-28 1997-03-26 Pyrrolopyrrolone derivatives as inhibitors of neutrophil elastase

Publications (1)

Publication Number Publication Date
DK0891362T3 true DK0891362T3 (da) 2004-07-12

Family

ID=26309008

Family Applications (1)

Application Number Title Priority Date Filing Date
DK97915439T DK0891362T3 (da) 1996-03-28 1997-03-26 Pyrrolopyrrolon derivater som inhibitorer for neutrofil elastase

Country Status (30)

Country Link
US (3) US5994344A (de)
EP (1) EP0891362B1 (de)
JP (1) JP4118337B2 (de)
KR (1) KR20000005039A (de)
CN (1) CN1067075C (de)
AP (1) AP823A (de)
AR (1) AR006401A1 (de)
AT (1) ATE261969T1 (de)
AU (1) AU726649B2 (de)
BR (1) BR9708449A (de)
CA (1) CA2250209A1 (de)
CO (1) CO4790152A1 (de)
CZ (1) CZ309798A3 (de)
DE (1) DE69728139T2 (de)
DK (1) DK0891362T3 (de)
EA (1) EA001437B1 (de)
EE (1) EE9800335A (de)
ES (1) ES2217404T3 (de)
HU (1) HUP9900567A3 (de)
IL (1) IL125859A0 (de)
IS (1) IS4837A (de)
NO (1) NO984470L (de)
NZ (1) NZ331490A (de)
PE (1) PE55298A1 (de)
PL (1) PL329153A1 (de)
PT (1) PT891362E (de)
SK (1) SK132498A3 (de)
TR (1) TR199801935T2 (de)
WO (1) WO1997036903A1 (de)
YU (1) YU41198A (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9719189D0 (en) * 1997-09-09 1997-11-12 Glaxo Group Ltd New therapeutic method
PE107899A1 (es) * 1997-09-09 1999-11-17 Glaxo Group Ltd Derivados de pirrolopirrolona como inhibidores de elastasa leucocitaria
GB9719172D0 (en) * 1997-09-09 1997-11-12 Glaxo Group Ltd Compounds
GB9719187D0 (en) * 1997-09-09 1997-11-12 Glaxo Group Ltd Compounds
GB9821199D0 (en) * 1998-09-30 1998-11-25 Glaxo Group Ltd Chemical compounds
GB9905418D0 (en) * 1999-03-09 1999-05-05 Glaxo Group Ltd Process
WO2004081015A1 (en) * 2003-03-10 2004-09-23 Hetero Drugs Limited Amorphous clopidogrel hydrogen sulfate
WO2004080966A1 (ja) 2003-03-14 2004-09-23 Ono Pharmaceutical Co., Ltd. 含窒素複素環誘導体およびそれらを有効成分とする薬剤
AU2007351866C1 (en) * 2003-06-20 2013-07-25 Siga Technologies, Inc. Chemicals, compositions, and methods for treatment and prevention of orthopoxvirus infections and associated diseases
US8530509B2 (en) 2003-06-20 2013-09-10 Siga Technologies, Inc. Compounds, compositions and methods for treatment and prevention of orthopoxvirus infections and associated diseases
US7692037B2 (en) * 2004-09-02 2010-04-06 Eastman Chemical Company Optimized liquid-phase oxidation
GB2418427A (en) 2004-09-02 2006-03-29 Univ Cambridge Tech Ligands for G-protein coupled receptors
KR101231466B1 (ko) 2004-09-13 2013-02-07 오노 야꾸힝 고교 가부시키가이샤 질소 함유 복소환 유도체 및 이들을 유효 성분으로 하는약제
GB0512238D0 (en) * 2005-06-15 2005-07-27 Univ Cambridge Tech Anti-inflammatory agents
CA2644368A1 (en) 2006-03-10 2007-09-20 Ono Pharmaceutical Co., Ltd. Nitrogenated heterocyclic derivative, and pharmaceutical agent comprising the derivative as active ingredient
MX2010005298A (es) 2007-11-16 2010-06-30 Rigel Pharmaceuticals Inc Compuestos de carboxamida, sulfonamida y amina para trastornos metabolicos.
US8129390B2 (en) 2007-12-12 2012-03-06 Rigel Pharmaceuticals, Inc. Carboxamide, sulfonamide and amine compounds and methods for using the same
CN102099357B (zh) 2008-04-23 2014-07-02 里格尔药品股份有限公司 用于治疗代谢障碍的甲酰胺化合物
EA028507B1 (ru) * 2012-12-18 2017-11-30 КЬЕЗИ ФАРМАЧЕУТИЧИ С.п.А. Соединения
US20220354833A1 (en) 2019-09-17 2022-11-10 Mereo Biopharma 4 Limited Alvelestat for use in the treatment of graft rejection, bronchiolitis obliterans syndrome and graft versus host disease
IL297211A (en) 2020-04-16 2022-12-01 Mereo Biopharma 4 Ltd Methods involving the neutrophil elastase inhibitor albalstat for the treatment of respiratory disease mediated by alpha-1 antitrypsin deficiency
CA3234399A1 (en) 2021-10-20 2023-04-27 Mereo Biopharma 4 Limited Neutrophil elastase inhibitors for use in the treatment of fibrosis

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2932650A (en) * 1957-11-19 1960-04-12 Arthur C Cope 2-6-diazabicyclo (3. 3. 0) octanes
US4997950A (en) * 1989-04-20 1991-03-05 Richard Finbar Murphy Novel C-terminal gastrin antagonists
GB9211783D0 (en) * 1992-06-04 1992-07-15 Ici Plc Amide derivatives
GB9402680D0 (en) * 1994-02-11 1994-04-06 Zeneca Ltd Pyrrolidine derivatives
US5610296A (en) * 1994-12-05 1997-03-11 G. D. Searle & Co. Process for the preparation of amidino phenyl pyrrolidine beta-alanine urea analogs

Also Published As

Publication number Publication date
HUP9900567A3 (en) 2001-02-28
ES2217404T3 (es) 2004-11-01
PT891362E (pt) 2004-08-31
PL329153A1 (en) 1999-03-15
CN1067075C (zh) 2001-06-13
CA2250209A1 (en) 1997-10-09
NO984470D0 (no) 1998-09-25
AU726649B2 (en) 2000-11-16
CZ309798A3 (cs) 1999-02-17
NZ331490A (en) 2000-06-23
EA199800773A1 (ru) 1999-06-24
EP0891362A1 (de) 1999-01-20
HUP9900567A2 (hu) 1999-06-28
IS4837A (is) 1998-08-28
EE9800335A (et) 1999-04-15
US5994344A (en) 1999-11-30
YU41198A (sh) 1999-09-27
CN1219935A (zh) 1999-06-16
NO984470L (no) 1998-11-25
AU2291797A (en) 1997-10-22
SK132498A3 (en) 1999-08-06
US6057457A (en) 2000-05-02
DE69728139T2 (de) 2004-10-21
ATE261969T1 (de) 2004-04-15
PE55298A1 (es) 1998-09-19
KR20000005039A (ko) 2000-01-25
AR006401A1 (es) 1999-08-25
DE69728139D1 (de) 2004-04-22
AP823A (en) 2000-04-25
CO4790152A1 (es) 1999-05-31
IL125859A0 (en) 1999-04-11
US6215002B1 (en) 2001-04-10
EA001437B1 (ru) 2001-02-26
AP9801351A0 (en) 1998-09-30
BR9708449A (pt) 1999-08-03
JP4118337B2 (ja) 2008-07-16
TR199801935T2 (xx) 1999-03-22
WO1997036903A1 (en) 1997-10-09
EP0891362B1 (de) 2004-03-17
JP2000507950A (ja) 2000-06-27

Similar Documents

Publication Publication Date Title
DK0891362T3 (da) Pyrrolopyrrolon derivater som inhibitorer for neutrofil elastase
FI944804A0 (fi) Pyrimidinyyliasetamideja elastaasin estäjinä
NO992725L (no) 6-Fenylpyridyl-2-amin-derivater anvendelige som NOS-inhibitorer
NO980467L (no) 4-mercaptopyrrolidin-derivater som farnesyl-transerase-inhibitorer
NO986090D0 (no) Fenylalaninderivater som integrininhibitorer
DK2253620T3 (da) Substituerede 3-cyanoquinoliner som protein-tyrosinkinase-inhibitorer
NO992821D0 (no) Ketobenzamider som calpain-inhibitorer
NO985874D0 (no) Bestemte fosfinylderivater nyttige som naaladase inhibitorer
NO20002958D0 (no) Benzamidinderivater som koagulasjonsfaktor Xa-hemmere
NO973539D0 (no) Prolinderivater anvendelige som inhibitorer for human leukocyttelastase
NO20010331L (no) Ftalazinderivater som fosfodiesterase 4-inhibitorer
EE200000138A (et) Pürrolopürrolooni derivaadid neutrofiili elastaasi inhibiitoritena
DE69706823T2 (de) Bicyclische 4-aralkylaminopyrimidin-derivate als tyrosinkinase-inhibitoren
DE69736109D1 (de) Differenzierungsinhibitor
NO991316D0 (no) 3-mercaptoacetylamino-1,5-substituerte-2-okso-azepanderivater som er anvendbare som inhibitorer av matriksmetalloproteinase
DK0937036T3 (da) Substituerede 4-biphenyl-4-hydroxysmørsyrederivater som matrixmetalprotease-inhibitorer
EE200000137A (et) Pürrolopürrolooni derivaadid neutrofiili elastaasi inhibiitoritena
NO992858L (no) Inhibitor for portahypertensjon
ID23866A (id) Komposisi untuk menyelamatkan beras terhadap asetoklor
ZA988160B (en) Pyrrolopyrrolone derivatives as inhibitors of neutrophil elastase.
DE69418656T2 (de) 2-acyloxycephemderivate als elastaseinhibitoren
SI0891362T1 (en) Pyrrolopyrrolone derivatives as inhibitors of neutrophil elastase
NO965353D0 (no) 3-amino-2-okso-1-piperidineddiksyrederivater som enzyminhibitorer
NO20000860D0 (no) Syklopeptidderivater som adhesjonsinhibitorer