DK0832075T3 - N-(2,4-dioxo-2,3,4,5-tetrahydro-1H-1,5-benzo-diazepin-3-yl)-3-amider - Google Patents

N-(2,4-dioxo-2,3,4,5-tetrahydro-1H-1,5-benzo-diazepin-3-yl)-3-amider

Info

Publication number
DK0832075T3
DK0832075T3 DK96916983T DK96916983T DK0832075T3 DK 0832075 T3 DK0832075 T3 DK 0832075T3 DK 96916983 T DK96916983 T DK 96916983T DK 96916983 T DK96916983 T DK 96916983T DK 0832075 T3 DK0832075 T3 DK 0832075T3
Authority
DK
Denmark
Prior art keywords
diazepin
dioxo
benzo
tetrahydro
amides
Prior art date
Application number
DK96916983T
Other languages
Danish (da)
English (en)
Inventor
David A Claremon
Roger M Freidinger
Nigel Liverton
Harold G Selnick
Garry R Smith
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Application granted granted Critical
Publication of DK0832075T3 publication Critical patent/DK0832075T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/12—1,5-Benzodiazepines; Hydrogenated 1,5-benzodiazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DK96916983T 1995-06-07 1996-06-03 N-(2,4-dioxo-2,3,4,5-tetrahydro-1H-1,5-benzo-diazepin-3-yl)-3-amider DK0832075T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/474,801 US5691331A (en) 1995-06-07 1995-06-07 N-(2,4-Dioxo-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-3yl) -3- amides
PCT/US1996/008400 WO1996040655A1 (en) 1995-06-07 1996-06-03 Novel n-(2,4-dioxo-2,3,4,5-tetrahydro-1h-1,5-benzodiazepin-3y l)-3-amides

Publications (1)

Publication Number Publication Date
DK0832075T3 true DK0832075T3 (da) 2000-11-20

Family

ID=23884989

Family Applications (1)

Application Number Title Priority Date Filing Date
DK96916983T DK0832075T3 (da) 1995-06-07 1996-06-03 N-(2,4-dioxo-2,3,4,5-tetrahydro-1H-1,5-benzo-diazepin-3-yl)-3-amider

Country Status (12)

Country Link
US (1) US5691331A (pt)
EP (1) EP0832075B1 (pt)
JP (1) JPH11506758A (pt)
AT (1) ATE196899T1 (pt)
AU (1) AU704015B2 (pt)
CA (1) CA2222492A1 (pt)
DE (1) DE69610628T2 (pt)
DK (1) DK0832075T3 (pt)
ES (1) ES2151168T3 (pt)
GR (1) GR3034602T3 (pt)
PT (1) PT832075E (pt)
WO (1) WO1996040655A1 (pt)

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US6509331B1 (en) 1998-06-22 2003-01-21 Elan Pharmaceuticals, Inc. Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US6552013B1 (en) 1998-06-22 2003-04-22 Elan Pharmaceuticals, Inc. Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US6774125B2 (en) 1998-06-22 2004-08-10 Elan Pharmaceuticals, Inc. Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US6958330B1 (en) 1998-06-22 2005-10-25 Elan Pharmaceuticals, Inc. Polycyclic α-amino-ε-caprolactams and related compounds
US6528505B1 (en) 1998-06-22 2003-03-04 Elan Pharmaceuticals, Inc. Cyclic amino acid compounds pharmaceutical compositions comprising same and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
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JP2004500419A (ja) * 2000-04-11 2004-01-08 デュポン　ファーマシューティカルズ　カンパニー Ａβタンパク質産生阻害剤としての置換ラクタム
US20100009966A1 (en) * 2001-04-11 2010-01-14 Bristol-Myers Squibb Pharma Company Substituted lactams as inhibitors of abeta protein production
CN103554088B (zh) * 2008-02-22 2016-02-24 大塚制药株式会社 苯并二氮杂*化合物及药物组合物
IN2012DN00986A (pt) 2009-08-21 2015-04-10 Otsuka Pharma Co Ltd
TWI481601B (zh) * 2009-08-21 2015-04-21 Otsuka Pharma Co Ltd 含氮化合物及藥學組成物
JP2012184225A (ja) * 2011-02-18 2012-09-27 Otsuka Pharmaceut Co Ltd 医薬組成物
CA3012832A1 (en) 2016-02-05 2017-08-10 Denali Therapeutics Inc. N-azepinyl-carboxamide inhibitors of receptor-interacting protein kinase1
RS63203B1 (sr) 2016-12-09 2022-06-30 Denali Therapeutics Inc Jedinjenja korisna kao inhibitori ripk1
WO2023137035A1 (en) 2022-01-12 2023-07-20 Denali Therapeutics Inc. Crystalline forms of (s)-5-benzyl-n-(5-methyl-4-oxo-2, 3,4,5- tetrahydropyrido [3,2-b] [l,4]oxazepin-3-yl)-4h-l,2,4-triazole-3-carboxamide

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Also Published As

Publication number Publication date
US5691331A (en) 1997-11-25
JPH11506758A (ja) 1999-06-15
ES2151168T3 (es) 2000-12-16
WO1996040655A1 (en) 1996-12-19
AU704015B2 (en) 1999-04-01
EP0832075A1 (en) 1998-04-01
AU5968896A (en) 1996-12-30
PT832075E (pt) 2001-03-30
DE69610628T2 (de) 2001-05-23
CA2222492A1 (en) 1996-12-19
DE69610628D1 (de) 2000-11-16
EP0832075A4 (en) 1998-10-07
GR3034602T3 (en) 2001-01-31
EP0832075B1 (en) 2000-10-11
ATE196899T1 (de) 2000-10-15

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