ATE236888T1 - N-(2,4-dioxo-2,3,4,5-tetrahydro-1h-1,5- benzodiazepin-3-yl)-3-amide - Google Patents

N-(2,4-dioxo-2,3,4,5-tetrahydro-1h-1,5- benzodiazepin-3-yl)-3-amide

Info

Publication number
ATE236888T1
ATE236888T1 AT96916954T AT96916954T ATE236888T1 AT E236888 T1 ATE236888 T1 AT E236888T1 AT 96916954 T AT96916954 T AT 96916954T AT 96916954 T AT96916954 T AT 96916954T AT E236888 T1 ATE236888 T1 AT E236888T1
Authority
AT
Austria
Prior art keywords
benzodiazepine
dioxo
tetrahydro
amide
formula
Prior art date
Application number
AT96916954T
Other languages
English (en)
Inventor
David A Claremon
Nigel Liverton
Harold G Selnick
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Application granted granted Critical
Publication of ATE236888T1 publication Critical patent/ATE236888T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/12—1,5-Benzodiazepines; Hydrogenated 1,5-benzodiazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT96916954T 1995-06-07 1996-06-03 N-(2,4-dioxo-2,3,4,5-tetrahydro-1h-1,5- benzodiazepin-3-yl)-3-amide ATE236888T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/476,301 US5700797A (en) 1995-06-07 1995-06-07 N-(2,4-dioxo-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-3-yl)-3-amides
PCT/US1996/008339 WO1996040654A1 (en) 1995-06-07 1996-06-03 Novel n-(2,4-dioxo-2,3,4,5-tetrahydro-1h-1,5-benzodiazepin-3yl)-3-amides

Publications (1)

Publication Number Publication Date
ATE236888T1 true ATE236888T1 (de) 2003-04-15

Family

ID=23891302

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96916954T ATE236888T1 (de) 1995-06-07 1996-06-03 N-(2,4-dioxo-2,3,4,5-tetrahydro-1h-1,5- benzodiazepin-3-yl)-3-amide

Country Status (9)

Country Link
US (1) US5700797A (de)
EP (1) EP0842156B1 (de)
JP (1) JPH11506746A (de)
AT (1) ATE236888T1 (de)
AU (1) AU703665B2 (de)
CA (1) CA2222472A1 (de)
DE (1) DE69627344T2 (de)
ES (1) ES2194102T3 (de)
WO (1) WO1996040654A1 (de)

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US6774125B2 (en) 1998-06-22 2004-08-10 Elan Pharmaceuticals, Inc. Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US6552013B1 (en) 1998-06-22 2003-04-22 Elan Pharmaceuticals, Inc. Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US6528505B1 (en) 1998-06-22 2003-03-04 Elan Pharmaceuticals, Inc. Cyclic amino acid compounds pharmaceutical compositions comprising same and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US6958330B1 (en) 1998-06-22 2005-10-25 Elan Pharmaceuticals, Inc. Polycyclic α-amino-ε-caprolactams and related compounds
US6509331B1 (en) 1998-06-22 2003-01-21 Elan Pharmaceuticals, Inc. Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US6569851B1 (en) 1998-06-22 2003-05-27 Elan Pharmaceutials, Inc. Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
UA103018C2 (uk) 2008-02-22 2013-09-10 Оцука Фармасьютікал Ко., Лтд. Сполуки бензодіазепіну і фармацевтична композиція
TWI481601B (zh) 2009-08-21 2015-04-21 Otsuka Pharma Co Ltd 含氮化合物及藥學組成物
JP5649577B2 (ja) 2009-08-21 2015-01-07 大塚製薬株式会社 ベンゾ［ｂ］［１，４］ジアゼピン−２，４−ジオン化合物の製造方法
KR20180114910A (ko) 2016-02-05 2018-10-19 데날리 테라퓨틱스 인크. 수용체-상호작용 단백질 키나제 1의 억제제
WO2018107060A1 (en) 2016-12-09 2018-06-14 Denali Therapeutics Inc. Compounds, compositions and methods
US11999750B2 (en) 2022-01-12 2024-06-04 Denali Therapeutics Inc. Crystalline forms of (S)-5-benzyl-N-(5-methyl-4-oxo-2,3,4,5-tetrahydropyrido [3,2-B][1,4]oxazepin-3-yl)-4H-1,2,4-triazole-3-carboxamide

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US4692522A (en) * 1985-04-01 1987-09-08 Merck & Co., Inc. Benzofused lactams useful as cholecystokinin antagonists
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EP0538945A1 (de) * 1991-10-24 1993-04-28 Glaxo Group Limited Benzodiazepinderivate, und ihre Verwendung als Gastrin und/oder Cholecystokinin-Antagonisten
US5428031A (en) * 1991-12-03 1995-06-27 Merck & Co., Inc. Methods of treating cardiac arrhythmia
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Also Published As

Publication number Publication date
DE69627344T2 (de) 2003-12-04
US5700797A (en) 1997-12-23
JPH11506746A (ja) 1999-06-15
DE69627344D1 (de) 2003-05-15
EP0842156B1 (de) 2003-04-09
EP0842156A1 (de) 1998-05-20
WO1996040654A1 (en) 1996-12-19
CA2222472A1 (en) 1996-12-19
ES2194102T3 (es) 2003-11-16
AU5966496A (en) 1996-12-30
AU703665B2 (en) 1999-04-01
EP0842156A4 (de) 1998-11-11

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