ZW985A1 - Imidazodiazepine derivatives - Google Patents
Imidazodiazepine derivativesInfo
- Publication number
- ZW985A1 ZW985A1 ZW9/85A ZW985A ZW985A1 ZW 985 A1 ZW985 A1 ZW 985A1 ZW 9/85 A ZW9/85 A ZW 9/85A ZW 985 A ZW985 A ZW 985A ZW 985 A1 ZW985 A1 ZW 985A1
- Authority
- ZW
- Zimbabwe
- Prior art keywords
- signifies
- image
- lower alkyl
- hydrogen
- propenylene
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/14—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Neurology (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pain & Pain Management (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Anesthesiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Lubricants (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
Abstract
There is presented compounds of the formula <IMAGE> I wherein A together with the two carbon atoms denoted by alpha and beta signifies one of the groups <IMAGE> (1) <IMAGE> (2) <IMAGE> (3) and <IMAGE> (4) and the dotted line signifies the double bond present in cases (1), (2) and (4) and wherein R1 signifies a 5- or 6-membered aromatic heterocyclic group or the group -C(R6)=NOR7(B), R2 signifies hydrogen and R3 signifies hydrogen or lower alkyl or R2 and R3 together signify dimethylene, trimethylene or propenylene, R4 and R5 each signify hydrogen, halogen, trifluoromethyl, cyano, nitro, amino or lower alkyl, R6 signifies hydrogen or lower alkyl and R7 signifies lower alkyl, the compound of formula I having the (S) or (R,S) configuration with reference to the carbon atom denoted by gamma when R2 and R3 together signify dimethylene, trimethylene or propenylene, and pharmaceutically acceptable acid addition salts thereof have a pronounced affinity to the central benzodiazepine receptors and have anxiolytic, anticonvulsant, muscle relaxant and sedative-hypnotic properties.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH22584 | 1984-01-19 | ||
CH314984 | 1984-06-29 | ||
CH512384 | 1984-10-26 |
Publications (1)
Publication Number | Publication Date |
---|---|
ZW985A1 true ZW985A1 (en) | 1985-08-28 |
Family
ID=27171919
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZW9/85A ZW985A1 (en) | 1984-01-19 | 1985-01-16 | Imidazodiazepine derivatives |
Country Status (20)
Country | Link |
---|---|
US (1) | US4775671A (en) |
EP (1) | EP0150040B1 (en) |
JP (1) | JPH0657710B2 (en) |
AT (1) | ATE110726T1 (en) |
AU (1) | AU577079B2 (en) |
CA (1) | CA1252462A (en) |
CS (2) | CS249146B2 (en) |
DE (1) | DE3587913D1 (en) |
DK (1) | DK24585A (en) |
DO (1) | DOP1985004334A (en) |
ES (2) | ES8604964A1 (en) |
FI (1) | FI850191L (en) |
HU (1) | HU195818B (en) |
IL (1) | IL74070A (en) |
MC (1) | MC1640A1 (en) |
NO (1) | NO850232L (en) |
NZ (1) | NZ210850A (en) |
PH (1) | PH21052A (en) |
PT (1) | PT79845B (en) |
ZW (1) | ZW985A1 (en) |
Families Citing this family (41)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3477669D1 (en) * | 1983-09-26 | 1989-05-18 | Nissan Chemical Ind Ltd | Dihydropyridine-5-phosphonic acid cyclic ester |
CA1259612A (en) * | 1985-02-28 | 1989-09-19 | Emilio Kyburz | Imidazodiazepine derivatives |
AU587802B2 (en) * | 1985-03-08 | 1989-08-31 | Ferrosan A/S | Novel oxadiazolyl imidazobenzodiazepine derivatives and methods of preparing such compounds |
GB2174695A (en) * | 1985-05-08 | 1986-11-12 | Merck Sharp & Dohme | Heteroanalogs of imidazobenzodiazepines |
ATE38671T1 (en) * | 1985-05-17 | 1988-12-15 | Ferrosan As | OXADIAZOLYLIMIDAZOBENZODIAZEPINE, PROCESS FOR THEIR MANUFACTURE AND PHARMACEUTICAL PREPARATIONS. |
US4771051A (en) * | 1985-05-17 | 1988-09-13 | A/S Ferrosan | 3-substituted-4,5-dihydro-5-oxo imidazoquinazolines, their preparation, and their use in treating benzodiazepin receptor-related ailments |
DK476885D0 (en) * | 1985-10-17 | 1985-10-17 | Ferrosan As | HETEROCYCLIC RELATIONS AND PROCEDURES FOR PREPARING IT |
AU594676B2 (en) * | 1985-05-17 | 1990-03-15 | Novo Nordisk A/S | Oxadiazolyl imidazobenaodiazepine compound, pharmaceutical composition containing said compound, method of preparing said compound and method of treating a central nervous system ailment |
US4745112A (en) * | 1985-05-17 | 1988-05-17 | A/S Ferrosan | Oxadiazolylimidazobenzodiazepine, compositions, and method III |
US4622320A (en) * | 1985-05-17 | 1986-11-11 | As Ferrosan | Oxadiazolylimidazobenzodiazepine, compositions, and method |
DK174086D0 (en) * | 1986-04-16 | 1986-04-16 | Ferrosan As | NEW BENZODIAZEPINE DERIVATIVES AND PROCEDURES FOR PREPARING THE SAME |
ZA881538B (en) * | 1987-03-10 | 1988-09-12 | F. Hoffmann-La Roche & Co. Aktiengesellschaft | Imidazodiazepine derivatives |
FI880814A (en) * | 1987-03-10 | 1988-09-11 | Hoffmann La Roche | IMIDAZODIAZEPIN-derivate. |
CA1327572C (en) * | 1988-08-31 | 1994-03-08 | F. Hoffmann-La Roche Ag | Imidazodiazepine derivatives |
GB8823475D0 (en) * | 1988-10-06 | 1988-11-16 | Merck Sharp & Dohme | Chemical compounds |
CA2015336A1 (en) * | 1989-05-19 | 1990-11-19 | F. Hoffmann-La Roche Ag | Imidazodiazepines for the treatment of neurological symptoms |
US4939139A (en) * | 1989-07-26 | 1990-07-03 | Merck & Co., Inc. | 7-chloro-5,6-dihydro-3-(5-(1,2-dihydroxy-isopropyl)-1,2,4-oxadiazol-3-yl)-5-methyl-6-oxo-4H-imidazo[1,5A][1,4]benzodiazepine |
US4904654A (en) * | 1989-07-26 | 1990-02-27 | Merck & Co., Inc. | 7-chloro-5,6-dihydro-3-(5-(2-hydroxy-isopropyl)-1,2,4-oxadiazol-3-yl)-5-methyl-6-oxo-4H-imidazo[1,5a][1,4]benzodiazepine |
GB8923008D0 (en) * | 1989-10-12 | 1989-11-29 | Roussel Lab Ltd | Chemical compounds |
GB8927928D0 (en) * | 1989-12-11 | 1990-02-14 | Roussel Lab Ltd | Chemical compounds |
TW201311B (en) * | 1991-06-17 | 1993-03-01 | Hoffmann La Roche | |
US5428031A (en) * | 1991-12-03 | 1995-06-27 | Merck & Co., Inc. | Methods of treating cardiac arrhythmia |
US5453424A (en) * | 1993-11-22 | 1995-09-26 | Merck & Co., Inc. | Furanodiazepines |
US5439906A (en) * | 1993-11-22 | 1995-08-08 | Merck & Co., Inc. | Antiarrhythmic benzodiazepines |
ATE206402T1 (en) * | 1993-11-22 | 2001-10-15 | Merck & Co Inc | 3-ACYLAMINOBENZAZEPINE |
CA2143246C (en) * | 1994-03-16 | 2000-08-22 | Thierry Godel | Imidazodiazepines |
HU220635B1 (en) * | 1994-08-18 | 2002-03-28 | Merck & Co. Inc. | 2,3-dihydro-1-(2,2,2-trifluoroethyl)-2-oxo-5-phenyl-1h-1,4-benzodiazepines, pharmaceutical compositions containing them and their use for preparation of pharmaceutical compositions |
TW349100B (en) * | 1994-11-11 | 1999-01-01 | Hoffmann La Roche | Oxazolyl- and thiazolylimidazo-benzo- and thienodiazepines |
US5631251A (en) * | 1995-06-07 | 1997-05-20 | Merck & Co., Inc. | 5-cyclopropyl-1,4 benzodiazepine-2-ones |
US5700797A (en) * | 1995-06-07 | 1997-12-23 | Merck & Co, Inc. | N-(2,4-dioxo-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-3-yl)-3-amides |
JPH11506760A (en) * | 1995-06-07 | 1999-06-15 | メルク エンド カンパニー インコーポレーテッド | Novel N- (2,4-dioxo-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-3-yl) -3-amide |
US5691331A (en) * | 1995-06-07 | 1997-11-25 | Merck & Co., Inc. | N-(2,4-Dioxo-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-3yl) -3- amides |
US5726171A (en) * | 1995-06-07 | 1998-03-10 | Merck & Co Inc | N-(1-alkyl-5-phenyl-2,3,4,5-tetrahydro-1H-benzo B! 1,4!diazepin-3yl)-acetamides |
JP5117192B2 (en) | 2004-10-12 | 2013-01-09 | エフ.ホフマン−ラ ロシュ アーゲー | Substituted benzodiazepine derivatives |
CA2584757C (en) | 2004-10-20 | 2012-07-03 | F. Hoffmann-La Roche Ag | Halogen substituted benzodiazepine derivatives |
RU2007112940A (en) | 2004-10-20 | 2008-11-27 | Ф.Хоффманн-Ля Рош Аг (Ch) | IMIDAZOBENBENZODIAZEPINE DERIVATIVES |
CA2590333C (en) | 2004-12-14 | 2013-01-08 | F. Hoffmann-La Roche Ag | Tetracyclic imidazo-benzodiazepines as gaba receptors modulators |
AU2006276998A1 (en) * | 2005-05-16 | 2007-02-15 | Wisys Technology Foundation, Inc. | Gabaergic agents to treat memory deficits |
BRPI0815579A2 (en) | 2007-08-20 | 2015-02-18 | Evotec Neurosciences Gmbh | SLEEP DISORDER TREATMENT |
US20090054412A1 (en) * | 2007-08-20 | 2009-02-26 | John Alan Kemp | Treatment of Sleep Disorders |
UA110640C2 (en) | 2011-05-05 | 2016-01-25 | Янссен Фармацевтика Нв | Antifungal 5,6-dihydro-4h-pyrrolo-[l,2-a][l,4]benzodiazepines and 6h-pyrrolo[1,2-a][l,4]benzodiazepines substituted with heterocyclic derivatives |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4031079A (en) * | 1975-09-22 | 1977-06-21 | Mcneil Laboratories, Incorporated | Intermediates for 2-aminobenzodiazepine-5-ones |
ZA806016B (en) * | 1979-10-04 | 1981-09-30 | Hoffmann La Roche | Imidazodiazepine derivatives |
CA1143728A (en) * | 1979-10-04 | 1983-03-29 | Max Gerecke | Imidazodiazepine derivatives |
JPS57123180A (en) * | 1980-12-17 | 1982-07-31 | Schering Ag | 3-substituted beta-carboline, manufacture and psychotropic drug containing same |
CA1184175A (en) * | 1981-02-27 | 1985-03-19 | Walter Hunkeler | Imidazodiazepines |
CA1174673A (en) * | 1981-02-27 | 1984-09-18 | Walter Hunkeler | Imidazodiazepines |
CA1185602A (en) * | 1981-02-27 | 1985-04-16 | Emilio Kyburz | Imidazodiazepines |
US4352817A (en) * | 1981-02-27 | 1982-10-05 | Hoffmann-La Roche Inc. | Imidazo-diazepines and their use |
CA1185601A (en) * | 1981-02-27 | 1985-04-16 | Walter Hunkeler | Imidazodiazepines |
CA1173441A (en) * | 1981-02-27 | 1984-08-28 | Hoffmann-La Roche Limited | Imidazodiazepines |
MC1528A1 (en) * | 1982-07-21 | 1984-04-13 | Hoffmann La Roche | IMIDAZOBENZODIAZEPINES |
DK151808C (en) * | 1982-11-16 | 1988-06-20 | Ferrosan As | ANALOGY PROCEDURE FOR THE PREPARATION OF OXADIAZOLYLIMIDAZO-OE1,4AA-BENZODIAZEPINE DERIVATIVES |
AU587802B2 (en) * | 1985-03-08 | 1989-08-31 | Ferrosan A/S | Novel oxadiazolyl imidazobenzodiazepine derivatives and methods of preparing such compounds |
US4622320A (en) * | 1985-05-17 | 1986-11-11 | As Ferrosan | Oxadiazolylimidazobenzodiazepine, compositions, and method |
-
1985
- 1985-01-16 CS CS85295A patent/CS249146B2/en unknown
- 1985-01-16 CS CS856106A patent/CS249148B2/en unknown
- 1985-01-16 CA CA000472158A patent/CA1252462A/en not_active Expired
- 1985-01-16 FI FI850191A patent/FI850191L/en not_active Application Discontinuation
- 1985-01-16 IL IL74070A patent/IL74070A/en unknown
- 1985-01-16 DE DE3587913T patent/DE3587913D1/en not_active Expired - Fee Related
- 1985-01-16 NZ NZ210850A patent/NZ210850A/en unknown
- 1985-01-16 AT AT85100381T patent/ATE110726T1/en not_active IP Right Cessation
- 1985-01-16 ZW ZW9/85A patent/ZW985A1/en unknown
- 1985-01-16 EP EP85100381A patent/EP0150040B1/en not_active Expired - Lifetime
- 1985-01-17 AU AU37754/85A patent/AU577079B2/en not_active Ceased
- 1985-01-17 DO DO1985004334A patent/DOP1985004334A/en unknown
- 1985-01-17 PH PH31734A patent/PH21052A/en unknown
- 1985-01-17 MC MC851754A patent/MC1640A1/en unknown
- 1985-01-17 JP JP60005127A patent/JPH0657710B2/en not_active Expired - Lifetime
- 1985-01-18 HU HU85212A patent/HU195818B/en not_active IP Right Cessation
- 1985-01-18 PT PT79845A patent/PT79845B/en unknown
- 1985-01-18 DK DK24585A patent/DK24585A/en not_active Application Discontinuation
- 1985-01-18 ES ES539663A patent/ES8604964A1/en not_active Expired
- 1985-01-18 NO NO850232A patent/NO850232L/en unknown
- 1985-10-31 ES ES548399A patent/ES8605791A1/en not_active Expired
-
1987
- 1987-11-18 US US07/122,106 patent/US4775671A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
HU195818B (en) | 1988-07-28 |
IL74070A (en) | 1988-12-30 |
MC1640A1 (en) | 1986-01-09 |
ES8604964A1 (en) | 1986-03-01 |
CS249146B2 (en) | 1987-03-12 |
NO850232L (en) | 1985-07-22 |
PT79845A (en) | 1985-02-01 |
AU3775485A (en) | 1985-07-25 |
CA1252462A (en) | 1989-04-11 |
AU577079B2 (en) | 1988-09-15 |
JPH0657710B2 (en) | 1994-08-03 |
IL74070A0 (en) | 1985-04-30 |
ES8605791A1 (en) | 1986-04-01 |
FI850191A0 (en) | 1985-01-16 |
ES548399A0 (en) | 1986-04-01 |
US4775671A (en) | 1988-10-04 |
ES539663A0 (en) | 1986-03-01 |
ATE110726T1 (en) | 1994-09-15 |
FI850191L (en) | 1985-07-20 |
DE3587913D1 (en) | 1994-10-06 |
DK24585A (en) | 1985-07-20 |
EP0150040B1 (en) | 1994-08-31 |
NZ210850A (en) | 1988-10-28 |
EP0150040A2 (en) | 1985-07-31 |
DK24585D0 (en) | 1985-01-18 |
PH21052A (en) | 1987-07-03 |
JPS60161989A (en) | 1985-08-23 |
EP0150040A3 (en) | 1986-07-30 |
PT79845B (en) | 1986-12-18 |
HUT36796A (en) | 1985-10-28 |
DOP1985004334A (en) | 1990-09-13 |
CS249148B2 (en) | 1987-03-12 |
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