DK0828726T3 - Tricykliske inhibitorer af matrixmetalloproteinaser - Google Patents

Tricykliske inhibitorer af matrixmetalloproteinaser

Info

Publication number
DK0828726T3
DK0828726T3 DK96913185T DK96913185T DK0828726T3 DK 0828726 T3 DK0828726 T3 DK 0828726T3 DK 96913185 T DK96913185 T DK 96913185T DK 96913185 T DK96913185 T DK 96913185T DK 0828726 T3 DK0828726 T3 DK 0828726T3
Authority
DK
Denmark
Prior art keywords
matrix metalloproteinases
gelatinase
inhibitors
tricyclic inhibitors
tricyclic
Prior art date
Application number
DK96913185T
Other languages
Danish (da)
English (en)
Inventor
Andrew David White
Donald Hupe
Joseph Armand Picard
Linda Lea Johnson
Qi-Zhuang Ye
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/460,437 external-priority patent/US5627206A/en
Priority claimed from US08/460,436 external-priority patent/US5665764A/en
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Application granted granted Critical
Publication of DK0828726T3 publication Critical patent/DK0828726T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/91Dibenzofurans; Hydrogenated dibenzofurans
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DK96913185T 1995-06-02 1996-04-26 Tricykliske inhibitorer af matrixmetalloproteinaser DK0828726T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/460,437 US5627206A (en) 1995-06-02 1995-06-02 Tricyclic inhibitor of matrix metalloproteinases
US08/460,436 US5665764A (en) 1995-06-02 1995-06-02 Tricyclic inhibitors of matrix metalloproteinases
PCT/US1996/005830 WO1996038434A1 (en) 1995-06-02 1996-04-26 Tricyclic inhibitors of matrix metalloproteinases

Publications (1)

Publication Number Publication Date
DK0828726T3 true DK0828726T3 (da) 2002-01-21

Family

ID=27039692

Family Applications (1)

Application Number Title Priority Date Filing Date
DK96913185T DK0828726T3 (da) 1995-06-02 1996-04-26 Tricykliske inhibitorer af matrixmetalloproteinaser

Country Status (13)

Country Link
EP (1) EP0828726B1 (de)
JP (1) JPH11506097A (de)
KR (1) KR19990022171A (de)
AT (1) ATE206416T1 (de)
AU (1) AU717570B2 (de)
CA (1) CA2220040A1 (de)
DE (1) DE69615680T2 (de)
DK (1) DK0828726T3 (de)
ES (1) ES2165496T3 (de)
MX (1) MX9708728A (de)
PT (1) PT828726E (de)
WO (1) WO1996038434A1 (de)
ZA (1) ZA964508B (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0931045A1 (de) * 1996-09-04 1999-07-28 Warner-Lambert Company Inhibitoren von matrix-metallproteinasen und ihre therapeutische anwendung
US6624177B1 (en) 1996-09-04 2003-09-23 Warner-Lambert Company Matrix metalloproteinase inhibitors and their therapeutic uses
AU736347B2 (en) 1996-09-04 2001-07-26 Warner-Lambert Company Compounds for and a method of inhibiting matrix metalloproteinases
JP2001526631A (ja) * 1996-12-09 2001-12-18 ワーナー−ランバート・コンパニー 心不全および心拡張症の治療および予防方法
EP1366765A1 (de) * 1996-12-17 2003-12-03 Warner-Lambert Company Llc VerWendung von Matrix-Metalloproteinase Inhibitoren zur Behandlung von neurologischen Erkrankungen und zur Förderung der Wundheilung
ES2212142T3 (es) * 1996-12-17 2004-07-16 Warner-Lambert Company Llc Uso de inhibidores de metaloproteinasas de la matriz para promover la curacion de heridas.
WO1999018079A1 (en) * 1997-10-06 1999-04-15 Warner-Lambert Company Heteroaryl butyric acids and their derivatives as inhibitors of matrix metalloproteinases
AU758619B2 (en) 1998-07-30 2003-03-27 Warner-Lambert Company Tricyclic sulfonamides and their derivatives as inhibitors of matrix metalloproteinases
AU4229499A (en) * 1998-07-30 2000-02-21 Warner-Lambert Company Tricyclic heteroaromatics and their derivatives as inhibitors of matrix metalloproteinases
DOP2002000334A (es) * 2001-02-14 2002-08-30 Warner Lambert Co Pirimidinas biciclicas como inhibidores de metaloproteinasas de matriz
WO2004014880A1 (en) * 2002-08-13 2004-02-19 Warner-Lambert Company Llc Chromone derivatives as matrix metalloproteinase inhibitors
ME00594B (me) * 2006-08-22 2011-12-20 Ranbaxy Laboratories Ltd Inhibitori matriksne metaloproteinaze

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3649651A (en) * 1969-07-02 1972-03-14 American Home Prod Dibenzofuran derivatives and preparation thereof
US5326760A (en) * 1992-06-29 1994-07-05 Glaxo, Inc. Aminobutanoic acid compounds having metalloprotease inhibiting properties

Also Published As

Publication number Publication date
AU717570B2 (en) 2000-03-30
ES2165496T3 (es) 2002-03-16
ZA964508B (en) 1996-12-09
EP0828726A1 (de) 1998-03-18
KR19990022171A (ko) 1999-03-25
PT828726E (pt) 2002-03-28
CA2220040A1 (en) 1996-12-05
ATE206416T1 (de) 2001-10-15
DE69615680T2 (de) 2002-07-11
WO1996038434A1 (en) 1996-12-05
EP0828726B1 (de) 2001-10-04
DE69615680D1 (de) 2001-11-08
AU5577796A (en) 1996-12-18
JPH11506097A (ja) 1999-06-02
MX9708728A (es) 1997-12-31

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