DE69615680D1 - Trizyklische verbindungen als matrix-metalloproteinase inhibitoren - Google Patents
Trizyklische verbindungen als matrix-metalloproteinase inhibitorenInfo
- Publication number
- DE69615680D1 DE69615680D1 DE69615680T DE69615680T DE69615680D1 DE 69615680 D1 DE69615680 D1 DE 69615680D1 DE 69615680 T DE69615680 T DE 69615680T DE 69615680 T DE69615680 T DE 69615680T DE 69615680 D1 DE69615680 D1 DE 69615680D1
- Authority
- DE
- Germany
- Prior art keywords
- tricyclic compounds
- matrix metalloproteinase
- metalloproteinase inhibitors
- gelatinase
- inhibitors
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/91—Dibenzofurans; Hydrogenated dibenzofurans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/460,436 US5665764A (en) | 1995-06-02 | 1995-06-02 | Tricyclic inhibitors of matrix metalloproteinases |
US08/460,437 US5627206A (en) | 1995-06-02 | 1995-06-02 | Tricyclic inhibitor of matrix metalloproteinases |
PCT/US1996/005830 WO1996038434A1 (en) | 1995-06-02 | 1996-04-26 | Tricyclic inhibitors of matrix metalloproteinases |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69615680D1 true DE69615680D1 (de) | 2001-11-08 |
DE69615680T2 DE69615680T2 (de) | 2002-07-11 |
Family
ID=27039692
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69615680T Expired - Fee Related DE69615680T2 (de) | 1995-06-02 | 1996-04-26 | Trizyklische verbindungen als matrix-metalloproteinase inhibitoren |
Country Status (13)
Country | Link |
---|---|
EP (1) | EP0828726B1 (de) |
JP (1) | JPH11506097A (de) |
KR (1) | KR19990022171A (de) |
AT (1) | ATE206416T1 (de) |
AU (1) | AU717570B2 (de) |
CA (1) | CA2220040A1 (de) |
DE (1) | DE69615680T2 (de) |
DK (1) | DK0828726T3 (de) |
ES (1) | ES2165496T3 (de) |
MX (1) | MX9708728A (de) |
PT (1) | PT828726E (de) |
WO (1) | WO1996038434A1 (de) |
ZA (1) | ZA964508B (de) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ333064A (en) | 1996-09-04 | 2000-11-24 | Warner Lambert Co | Subsituted dibenzofurans as inhibitors of matrix metalloproteinases |
JP2000517341A (ja) * | 1996-09-04 | 2000-12-26 | ワーナー―ランバート・コンパニー | マトリックスメタロプロテイナーゼ阻害剤およびそれらの治療的使用 |
US6624177B1 (en) | 1996-09-04 | 2003-09-23 | Warner-Lambert Company | Matrix metalloproteinase inhibitors and their therapeutic uses |
BR9714385A (pt) * | 1996-12-09 | 2000-05-16 | Warner Lambert Co | Método para tratamento e prevenção de deficiência cardìaca e dilatação ventricular |
EP1366765A1 (de) * | 1996-12-17 | 2003-12-03 | Warner-Lambert Company Llc | VerWendung von Matrix-Metalloproteinase Inhibitoren zur Behandlung von neurologischen Erkrankungen und zur Förderung der Wundheilung |
EP0946166B1 (de) * | 1996-12-17 | 2004-02-18 | Warner-Lambert Company LLC | Verwendung von matrix-metalloproteinase inhibitoren zur förderung der wundheilung |
US6399612B1 (en) | 1997-10-06 | 2002-06-04 | Warner-Lambert Company | Heteroaryl butyric acids and their derivatives as inhibitors of matrix metalloproteinases |
WO2000006560A1 (en) * | 1998-07-30 | 2000-02-10 | Warner-Lambert Company | Tricyclic heteroaromatics and their derivatives as inhibitors of matrix metalloproteinases |
ES2216614T3 (es) | 1998-07-30 | 2004-10-16 | Warner-Lambert Company Llc | Sulfonamidas triciclicas y sus derivados como inhibidores de metaloproteinasas de matriz. |
DOP2002000334A (es) * | 2001-02-14 | 2002-08-30 | Warner Lambert Co | Pirimidinas biciclicas como inhibidores de metaloproteinasas de matriz |
AU2003253150A1 (en) * | 2002-08-13 | 2004-02-25 | Warner-Lambert Company Llc | Chromone derivatives as matrix metalloproteinase inhibitors |
EA016567B1 (ru) * | 2006-08-22 | 2012-05-30 | Ранбакси Лабораториз Лимитед | Ингибиторы матриксных металлопротеиназ |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3649651A (en) * | 1969-07-02 | 1972-03-14 | American Home Prod | Dibenzofuran derivatives and preparation thereof |
US5326760A (en) * | 1992-06-29 | 1994-07-05 | Glaxo, Inc. | Aminobutanoic acid compounds having metalloprotease inhibiting properties |
-
1996
- 1996-04-26 CA CA002220040A patent/CA2220040A1/en not_active Abandoned
- 1996-04-26 JP JP8536475A patent/JPH11506097A/ja not_active Abandoned
- 1996-04-26 MX MX9708728A patent/MX9708728A/es not_active IP Right Cessation
- 1996-04-26 AU AU55777/96A patent/AU717570B2/en not_active Ceased
- 1996-04-26 WO PCT/US1996/005830 patent/WO1996038434A1/en not_active Application Discontinuation
- 1996-04-26 KR KR1019970708650A patent/KR19990022171A/ko not_active Application Discontinuation
- 1996-04-26 PT PT96913185T patent/PT828726E/pt unknown
- 1996-04-26 EP EP96913185A patent/EP0828726B1/de not_active Expired - Lifetime
- 1996-04-26 DK DK96913185T patent/DK0828726T3/da active
- 1996-04-26 ES ES96913185T patent/ES2165496T3/es not_active Expired - Lifetime
- 1996-04-26 AT AT96913185T patent/ATE206416T1/de not_active IP Right Cessation
- 1996-04-26 DE DE69615680T patent/DE69615680T2/de not_active Expired - Fee Related
- 1996-05-31 ZA ZA964508A patent/ZA964508B/xx unknown
Also Published As
Publication number | Publication date |
---|---|
KR19990022171A (ko) | 1999-03-25 |
EP0828726A1 (de) | 1998-03-18 |
DK0828726T3 (da) | 2002-01-21 |
AU717570B2 (en) | 2000-03-30 |
ATE206416T1 (de) | 2001-10-15 |
JPH11506097A (ja) | 1999-06-02 |
AU5577796A (en) | 1996-12-18 |
DE69615680T2 (de) | 2002-07-11 |
CA2220040A1 (en) | 1996-12-05 |
PT828726E (pt) | 2002-03-28 |
EP0828726B1 (de) | 2001-10-04 |
MX9708728A (es) | 1997-12-31 |
ES2165496T3 (es) | 2002-03-16 |
WO1996038434A1 (en) | 1996-12-05 |
ZA964508B (en) | 1996-12-09 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IL123901A (en) | Sulfonamide inhibitors of matrix metalloproteinases and pharmaceutical compositions comprising them | |
ATE206416T1 (de) | Trizyklische verbindungen als matrix- metalloproteinase inhibitoren | |
NZ509439A (en) | Tricyclic sulfonamides and their derivatives as inhibitors of matrix metalloproteinases | |
ATE214368T1 (de) | Aromatische keto-säure und ihre derivate als inhibitoren der matrix metalloproteinase | |
ATE277929T1 (de) | Immunsuppressive wirkungen von pteridinderivaten | |
DE69032609T2 (de) | Metalloproteinase-Inhibitoren | |
FI953139A (fi) | Atovakonia käsittäviä farmaseuttisia koostumuksia | |
NO972391D0 (no) | 2-substituerte 1,2,5-tiadiazolidin-3-on 1,1-dioksider og preparater og metoder for anvendelse derav | |
WO2001012592A3 (en) | Hydroxamic acid compounds useful as matrix metalloproteinase inhibitors | |
DE69824748D1 (de) | Pharmazeutische zusammensetzung für die behandlung von enzündlichen darmerkrankungen | |
NO20000771D0 (no) | Anvendelse av fankinon for behandling av Alzheimers sykdom | |
CA2233560A1 (en) | Sulfonamide inhibitors of matrix metalloproteinases | |
FR2691360B1 (fr) | Compositions pharmaceutiques destinees en particulier au traitement des poches parondontales et procede de fabrication. | |
EA199800372A1 (ru) | Новые макроциклические соединения-ингибиторы |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |