DE69032609T2 - Metalloproteinase-Inhibitoren - Google Patents
Metalloproteinase-InhibitorenInfo
- Publication number
- DE69032609T2 DE69032609T2 DE69032609T DE69032609T DE69032609T2 DE 69032609 T2 DE69032609 T2 DE 69032609T2 DE 69032609 T DE69032609 T DE 69032609T DE 69032609 T DE69032609 T DE 69032609T DE 69032609 T2 DE69032609 T2 DE 69032609T2
- Authority
- DE
- Germany
- Prior art keywords
- metalloproteinase inhibitors
- disclosed
- methods
- metalloproteinase
- analogs
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/8146—Metalloprotease (E.C. 3.4.24) inhibitors, e.g. tissue inhibitor of metallo proteinase, TIMP
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/38—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against protease inhibitors of peptide structure
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/10—Plasmid DNA
- C12N2800/108—Plasmid DNA episomal vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2840/00—Vectors comprising a special translation-regulating system
- C12N2840/44—Vectors comprising a special translation-regulating system being a specific part of the splice mechanism, e.g. donor, acceptor
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Lubricants (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/355,027 US7994136B1 (en) | 1989-05-19 | 1989-05-19 | Metalloproteinase inhibitor |
US50190490A | 1990-03-29 | 1990-03-29 |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69032609D1 DE69032609D1 (de) | 1998-10-08 |
DE69032609T2 true DE69032609T2 (de) | 1999-05-06 |
Family
ID=26998675
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69032609T Expired - Lifetime DE69032609T2 (de) | 1989-05-19 | 1990-05-18 | Metalloproteinase-Inhibitoren |
Country Status (12)
Country | Link |
---|---|
US (1) | US6946264B1 (de) |
EP (2) | EP0623676A1 (de) |
JP (1) | JP2877509B2 (de) |
AT (1) | ATE170560T1 (de) |
AU (1) | AU648505B2 (de) |
CA (1) | CA2017166C (de) |
DE (1) | DE69032609T2 (de) |
DK (1) | DK0398753T3 (de) |
ES (1) | ES2123495T3 (de) |
HK (1) | HK1008342A1 (de) |
SG (2) | SG43824A1 (de) |
WO (1) | WO1990014363A1 (de) |
Families Citing this family (81)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5714465A (en) * | 1989-05-19 | 1998-02-03 | Amgen Inc. | Method of inhibiting tumor cell dissemination with a metalloproteinase inhibitor |
US5180820A (en) * | 1989-08-30 | 1993-01-19 | Barde Yves Alain | Brain-derived neurotrophic factor |
US7217689B1 (en) | 1989-10-13 | 2007-05-15 | Amgen Inc. | Glycosylation analogs of erythropoietin |
US5389529A (en) * | 1991-06-12 | 1995-02-14 | Regeneron Pharmaceuticals, Inc. | Modified lamβ signal sequence and processes for producing recombinant neurotrophins |
CA2164498C (en) | 1993-07-09 | 2007-09-11 | Paul A. Price | Assay for ykl-40 as a marker for degradation of mammalian connective tissue matrices |
DE69435141D1 (de) * | 1993-07-19 | 2008-10-30 | Angiotech Pharm Inc | Anti-angiogene Mittel und Verfahren zu deren Verwendung |
US6562596B1 (en) | 1993-10-06 | 2003-05-13 | Amgen Inc. | Tissue inhibitor of metalloproteinase type three (TIMP-3) composition and methods |
US5831004A (en) | 1994-10-27 | 1998-11-03 | Affymax Technologies N.V. | Inhibitors of metalloproteases, pharmaceutical compositions comprising same and methods of their use |
US5840698A (en) * | 1994-10-27 | 1998-11-24 | Affymax Technologies N.V. | Inhibitors of collagenase-1 and stormelysin-I metalloproteases, pharmaceutical compositions comprising same and methods of their use |
ATE354638T1 (de) | 1994-12-13 | 2007-03-15 | Human Genome Sciences Inc | Menschlicher gewebsinhibitor von metalloproteinase-4 |
US6544761B2 (en) | 1994-12-13 | 2003-04-08 | Human Genome Sciences, Inc. | Human tissue inhibitor of metalloproteinase-4 |
US6057124A (en) * | 1995-01-27 | 2000-05-02 | Amgen Inc. | Nucleic acids encoding ligands for HEK4 receptors |
IL117175A (en) | 1995-02-20 | 2005-11-20 | Sankyo Co | Osteoclastogenesis inhibitory factor protein |
US6184200B1 (en) | 1995-09-28 | 2001-02-06 | Amgen Inc. | Truncated glial cell line-derived neurotrophic factor |
US7632922B1 (en) | 1995-12-22 | 2009-12-15 | Amgen, Inc. | Osteoprotegerin |
US6369027B1 (en) | 1995-12-22 | 2002-04-09 | Amgen Inc. | Osteoprotegerin |
US6455277B1 (en) | 1996-04-22 | 2002-09-24 | Amgen Inc. | Polynucleotides encoding human glial cell line-derived neurotrophic factor receptor polypeptides |
US7138251B1 (en) | 1996-04-22 | 2006-11-21 | Amgen Inc. | Polynucleotides encoding a neurotrophic factor receptor |
IL129787A0 (en) | 1996-11-06 | 2000-02-29 | Univ California | Isolated tumor necrosis factor receptor releasing enzyme compositions comprising the enzyme and methods of the use thereof |
JP4138013B2 (ja) | 1996-12-23 | 2008-08-20 | イミュネックス・コーポレーション | Tnfスーパーファミリーのメンバーであるnf−kappa bの受容体アクティベーターに対するリガンド |
CA2257247C (en) | 1997-04-15 | 2012-09-11 | Snow Brand Milk Products Co., Ltd. | Novel protein binding to osteoclastogenesis inhibitory factor and process for producing the same |
US5843678A (en) * | 1997-04-16 | 1998-12-01 | Amgen Inc. | Osteoprotegerin binding proteins |
US6316408B1 (en) | 1997-04-16 | 2001-11-13 | Amgen Inc. | Methods of use for osetoprotegerin binding protein receptors |
JP2001525669A (ja) * | 1997-05-12 | 2001-12-11 | ネーデルランセ オルハニサチエ フォール トゥーヘパスト−ナツールウェーテンシャッペルック オンデルズク テーエヌオー | 細胞遊走の阻害のための方法および構築物 |
US6790823B1 (en) | 1998-04-23 | 2004-09-14 | Amgen Inc. | Compositions and methods for the prevention and treatment of cardiovascular diseases |
US7304150B1 (en) | 1998-10-23 | 2007-12-04 | Amgen Inc. | Methods and compositions for the prevention and treatment of anemia |
JP4342027B2 (ja) | 1999-04-01 | 2009-10-14 | オリエンタル酵母工業株式会社 | Timp修飾体 |
US7459540B1 (en) | 1999-09-07 | 2008-12-02 | Amgen Inc. | Fibroblast growth factor-like polypeptides |
US20030103978A1 (en) | 2000-02-23 | 2003-06-05 | Amgen Inc. | Selective binding agents of osteoprotegerin binding protein |
AU2001233957A1 (en) * | 2000-02-24 | 2001-09-03 | Oxford Glycosciences (Uk) Limited | Proteins, genes and their use for diagnosis and treatment of bipolar affective disorder (bad) and unipolar depression |
US7514239B2 (en) | 2000-03-28 | 2009-04-07 | Amgen Inc. | Nucleic acid molecules encoding beta-like glycoprotein hormone polypeptides and heterodimers thereof |
AU2001252278A1 (en) * | 2000-04-05 | 2001-10-15 | Ipf Pharmaceuticals Gmbh | Medicament containing a tissue inhibitor of metalloproteinases-2 (timp-2) as an osteo-anabolically active substance |
ES2317917T3 (es) | 2000-06-28 | 2009-05-01 | Amgen Inc. | Moleculas de receptor de linfopoyetina estromal timica y sus usos de las mismas. |
EP1174129A1 (de) * | 2000-07-17 | 2002-01-23 | Zenner, Hans Peter, Prof. Dr. med. | Verwendung eines Matrix-Metalloproteinase-Inhibitors zur Behandlung von Krebs |
NZ530765A (en) | 2001-06-26 | 2006-11-30 | Amgen Fremont Inc | Antibodies that bind OPGL and compositions and methods for the treatment of bone diseases |
EP2314316A1 (de) | 2002-04-05 | 2011-04-27 | Amgen, Inc | Humane neutralizierende anti-OPGL Antikörper als selektive OPGL Pathway Inhibitoren |
US7786278B2 (en) | 2002-04-09 | 2010-08-31 | Sanofi Pasteur Limited | Modified CEA nucleic acid and expression vectors |
AUPS282002A0 (en) * | 2002-06-06 | 2002-06-27 | Gropep Limited | Metalloproteinase inhibitors |
MXPA05002514A (es) | 2002-09-06 | 2005-05-27 | Amgen Inc | Anticuerpo monoclonal anti-il-1r1 humano terapeutico. |
AU2003285874A1 (en) | 2002-10-16 | 2004-05-04 | Amgen Inc. | HUMAN ANTI-IFN-Gamma NEUTRALIZING ANTIBODIES AS SELECTIVE IFN-Gamma PATHWAY INHIBITORS |
TWI476206B (zh) | 2003-07-18 | 2015-03-11 | Amgen Inc | 對肝細胞生長因子具專一性之結合劑 |
ME00226B (me) | 2004-07-15 | 2011-02-10 | Medarex Llc | Humana anti-ngf neutrališuća antitijela kao selektivni inhibitori ngf signalne kaskade |
MY146381A (en) | 2004-12-22 | 2012-08-15 | Amgen Inc | Compositions and methods relating relating to anti-igf-1 receptor antibodies |
PA8660701A1 (es) | 2005-02-04 | 2006-09-22 | Pfizer Prod Inc | Agonistas de pyy y sus usos |
US7629315B2 (en) | 2005-03-09 | 2009-12-08 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Compositions for blocking the inhibitory effect of human CRP on human leptin |
ES2827247T3 (es) | 2005-06-21 | 2021-05-20 | Xoma Us Llc | Anticuerpos y fragmentos de los mismos que se unen a IL-1beta |
NO345593B1 (no) | 2005-07-18 | 2021-05-03 | Amgen Inc | Humane anti-B7RP1 nøytraliserende antistoffer |
PE20070684A1 (es) | 2005-11-14 | 2007-08-06 | Amgen Inc | MOLECULAS QUIMERICAS DE ANTICUERPO RANKL-PTH/PTHrP |
ATE524493T1 (de) | 2006-07-24 | 2011-09-15 | Biorexis Pharmaceutical Corp | Exendin-fusionsproteine |
TWI573802B (zh) | 2007-03-06 | 2017-03-11 | 安美基公司 | 變異之活動素受體多肽及其用途 |
BRPI0920962A2 (pt) | 2008-11-26 | 2016-07-12 | Amgen Inc | variantes de polipeptídeos receptores de activina iib e usos dos mesmos |
EP2376526A4 (de) | 2008-12-24 | 2013-02-27 | Kingdom Of The Netherlands Represented By The Min Ister Of Health Welfare & Sport On Behalf Of The M | Modifizierte streptococcus pneumoniae pneumolysin (ply)-polypeptide |
EP2668201A2 (de) | 2011-01-28 | 2013-12-04 | Sanofi Pasteur SA | Immunologische zusammensetzungen mit hiv-gp41-polypeptidderivaten |
AU2012212075A1 (en) | 2011-02-02 | 2013-07-18 | Amgen Inc. | Methods and compositons relating to inhibition of IGF-1R |
WO2013022991A2 (en) | 2011-08-08 | 2013-02-14 | Curelab Oncology, Inc. | Methods and compositions relating to p62 for the treatment and prophylaxis of cancer |
US9303071B2 (en) | 2012-09-17 | 2016-04-05 | Novartis Tiergesundheit Ag | Salmonid alphavirus and uses thereof |
US9809863B2 (en) | 2012-11-02 | 2017-11-07 | Elanco Tiergesundheit Ag | Flavivirus associated with Theiler's disease |
SG11201505960VA (en) | 2013-02-01 | 2015-08-28 | Santa Maria Biotherapeutics Inc | Administration of an anti-activin-a compound to a subject |
JOP20140087B1 (ar) | 2013-03-13 | 2021-08-17 | Amgen Inc | بروتينات مخصصة ل baff و b7rp1 وإستخداماتها |
US9458246B2 (en) | 2013-03-13 | 2016-10-04 | Amgen Inc. | Proteins specific for BAFF and B7RP1 |
WO2014140938A2 (en) | 2013-03-14 | 2014-09-18 | Centre Hospitalier Universitaire Vaudois | Immunological methods |
US20160324944A1 (en) | 2013-12-29 | 2016-11-10 | Franco Venanzi | Methods and compositions relating to p62/SQSTM1 for the treatment and prevention of inflammation-associated diseases |
US10571468B2 (en) | 2014-05-09 | 2020-02-25 | One Lambda, Inc. | Modified Fc gamma receptor type III (FCγIII, HNA-1) polypeptides and the uses thereof |
TW201625675A (zh) | 2014-06-13 | 2016-07-16 | 聖塔瑪麗亞生物治療公司 | 經調配之受體多肽及相關方法 |
JP6629321B2 (ja) | 2014-08-05 | 2020-01-15 | マブクエスト エスエーMabQuest SA | 免疫学的試薬 |
KR20180006386A (ko) | 2015-04-22 | 2018-01-17 | 얼라이브젠 유에스에이 인코포레이티드 | 신규한 근육 소모 질환 치료용 하이브리드 actriib 리간드 트랩 단백질 |
WO2017093985A1 (en) | 2015-12-05 | 2017-06-08 | Centre Hospitalier Universitaire Vaudois | Hiv binding agents |
AU2017208819B2 (en) | 2016-01-22 | 2023-10-19 | MabQuest SA | PD1 specific antibodies |
GB201710973D0 (en) | 2017-07-07 | 2017-08-23 | Avacta Life Sciences Ltd | Scaffold proteins |
WO2020012435A1 (en) | 2018-07-13 | 2020-01-16 | Lausanne University Hospital | Hiv binding agents |
JP2022541900A (ja) | 2019-07-15 | 2022-09-28 | ローザンヌ ユニヴァーシティ ホスピタル | Hiv結合剤 |
TW202128775A (zh) | 2019-10-16 | 2021-08-01 | 英商阿法克塔生命科學有限公司 | PD-L1抑制劑-TGFβ抑制劑雙特異性藥物部分 |
GB202101299D0 (en) | 2020-06-09 | 2021-03-17 | Avacta Life Sciences Ltd | Diagnostic polypetides and methods |
TW202206098A (zh) | 2020-08-11 | 2022-02-16 | 美商碩騰服務公司 | 抗冠狀病毒疫苗 |
CN114315985A (zh) | 2020-09-29 | 2022-04-12 | 硕腾服务有限责任公司 | 减毒猪流行性腹泻病毒 |
WO2022234003A1 (en) | 2021-05-07 | 2022-11-10 | Avacta Life Sciences Limited | Cd33 binding polypeptides with stefin a protein |
WO2023034804A1 (en) | 2021-08-31 | 2023-03-09 | Zoetis Services Llc | Attenuated alphavirus |
WO2023057567A1 (en) | 2021-10-07 | 2023-04-13 | Avacta Life Sciences Limited | Pd-l1 binding affimers |
TW202332694A (zh) | 2021-10-07 | 2023-08-16 | 英商阿凡克塔生命科學公司 | 血清半衰期延長之pd-l1結合多肽 |
WO2023108137A1 (en) | 2021-12-10 | 2023-06-15 | Biogen Ma Inc. | Modified actriib proteins and methods of use thereof |
WO2023218243A1 (en) | 2022-05-12 | 2023-11-16 | Avacta Life Sciences Limited | Lag-3/pd-l1 binding fusion proteins |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6936694B1 (en) | 1982-05-06 | 2005-08-30 | Intermune, Inc. | Manufacture and expression of large structural genes |
US4710473A (en) | 1983-08-10 | 1987-12-01 | Amgen, Inc. | DNA plasmids |
EP0188312A3 (de) * | 1985-01-07 | 1988-01-13 | Celltech Limited | Verfahren zur Herstellung eines Proteins |
DE3666826D1 (en) * | 1985-01-18 | 1989-12-14 | Searle & Co | Human natural inhibitor of collagenases |
JPH088870B2 (ja) * | 1985-02-05 | 1996-01-31 | サイナ−ゲン バイオロジカルズ,インコ−ポレ−テツド | メタロプロテイナ−ゼ阻害剤の配列をもつ組換ベクタ−系及びメタロプロテイナ−ゼ阻害剤製造のための組換dna |
JP2609858B2 (ja) * | 1987-02-27 | 1997-05-14 | 富士薬品工業 株式会社 | コラゲナーゼインヒビターの酵素免疫学的定量法 |
EP0464147B1 (de) * | 1989-03-21 | 2002-06-26 | THE UNITED STATES OF AMERICA as represented by the Secretary UNITED STATES DEPARTMENT OF COMMERCE | Matrizenmetalloproteinase-inhibitor-peptide |
ES2060134T3 (es) * | 1989-05-26 | 1994-11-16 | Univ Washington | Inhibidor de tejido de metaloproteasas (timp-2). |
-
1990
- 1990-05-10 WO PCT/US1990/002655 patent/WO1990014363A1/en unknown
- 1990-05-10 JP JP2507615A patent/JP2877509B2/ja not_active Expired - Lifetime
- 1990-05-10 AU AU56388/90A patent/AU648505B2/en not_active Expired
- 1990-05-18 ES ES90305433T patent/ES2123495T3/es not_active Expired - Lifetime
- 1990-05-18 AT AT90305433T patent/ATE170560T1/de not_active IP Right Cessation
- 1990-05-18 DE DE69032609T patent/DE69032609T2/de not_active Expired - Lifetime
- 1990-05-18 DK DK90305433T patent/DK0398753T3/da active
- 1990-05-18 EP EP94109856A patent/EP0623676A1/de not_active Withdrawn
- 1990-05-18 EP EP90305433A patent/EP0398753B1/de not_active Expired - Lifetime
- 1990-05-18 SG SG1996001526A patent/SG43824A1/en unknown
- 1990-05-18 CA CA002017166A patent/CA2017166C/en not_active Expired - Lifetime
- 1990-06-18 SG SG1996001440A patent/SG48766A1/en unknown
-
1995
- 1995-03-02 US US08/397,320 patent/US6946264B1/en not_active Expired - Fee Related
-
1998
- 1998-07-10 HK HK98109066A patent/HK1008342A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
CA2017166A1 (en) | 1990-11-19 |
JPH04500683A (ja) | 1992-02-06 |
AU5638890A (en) | 1990-12-18 |
ES2123495T3 (es) | 1999-01-16 |
HK1008342A1 (en) | 1999-05-07 |
CA2017166C (en) | 2003-10-21 |
WO1990014363A1 (en) | 1990-11-29 |
DE69032609D1 (de) | 1998-10-08 |
EP0398753A3 (de) | 1991-10-16 |
EP0623676A1 (de) | 1994-11-09 |
EP0398753A2 (de) | 1990-11-22 |
JP2877509B2 (ja) | 1999-03-31 |
SG48766A1 (en) | 1998-05-18 |
US6946264B1 (en) | 2005-09-20 |
SG43824A1 (en) | 1997-11-14 |
ATE170560T1 (de) | 1998-09-15 |
DK0398753T3 (da) | 1999-02-01 |
EP0398753B1 (de) | 1998-09-02 |
AU648505B2 (en) | 1994-04-28 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ATE170560T1 (de) | Metalloproteinase-inhibitoren | |
AR227063A1 (es) | Procedimiento para la produccion de nuevos acidos 7-amino-1-ciclopropil-4-oxo-1,4-dihidro-(1,6-y 1,8-naftiridina o quinolina)-3-carboxilicos | |
NO923744L (no) | Nye 2-substituerte indan-2-mercaptoacetylamidderivater anvendbare som inhibitorer av enkefalinase og ace | |
IT8521619A0 (it) | Apparato per profilatura. | |
DE68929460T2 (de) | Substituierte Phenylpyrimidine Derivate, für die Behandlung oder Prevention von ZNS-Erkrankungen | |
ES2138956T3 (es) | Imidazoquinoxalinonas, sus analogos aza y procedimiento para su preparacion. | |
DK0435443T3 (da) | Anvendelse af en 15-ketoprostaglandinforbindelse til forbedring af den encephaliske funktion | |
FI904734A0 (fi) | Anordning foer maetning av tryckdifferens. | |
ITMI921909A0 (it) | Procedimento per il rinnovo di un binario nonche' complesso di macchine | |
IT8820392A0 (it) | Macchina per il ricambio di traversine. | |
ATE56211T1 (de) | 2-phenylbenzoxepin-derivat. | |
FR2454438A1 (fr) | Procede de preparation de 2,5-bis(2,2,2-trifluorethoxy)-n-(2-piperidylmethyl)benzamide | |
DK345588D0 (da) | 1,2-diketo-derivater til anvendelse som renin-inhibitorer | |
FI864246A0 (fi) | N-substituerade 3-piperidin- eller 3-pyridinkarboxylsyror samt deras derivat. | |
IT8520246A0 (it) | Procedimento stereocontrollato per la produzione di acetossiazetidinone. | |
IT1098853B (it) | Processo per la produzione di 1,1,1,2-tetrafluoroetano | |
IT8821725A0 (it) | Elemento costruttivo, nonche' metodo per la produzione dello stesso. | |
IT1204414B (it) | Analoghi di amminoprostaglandine 5,6-epossi-7-ossabicicloeptano sostituite,utili nel trattamento di trombosi | |
IT1063195B (it) | Procedimento per la produzione di un fertilizzante azotato avente un efficacia prolungata | |
IT1172398B (it) | Procedimento per la produzione di 1,2-diclorcetano | |
BR8102920A (pt) | Processo para a producao de 2,3,5-tricloropiridina | |
DK281186D0 (da) | 1,4 dihydropyridinderivater, der er nyttige til behandling af cardiovaskulaere lidelser | |
PT86611A (pt) | Process for the manufacture of n,n-(dibenzohexatrienylene)ureas | |
DE69024869D1 (de) | Wirbelbett zum Abschrecken von Stahldrähten | |
IT1180735B (it) | Procedimento per la produzione di talloni sulle calze,specialmente sui peduli |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |